Glycated substances & Diabetes?
kumar
"Advanced Glycation in Health and Disease: Role of the Modern
Environment
HELEN VLASSARA
It is believed that intracellular and extracellular advanced glycation
(AGEs) or lipoxidation end products (ALEs), together with dysregulated
glucose and lipid metabolism, are important contributors to oxidant or
carbonyl stress, enhanced cellular redox-sensitive transcription factor
activity, and impaired innate immune defense, causing over time
inappropriate inflammatory responses. However, neither the magnitude
nor the persistent nature of this increased prooxidant state are
completely understood. A significant correlation has been found between
ingested and circulating AGEs in humans in recent years. Based on
animal studies, the injurious impact of diet-derived AGEs to vascular
and kidney tissues is estimated to rival or even exceed that caused by
hyperglycemia or hyperlipidemia. Consistent with this view, dietary AGE
restriction has been associated with suppression of several immune
defects, insulin resistance, and diabetic complications, whether
genetically or diet induced, despite persistent diabetes. These
findings are in support of clinical evidence from subjects with
diabetes or vascular or kidney disease. Most recently, evidence from
animal studies points to AGE restriction as an effective means for
extending median life span, similar to that previously shown by marked
caloric restriction. We conclude that excessive AGE consumption, in the
current dietary/social structure, represents an independent factor for
inappropriate oxidant stress responses, which may promote the premature
expression of complex diseases associated with adult life, such as
diabetes and cardiovascular disease.
http://www.annalsnyas.org/cgi/content/abstract/1043/1/452 "
"..Exogenous glycations and Advanced Glycation Endproducts (AGEs) are
typically formed when sugars are cooked with proteins or fats.
Temperatures over 120°C (~248°F) greatly accelerate the reactions,
but lower temperatures with longer cooking times also promote their
formation.
These compounds are absorbed by the body during digestion with about
30% efficiency....
..Endogenous glycations occur mainly in the bloodstream to a small
proportion of the absorbed simple sugars: glucose, fructose and
galactoseThis range of diseases is the result of the very basic level
at which glycations interfere with molecular and cellular functioning
throughout the body and the release of highly-oxidizing side products
such as hydrogen peroxide.
Glycated substances are eliminated from the body slowly, since the
renal clearance factor is only about 30%.
http://en.wikipedia.org/wiki/Glycation
"
In view of above quotes, can exogenous and endogenously made glycated
substances be considered as significant factor to cause systemic
inflammation, insulin resistance, diabetes and complications causing
agents in diabetics type2?
Many cooked, fried, prepared foods and fructose(fruits etc.) and
glactose(diary,milk) are bit indicative to be linked to such effect by
glycated substances.
It is to be uinderstood that whether glycated substances are formed by
mixing and cooking just only sugar with protiens and fats OR also all
carbohydrates with protiens and fats?
Bill
Thanks for the post !I looked into a bit found an interesting idea.
Microwave as precooking.
Perhaps Bob this one can comment.
Public release date: 31-Oct-2006
Contact: Polly Young
pyo...@wiley.co.uk
44-012-437-70633
John Wiley & Sons, Inc.
Microwave pre-cooking of French fries reduces cancer chemicals
Research news from the Journal of the Science of Food and Agriculture
Microwaving your French fries before you fry them reduces the levels of
a cancer-causing substance, reveals findings published today in the
SCI's Journal of the Science of Food and Agriculture.
The discovery of acrylamide - a possible carcinogenic in humans - has
led to much research being done to investigate the benefits of
alternative cooking methods. Acrylamide forms during processes such as
frying, baking and roasting where high-temperature and low-moisture
conditions exist.
Although numerous studies have been conducted to explore the
possibilities of reducing acrylamide levels in French fries, a team of
researchers from Turkey has shown that by reducing the frying time and
hence the acrylamide formation by microwave pre-cooking of potato
strips prior to frying.
