Oxidative Stress and Osteoporosis
ironjustice
OSTEOPOROSIS
Indian Journal of Clinical Biochemistry, 2007 / 22 (2) 101-105
Sarita N. Chavan, Umesh More, Shruti Mulgund, Vishal Saxena and Alka
N. SontakkeDepartment Of Biochemistry, Pad.
Dr. D.Y. Patil Medical College, Pimpri, Pune-18
ABSTRACT
Osteoporosis encompasses a wide spectrum of conditions associated with
imbalance of osteoclastic and osteoblastic activities.
The increased activity of osteoclasts leads to increased free radical
formation and hence lipid peroxidation.
Present study probes into the role of antioxidants as a palliative
treatment for osteoporosis.
It involved 50 healthy controls and 75 clinically diagnosed
osteoporosis patients.
Both the groups underwent baseline assessment of biochemical markers
viz. osteoblastic markers: serum Alkaline phosphatase,Free or ionic
calcium and Inorganic phosphorus, osteoclastic markers: serum
Tartarate resistant acidphosphatase and Malondialdehyde and the
antioxidant status: serum Superoxide dismutase and Erythrocyte reduced
glutathione.
The osteoporotic group was then divided into groups A (Vitamin E-
Evinal 400 mg), B(Vitamin C- Celin 500 mg), C (Vitamin E+C- Evinal +
Celin) for antioxidant supplementation for a period of 90days.
The results reveal that there is significant fall in concentration of
serum MDA (p< 0.001), TrACP (p<0.01).
Improvement in antioxidant status is reflected by significant rise in
concentration of serum SOD (p<0.001) and erythrocyte GSH (p<0.001)
after 90 days of antioxidant supplementation in osteoporosis.
The findings indicate that on the whole bone status improved with
prolonged antioxidant vitamin supplementation,which can be used as a
palliative treatment for osteoporosis.
The efficacy is not affected whether the vitamins are administered
singly or conjointly.
KEY WORDS Osteoporosis, Antioxidants, Lipid peroxidation
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