"MD" is an unscientificate (Here we go again with the Lyme-abuse tactics by certified morons)
Mort Zuckerman
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Subject: "MD" is an unscientificate (Here we go again with the Lyme-
abuse tactics by certified morons)
Date: Apr 12, 2010 8:00 AM
ARTICLE BELOW- THE LATEST ATTACK,
THIS TIME BY A DUDE NAMED BAKKEN
Why doesn't he just aks Gary Wormser
ABOUDIT??
http://www.actionlyme.org.index.htm
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=10865170%5Buid
It's a sad statement when MDs don't know
how to read scientifical stuff, but Attorneys
General do.
==============================================
http://topnews.us/content/216336-activists-and-physicians-dispute-over-lyme-disease-treatment
Okay, allows me ta refuterate with
very, very big Big-Word-Saying:
1) UConn's Justin Radolf:
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=11441098[uid
"Toll-like receptor 2-dependent inhibition of macrophage class II MHC
expression and antigen processing by 19-kDa lipoprotein of
Mycobacterium tuberculosis."
TRANSLATION:
"TLR2 Agonist OspA suppresses
the immune response, resulting
in no antibodies"
=====================
2) CDC Officer Alan Barbour:
http://www.actionlyme.org/BARBOURS_STEALTH_BOMBERS.htm
"Lyme bacteria auto-vaccinate
its victims with OspA through
spirochetal blebbing. You can
become "seronegative" through
chronic Lyme being chronic."
=======================================
3) Tuberculosis Lipoprotein Vaccines Failures
10792376, 2000 Blackwell Science Ltd
The 19-kD antigen and protective immunity in a murine model of
tuberculosis:
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=10792376[uid]
“These results are consistent with a model in which the presence of
the 19-kD protein has a ***detrimental effect*** on the efficacy of
vaccination with live mycobacteria. “
=============================================
4) PubMed ID 11179309
Infect Immun. 2001 Mar;69(3):1433-9.
Mycobacterium tuberculosis 19-kilodalton lipoprotein inhibits
Mycobacterium smegmatis-induced cytokine production by human
macrophages in vitro.
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=11179309[uid]
“Thus, ***the immunosuppressive effect*** is dependent on glycosylated
and acylated 19-kDa lipoprotein present in the phagosome containing
the mycobacterium. These results suggest that the ***diminished
protectio***n against challenge with M. tuberculosis seen in mice
vaccinated with M. smegmatis expressing the 19-kDa lipoprotein is the
result of ***reduced TNF-alpha and IL-12 production, possibly leading
to reduced induction of T-cell activation.”***
=======================================
5) Slide 78 PubMed ID # 12761093
Infect Immun. 2003 Jun;71(6):3146-54. The Mycobacterium tuberculosis
Recombinant 27-Kilodalton Lipoprotein Induces a Strong Th1-Type Immune
Response ***Deleterious to Protection***
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=12761093[uid]
=========================================
6) Gary Wormser reporting that OspA suppresses the immune response in
2000 PMID# 10865170:
Modulation of lymphocyte proliferative responses by a canine Lyme
disease vaccine of recombinant outer surface protein A (OspA).
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=10865170[uid]
“After exposure to either the unaltered vaccine preparation or OspA
prepared in saline, ***normal lymphocyte responses*** to the mitogens
concanavalin A, phytohemagglutinin-M or pokeweed mitogen, or the
antigen ***BCG [TUBERCULOSIS-OspA] ***were consistently reduced.***
Whole cell extracts of B. burgdorferi also modulated immune responses
but required a much greater quantity of protein than needed for the
OspA preparation. The magnitude of modulation was directly dependent
on the quantity of OspA. ***OspA interferes with the response of
lymphocytes to proliferative stimuli including a blocking of cell
cycle phase progression.*** Future studies designed to delete the
particular region or component of the OspA molecule responsible for
this effect may lead to improved vaccine preparations.