Publishing their work in the Journal of the Science of Food and
Agriculture, the researches showed that microwave application prior to
frying resulted in a marked reduction of the acrylamide level in the
surface region. When the potato strips were subjected to frying after a
microwave pre-cooking step, acrylamide content in the whole potato
strip was reduced by 36%, 41% and 60% for frying at 150, 170 and 190oC
respectively.
"Microwaving French fries before cooking takes little time and in fact,
microwave pre-cooked samples fried to the same degree of cooking
appeared to have a more acceptable colour, probably due to the more
gentle heat treatment they experienced during frying," says lead author
Koray Palazoglu, of the University of Mersin, Turkey.
###
Notes For Editors:
Palazoglu, K: Reduction of acrylamide formation in French fries by
microwave pre-cooking of potato strips, DOI: 10.1002/jsfa.2688
The url for this article is: http://www.interscience.wiley.com/jsfa
To obtain a full copy of the article or for any further information
please contact Polly Young
About the Journal of the Science of Food and Agriculture
Journal of the Science of Food and Agriculture is an SCI journal,
published by John Wiley & Sons, on behalf of the Society of Chemical
Industry, and is available in print (ISSN: 0022-5142) and online (ISSN:
1097-0010) via Wiley Interscience www.interscience.wiley.com For
further information about the journal go to www.wiley.com/sci.
About SCI
SCI is 'where science meets business'; an interdisciplinary network
connecting Science, Commerce and Industry at all levels worldwide.
Founded in London in 1881 and in New York in 1894, SCI provides
opportunities for forward looking people in the pharmaceuticals,
chemical, energy, water, materials, agriculture, environmental
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perspectives on technologies, markets, strategies and people. SCI's
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prizes and scholarships, books, and the respected twice-monthly
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About Wiley
John Wiley & Sons, Ltd., based in Chichester, England, is the largest
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and JWb. Wiley's recently relaunched Internet site can be accessed at
http://www.wiley.com.
............................
Glycation
>From Wikipedia, the free encyclopedia
Glycation (sometimes called non-enzymatic glycosylation) is the result
of a sugar molecule, such as fructose or glucose, bonding to a protein
or lipid molecule without the controlling action of an enzyme. All
blood sugars are reducing molecules. Glycation may occur either inside
(endogenous) or outside (exogenous) the body. Enzyme-controlled
addition of sugars to protein or lipid molecules is termed
glycosylation; this process is less haphazard than glycation. Much of
early laboratory research work on fructose glycations used inaccurate
assay techniques that drastically understated the importance of
fructose in glycation formation (Ahmed & Furth 1992).
Contents
[hide]
1 Exogenous
2 Endogenous
3 References
4 See also
[edit]Exogenous
Exogenous, which literally means 'outside the body' may also be
referred to as "dietary" or "pre-formed." Exogenous glycations and
Advanced Glycation Endproducts (AGEs) are typically formed when sugars
are cooked with proteins or fats. Temperatures over 120°C (~248°F)
greatly accelerate the reactions, but lower temperatures with longer
cooking times also promote their formation.
These compounds are absorbed by the body during digestion with about
30% efficiency. Browning reactions (usually Maillard type reactions)
are evidence of pre-formed glycations. Indeed, sugar is often added to
products such as French fries and baked goods to enhance browning.
Glycation may also contribute to the formation of acrylamide (Stadler
et al 2002), a potential carcinogen, during cooking. Until recently, it
was thought that exogenous glycations and AGEs were negligible
contributors to inflammation and disease states, but recent work has
shown that they are important (Vlassara, 2005). Although most of the
research work has been done with reference to diabetes, these results
are most likely important for all people as exogenous AGEs are
implicated in the initiation of retinal dysfunction, cardiovascular
diseases, type II diabetes, and many other age related chronic
diseases.
