Pathogenic Iron In Hepatitis

[ironjustice]

Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during
the Development of Chronic Hepatitis C.
Mitsuyoshi H, Yasui K, Yamaguchi K, Minami M, Okanoue T, Itoh Y.
Int J Hepatol. Epub 2013 Apr 4.
Molecular Gastroenterology and Hepatology, Graduate School of Medical
Science,
Kyoto Prefectural University of Medicine, Kawaramachi Hirokouji,
Kamigyo-ku, Kyoto 602-8566,
Osaka 564-0013, Japan.

Abstract
Aim.
Chronic hepatitis C (CHepC) is frequently associated with hepatic iron
overload, yet mechanisms underlying iron-induced liver injury have not
been elucidated.
We examined the significance of iron deposition in hepatocytes (HC)
and reticuloendothelial cells (REC) in CHepC.
Methods.
Stainable hepatic iron was scored according to the iron deposition
pattern in 373 patients.
The levels of serum soluble TNF- α receptor (sTNFR2) and hepatic
hepcidin mRNA and the efficacy of phlebotomy were compared among
patients with different iron deposition patterns.
Results.
Serum transaminase levels and hepatic scores of stage, grade, and
steatosis were higher in patients with REC iron staining than in those
without.
REC iron scores were independently associated with advanced stage.
Serum sTNFR2 levels were significantly higher in patients with REC
iron than in those without.
REC iron scores were independently correlated with sTNFR2 levels.
Compared with patients without stainable iron, those with iron
overload had decreased ratios of hepcidin mRNA to serum ferritin.
The efficacy of phlebotomy was greater in patients with REC iron than
in those without REC iron. Conclusions.
The present results show the importance of REC iron for the
development of CHepC and the therapeutic effect of phlebotomy in
CHepC.

2013;2013:686420. doi: 10.1155/2013/686420.

PMID:23653861


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