Subject: Lyme Crooks Finally Admit/Submit to LYMErix/Lyme Immunosuppression (Tufts)
Date: Mar 11, 2011 5:40 AM
ARTICLE BELOW ===================================
Had to happen, cuz like I said on the homepage of ActionLyme.org, no one can make a move unless they admit what LYMErix Is/Does: http://www.actionlyme.org/
More Info (better and more accurate summary of the mechanisms of immunosuppression/activation of latent common viruses than this, below) at http://www.actionlyme.org/101016.htm
This tosses Yale's/IDSA's "disease" (hypersensitivity-only) model and the diagnostic standard for Lyme out the window, and with it, Klempner's garbage and IDSA's downstream, "Lyme Causes Nothing" insanity ("Guidelines on the Diagnosis and Treatment of Lyme Disease" http://www.actionlyme.org/MKLEMPNER.htm )
====================================== http://www.ncbi.nlm.nih.gov/pubmed/21387014 PLoS One. 2011 Feb 28;6(2):e17414. Nod2 Suppresses Borrelia burgdorferi Mediated Murine Lyme Arthritis and Carditis through the Induction of Tolerance.
Petnicki-Ocwieja T, Defrancesco AS, Chung E, Darcy CT, Bronson RT, Kobayashi KS, Hu LT.
Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, Massachusetts, United States of America. Abstract
The internalization of Borrelia burgdorferi, the causative agent of Lyme disease, by phagocytes is essential for an effective activation of the immune response to this pathogen. The intracellular, cytosolic receptor Nod2 has been shown to play varying roles in either enhancing or attenuating inflammation in response to different infectious agents. We examined the role of Nod2 in responses to B. burgdorferi. In vitro stimulation of Nod2 deficient bone marrow derived macrophages (BMDM) resulted in decreased induction of multiple cytokines, interferons and interferon regulated genes compared with wild-type cells. However, B. burgdorferi infection of Nod2 deficient mice resulted in increased rather than decreased arthritis and carditis compared to control mice. We explored multiple potential mechanisms for the paradoxical response in in vivo versus in vitro systems and found that prolonged stimulation with a Nod2 ligand, muramyl dipeptide (MDP), resulted in tolerance to stimulation by B. burgdorferi. This tolerance was lost with stimulation of Nod2 deficient cells that cannot respond to MDP. Cytokine patterns in the tolerance model closely paralleled cytokine profiles in infected Nod2 deficient mice. We propose a model where Nod2 has an enhancing role in activating inflammation in early infection, but moderates inflammation after prolonged exposure to the organism through induction of tolerance.