Food manufacturers have added AGEs to foods, especially in the last 50
years, as flavor enhancers and colorants to improve appearance (Peppa
et. al. 2003). Foods with significant browning, caramelization, or with
directly added preformed AGEs can be exceptionally high in these
proinflammatory and disease initiating compounds. A very partial
listing of foods with very high exogenous AGEs includes: donuts,
barbecued meats, cake, and dark colored soda pop (Koschinsky, et. al.
1997).
[edit]Endogenous
Endogenous glycations occur mainly in the bloodstream to a small
proportion of the absorbed simple sugars: glucose, fructose and
galactose. The balance of the sugar molecules is used for metabolic
processes. It appears that fructose and galactose have approximately
ten times the glycation activity of glucose, the primary body fuel
(McPherson et al 1988). Glycation is the first step in the evolution of
these molecules through a complex series of very slow reactions in the
body known as Amadori reactions, Schiff base reactions, and Maillard
reactions; all lead to advanced glycation endproducts (AGEs). Some AGEs
are benign, but others are more reactive than the sugars they are
derived from, and are implicated in many age-related chronic diseases
such as: type II diabetes mellitus (beta cell damage), cardiovascular
diseases (the endothelium, fibrinogen and collagen are damaged),
Alzheimer's disease (amyloid proteins are side products of the
reactions progressing to AGEs), cancer (acrylamide and other side
products are released), peripheral neuropathy (the myelin is attacked),
and other sensory losses such as deafness (due to demyelination) and
blindness (mostly due to microvascular damage in the retina). This
range of diseases is the result of the very basic level at which
glycations interfere with molecular and cellular functioning throughout
the body and the release of highly-oxidizing side products such as
hydrogen peroxide.
Glycated substances are eliminated from the body slowly, since the
renal clearance factor is only about 30%. This implies that the
half-life of a glycation within the body is about double the average
cell life. Red blood cells are the shortest-lived cells in the body
(120 days), so, the half life is about 240 days. This fact is used in
monitoring blood sugar control in diabetes by monitoring the glycated
hemoglobin level. As a consequence, long-lived cells (such as nerves,
brain cells), long-lasting proteins (such as eye crystalline and
collagen), and DNA may accumulate substantial damage over time.
Metabolically-active cells such as the glomeruli in the kidneys, retina
cells in the eyes, and beta cells (insulin-producing) in the pancreas
are also at high risk of damage. The epithelial cells of the blood
vessels are damaged directly by glycations, which are implicated in
atherosclerosis, for example. Atherosclerotic plaque tends to
accumulate at areas of high blood flow (such as the entrance to the
coronary arteries) due to the increased presentation of sugar
molecules, glycations and glycation end-products at these points.
Damage by glycation results in stiffening of the collagen in the blood
vessel walls, leading to high blood pressure. Glycations also cause
weakening of the collagen in the blood vessel walls, which may lead to
micro- or macro-aneurisms; this may cause strokes if in the brain.
[edit]References
Ahmed N, Furth AJ. Failure of common glycation assays to detect
glycation by fructose. Clin Chem 1992;38:1301-3 PMID 1623595.
McPherson JD, Shilton BH, Walton DJ. Role of fructose in glycation and
cross-linking of proteins. Biochemistry 1988;27:1901-7. PMID 3132203.
Stadler RH, Blank I, Varga N, Robert F, Hau J, Guy PA, Robert MC,
Riediker S. Acrylamide from Maillard reaction products. Nature
2002;419:449-50. PMID 12368845.
Vlassara, Helen, Advanced Glycation in Health and Disease: Role of the
Modern Environment. Annals of the New York Academy of Science. 1043:
452-460 (2005). doi: 10.1196/annals.1333.051
Melpomeni Peppa, et al, Glucose, Advanced Glycation End Products, and
Diabetes Complications: What Is New and What Works. Clinical Diabetes
· Volume 21, Number 4, 2003
Theodore Koschinsky, et. al. An environmental risk factor in diabetic
nephropathy, An environmental risk factor in diabetic nephropathy.
