Jesus Diet Induces Neurogenesis
ironjustice
neurons
November 24, 2009 Universitat Autňnoma de Barcelona (UAB, Spain)
researchers have confirmed that a diet rich in polyphenols and
polyunsaturated fatty acids, patented as an LMN diet, helps boost the
production of the brain's stem cells -neurogenesis- and strengthens
their differentiation in different types of neuron cells.
The research revealed that mice fed an LMN diet, when compared to
those fed a control diet, have more cell proliferation in the two
areas of the brain where neurogenesis is produced, the olfactory bulb
and the hippocampus, both of which are greatly damaged in patients
with Alzheimer's disease. These results give support to the hypothesis
that a diet made up of foods rich in these antioxidant substances
could delay the onset of this disease or even slow down its evolution.
The study will be published in the December issue of the Journal of
Alzheimer's Disease and was directed by Mercedes Unzeta, professor of
the UAB Department of Biochemistry and Molecular Biology.
Participating in the study were researchers from this department and
from the departments of Cell Biology, Physiology and Immunology, and
of Psychiatry and Legal Medicine, all of which are affiliated centres
of the Institute of Neuroscience of Universitat Autňnoma de Barcelona.
The company La Morella Nuts from Reus and the ACE Foundation of the
Catalan Institute of Applied Neurosciences also collaborated in the
study.
Polyphenols can be found in tea, beer, grapes, wine, olive oil, cocoa,
nuts and other fruits and vegetables. Polyunsaturated fatty acids can
be found in blue fish and vegetables such as corn, soya beans,
sunflowers and pumpkins. The LMN cream used in this study was composed
of a mixture of natural products: dried fruits and nuts, coconut,
vegetable oils rich in polyunsaturated fat and flour rich in soluble
fiber. These creams were created and patented by the company La
Morella Nuts, located in Reus near Tarragona. Previous studies had
verified their effects on regulating cholesterol levels and
hypertension, two risk factors commonly associated with heart disease
and Alzheimer's disease.
During the development of the brain, stem cells generate different
neural cells (neurons, astrocytes and oligodendrocytes) which end up
forming the adult brain. Until the 1960s it was thought that the
amount of neurons in adult mammals decreased with age and that the
body was not able to renew these cells. Now it is known that new
neurons are formed in the adult brain. This generative capacity of the
cells however is limited to two areas of the brain: the olfactory bulb
and the hippocampus (area related to the memory and to cognitive
processes). Although the rhythm of cell proliferation decreases with
age and with neurodegenerative diseases, it is known that exercise and
personal well being can combat this process.
The main objective of this research was to study the effect of an LMN
cream-enriched diet on the neurogenesis of the brain of an adult
mouse. Scientists used two groups of mice for the study. One group was
given a normal diet and the other was given the same diet enriched
with LMN cream. Both groups were fed during 40 days (approximately
five years in humans). The analyses carried out in different brain
regions demonstrated that those fed with LMN cream had a significantly
higher amount of stem cells, as well as new differentiated cells, in
the olfactory bulb and hippocampus.
The second objective was to verify if the LMN cream could prevent
damage caused by oxidation or neural death in cell cultures. Cultures
of the hippocampal and cortical cells were pretreated with LMN cream.
After causing oxidative damage with hydrogen peroxide, which killed
40% of the cells, scientists observed that a pretreatment with LMN
cream was capable of diminishing, and in some cases completely
preventing, oxidative damage. The hippocampal and cortical cells were
also damaged using amyloid beta (anomalous deposits of this protein
are related to Alzheimer's disease). The results obtained were similar
to those obtained using hydrogen peroxide.
These results demonstrate that an LMN diet is capable of inducing the
generation of new cells in the adult brain, and of strengthening the
neural networks which become affected with age and in neurogenerative
processes such as Alzheimer's disease, as well as protecting neurons
from oxidative and neural damage, two phenomena which occur at the
origin of many diseases affecting the central nervous system.
In this study researchers have used different biochemical and
molecular analysis techniques, with the help of specific antibodies,
to detect different neuronal markers implied in the process of
differentiation.
The group of researchers led by Dr Unzeta has spent years studying the
effects oxidases have on oxidative stress as a factor implied in
neurodegenerative disorders such as Parkinson and Alzheimer's disease,
and the effects of different natural products with anti-inflammatory
and antioxidant properties in different experimental models of
Alzheimer's disease.
The study forms part of the CENIT project, which was awarded to La
Morella Nuts in 2006 under the auspices of the INGENIO 2010 programme,
with the objective of establishing methodologies for the design,
evaluation and verification of functional foods which may protect
against cardiovascular diseases and Alzheimer's disease. With 21.15m
euros in funding and a duration of four years, the project has
included the participation of 50 doctors and technicians from nine
different companies, four universities (7 departments) and 2 research
centres.
More information: "A diet enriched in polyphenols and polyunsaturated
fatty acids, LMN diet, induces neurogenesis in the subventricular zone
and hippocampus of adults mouse brain". Valente et al., 2009, Journal
of Alzheimer's Disease, Volume 18:4. Valente T., Hidalgo, J., Bolea,
I., Ramírez B., Anglés, N., Reguant, J., Morelló, J.R., Gutiérrez, C.,
Boada, M., Unzeta, M.
Source: Universitat Autonoma de Barcelona
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
fi...@guy.com
neurons"
Yup, the mediterranean is very rich in these things.
Jesus ate a mediterranean diet.