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Danshen Decreases Iron Deposition
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ironjustice
May 24, 2013, 4:40:48 PM5/24/13
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Salvia miltiorrhiza (Danshen) Injection Ameliorates Iron Overload-
Induced Cardiac Damage in Mice. Zhang JP, Zhang YY, Chu L
Planta Med 2013 May 22
Abstract
The traditional Chinese medicinal herb Danshen (Salvia miltiorrhiza),
first recorded in the "Shen Nong's Herbal Classic", has long been used
to treat cardiovascular conditions, although the mechanism(s)
underlying its effects remain unclear.
Here, an iron dextran injection (50 mg · kg-1 per day) was delivered
intraperitoneally to establish a mouse model for investigating the
ameliorative effects of Danshen injection (low dose at 3 g · kg-1 per
day or high dose at 6 g · kg-1 per day) on iron overload-induced
cardiac damage.
The iron-chelating agent deferoxamine (100 mg · kg-1 per day) was
administered as a positive control.
The main constituents of Danshen injection, salvianic acid A
(danshensu), protocatechuic aldehyde, and salvianolic acid B, were
quantified at concentrations of 2.15, 0.44, and 1.01 mg · mL-1,
respectively, using HPLC with UV detection.
Danshen injection significantly lowered cardiac iron deposition and
the concentration of the lipid oxidation product malondialdehyde, as
well as improved cardiac superoxide dismutase and glutathione
peroxidase levels in iron-overloaded mice.
Serum levels of creatine kinase, creatine kinase isoenzyme, and
lactate dehydrogenase in the iron-overloaded mice were significantly
elevated (up to ~ 160 %), whereas their activities were downregulated
by Danshen injection by 25 ~ 35 % at the high dose and by ~ 20 % at
the low dose.
Morphological changes of cardiac tissue analyzed by hematoxylin and
eosin staining indicated that lesions induced by iron overload could
be ameliorated by Danshen injection dose-dependently.
Altogether, these results illustrated that the protective effects of
Danshen injection were at least in part due to decreased iron
deposition and inhibition of lipid peroxidation.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
Induced Cardiac Damage in Mice. Zhang JP, Zhang YY, Chu L
Planta Med 2013 May 22
Abstract
The traditional Chinese medicinal herb Danshen (Salvia miltiorrhiza),
first recorded in the "Shen Nong's Herbal Classic", has long been used
to treat cardiovascular conditions, although the mechanism(s)
underlying its effects remain unclear.
Here, an iron dextran injection (50 mg · kg-1 per day) was delivered
intraperitoneally to establish a mouse model for investigating the
ameliorative effects of Danshen injection (low dose at 3 g · kg-1 per
day or high dose at 6 g · kg-1 per day) on iron overload-induced
cardiac damage.
The iron-chelating agent deferoxamine (100 mg · kg-1 per day) was
administered as a positive control.
The main constituents of Danshen injection, salvianic acid A
(danshensu), protocatechuic aldehyde, and salvianolic acid B, were
quantified at concentrations of 2.15, 0.44, and 1.01 mg · mL-1,
respectively, using HPLC with UV detection.
Danshen injection significantly lowered cardiac iron deposition and
the concentration of the lipid oxidation product malondialdehyde, as
well as improved cardiac superoxide dismutase and glutathione
peroxidase levels in iron-overloaded mice.
Serum levels of creatine kinase, creatine kinase isoenzyme, and
lactate dehydrogenase in the iron-overloaded mice were significantly
elevated (up to ~ 160 %), whereas their activities were downregulated
by Danshen injection by 25 ~ 35 % at the high dose and by ~ 20 % at
the low dose.
Morphological changes of cardiac tissue analyzed by hematoxylin and
eosin staining indicated that lesions induced by iron overload could
be ameliorated by Danshen injection dose-dependently.
Altogether, these results illustrated that the protective effects of
Danshen injection were at least in part due to decreased iron
deposition and inhibition of lipid peroxidation.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
John H. Gohde
May 25, 2013, 5:07:02 AM5/25/13
to
On May 24, 4:40 pm, ironjustice <ironjust...@rock.com> wrote:
> Salvia miltiorrhiza (Danshen) Injection Ameliorates Iron Overload-
> Induced Cardiac Damage in Mice. Zhang JP, Zhang YY, Chu L
> Planta Med 2013 May 22
>
> Abstract
> The traditional Chinese medicinal herb Danshen (Salvia miltiorrhiza),
> first recorded in the "Shen Nong's Herbal Classic", has long been used
> to treat cardiovascular conditions, although the mechanism(s)
> underlying its effects remain unclear.