Proceedings of the National Academy of Science, USA Vol. 94, pp.
6474-6479, June 1997
[edit]See also
Alagebrium
Glycosylation
fructose
glucose
http://en.wikipedia.org/wiki/Glycation
Kumar
Bill wrote:
snips
> kumar wrote:
> > Hello,
> >
> > "Advanced Glycation in Health and Disease: Role of the Modern
> > Environment
>microwave...
>sugar is often added to
products such as French fries and baked goods to enhance browning.
Glycation may also contribute to the formation of acrylamide (Stadler
et al 2002), a potential carcinogen, during cooking...
> Alagebrium
> Glycosylation
> fructose
> glucose
> http://en.wikipedia.org/wiki/Glycation
Good Idea,thanks. We can dig more into microwave cooking for this
purpose. As such, Can we avoid glycation of foods by using microwave?
coon...@amestwp.com
we avoid glycation of foods by using microwave?"
Any method can minimize this. It is mostly a product of cooking at high
temperatures such as with frying and baking for long times. Steaming,
boiling, stewing, microwaving, etc. will produce little. The best guide
is the color of or darkness of finished food. These glycation products
produce the browning effect from long fried and baked foods so any
method, including frying and baking, which produce little or none of the
browning is much safer.
Bill
Boiled ham and cabbage Umm. Thanks for the info Coons makes sense.
I thought the interesting point was we can pre--cook and then get our
brown turkey / etc and reduce glycation.
Fire good Umm Fire bad ...............
Etc might be carrots??
Bill who says if it is too difficult I'll change.
Andrew B. Chung, MD/PhD
Wiser to simply eat less down to the right amount and lose all the
visceral adipose tissue (VAT) which is the proximate cause of metabolic
syndrome (MetS), which is the precursor of type-2 diabetes:
http://HeartMDPhD.com/HolySpirit/Overweight.asp
Reducing intake has been shown to double the lifespan of laboratory
animals.
May GOD continue to help you with your needs, dear Bill whom I love
unconditionally.
Prayerfully in Christ's amazing love,
Andrew <><
--
Andrew B. Chung
Cardiologist, Atlanta, Georgia, USA
http://HeartMDPhD.com/HolySpirit
As for knowing who are the very elect, these you will know by the
unconditional love they have for everyone including their enemies
(Matthew 5:44-45, 1 Corinthians 13:3, James 2:14-17).
http://HeartMDPhD.com/Love
coon...@amestwp.com
foods:
"Wiser to simply eat less down to the right amount and lose all the
visceral adipose tissue (VAT) which is the proximate cause of metabolic
syndrome (MetS), which is the precursor of type-2 diabetes:"
Incorrect by being incomplete. Irrelevant by not addressing the
question. Not useful by failing to provide applicable information
beyond private agenda driven opinion.
"Reducing intake has been shown to double the lifespan of laboratory
animals."
Again incorrect by being misinformed and not complete, it pays to keep
up with the literature on such matters and forgo non-relevant agendas
which distort the science involved.
Bob
coon...@amestwp.com wrote:
> "We can dig more into microwave cooking for this purpose. As such, Can
> we avoid glycation of foods by using microwave?"
Maybe not.
"Also, microwaving increased AGE content more rapidly compared with
conventional cooking methods."
Alan S
Interesting. For totally different reasons - fat reduction -
I have cooked "oven fries" as described below as part of my
own cooking plan, without realising that it may have other
benefits:
"Oven fry french fries – cut them large (not like thin
McDonalds), throw them in boiling water until not quite
cooked (still firm), spray an oven tray with cooking oil
then place the "fries" on the tray and spray again lightly.
Cook in the oven at about 200c (390F) until done. Use your
meter to see what portion size you can handle. Mine is three
chips."
