...
> >Subject: Re: What is it with the iron ?
> >From: ironjust
...@aol.comdoe (doe)
> <<snip>>
> Tissue iron levels were significantly higher in the NPC tissues compared
with
> normal tissues
> <<snip>>
Yes, Tom. We can all read, and you don't need to repeat what you've already
copied once.
> Arch Otolaryngol Head Neck Surg 2002 Dec;128(12):1396-9
> Glutathione S-Transferase pi Expression in Nasopharyngeal Cancer.
> Jayasurya A, Yap WM, Tan NG, Tan BK, Bay BH
> Department of Anatomy, National University of Singapore, 4 Medical Dr, Blk
MD
> 10, S117 597 Singapore. antba...@nus.edu.sg
> [Medline record in process]
> BACKGROUND: Glutathione S-transferase pi (GST-pi) is an enzyme that
catalyzes
> the conjugation of electrophilic substrates and prevents oxidative damage.
> Although GST-pi expression has been analyzed in many cancers, the
significance
> of GST-pi expression in nasopharyngeal cancer (NPC), a tumor with a high
> treatment failure rate, is still unclear. OBJECTIVE: To elucidate the
> significance of GST-pi expression in NPC. DESIGN: Evaluation of GST-pi
> expression in NPC tissue specimens and determination of its relationship
with
> tissue iron (a pro-oxidant) and clinicopathological factors in NPC.
MATERIALS
> AND METHODS: Immunohistochemical expression of GST-pi was carried out in
55 NPC
> and 4 normal nasopharyngeal tissue sections. Eleven nasopharyngeal biopsy
> specimens (4 normal and 7 NPC) were analyzed for tissue iron levels. The
> expression of GST-pi in NPC was correlated with corresponding tissue iron
> levels. The relationships between GST-pi expression with sex, race, tumor
> stage, cervical nodal status, and clinical staging were also analyzed.
RESULTS:
> Glutathione S-transferase pi immunoreactivity was observed in all NPC
sections,
> with the percentage of immunopositive cells ranging from 1.0% to 72.0%.
Tissue
> iron levels were significantly higher in the NPC tissues compared with
normal
> tissues (P =.001). A direct correlation was observed between GST-pi
expression
> and total and nuclear iron levels in NPC (P =.01 and P =.047,
respectively). A
> significant association was also observed between GST-pi expression and
> cervical nodal disease (P =.007). CONCLUSIONS: Nasopharyngeal tumor cells
may
> respond to pro-oxidant conditions by modulating intracellular antioxidant
> defense. Glutathione S-transferase pi expression appears to be associated
with
> lymphogenous metastasis in NPC.
> PMID: 12479727, UI: 22368010
> Who loves ya.
> Tom
> Jesus was a vegetarian!
> http://jesuswasavegetarian.7h.com
> Jesus was a vegetarian! http://www.nucleus.com/watchman
> Moses was a mystic! http://www.nucleus.com/watchman/light.html
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