=========================================
7) US Army and National Cancer Institute
Pathologist Paul Duray (1992, COLDSPRINGHARBOR):
http://www.actionlyme.org/Duray.htm
http://www.actionlyme.org/080924.htm
◄"On occasion, these atypical-appearing large lymphocytes have been
misinterpreted in biopsy by several laboratories as cells of a
malignant lymphoma or leukemia. Bb antigens, then, may stimulate
growth of immature lymphocytic suibsets in some target organs, as well
as in the cerebrospinal fluid (Szyfelbein and Ross 1988). Usual
bacterial infections do not produce such lymphocytic infiltrates in
tissue. ***These immunoblastoid cells in Bb infections at times
resemble those found in Epstein-Barr virus infections. Does Bb
reactivate latent virus infections in tissues?*** Do some tick
inocula harbor simultaneous infectious agents (ixodid ticks can harbor
Rickettsiae, Babesia microti, and Ehrlichia bacteria, in addition to
Bb), producing multi-agent infections in some hosts? Further studies
can clarify these issues by mans of tissue-based molecular probe
analysis." -
Paul Duray, NCI, NIH, Ft. Detrick, at the 1992 Cold Spring Harbor
Crooks' Conference, published in Steve Schutzer's Lyme Disease:
Molecular and Immunologic Approaches.
http://www.amazon.com/Lyme-Disease-Immunologic-Approaches-Communications/dp/0879693770/ref=sr_1_2?ie=UTF8&s=books&qid=1214848669&sr=1-2
====================================
8) Tolerance Induced by the Lipopeptide Pam3Cys Is Due to Ablation of
IL-1R-Associated Kinase-11 [PMID# 15294992, 2004]
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=15294992[uid]
“Preculture of the cells with Pam3Cys at 1 µg/ml leads to a reduced
response after subsequent stimulation with Pam3Cys at 10 µg/ml,
indicating that ***the cells have become tolerant to Pam3Cys.*** …
==========================================
9) Mycoplasma fermentans infection promotes ***immortalization***
[Duray] of human peripheral blood mononuclear cells in culture, 2004,
PMID #15331449
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=15331449[uid]
Blood, 15 December 2004, Vol. 104, No. 13, pp. 4252-4259.
http://bloodjournal.hematologylibrary.org/cgi/content/full/104/13/4252
“Our present study revealed that infection of human PBMCs in culture
with the incognitus and PG18 strains of M fermentans, but surprisingly
not with some other strains tested in parallel, markedly enhanced the
rate of EBV-positive B lymphocytes to undergo immortalization (74% vs
17%). Compared with spontaneously immortalized PBMCs, the PBMCs
immortalized in cultures infected with the mycoplasmas often had
prominent karyotype changes with chromosomal loss, gain, or
translocations. Furthermore, many of these immortalized B lymphocytes
were found to be monoclonal in nature. The in vitro findings would be
of relevance to lymphoproliferative disorders that occurred in
patients with immune suppression. The mycoplasma-mediated promotional
effect in cell immortalization and its potential clinical implications
warrant further study.
================================================
10) Review of where Pam3Cys is found (previous slides, slide 28, PMID
15294986, 2004)
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=15294986[uid]
http://www.jimmunol.org/cgi/content/full/173/4/2683
“…subsequent studies investigating immune responses to spirochetes
used synthetic lipopeptides (22). The Pam3Cys moiety was also reported
to be present in cytokine-inducing lipoproteins of Mycobacterium and
Mycoplasma spp. (23, 24); thus, it can be regarded as a highly
conserved molecular motif among different classes of bacteria. In
Mycoplasma fermentans, the presence of a macrophage stimulating
lipopeptide, termed 2-kDa macrophage-activating lipopeptide (MALP-2),
…”
==================================
11) Mycoplasma fermentans ***inhibits*** tumor necrosis factor alpha-
induced apoptosis.
Mycoplasma fermentans inhibits tumor necrosis factor alpha-induced
apoptosis in the human myelomonocytic U937 cell line. [PMID #
15286682, Nov 2004]
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=15286682[uid]
=========================================
12) Induction of in vitro reprogramming by Toll-like receptor (TLR)2
and TLR4 agonists in murine macrophages: effects of TLR
"homotolerance" versus "heterotolerance" on NF-kappa B signaling
pathway components, 2003 PMID # 12496438
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=12496438[uid]
============================================
13) Yale on Epstein-Barr as the activator
of Lyme (and LYMErix) -induced-Lupus:
http://www.ncbi.nlm.nih.gov/pubmed/20178121
Yale on Lyme as a cause of Lupus, 1989:
http://www.actionlyme.org/LYME_AND_LUPUS_STEERE.htm
Same Data given to Special Ed DCF in November,
2003:
http://www.actionlyme.org/Psychiatric_MumboJumbo.wmv
(Viewed over 10,000 times)
==================================================
14) What was told to the FDA LYMErix Vaccine Committee in January 2001
http://www.fda.gov/ohrms/dockets/ac/01/slides/3680s2_11.pdf
“By what mechanism vaccination of the asymptomatic Bb infected
patients is causing the Lyme like illness, we do not know exactly.