I also pre-cook potatos and pumpkin(squash) in the microwave
before browning the surfaces on the BBQ; in that case it was
to match cooking times to the meats to produce a "baked"
effect. Again, I may have achieved a benefit I was ignorant
of. They taste good that way too:-)
Thanks.
Cheers, Alan, T2, Australia.
d&e, metformin 1000mg, ezetrol 10mg
Everything in Moderation - Except Laughter.
--
http://loraldiabetes.blogspot.com/
http://loraltravel.blogspot.com/
latest: Tuscany, Radicofani, Lake Bolsena
Andrew B. Chung, MD/PhD
LORD GOD Almighty is the Source of all knowledge and wisdom.
May GOD continue to keep your heart beating, dear neighbor whom I love
unconditionally
Prayerfully in Christ's amazing love,
Andrew <><
--
Andrew B. Chung
Cardiologist, Atlanta, Georgia, USA
http://HeartMDPhD.com/HolySpirit
As for knowing who are the very elect, these you will know by the
unconditional love they have for everyone including their enemies
(Matthew 5:44-45, 1 Corinthians 13:3, James 2:14-17).
http://HeartMDPhD.com/Love
Kumar
Thanks. It looks our intake of glycated foods may not be much, still we
can avoid if diabetic.
What about intake of fructose(fruits etc.) and glactose(diary,milk)
which are indicated to to cause glycated substances endogenously?
Kumar
Andrew B. Chung, MD/PhD wrote:
> Bill wrote:
> > coon...@amestwp.com wrote:
> > > "We can dig more into microwave cooking for this purpose. As such, Can
> > > we avoid glycation of foods by using microwave?"
> > >
> > > Any method can minimize this. It is mostly a product of cooking at high
> > > temperatures such as with frying and baking for long times. Steaming,
> > > boiling, stewing, microwaving, etc. will produce little. The best guide
> > > is the color of or darkness of finished food. These glycation products
> > > produce the browning effect from long fried and baked foods so any
> > > method, including frying and baking, which produce little or none of the
> > > browning is much safer.
> >
> > Boiled ham and cabbage Umm. Thanks for the info Coons makes sense.
> >
> >
> > I thought the interesting point was we can pre--cook and then get our
> > brown turkey / etc and reduce glycation.
> >
> > Fire good Umm Fire bad ...............
> >
> > Etc might be carrots??
> >
> > Bill who says if it is too difficult I'll change.
>
> Wiser to simply eat less down to the right amount and lose all the
> visceral adipose tissue (VAT) which is the proximate cause of metabolic
> syndrome (MetS), which is the precursor of type-2 diabetes:
>
> http://HeartMDPhD.com/HolySpirit/Overweight.asp
Can fruits and milk/diary intake cause production of glycated
substances endogenously?
Noway2
Andrew B. Chung, MD/PhD wrote:
>
documented.
> LORD GOD Almighty is the Source of all knowledge and wisdom.
>
Now I guess we all know where you got yours. Or didn't.
> May GOD continue to keep your heart beating, dear neighbor whom I love
> unconditionally
>
The only thing you love is the site of your own drivol.
> Prayerfully in Christ's amazing love,
>
Why don't you go back to blowing bubbles in your soup like you used to
do before discovering Usenet.
> Andrew <><
> --
> Andrew B. Chung
> Cardiologist, Atlanta, Georgia, USA
> http://HeartMDPhD.com/HolySpirit
>
Is that what you are calling your self this time around?
> As for knowing who are the very elect, these you will know by the
> unconditional love they have for everyone including their enemies
> (Matthew 5:44-45, 1 Corinthians 13:3, James 2:14-17).
> http://HeartMDPhD.com/Love
>
If you really loved everyone you would go away
coon...@amestwp.com
which are indicated to to cause glycated substances endogenously?"
These sources are the same as glucose. It is not that we consume them
that directly causes glycation, it is that when they rise to high levels
they prompt glycation by overwhelming the bodies ability to prevent it.