> Here, an iron dextran injection (50 mg · kg-1 per day) was delivered
> intraperitoneally to establish a mouse model for investigating the
> ameliorative effects of Danshen injection (low dose at 3 g · kg-1 per
> day or high dose at 6 g · kg-1 per day) on iron overload-induced
> cardiac damage.
To Echo Ken, only a Mentally Unbalanced Obsessive Compulsive Quack
> Salvia miltiorrhiza (Danshen) Injection Ameliorates Iron Overload-
> Induced Cardiac Damage in Mice. Zhang JP, Zhang YY, Chu L
> Planta Med 2013 May 22
>
> Abstract
> The traditional Chinese medicinal herb Danshen (Salvia miltiorrhiza),
> first recorded in the "Shen Nong's Herbal Classic", has long been used
> to treat cardiovascular conditions, although the mechanism(s)
> underlying its effects remain unclear.
> Here, an iron dextran injection (50 mg · kg-1 per day) was delivered
> intraperitoneally to establish a mouse model for investigating the
> ameliorative effects of Danshen injection (low dose at 3 g · kg-1 per
> day or high dose at 6 g · kg-1 per day) on iron overload-induced
> cardiac damage.
like ironjustice would spend several hours EVERY DAY endlessly
repeating his same worthless, mindless, pointless, useless BULLSHIT
that everyone ignores.
ironjustice
May 25, 2013, 5:01:12 PM5/25/13
to
John H. Gohde
May 25, 2013, 7:38:45 PM5/25/13
to
On May 25, 5:01 pm, ironjustice <ironjust...@rock.com> wrote:
> Salvia miltiorrhiza (Danshen) Injection Ameliorates Iron Overload-
> Induced Cardiac Damage in Mice. Zhang JP, Zhang YY, Chu L
> Planta Med 2013 May 22
>
> Abstract
> The traditional Chinese medicinal herb Danshen (Salvia miltiorrhiza),
> first recorded in the "Shen Nong's Herbal Classic", has long been
> used
> to treat cardiovascular conditions, although the mechanism(s)
> underlying its effects remain unclear.
> Here, an iron dextran injection (50 mg · kg-1 per day) was delivered
> intraperitoneally to establish a mouse model for investigating the
> ameliorative effects of Danshen injection (low dose at 3 g · kg-1 per
> day or high dose at 6 g · kg-1 per day) on iron overload-induced
> cardiac damage.
> The iron-chelating agent deferoxamine (100 mg · kg-1 per day) was
> administered as a positive control.
> The main constituents of Danshen injection, salvianic acid A
> (danshensu), protocatechuic aldehyde, and salvianolic acid B, were
> quantified at concentrations of 2.15, 0.44, and 1.01 mg · mL-1,
> respectively, using HPLC with UV detection.
> Salvia miltiorrhiza (Danshen) Injection Ameliorates Iron Overload-
> Induced Cardiac Damage in Mice. Zhang JP, Zhang YY, Chu L
> Planta Med 2013 May 22
>
> Abstract
> The traditional Chinese medicinal herb Danshen (Salvia miltiorrhiza),
> first recorded in the "Shen Nong's Herbal Classic", has long been
> used
> to treat cardiovascular conditions, although the mechanism(s)
> underlying its effects remain unclear.
> Here, an iron dextran injection (50 mg · kg-1 per day) was delivered
> intraperitoneally to establish a mouse model for investigating the
> ameliorative effects of Danshen injection (low dose at 3 g · kg-1 per
> day or high dose at 6 g · kg-1 per day) on iron overload-induced
> cardiac damage.
> The iron-chelating agent deferoxamine (100 mg · kg-1 per day) was
> administered as a positive control.
> The main constituents of Danshen injection, salvianic acid A
> (danshensu), protocatechuic aldehyde, and salvianolic acid B, were
> quantified at concentrations of 2.15, 0.44, and 1.01 mg · mL-1,
> respectively, using HPLC with UV detection.
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