Curcumin Combats Cancer
ironjustice
http://www.medicalnewstoday.com/articles/168987.php
Researchers from Ireland and Poland found that curcumin, a compound
found in the popular Indian spice turmeric that gives curry powder its
distinct yellow colour, killed oesophageal cancer cells in the lab via
an unexpected cell-death mechanism that did not involve apoptosis or
cell suicide.
Moreover, they found that the compound started killing cancer cells
within 24 hours and the cells began to digest themselves.
The study was the work of lead author Dr Sharon McKenna at the Cork
Cancer Research Centre, University College Cork (UCC) in Ireland, and
colleagues, and appears in the 28 October issue of the British Journal
of Cancer.
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Iron chelation in the biological activity of curcumin.
Jiao Y, Wilkinson J, Christine Pietsch E, Buss JL, Wang W, Planalp R,
Torti FM, Torti SV
Free Radic Biol Med. 2006 Apr 1; 40(7): 1152-60
Curcumin is among the more successful chemopreventive compounds
investigated in recent years, and is currently in human trials to
prevent cancer. The mechanism of action of curcumin is complex and
likely multifactorial. We have made the unexpected observation that
curcumin strikingly modulates proteins of iron metabolism in cells
and
in tissues, suggesting that curcumin has properties of an iron
chelator. Curcumin increased mRNA levels of ferritin and GSTalpha in
cultured liver cells. Unexpectedly, however, although levels of
GSTalpha protein increased in parallel with mRNA levels in response
to
curcumin, levels of ferritin protein declined. Since iron chelators
repress ferritin translation, we considered that curcumin may act as
an
iron chelator. To test this hypothesis, we measured the effect of
curcumin on transferrin receptor 1, a protein stabilized under
conditions of iron limitation, as well as the ability of curcumin to
activate iron regulatory proteins (IRPs). Both transferrin receptor 1
and activated IRP, indicators of iron depletion, increased in
response
to curcumin. Consistent with the hypothesis that curcumin acts as an
iron chelator, mice that were fed diets supplemented with curcumin
exhibited a decline in levels of ferritin protein in the liver. These
results suggest that iron chelation may be an additional mode of
action
of curcumin.
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Curcumin as a Possible Lead Compound against Hormone-Independent,
Multidrug-Resistant Breast Cancer
Annals of the New York Academy of SciencesManuela Labbozzetta a ,
Monica Notarbartolo a , Paola Poma a , Annamaria Maurici a ,
Luigi Inguglia a , Paolo Marchetti b , Michele Rizzi b ,
Riccardo Baruchello b , Daniele Simoni b , and Natale D'Alessandro a
a Dipartimento di Scienze Farmacologiche Pietro Benigno,
Universit¨¤ di Palermo, Palermo, Italy
b Dipartimento di Scienze Farmaceutiche, Universit¨¤ di Ferrara,
Ferrara, Italy
Address for correspondence: Prof. Natale D'Alessandro,
Dipartimento di Scienze Farmacologiche Pietro Benigno,
Via del Vespro 129, 90127 Palermo, Italy.
Voice: +39-091-655-3258; fax: +39-091-655-3220. dale...@unipa.it
KEYWORDS
breast cancer * multidrug resistance * hormone-independence * curcumin
* analogues
ABSTRACT
We examine the possible evidence that the phytochemical curcumin
may overcome resistance to hormonal and cytotoxic agents in breast
cancer.
We present our observations on MCF-7R, a multidrug-resistant (MDR)
variantof the MCF-7 breast cancer cell line.
In contrast to MCF-7, MCF-7R lacks aromatase and estrogen receptor
¦Á(ER¦Á) and overexpresses the multidrug transporter ABCB1 and the
products ofdifferent genes implicated in cell proliferation and
survival, like c-IAP-1, NAIP,survivin, and COX-2.
Nevertheless, in cytotoxicity and cell death induction assays, we
found thatthe antitumor activity of curcumin is substantial both in
MCF-7 and inMCF-7R.
We elaborated the diketone system of curcumin into different
analogues; thebenzyloxime and the isoxazole and pyrazole heterocycles
showedremarkableincreases in the antitumor potency both in the
parental
and in the MDRMCF-7 cells.
Furthermore, curcumin or, more potently, the isoxazole analogue,
produced early reductions in the amounts of relevant gene transcripts
that were diverse (i.e., they were relative to Bcl-2 and Bcl-XL in
MCF-7 and the inhibitory of apoptosis proteins and COX-2 in MCF-7R)
in the two cell lines.
Thus, the two compounds exhibited the remarkable property of being
able tomodify their molecular activities according to the distinct
characteristics of the parental and MDR cells.
We discuss also how curcumin may (1) exert antitumor effects in
breast cancer through ER-dependent and ER-independent mechanisms; and
(2) act as a drug transporter-mediated MDR reversal agent.
Overall, the structure of curcumin may represent the basis for the
developmentof new, effective anticancer agents in hormone-independent
MDR breast cancer.
