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Iron In Periodontal Disease
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ironjustice
Nov 20, 2011, 12:25:37 PM11/20/11
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In vitro activity of deferoxamine against Porphyromonas gingivalis.
FEMS Microbiol Lett. 2011 Oct;323(1):61-7. Epub 2011 Aug 5.
Moon JH, Herr Y, Kim SW, Lee JY, Hantke K.
Department of Maxillofacial Biomedical Engineering, School of
Dentistry, Kyung Hee University, Seoul, Korea; Institute of Oral
Biology, Kyung Hee University, Seoul, Korea.
Abstract
Deferoxamine (DFO), an FDA-approved iron chelator used for treatment
of iron poisoning, affects bacteria as iron availability is intimately
connected with growth and several virulence determinants.
However, little is known about the effect on oral pathogens.
In this study, the effect of DFO on Porphyromonas gingivalis, a major
periodontopathogen which has an essential growth requirement for hemin
(Fe(3+) -protoporphyrin IX), was evaluated.
The viability of P. gingivalis W83 was not affected by 0.06-0.24 mM
DFO, whereas the doubling time of the bacterium was considerably
prolonged by DFO.
The inhibitory effect was evident at earlier stages of growth and
reduced by supplemental iron.
UV-visible spectra using the pigments from P. gingivalis cells grown
on blood agar showed that DFO inhibited μ-oxo bisheme formation by the
bacterium.
DFO decreased accumulation and energy-driven uptake of hemin by P.
gingivalis.
Antibacterial effect of H(2) O(2) and metronidazole against P.
gingivalis increased in the presence of DFO. Collectively, DFO is
effective for hemin deprivation in P. gingivalis suppressing the
growth and increasing the susceptibility of the bacterium to other
antimicrobial agents such as H(2) O(2) and metronidazole.
Further experiments are necessary to show that DFO may be used as a
therapeutic agent for periodontal disease.
© 2011 Federation of European Microbiological Societies.
PMID:22092680
doi: 10.1111/j.1574-6968.2011.02357.x.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
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FEMS Microbiol Lett. 2011 Oct;323(1):61-7. Epub 2011 Aug 5.
Moon JH, Herr Y, Kim SW, Lee JY, Hantke K.
Department of Maxillofacial Biomedical Engineering, School of
Dentistry, Kyung Hee University, Seoul, Korea; Institute of Oral
Biology, Kyung Hee University, Seoul, Korea.
Abstract
Deferoxamine (DFO), an FDA-approved iron chelator used for treatment
of iron poisoning, affects bacteria as iron availability is intimately
connected with growth and several virulence determinants.
However, little is known about the effect on oral pathogens.
In this study, the effect of DFO on Porphyromonas gingivalis, a major
periodontopathogen which has an essential growth requirement for hemin
(Fe(3+) -protoporphyrin IX), was evaluated.
The viability of P. gingivalis W83 was not affected by 0.06-0.24 mM
DFO, whereas the doubling time of the bacterium was considerably
prolonged by DFO.
The inhibitory effect was evident at earlier stages of growth and
reduced by supplemental iron.
UV-visible spectra using the pigments from P. gingivalis cells grown
on blood agar showed that DFO inhibited μ-oxo bisheme formation by the
bacterium.
DFO decreased accumulation and energy-driven uptake of hemin by P.
gingivalis.
Antibacterial effect of H(2) O(2) and metronidazole against P.
gingivalis increased in the presence of DFO. Collectively, DFO is
effective for hemin deprivation in P. gingivalis suppressing the
growth and increasing the susceptibility of the bacterium to other
antimicrobial agents such as H(2) O(2) and metronidazole.
Further experiments are necessary to show that DFO may be used as a
therapeutic agent for periodontal disease.
© 2011 Federation of European Microbiological Societies.
PMID:22092680
doi: 10.1111/j.1574-6968.2011.02357.x.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
Ankur
Nov 21, 2011, 12:33:08 AM11/21/11
to
* ironjustice <ironj...@cool.zzn.com>
--
Ankur
> In vitro activity of deferoxamine against Porphyromonas gingivalis.
Why did you post this?
--
Ankur
Maier Yancov
Nov 21, 2011, 1:19:49 AM11/21/11
to
because it's encouraging news ?
Ankur
Nov 21, 2011, 6:45:09 AM11/21/11
to
* Maier Yancov <mya...@gmail.com>
Encouraging as in possible clinical application? Discovery of some new thing?
(I don't see how it is anything exciting. Isn't this pretty
much expected, as bacteria have an obligate requirement for iron?
<http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1000949>)
--
Ankur
> because it's encouraging news ?
How so?
Encouraging as in possible clinical application? Discovery of some new thing?
(I don't see how it is anything exciting. Isn't this pretty
much expected, as bacteria have an obligate requirement for iron?
<http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1000949>)
--
Ankur
Steven Bornfeld
Nov 21, 2011, 12:51:12 PM11/21/11
to
there.
Steve
--
Mark & Steven Bornfeld DDS
http://www.dentaltwins.com
Brooklyn, NY
718-258-5001
Stormin Mormon
Nov 21, 2011, 9:45:56 PM11/21/11
to
I'll leave you to iron out the details. But maybe you should
go to the restaurant, and get a couple steaks, high in iron.
After that, you can go to the carnivorous carnival, and ride
the ferrous wheel? Unless that's getting long in the tooth,
being dentists and all.
--
Christopher A. Young
Learn more about Jesus
www.lds.org
.
"Steven Bornfeld" <bornfe...@dentaltwins.com> wrote in
message news:jae32c$r8k$1...@dont-email.me...
go to the restaurant, and get a couple steaks, high in iron.
After that, you can go to the carnivorous carnival, and ride
the ferrous wheel? Unless that's getting long in the tooth,
being dentists and all.
--
Christopher A. Young
Learn more about Jesus
www.lds.org
.
"Steven Bornfeld" <bornfe...@dentaltwins.com> wrote in
message news:jae32c$r8k$1...@dont-email.me...
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