Blood Clots And Erythrocytosis
ironjustice
I say it is the erythrocytosis which leads to thromboembolism the SAME
erythrocytyosis which causes one to die when flying .. blood clot.
One way to test this would be to give a drug to people which increases
their red blood cells and see if they .. die ..
They .. doooo ..
http://www.medscape.com/viewarticle/712143
From Medscape Medical News
Sleep Apnea a Risk Factor for Venous Thromboembolism
Kristina Rebelo
November 11, 2009 (San Diego, California) — Sleep-disordered breathing
(SDB) is a condition rife with significant risk factors for blood clot
events that should be identified in the clinical setting, according to
the findings of a large retrospective study, presented here at CHEST
2009: American College of Chest Physicians Annual Meeting.
Intermittent hypoxia and hypercapnia have been associated with adverse
cardiovascular outcomes, but this study found an association with
venous thromboembolism (VTE) — either pulmonary embolism (PE) or deep
vein thrombosis (DVT).
---------------------
Drugs to treat anemia in cancer patients linked to thromboembolism
Published: Tuesday, November 10, 2009 - 17:46 in Health & Medicine
Medications frequently given to cancer patients to reduce their risk
of anemia are associated with an increased risk of deep vein
thrombosis or pulmonary embolism, according to new research led by
Dawn Hershman, M.D, M.S., co-director of the breast cancer program at
the Herbert Irving Comprehensive Cancer Center at NewYork-Presbyterian
Hospital/Columbia University Medical Center. The findings will be
published online on Nov. 10, 2009 in the Journal of the National
Cancer Institute (ahead of the Dec. 2, 2009 print edition). The anemia-
reducing medications, known as erythropoiesis-stimulating agents
(i.e., erythropoietin and darbopoietin) or ESAs, stimulate red blood
cell production and are intended to reduce the number of blood
transfusions required during chemotherapy. However, concerns about the
risks of deep vein thrombosis or pulmonary embolism (manifestations of
venous thromboembolism) and mortality exist.
"This research answers important questions about outcomes of ESAs when
used in long-term clinical practice with oncology patients," said Dr.
Hershman, the Florence Irving Assistant Professor of Medicine and
Epidemiology at Columbia University Medical Center, whose research is
dedicated to examining cancer survivorship. "While ESAs were given to
reduce the need for blood transfusions, a substantial reduction in the
use of blood transfusions was not observed. However, an increase risk
of deep vein thrombosis or pulmonary embolism was confirmed."
"This analysis confirms the association between ESAs and venous
thromboembolism, which was observed in previous meta-analysis," said
Dr. Hershman. "This new finding is significant because where the meta-
analysis looked at pooled data from randomized clinical trials, this
data is from community practice – real-life clinical settings – where
you can often see things that wouldn't necessarily show-up in a short-
term, 12-week study. Additionally, this analysis included data from
more than 50,000 patients– including those with more advanced cancer
or high-risk status, who therefore might not have been candidates for
clinical trials."
Based on previous findings, in the spring of 2007, the FDA required a
black-box warning on ESAs about the potential for venous
thromboembolism, tumor promotion, and decreased survival in ESA users.
The warning suggested limiting the use of ESAs to specific tumor
types, durations, doses, and targeted hemoglobin levels. In addition,
the Center for Medicare and Medicaid Services proposed eliminating or
limiting coverage for ESAs as treatment for some cancers.
"But what is reassuring about our findings are that they don't show an
increased risk of mortality when ESAs are given with chemotherapy,"
said Dr. Hershman.
Dr. Hershman and colleagues analyzed the association between use of
ESAs and venous thromboembolism and overall survival in patients who
were 65 years or older and diagnosed with colon, non-small cell lung,
or breast cancer or diffuse large B-cell lymphoma, between 1991-2002.
These cancers were chosen because they were thought to be common
cancers for which ESAs were frequently used. Patients were identified
in the Surveillance, Epidemiology, and End Results–Medicare database,
which at the time contained records of patients diagnosed with cancer
in regions that represented approximately 14 percent of the U.S.
population.
