Chronic Fatigue is Fungal-Viral Synergy (NYT)
Kathleen
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Subject: Chronic Fatigue is Fungal-Viral Synergy (NYT)
Date: Jan 4, 2011 3:52 PM
NYT ARTICLE BELOW
=============================================
The *data* says that CFS is
fungal-viral synergy, caused
by OspA vaccination, too:
http://www.actionlyme.org/101016.htm
See the 1998 FDA meeting transcripts
where Ray Dattwyler can't figure out
why after the second vaccination
(in the series of 3) people start
having a diminished antibody response
to OspA:
http://www.fda.gov/ohrms/dockets/ac/98/transcpt/3422t1.rtf
Dattwyler earlier noticed this
when he and David Volkman developed
the Seronegative Lyme Assay:
http://www.actionlyme.org/STEERES_SERONEG_LYME_ASSAY.htm
and studied the diminution of
NK cell activity (not numbers of
NK cells) in response to chronic
Lyme:
http://www.actionlyme.org/DATTWYLER_NK_SUPPRESSION.htm
He was talking about this occurring
in fungal infections, too.
We suspect activation of Epstein-Barr
as at least half the cause of illness
signs - since that's what the data says -
and we know the mechanisms of mutated
B cells (not necessarily to the point
of leukemia), or else a mouse herpesvirus,
as explained by Paul Duray:
http://www.actionlyme.org/101016.htm
(Look for his ^^ name in the page)
In my answer to the question of how
exactly Pam3Cys (OspA, a TLR2/1 agonist)
http://www.actionlyme.org/GREATEST_IMITATOR_INTERVIEW.htm
makes Pam3Cys usable as an optic
nerve rescue treatment, the data
says only that Pam3Cys seems to
activate BCL2 (anti-apoptotic)
molecules in cells.
No one knows the real reason at
this point in time. That's what
they say. They say they're not really
sure:
http://www.actionlyme.org/101016.htm
but they think ^^ TLR2 agonists like
OspA or Yale's LYMErix non-vaccine,
and mycoplasmal and mycobacterial
antigens of the Pam3Cys type, seem
to do this.
A person can have chronic fatigue
and not be anemic because: You can
look at what happens to the red blood
cells, once tolerized to other fungal
infections caused by OspA-induced tolerance:
http://www.actionlyme.org/BIOMARKERS2.htm
and ****see with your own eyeballs****
that this effect would change the osmotic
potential across the RBC membrane, and
therefore affect oxygen transfer.
The hemoglobin and oxygen are there,
but not getting across the membrane.
Mycoplasma also steal sugars from
RBCs (seen in Brian Fallon's PET
Scan-positive patients).
But the data also *says* this:
http://www.actionlyme.org/101016.htm
Search for the term ^^ Eperythrozoon.
That would be mycoplasma.
Ep *erythro* zoon.
Other references may be viewed here:
http://www.actionlyme.org/GARTHNICOLSON.pdf
in an article by Garth Nicolson about
the Chronic Fatigue in Gulf War
Illness veterans.
So, that's the evidence for what
Chronic Lyme/Fatigue is. You don't
necessarily get it from a tick bite
but also moldy homes etc. Anywhere
where you're chronically exposed to
fungal antigens.
The proper biomarkers are not looked
for in CFIDS victims and the bad guys
are playing a shell game with the DNA
and RNA primers (the bad guys include
"Insurance Medicine"):
http://www.actionlyme.org/PRIMERSHELLGAME.htm
When looking for organisms in the blood,
in addition to not using criminal primers,
use whole blood. Sonicate whole cells
and search within them.
Certainly Chronic Fatigue is real.
Unfortunately, we Lyme victims are not
allowed to talk to those groups
because the insurance company whores
make sure these groups are told that
*our* agenda is to compete for their
research dollars, which is the same
reason that flaming criminal James
Amann:
http://www.actionlyme.org/MARTIN_NINDS_MS_CHRONIC_LYME.htm
would not give us the time of day,
re Lyme and MS.