Everyone has glycation products, that is what the a1c test for diabetics
measures. But with the much higher levels of glucose and fructose that
diabetics have because they do not dispose of them quickly enough they
have a parallel high level of glycation. That leads to much wider
tissue damage and diabetic complications if glucose levels are not
controled near normal levels.
Andrew B. Chung, MD/PhD
Not in optimal amounts in folks without significant visceral adipose
tissue (VAT):
http://groups.google.com/group/sci.med.cardiology/msg/352546a7bf4a81ee?
> > Reducing intake has been shown to double the lifespan of laboratory
> > animals.
May GOD continue to heal your heart by curing your diabetes, dear
neighbor Kumar whom I love unconditionally.
coon...@amestwp.com
> substances endogenously?
Not in optimal amounts in folks without significant visceral adipose
tissue (VAT):"
Simply untrue, displays continuing failure to keep up with the
literature, a willful obsession to mislead to achieve an agenda driven
non-scientific goal, and more positive proof the source can be safely
ignored.
Andrew B. Chung, MD/PhD
May GOD continue to keep your heart beating, dear neighbor whom I love
unconditionally.
Prayerfully in Christ's amazing love,
Andrew <><
--
Andrew B. Chung
Cardiologist, Atlanta, Georgia, USA
http://HeartMDPhD.com/HolySpirit
As for knowing who are the very elect, these you will know by the
unconditional love they have for everyone including their enemies
(Matthew 5:44-45, 1 Corinthians 13:3, James 2:14-17).
http://HeartMDPhD.com/Love
coon...@amestwp.com
> substances endogenously?
Not in optimal amounts in folks without significant visceral adipose
tissue (VAT):"
Simply untrue, displays continuing failure to keep up with the
literature, a willful obsession to mislead to achieve an agenda driven
non-scientific goal, and more positive proof the source can be safely
ignored.
ditto
coon...@amestwp.com
in optimal amounts in folks without significant visceral adipose
sue (VAT):"
ply untrue, displays continuing failure to keep up with the
erature, a willful obsession to mislead to achieve an agenda driven
-scientific goal, and more positive proof the source can be safely
ored.
ditto
ditto
Andrew B. Chung, MD/PhD
T
lo...@thetruth.com says...
Sneaky little bastard, you changed domains again.
Plonk!
kumar
Andrew B. Chung, MD/PhD wrote:
Whether overeating causes increased nutrients availability to tissues
resulting more/early growth and replications, thus decreasing the
lifespan?
Can more or early replications of body cells effect aging?
kumar
"Endogenous glycations occur mainly in the bloodstream to a small
proportion of the absorbed simple sugars: glucose, fructose and
galactose. The balance of the sugar molecules is used for metabolic
processes. It appears that fructose and galactose have approximately
ten times the glycation activity of glucose, the primary body fuel
http://en.wikipedia.org/wiki/Glycation "
Can you make your reply more clear in view of above quote?
coon...@amestwp.com
Sure, if I knew what you want. My statement and the snip above are in
complete agreement but stress different aspects of the process. It
happens where evr the blood carries sugars to tissues made of protein
and fat. It can even glycate insulin because it is made of protein.
The higher the glucose/fructose level is, and for the longer times in
diabetics, the opportunity for glycation to happen is multiplied
greatly. The greater the glycation the greater the risk of diabetic
complications and heart disease and stroke. As mentioned, the a1c
number is a reflection of the degree of glycation happening and thus
correlates with the risk levels of the above.
mont...@lycos.com
peroxidation that is causing the glycation problems (in vivo). Here is
yet another study that makes this point:
Diabetes, Obesity and Metabolism
Volume 7 Page 448 - July 2005
doi:10.1111/j.1463-1326.2004.00387.x
Volume 7 Issue 4
Short Report
High-fat diet enhances visceral advanced glycation end products,
nuclear O-Glc-Nac modification, p38 mitogen-activated protein kinase
activation and apoptosis
S.-Y. Li1, Y. Liu1, V. K. Sigmon1, A. McCort1 and J. Ren1*
High-fat diet intake often leads to obesity, insulin resistance and
hypertension, which present a common and detrimental health problem.