Results demonstrated that more patients who received an ESA developed
deep vein thrombosis or pulmonary embolism, as compared to patients
who did not. Overall survival was similar in both groups. The number
of patients receiving ESAs increased approximately 10-fold from 1991
through 2002, with approximately 50 percent of patients with advanced
cancer undergoing chemotherapy receiving ESAs by 2002. The rate of
blood transfusion per year during the same time period, however,
remained constant at 22 percent.
"Further efforts at monitoring use and long-term toxicity of expensive
oncology drugs should be put in place to ensure that for any drug the
benefits outweigh the risks in community practice," the authors write
in the paper.
In the JNCI paper, the authors note that ESAs may be of particular
interest from a public policy perspective because of the costs
associated with their use. Total U.S. sales of ESAs were $10 billion
in 2006, accounting for a greater Medicare Part B expenditure than any
other drug.
Source: Columbia University Medical Center
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
John Gentile
successfully operated on and fixed the situation. I NEVER developed
erythrocytosis and or thromboembolism.
On 2009-11-11 12:38:59 -0500, ironjustice <ironj...@rock.com> said:
> People with sleep apnea have erythrocytosis and thromboembolism ..
> I say it is the erythrocytosis which leads to thromboembolism the SAME
> erythrocytyosis which causes one to die when flying .. blood clot.
> One way to test this would be to give a drug to people which increases
> their red blood cells and see if they .. die ..
>
> They .. doooo ..
>
No they dooooon't always.
--
John Gentile MS, M(ASCP)
Laboratory Information Mgr.
VA Medical Center
Providence, RI
yjg...@cox.net
ironjustice
had sleep apnea, and was
successfully operated on <<
You really think that with the RATE of sleep apnea BEING
'diagnosed' ..
"We are most likely designed poorly and MANY including myself require
surgical
intervention to correct this imperfection" ..
THAT is what you believe .. ?
REEM out a perfectly good pipe to a larger diameter .. ?
NOW we can take a .. wait and see .. to see whether or not the
'hypoxia' .. trigger ..
will happen again to see whether or not you have .. erythrocytosis ..
don't we ..
We'll have to wait and see if you develope a .. thrombi ..
Leave us all a message whether you dooo or not .. ?
If we fail to hear from ya after awhile .. we'll assuuume .. that ..
you .. diiiiid ..
----------
People with sleep apnea have erythrocytosis and thromboembolism ..
I say it is the erythrocytosis which leads to thromboembolism the
SAME
erythrocytyosis which causes one to die when flying .. blood clot.
One way to test this would be to give a drug to people which
increases
their red blood cells and see if they .. die ..
They .. doooo ..
http://www.medscape.com/viewarticle/712143
From Medscape Medical News
Sleep Apnea a Risk Factor for Venous Thromboembolism
Kristina Rebelo
November 11, 2009 (San Diego, California) — Sleep-disordered
breathing
(SDB) is a condition rife with significant risk factors for blood
clot
events that should be identified in the clinical setting, according
to
the findings of a large retrospective study, presented here at CHEST
2009: American College of Chest Physicians Annual Meeting.
Intermittent hypoxia and hypercapnia have been associated with
adverse
cardiovascular outcomes, but this study found an association with
venous thromboembolism (VTE) — either pulmonary embolism (PE) or deep
vein thrombosis (DVT).
---------------------
http://esciencenews.com/articles/2009/11/10/drugs.treat.anemia.cancer...
Who loves ya.
Tom
That was and is a very useful procedure .. attested to by many ..
including yourself ..
> At the risk of ...whatever, I have had sleep apnea, and was
> successfully operated on and fixed the situation. I NEVER developed
> erythrocytosis and or thromboembolism.
>
Ken
ironjustice
The risk would beeee .. odds are HIGH you
are an .. obese snoring polyurist .. ?
"82.6 percent reported Snoring and 84.8 percent reported nocturia"
"The condition is associated with overweight/obesity"
--------
Sleep Apnea May Cause Nighttime Urination
11.29.09, 09:00 AM EST
Many doctors unaware the sleep disorder boosts urine production,
experts say
SUNDAY, Nov. 29 (HealthDay News) -- People who wake up during the
night to urinate shouldn't automatically blame a urological problem.
Sleep apnea, a breathing-related sleep disorder, could be the cause.
A new study suggests that nighttime urination, or nocturia, is
comparable to loud snoring as a marker for obstructive sleep apnea, a
disorder in which soft tissue in the throat blocks the flow of air
into the lungs, disrupting sleep.