ALL OF THE GREAT and NEW GREAT IMITATOR
OUTCOMES - MS, Lupus, ALS, etc. - fit
this model of Fungal Viral Synergy:
http://www.actionlyme.org/101016.htm
Pick a starting point ^^^ anywhere in
there and follow your own leads
on MedLine. I 99% guarantee you
will end up at the same place.
Follow what Ray Dattwyler was saying
from 1988 to around 2001 when he
sold us out, presumably over threats
that he would be defunded if he did
not play along.
Dattwyler was all along looking for
the mystery element that caused the
immunosuppression in Chronic Lyme.
It was OspA or the shed, blebbed
antigens like it (they all mutate
which is called antigenic variation
and is the main reason there can
never be a vaccine against Relapsing
FeverLyme):
http://www.actionlyme.org/BARBOURS_STEALTH_BOMBERS.htm
What's the cure?
You have to ask the correct questions,
and throw out bullshit "data" from the
likes of Yale:
http://www.actionlyme.org/PLUMSTUPID.htm
Kathleen M. Dickson
http://www.actionlyme.org
=========================================================
http://www.nytimes.com/2011/01/04/health/04fatigue.html?_r=1&hpw=&pagewanted=print
anuary 3, 2011
Exhausted by Illness, and Doubts
By DAVID TULLER
Chronic fatigue syndrome causes a host of debilitating symptoms:
profound exhaustion, disordered sleep, muscle and joint pain and
severe cognitive problems, among others. But what causes the syndrome
itself?
Since the first cases in the United States were identified in the
1980s, scientists have been divided over that question. Some have
suspected that one or more viral infections are likely to play a
central role.
But many other researchers — not to mention relatives, friends,
employers, doctors and insurers of the million or more Americans
estimated to suffer from the illness — have dismissed it as stress-
related, psychosomatic or simply imaginary.
Now recent back-to-back announcements have highlighted both the
volatility of the issue and the ambiguity of the science, and have
alternately heartened and dismayed patients.
On Dec. 14, an advisory panel suggested that the Food and Drug
Administration ban blood donations by people with a history of C.F.S.,
as the illness is often called. The goal was to prevent the possible
spread of viruses that two high-profile studies had linked to the
condition.
But then, on Dec. 20, the journal Retrovirology published four papers
suggesting that key findings in those studies could have resulted from
laboratory contamination.
The F.D.A. is not required to accept the opinion of its advisory
panel. Yet patients still hailed the recommendation as a sign that
their illness was being taken seriously.
“When an F.D.A. panel suggests that patients with C.F.S. not donate
blood, that’s going to impact the way doctors think about it,” said
Mary Schweitzer, a former history professor at Villanova, who has
frequently written about living with the illness. Dr. Schweitzer said
she has been unable to work for 16 years because of the syndrome,
which was diagnosed after she suffered from a series of flulike
illnesses.
The studies that concerned the F.D.A. had reported that people with
the syndrome, which is also called myalgic encephalomyelitis or
myalgic encephalopathy in Europe, showed higher rates of infection
with the virus XMRV or others from the same category, known as MLV-
related viruses. (These viruses are all relatives of mouse leukemia
viruses, some of which can infect species other than mice; their role
in human disease, if any, remains poorly understood.)
But several other research teams in the last year have found no
connection between chronic fatigue syndrome and these viruses,
although none tried to replicate the exact methods used by researchers
who reported an association.
The new papers in Retrovirology reported that contamination of tissue
samples or other laboratory items with mouse DNA or viral genetic
material could lead to false positive results for XMRV, and by
extension other MLV-related viruses, specifically when using
polymerase chain reaction technology. The technique rapidly produces
millions of copies of genetic segments, so even minute traces of
genetic contamination can skew results.
