ENS 2009: First Signs of Parkinson's Often Not Motor-Related
Allison Gandey
Dr. Daniel Mikol discusses the findings from the multicenter
REGARD study.
July 1, 2009
(Milan, Italy) — Patients may have symptoms years before they
experience
the motor manifestations of Parkinson's disease, report experts.
Presenting here at the 19th Meeting of the European Neurological
Society,
researchers emphasized that an array of seemingly unrelated symptoms
may actually be the first signs of Parkinson's.
"Evidence is accumulating from clinical, neuroimaging, and
pathological
studies that olfactory dysfunction, dysautonomia, or mood and sleep
disorders can occur years and perhaps even decades before the
classical
motor symptoms arise," Eduardo Tolosa, MD, from the University of
Barcelona,
in Spain, said at the meeting.
"These data suggest that, at least in some cases, Parkinson's disease
may
start in the lower brain stem, olfactory structures, or the peripheral
autonomic
plexuses, reaching the substantia nigra only later," he noted.
"It is unclear when these structures become involved in the
neurodegenerative
process."
Although Parkinson’s disease is most common in elderly patients, some
may
be affected in their 40s or even younger.
Claudio Bassetti, MD, from the University Hospital of Zurich, in
Switzerland,
voiced concern about doctors relying too heavily on dopaminergic
medications.
"We increasingly notice that some patients with Parkinson's disease
and
restless-legs syndrome take more dopamine than they really need to,"
he said.
"The involvement of the dopamine system in reward mechanisms and
eventually
in the neurobiology of addiction may explain this overuse."
Dr. Bassetti and his research team studied sleep walking in patients
with
Parkinson's disease.
Using a questionnaire, they asked 417 patients about their sleep
quality and
sleep disorders.
Sleep Walking, Compulsive Behavior, and Suicide
Dr. Bassetti's group found that patients with Parkinson's disease were
more
likely to sleep walk and experience other sleep disturbances.
In all, 9% of patients reported sleep walking.
These patients had significantly longer disease duration (P = .035)
and were
more likely to have hallucinations and nightmares (P = .004 and P = .
003).
Sleep walking, the researchers suggest, appears to be a late
manifestation
of Parkinson's disease.
According to presenters, there is also increasing awareness about
compulsive
behavior in some patients with Parkinson's disease.
"These impulse-control disorders such as pathological gambling,
hypersexuality,
compulsive shopping, compulsive eating, or compulsive overuse of
dopaminergic
drugs can lead to monetary losses or worsen the social handicap of
Parkinson's
patients," Dr. Bassetti added in a news release.
"It is necessary to consider pathological gambling in young
Parkinson's disease
patients with regard to their treatment and possible clinical and
sociological
outcomes," conclude researchers from the University of Brno, in the
Czech Republic.
Their small study compared 20 patients and 20 controls using a
computerized
version of the Iowa Gambling Task.
They found that Parkinson's patients had significantly lower scores
and were more
likely to make bad choices.
Another study, from the Institute of Neurology in Belgrade, Serbia,
explored the
risk for suicide in patients with Parkinson's disease.
Investigators followed 102 patients for 8 years.
They found that suicide-specific mortality was more than 5 times
higher
(95% CI, 2.1 – 12.7).
In all, almost a quarter of the Parkinson's patients either died or
experienced
suicidal ideation, which may significantly influence quality of life.
"Nonmotor manifestations of Parkinson's disease are an important new
challenge
and increasingly recognized as an important feature in the diagnosis
and treatment
of this disorder," Dr. Bassetti said.
The researchers have disclosed no relevant financial relationships.
19th Meeting of the European Neurological Society: Abstracts 17, O38,
O39, P408.
Presented June 20-24, 2009.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
Tom you are so ghetto that that you use the word shteater. The
frequency of the use of the words "homosexual atheist shteater
atheist" more than likely due to sublimation and/or projection. In
lay terms it is likely that you are a homosexual and an atheist.
I suspect that if one was to profile you Tom you would: be
-single
-have difficulty with intimacy
-middle aged
-highest level of schooling is a GED
-unemployed
Fuck off you spamming kook cannuck!!!
Predator you do not understand ..
Predators cannot be heard over the sound
of how awesome I am.
Compulsions are repetitive behaviors that you feel driven to perform.
These repetitive behaviors are meant to prevent or reduce anxiety or
distress related to your obsessions. You may also make up rules or
rituals to follow that help control the anxiety you feel when having
obsessive thoughts.
BTW----Stay in your mama's
That's Tom in a nutshell. He can get fucked.
BTW----Sorry to steal you essay on him..Ken
BACKGROUND::
Extraintestinal manifestations of Crohn's disease (CD) have not
previously included the central nervous system (CNS).
Restless legs syndrome (RLS) is a CNS disorder that is either
idiopathic or secondary to a number of diseases.
The aim of this study was to determine if RLS was associated
with CD because both are associated with iron deficiency,
inflammation, and bacterial overgrowth.
METHODS::
Consecutive CD outpatients (N = 272) were prospectively
surveyed at 4 centers for criteria for RLS.
Incidence (having RLS at any point in time), prevalence
(having RLS at time of survey), clinical characteristics, risk
factors,
and potential qualitative relationship between RLS and
gastrointestinal symptoms were queried.
RESULTS::
The incidence of RLS in patients with CD was 42.7%.
Prevalence was 30.2% compared with 9% of spouses.
CD patients with and without RLS had a mean age of 46.8 versus
42.6 years, small intestine involvement in 77.9% versus 66.7%,
colon involvement in 39.7% versus 63.2%, and prior iron deficiency
anemia in 49.3% versus 33.1%.
There was no difference between the CD groups with respect to
current iron deficiency, RLS family history, or rare prevalence of
concomitant RLS disorders.
In 91.8% of patients with RLS and CD, RLS started during or
after the onset of CD diagnosis.
Among 73 patients with RLS, 67 (44.5%) stated there was a
relationship
between qualitative RLS symptom improvement with overall CD symptom
improvement.
CONCLUSIONS::
These results demonstrate that RLS occurs frequently in CD and
appears
to be a possible extraintestinal manifestation.
The potential relationship of RLS with CD activity warrants further
investigation.
(Inflamm Bowel Dis 2009;).
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More from this journal
Inflammatory bowel diseases [Inflamm Bowel Dis]
>Crohn's disease is associated with restless legs syndrome.
Crohn's Disease is NOT in any way sleepwalking.
--
Sehr reich ist auch der Vatikan * Sie lieben Prunk, sie lieben Pracht,
und stets dem Gelde zugetan. * vor allem aber ihre Macht.
Hinter den Kulissen der P�pstissen: http://www.reimbibel.de
Rusty has little, if any, concept of anything he CCP's
-----------
Crohn's disease is associated with restless legs syndrome.
--------------------------------------------------------------------------------
No joke, there are drugs for it now.
Im sorry predators cannot be heard over the sound of how
>SSpeaking of compulsive obsessive behaviors ...
>
>No joke, there are drugs for it now.
Yes, but if he sticks them in his ears, they don't work...
Let us see how many times we can get a response.
SSpeaking of compulsive obsessive behaviors ...
Rusty appears to suffer not only from OCD's but schizophrenia,
megalomania and masochism, coupled with low self-esteem and a hignly
confused sexuality.
No wonder he's unable to function in society and on the public dole
Predator you do not understand ..
Predators cannot be heard over the sound