Previous studies established a link between nocturia and sleep apnea,
a potentially serious condition that affects about 25 percent of U.S.
men and 10 percent of U.S. women, the researchers said. But they
believe this is among the first to show that screening for nocturia
could help doctors identify patients with apnea.
The study also suggests that a common treatment for sleep apnea --
positive airway pressure (PAP) therapy -- can reduce symptoms of
nocturia, thereby improving sleep and preventing debilitating falls
among elderly people who get out of bed at night to use the bathroom.
PAP involves wearing a pressurized air mask while sleeping.
Typically, doctors screen for apnea by assessing patients' weight
(the
condition is associated with overweight/obesity) and asking if they
snore heavily, notice breathing problems at night or feel tired
during
the day (because of interrupted sleep). But because many patients,
especially those who sleep alone, are unaware that they snore, apnea
often goes undiagnosed.
"When you ask people about symptoms like snoring and gasping, they
tend to say, 'No, I don't have them'," said study author Edward
Romero, research coordinator at the Sleep & Human Health Institute in
Albuquerque, N.M. "But it's very easy for them to realize that they
wake up at night to go to the bathroom."
One of Romero's co-authors, institute director Dr. Barry Krakow, said
doctors and patients are quick to blame nocturia on diabetes,
prostate
enlargement and other medical conditions with which it is associated.
"I see patients all the time who think they're waking up to urinate
because they have prostate trouble or a small bladder," Krakow said.
"About 80 percent of the time we discover that apnea is the cause of
their problem."
Besides nocturia and snoring, symptoms of sleep apnea include daytime
drowsiness, memory problems and depression. Untreated sleep apnea can
lead to high blood pressure, blood clots and heart disease.
For the study, published online recently in Sleep and Breathing, the
researchers reviewed data on 1,007 adults treated at two sleep
clinics
in New Mexico between 2005 and 2007. Of the participants, 797 were
diagnosed with sleep apnea, 777 reported snoring and 839 reported
nocturia. Neither snoring nor nocturia was proof of apnea, but the
two
symptoms were similar in their power to predict it: snoring was
reported by 82.6 percent of apnea sufferers, and 84.8 percent of
apnea
sufferers reported nocturia.
The authors propose further research be conducted to confirm the
effectiveness of nocturia as an apnea screening tool.
Mary Umlauf, a professor at the University of Alabama Capstone
College
of Nursing in Tuscaloosa and a noted nocturia researcher, said the
study could play an important role in dispelling "old wives' tales"
about nocturia.
"Many health-care providers and ordinary people think of nocturia as
a
urological or gynecological problem," she said. "They don't
understand
that sleep apnea can cause the body to produce too much urine at
night.
"People who wake up to urinate shouldn't assume that it's my
prostate,
or 'I'm just old'," she said.
--------------
Sleep apnea symptoms, nocturia, and diabetes in
African-American community dwelling older adults.
J Natl Black Nurses Assoc. 2000 Dec;11(2):25-33.
Chasens ER, Umlauf MG, Pillion DJ, Singh KP.
Wayne State College of Nursing, Detroit, Michigan, USA.
The primary aim of this exploratory study was to examine
the association between obstructive sleep apnea (OSA)
symptoms, nocturia and diabetes in African-American
community-dwelling older adults.
A pencil and paper survey was used to collect symptoms of
OSA, nocturia, excessive daytime sleepiness (EDS), lower
urinary tract symptoms (LUT), and self-rated health.
The convenience sample of community dwelling
African-Americans (n = 87) included a majority of women
(61%) and obese persons (60% with BMI > 30).
The mean age was 64 years (range 50-91), and 40% were self
reported Type 2 diabetics.
Diabetics had significantly more OSA symptoms, more
nocturia, and decreased self-rated health.
Results of a stepwise logistic regression showed that persons
with diabetes and those who reported EDS experienced
significant three to four-fold risks for OSA.
Similarly, diabetics, women, persons with LUT symptoms and
those reporting EDS, had significant three to six-fold risks
for nocturia > or = 2/night.
PMID: 11854986
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
> and was
successfully operated on and fixed the situation. I NEVER developed
> erythrocytosis and or thromboembolism.
>