Previous infection could be "priming" the immune system, as Denise
Huber of Tufts has suggested, in "Identification of LFA-1 as a
Candidate Autoantigen in Treatment-Resistent Lyme Arthritis" July 31,
1998, Science, Vol 281, p 703. “or the vaccine is activating a dormant
infection by the immune dysregulation it causes, as demonstrated by
the effect of Bb infection and Osp A alone, on NK cells population, T
cells, neutrophils, and the effects on the various inflammatory
regulating biomoleclues, such as IL-10. …
“We simply don't know all the variables, at present, that effect
systemic illness from immune dysregulation caused by Bb infection, and
especially the effect of a such a a large dose of a known immune
irritant, Osp A upon this system, the asymptomatic Lyme patient."
==============================================
The Schoen-Persing RICO patent:
http://patft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=6045804.PN.&OS=PN/6045804&RS=PN/6045804
"Additional uncertainty may arise if the vaccines are not completely
protective; ***vaccinated patients with multisystem complaints
characteristic of later presentations of Lyme disease may be difficult
to distinguish from patients with vaccine failure.***
==============================================
APPLICATIONS of the mechanisms of LYMErix Immunosuppression:
1) (GERMAN) "Stimulation of axon regeneration in the mature optic
nerve by intravitreal application of the toll-like receptor 2 agonist
Pam3Cys."
http://www.ncbi.nlm.nih.gov/pubmed/19661221
2) (GERMAN) Preconditioning by toll-like receptor 2 agonist Pam3CSK4
reduces CXCL1-dependent leukocyte recruitment in murine myocardial
ischemia/reperfusion injury.
http://www.ncbi.nlm.nih.gov/pubmed/20081527
3) (CHINESE) "We think we have discovered a mechanism to reverse or
inhibit the immune system damage from LYMErix" and the chronic
blebbing (the autovaccination with Pam3Cys and subsequent tolerization
to similar, fungal infections) chronic, persistent Relapsing Fever
(AKA "Lyme Disease")
http://www.ncbi.nlm.nih.gov/pubmed/20092701
4) (NETHERLANDS) Harnessing LYMErix-like immortalized cells to pharm
antibodies:
http://www.nature.com/scibx/journal/v3/n2/full/scibx.2010.37.html
" the team transfected the dormant memory cells with two transcription
factors—B-cell CLL lymphoma 6 (BCL6) and BCL-XL—the cells began to
proliferate and secrete antibodies." --
the antiapoptosis promoted by Lithium or Pam3Cys/Epstein-Barr.
======================================
=============================================
http://topnews.us/content/216336-activists-and-physicians-dispute-over-lyme-disease-treatment
.
Medical experts say that it is a careless, unconfirmed and possibly an
unsafe approach.
Today, Backes, 39, is healthy enough to run marathons and is helping
lead a grass-roots attempt to modify the way doctors treat patients
like her.
Lyme disease campaigners, who call themselves "Lymies", are talking in
courtrooms, state legislatures and even a new documentary, "Under Our
Skin", to argue that the specialists are wrong. They might have a
rising audience; around 1,000 Lyme disease cases were reported in
Minnesota in 2008, a fourfold boost since 1998.
Last month, with the help of some understanding legislators, activists
from the Minnesota Lyme Action Support Group forced the State Board of
Medicine to give up, for now, the ability to discipline doctors for
making use of the unconfirmed treatment.
Rob Leach, the Board's Executive Director, said that it was unusual,
in part since the board has never ordered or even received a complaint
about a doctor for using such treatments.
Supporters say that while some doctors have been disciplined in other
states for using the unverified treatment, some general practitioners
in Minnesota have said that they will not provide it because they're
scared of facing the same destiny.
Dr. Johan S. Bakken, an infectious-disease specialist at St. Luke's
Hospital in Duluth, dubs it, "a sad statement when politicians begin
to practice medicine without a license".
0diggsdigg
"[Real] scientists are *fiercely* independent. That's the good
news."-- NIH's Top Fool, Anthony Fauci
Dan Sullivan
Mort Zuckerman
Mort Zuckerman
> Dan Sullivan <dsull...@optonline.net> wrote:
> >zzzzzzzzzzzzzzzzzzzzzzz
>
> Will you knock this off, you ignorant fuckwit? You don't fix noise by
> making more stupid noise.
archived,
LOL