Subject: Frank Dressler's new report
Date: Mar 1, 2008 4:46 AM
Dear Mr. Dressler,
Thanks very much for the update, but we're not interested in Lyme
arthritis,
since that's a weird outcome, and Ray Dattwyler at State University of
New York,
Stony Brook, said he only sees about one such case per year.
We're more interested in whether or not all MDs, not just German or
Americans,
can learn the meaning of "scientific validity." This did not apply in
your analysis with Allen Steere of the Western Blotting outcomes in
Lyme victims:
http://www.actionlyme.org/DICKSON_FDA_SUBMISSION_FULL.htm
Your report with Allen Steere was not a validation of a method. I
gave your entire
Dressler/Steere report to the FDA Vaccine Committee on Jan 31, 2001,
to demonstrate
that it was a nonsense report.
Steere also used bogus strains in Europe:
http://www.actionlyme.org/CRYMEDISEASE_CHP3.htm
"High passage G39/40" and FRG, a German strain.
It was an interesting trick, but stupid.
Each antibody band is as accurate for diagnosis as its assigned
percent specificity,
and this only applies in early Lyme disease, since Lyme is a relapsing
fever organism
that does antigenic variation, and host-adapts.
In later "Lyme disease" (redefined by yourselves), we can only use
specific
recombinant flagellin proteins to Western Blot:
http://www.actionlyme.org/THE_CENTRAL_LYME_RICO_PATENTS.htm
Yale's flagellin method was a close to a validation for a Lyme
antibody method
as we are going to get. It detects 94.4% of all cases, and Yale
claims their region
of Bb flagellin DNA does not cross-react with other flagellins.
http://patft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5618533.PN.&OS=PN/5618533&RS=PN/5618533
I hope in the full text of your report (below), that you make clear
that not only
is "Lyme arthritis" a rare, genetically-linked outcome of Relapsing
Fever,
but that Allen Steere treats his chronic Lyme-bad-knee victims with
long term antibiotics:
http://groups.google.com/group/sci.med.diseases.lyme/browse_thread/thread/da7be98801161dc8/00a27cc312aa970b?hl=en&lnk=gst&q=steere+and+weinstein#00a27cc312aa970b
Thank you.
Kathleen M. Dickson
Pawcatuck, CT, "USA"
: Z Rheumatol. 2008 Feb 28 [Epub ahead of print]Click here to read
Links
[Lyme arthritis in children and adolescents.]
[Article in German]
Dressler F, Huppertz HI.
Pädiatrische Pneumologie und Neonatologie, Medizinische Hochschule
Hannover,
Carl-Neuberg-Straße 1, 30625, Hannover, Deutschland, dressler.frank@MH-
Hannover.de.
Lyme arthritis is one of the manifestations of Lyme disease and is
caused by
infection with Borrelia burgdorferi sensu lato. This article reviews
the current
knowledge regarding the epidemiology, etiology and pathogenesis as
well as the clinical
manifestations, the diagnosis, treatment and prognosis with special
emphasis on
children and adolescents.
PMID: 18301903 [PubMed - as supplied by publisher]