“Our conclusion is quite simple: XMRV is not the cause of chronic
fatigue syndrome,” said the senior author of one of the studies, Greg
Towers, a professor of virology at University College London, in a
statement released by Wellcome Trust Sanger Institute, the British
research center that co-sponsored it.
Other scientists and advocates for patients have sharply criticized
such certainty as unwarranted, noting that the Retrovirology papers
themselves expressed their findings in more cautious terms. The
critics agree that contamination can be a serious issue when using
polymerase chain reaction technology. But the new papers, said Eric
Gordon, a doctor in Santa Rosa, Calif., who treats many patients with
the illness, do not evaluate other strategies besides P.C.R., as the
technique is known, for detecting the MLV-related viruses, like
testing for an immune response and culturing the viruses in cell
lines.
“The articles make the point that P.C.R. doesn’t work that well for
these viruses, and then they act like that disproves the whole idea,”
said Dr. Gordon.
XMRV was first identified in 2006 and has been detected in prostate
cancer patients in some studies. It was linked to chronic fatigue
syndrome in October 2009 in a paper in the journal Science by
researchers from the Whittemore Peterson Institute for Neuro-Immune
Disease at the University of Nevada, Reno, the National Cancer
Institute and the Cleveland Clinic.
The researchers relied on P.C.R. technology to show that about two-
thirds of patients but less than 4 percent of control subjects
harbored XMRV. Using other technologies, however, they also documented
an antibody response in some chronic fatigue syndrome patients, and
reported that XMRV in human blood could infect other human cell lines.
In a statement responding to the new papers in Retrovirology, Judy A.
Mikovits, director of research at Whittemore Peterson and the senior
author of the Science study, said her team took extensive steps to
rule out P.C.R. contamination and also focused on other approaches to
finding XMRV. “Nothing that has been published to date refutes our
data,” she said.
Even some specialists stumbled over the meaning of the new findings.
Vincent Racaniello, a professor of microbiology at Columbia not
involved in the research, apologized on his Virology Blog for having
stated that it was likely to spell “the beginning of the end” for the
proposed connection between the viruses and chronic fatigue syndrome.
After reviewing the issue more thoroughly, he wrote, he realized that
the new studies “show that identification of XMRV can be fraught with
contamination problems, but they do not imply that previously
published studies are compromised.” He added, “If I had difficulties
interpreting these papers, how would nonscientists fare?”
Federal agencies have come down on different sides of the issue. In a
paper published in The Proceedings of the National Academy of Sciences
in August, researchers from the National Institutes of Health and the
F.D.A. found a link between the fatigue syndrome and MLV-related
viruses (although not specifically XMRV). In contrast, a study from
the Centers for Disease Control and Prevention was among those not
reporting a link.
Federal health officials have organized two research efforts to
resolve the inconsistencies, determine whether XMRV and MLV-related
viruses are possible human pathogens, and identify reliable ways to
detect them. Patients hope the increased attention will quickly lead
to research on treatments, including clinical trials of H.I.V. drugs,
some of which have been shown in lab studies to inhibit the
replication of XMRV.
The unsettled situation has created a quandary for patients with
chronic fatigue syndrome and the doctors who treat them. Some patients
are seeking to be treated with H.I.V. drugs, which doctors can legally
prescribe even though the F.D.A. has not approved them for that
purpose.
Many doctors and researchers say it is too early to prescribe the
drugs for chronic fatigue because of possible side effects, like bone
marrow suppression, gastrointestinal problems and liver or kidney
dysfunction, among others. But Michael Allen, a writer and a former
psychologist in San Francisco who has been disabled for more than 15
years, said he wouldn’t hesitate to try the medications if he found
out he was positive for an MLV-related virus.
“It feels patronizing when the medical establishment says the side
effects are too risky and we should keep waiting,” he said. “What that
says to me is they have no idea whatsoever how sick people like me
have been with this disease.”
KMDickson