Thymol

[ironjustice]

Inhibitory effect of thymol on suicidal erythrocyte death.
Mahmud H, Mauro D, Foller M, Lang F.
Cell Physiol Biochem. 2009;24(5-6):407-14. Epub 2009 Nov 4
Department of Physiology, University of Tubingen, Germany.

The antibacterial plant component thymol has antioxidant activity.
Oxidative stress is known to activate Ca(2+)-permeable cation
channels with subsequent Ca(2+) entry, activation of Ca(2+)-sensitive
K(+) channels, cell shrinkage, cell membrane scrambling and
phosphatidylserine exposure at the erythrocyte surface.
Cell shrinkage and phosphatidylserine exposure are typical features
of suicidal erythrocyte death or eryptosis.
Eryptotic cells are cleared from circulating blood thus causing
anemia
and may adhere to the vascular wall thus interfering with the
microcirculation.
The present experiments explored whether thymol interacts with
eryptosis.
Annexin V-binding was utilized to determine phosphatidylserine
exposure, forward scatter to detect alterations of cell volume and
Fluo3
fluorescence to depict changes of the cytosolic Ca(2+) activity.
Oxidative stress (30 min. 0.3 mM tert-butylhydroperoxide), energy
depletion (48 h glucose removal) and isotonic cell shrinkage (48 h
replacement of extracellular Cl(-) with gluconate) significantly
increased
annexin V-binding and decreased the forward scatter, effects
significantly
blunted in the presence of thymol 2.5 - 20 microg/ml.
Thymol is a potent inhibitor of suicidal erythrocyte death
particularly
following oxidative stress.
In conclusion, thymol may be useful in counteracting anemia and
impairment of microcirculation.

2009 S. Karger AG, Basel.

PMID: 19910681

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"ironjustice" <ironj...@rock.com> wrote in message
news:932bc18a-84c5-41ec...@g22g2000prf.googlegroups.com...

good thing it was a German study do i can ignore it