NIH says Lymies will be seronegative for Flagellin antibodies, too, after exposure to OspA
Mort Zuckerman
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Subject: NIH says Lymies will be seronegative for Flagellin
antibodies, too, after exposure to OspA
Date: Jul 23, 2011 4:52 AM
NIH says everyone will eventually be seronegative for flagellin, too:
http://www.ncbi.nlm.nih.gov/pubmed/16479520
After exposure to OspA.
Put that in Marty Scheifer's hat
and smoke it; Even the NIH says OspA
turns off the immune system.
They DO *NOT* SAY what Allen Steere
and the gang sued by Blumenthal continue
to say, which is the same Lyme is
a "TOO MANY ANTIBODIES DISEASE."
The crooks at Yale and UConn do not
want to go to jail for MASS MURDER
and FRAUD, so they continue to spew
their same old nonsense,... despite not
having the funding in 5+ years to produce
any scientific reports at all.
The last time they published anything
remotely scientific was when Gary Wormser
reported that OspA suppressed the
immune system:
http://www.ncbi.nlm.nih.gov/pubmed/10865170
That was while LYMErix was still on the
market.
'Too amazingly stupid for words.
KMDickson
http://www.actionlyme.org
===============================
J Infect Dis. 2006 Mar 15;193(6):849-59. Epub 2006 Feb 8.
Borrelia burgdorferi lipoprotein-mediated TLR2 stimulation causes the
down-regulation of TLR5 in human monocytes.
Cabral ES, Gelderblom H, Hornung RL, Munson PJ, Martin R, Marques AR.
Source
Clinical Studies Unit, Laboratory of Clinical Infectious Diseases,
National Institute of Allergy and Infectious Diseases, National
Institutes of Health, Bethesda, Maryland 20892-1888, USA.
Abstract
Toll-like receptors (TLRs) trigger innate immune responses via the
recognition of conserved pathogen-associated molecular patterns.
Lipoproteins from Borrelia burgdorferi, the agent of Lyme disease,
activate inflammatory cells through TLR2 and TLR1. We show that
stimulation of human monocytes with B. burgdorferi lysate, lipidated
outer surface protein A, and triacylated lipopeptide Pam3CysSerLys4
results in the up-regulation of both TLR2 and TLR1 but the down-
regulation of TLR5, the receptor for bacterial flagellin, and that
this effect is mediated via TLR2. TLR4 stimulation had no effect on
TLR2, TLR1, and TLR5 expression. Human monocytes stimulated with TLR5
ligands (including p37 or flaA, the minor protein from B. burgdorferi
flagella) up-regulated TLR5. In addition, TLR2 stimulation rendered
cells hyporesponsive to a TLR5 agonist. These results indicate that
diverse stimuli can cause differential TLR expression, and we
hypothesize that these changes may be useful for either the pathogen
and/or the host.
PMID:
16479520
[PubMed - indexed for MEDLINE]
Free full
======================
WORMSER:
http://www.ncbi.nlm.nih.gov/pubmed/10865170
Modulation of lymphocyte proliferative responses by a canine Lyme
disease vaccine of recombinant outer surface protein A (OspA).
Chiao JW, Villalon P, Schwartz I, Wormser GP.
Source
Department of Medicine, New York Medical College, Valhalla, NY 10595,
USA.
Abstract
The modulation of human lymphocyte proliferative responses was
demonstrated with a recombinant outer surface protein A (OspA) vaccine
preparation for the prevention of Borrelia burgdorferi infection.
After exposure to either the unaltered vaccine preparation or OspA
prepared in saline, normal lymphocyte responses to the mitogens
concanavalin A, phytohemagglutinin-M or pokeweed mitogen, or the
antigen BCG were consistently reduced. Whole cell extracts of B.
burgdorferi also modulated immune responses but required a much
greater quantity of protein than needed for the OspA preparation. The
magnitude of modulation was directly dependent on the quantity of
OspA. OspA interferes with the response of lymphocytes to
proliferative stimuli including a blocking of cell cycle phase
progression. Future studies designed to delete the particular region
or component of the OspA molecule responsible for this effect may lead
to improved vaccine preparations.
==============
The CDC and the Lyme Cryme gang are
mass murderers in addition to being
the most amazingly stupid excuses
for scientists the world has ever
witnessed.
They out-do Monte Python.
KMDickson
KMDickson
Lipanj
They DO *NOT* SAY what Allen Steere
and the gang sued by Blumenthal continue
to say, which is the same Lyme is
a "TOO MANY ANTIBODIES DISEASE."
All double talking creeps, one time it is this then another time that.
Also I believe was said by Sigal- even after one is cured they will
still show certain antibodies...Let's get with it guys?? what in the H
are you talking about - oh yes the "experts".
Mort Zuckerman
Well, they've been totally slammed
by everyone, now.
It's only ILADS who has no clue
why IDSA lost all respect.
LOL
K