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Iron Identified All Heart Attacks

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ironjustice

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Sep 9, 2009, 5:50:39 PM9/9/09

"Catalytic iron identified all patients with acute MI"

Serum catalytic iron as a novel biomarker of vascular
injury in acute coronary syndromes.
EuroIntervention. 2009 Aug;5(3):336-42.
Lele S, Shah S, McCullough PA, Rajapurkar M.

Department of Cardiology,
Bhailal Amin General Hospital,
Baroda, India.

Aims:
Catalytic iron is associated with high oxidative stress
during vascular injury.
We measured catalytic iron in patients with suspected acute
coronary syndromes (ACS) and healthy volunteers to evaluate
its utility in early detection of patients with acute myocardial
infarction (MI) and predicting major adverse cardiac events
(MACE).
Methods and results:
Catalytic iron was measured on admission and 24 hours later in
127 patients with acute MI, 51 patients with suspected ACS
without MI, and 250 healthy volunteers.
Descriptive and decision statistics were performed for catalytic
iron and troponin I.
Catalytic iron levels at presentation were 1.5+2.0 micromol/l,
0.2+0.16 micromol/l, and 0.1+0.06 micromol/l for acute MI,
suspected ACS without MI, and normals, respectively p<0.0001.
Catalytic iron was elevated in all patients with MI at presentation.
At a cutpoint of 0.30 micromol/L, the sensitivity, specificity, and
diagnostic accuracy for identifying MI was 84%, 95%, and 92%,
respectively.
Increase in catalytic iron at 24 hours compared to baseline was
associated with MACE at 30 days.
Conclusions:
Catalytic iron identified all patients with acute MI at presentation
and serial elevation was independently associated with MACE.
This biomarker of vascular injury is useful in the rapid serologic
assessment of patients with suspected ACS.