DIGITAL OBJECT IDENTIFIER (DOI)
10.1111/j.1749-6632.2009.03699.x About DOI
Volume 1155 Issue Steroid Enzymes and Cancer, Pages 278 - 283
Published Online: 26 Feb 2009
(c) 2009 The New York Academy of Sciences
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
sp...@dude.com
gut. So having some in the usual spice source is not very effective for
that reason and for the purposes suggested as it is a minor part of
curry powder. There is one substance often found in the kitchen which
greatly increases its absorption and would best be used in the refined
"Curcumin form..
ironjustice
sp...@dude.com
Now why didn't you ask what common substance promotes absorption? We
will give you another chance to ask that question.
ironjustice
"Curcumin is that it is very poorly absorbed from the
gut. <<
I'm not sure where you get your quotes from but that doesn't
appear in the articles ..
On Nov 23, 9:26 am, sp...@dude.com wrote:
Now why didn't you ask what common substance promotes absorption? We
will give you another chance to ask that question. <<
The quote came from one of the .. we's .. you have in your
haid .. ?
sp...@dude.com
gut. So having some in the usual spice source is not very effective for
that reason and for the purposes suggested as it is a minor part of
curry powder. There is one substance often found in the kitchen which
greatly increases its absorption and would best be used in the refined
"Curcumin form..
Now why didn't you ask what common substance promotes absorption? We
will give you another chance to ask that question.
"I'm not sure where you get your quotes from but that doesn't appear in
the articles .."
It comes from my extensive look at the research on it. The article
posted did not ask the question of absorption and how available from
curry powder it is.
Do you want to know the substance that greatly increases absorption?
Reference provided.
Jack Campin - bogus address
> greatly increases its absorption and would best be used in the refined
> "Curcumin form..
> Now why didn't you ask what common substance promotes absorption? We
> will give you another chance to ask that question.
>
> "I'm not sure where you get your quotes from but that doesn't appear in
> the articles .."
>
> It comes from my extensive look at the research on it. The article
> posted did not ask the question of absorption and how available from
> curry powder it is.
>
> Do you want to know the substance that greatly increases absorption?
> Reference provided.
Black pepper, from my extensive look at the label on one packet of
turmeric extract capsules. Why are you making such a grand opera
out of it?
-----------------------------------------------------------------------------
e m a i l : j a c k @ c a m p i n . m e . u k
Jack Campin, 11 Third Street, Newtongrange, Midlothian EH22 4PU, Scotland
mobile 07800 739 557 <http://www.campin.me.uk> Twitter: JackCampin
ironjustice
<bo...@purr.demon.co.uk> wrote:
The problem with "Curcumin is that it is very poorly absorbed from the
gut. [...] There is one substance often found in the kitchen which
greatly increases its absorption and would best be used in the refined
one packet of turmeric extract capsules.<<
Curcumin and Piperine May Help to Prevent Cancer
“Targeting breast stem cells with the cancer preventive
compounds curcumin and piperine,” Kakarala M, Brenner DE, et al,
Breast Cancer Res Treat,
2009 Nov 7;
Division of Hematology/Oncology, Department of Internal
Medicine and Comprehensive Cancer Center,
University of Michigan, 2150 Cancer Center,
1500 E. Medical Center Dr., Ann Arbor, MI, USA.
E-mail: mkak...@umich.edu ).
Summary: In a study involving unsorted breast epithelial
cells, normal cells, and early progenitor cells (selected by
aldehyde dehydrogenase (ALDH) - a breast stem cell marker -
positivity), treatment with the dietary polyphenols, curcumin
(from turmeric) and piperine (from black pepper), individually
and in combination, was found to inhibit mammosphere formation,
serial passaging, and percent of ALDH + cells by 50% at 5 muM
and completely at 10 muM, while Wnt signaling was inhibited by
50% at 5 muM and completely at 10 muM.
Treatment with curcumin and piperine, individually and in
combination, inhibited breast stem cell self-renewal, without
causing toxicity to differentiated cells.
The authors conclude, “These compounds could be potential
cancer preventive agents.
Mammosphere formation assays may be a quantifiable biomarker
to assess cancer preventive agent efficacy and Wnt signaling
assessment can be a mechanistic biomarker for use in human
clinical trials.”
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
>
> -----------------------------------------------------------------------------
> e m a i l : j a c k @ c a m p i n . m e . u k
> Jack Campin, 11 Third Street, Newtongrange, Midlothian EH22 4PU, Scotland
> mobile 07800 739 557 <http://www.campin.me.uk> Twitter: JackCampin- Hide quoted text -
>
> - Show quoted text -
Ken
worthless BS, the truer it becomes
ironjustice
http://www.medicalnewstoday.com/articles/168987.php
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“Targeting breast stem cells with the cancer preventive
compounds curcumin and piperine,” Kakarala M, Brenner DE, et al,
Breast Cancer Res Treat,
2009 Nov 7;
Division of Hematology/Oncology, Department of Internal
Medicine and Comprehensive Cancer Center,
University of Michigan, 2150 Cancer Center,
1500 E. Medical Center Dr., Ann Arbor, MI, USA.
E-mail: mkaka...@umich.edu ).