However, precise mechanism underlying tissue damage due to high-fat
diet-induced obesity has not been carefully elucidated. The present
study was designed to examine the effect of high-fat diet intake on
visceral advanced glycation end products (AGEs) formation, nuclear
O-Glc-NAc modification and apoptosis in heart, liver and kidney. Adult
male Sprague-Dawley weight-matched rats were fed for 12 weeks with a
high-fat diet (45% kcal from fat) or an isocaloric low-fat diet (10%
kcal from fat). High-fat diet feeding significantly elevated body
weight. Blood pressure and heart rate were comparable between the two
rat groups. Competitive enzyme-linked immunosorbent assay showed
significantly elevated serum AGE levels, visceral AGE formation,
caspase-3 activation and cytoplasmic DNA fragmentation in heart and
liver but not kidney samples of high-fat diet fed rats compared with
those from low-fat diet fed group. Western blot analysis further
revealed that high-fat diet feeding induced overt nuclear O-Glc-NAc
modification and p38 mitogen-activated protein kinase activation in
heart and liver although not in kidney samples of the high-fat diet-fed
rats. Collectively, our results indicated that high-fat diet intake is
associated with obesity accompanied by elevated serum and visceral
AGEs, visceral post-translational nuclear O-Glc-NAcylated modification
and apoptosis, which may contribute to high-fat diet-induced tissue
damage.
Now, if they were more knowledgable they would do another experiment,
this time using fresh coconut oil, and giving the animals a "high fat"
diet. What they would find is that this diet is not a problem at all,
but because they are assuming that "saturated fat is bad," they
apparently don't even consider this possibility, and this is why much
"science" today is unscientific. You must control for all possibly
relevant factors in order to follow the scientific method.
Andrew B. Chung, MD/PhD
The p38 MAP kinase activation would be mediated by the inflammatory
cytokines from the visceral adipose tissue (VAT). Also a high fat (low
carb) diet would also lead to the hyperketonemia which is associated
with accelerated lipid peroxidation.
May GOD continue to heal our hearts with HIS living water, dear
neighbor Monty whomI love unconditionally.
coon...@amestwp.com
this time using fresh coconut oil, and giving the animals a "high fat"
diet. What they would find is that this diet is not a problem at all,
but because they are assuming that "saturated fat is bad," they
apparently don't even consider this possibility, and this is why much
"science" today is unscientific. You must control for all possibly
relevant factors in order to follow the scientific method."
There is a high fat diet used in rodents, including one strain who
become diabetic on it where diabetes is being studied. This diet has
become standardized and in common use where high fat saturated diets are
called for as one factor in research to create metabolic disorders
related to nutrition. It is used as 60 percent of calories and is 100
percent coconut oil.
Kumar
In view of my quote, how want to understand, if fruits(fructose) &
milk/diary(glactose) can be responsible for getting glycation in
diabetics? These foods are taken in lowt of quantity--sometimes
indicated as good and sometimes bad. The above quote indicated these
can be much more responsible for glycation in diabetics. It is also
indicatibe that these are converted to glucose immediately after
absorption but these can be some disorder in such conversion in
diabetics?
kumar
This is quite importand study. We may gave to understand, how so
thought greter visceral adiposity resulting into insulin resistance is
also associated with glycation and elevated AGEs.
anon...@nowhere.you.know
milk/diary(glactose) can be responsible for getting glycation in
diabetics? These foods are taken in lowt of quantity--sometimes
indicated as good and sometimes bad. The above quote indicated these
can be much more responsible for glycation in diabetics. It is also
indicatibe that these are converted to glucose immediately after
absorption but these can be some disorder in such conversion in
diabetics?"
Adigested carbohydrates are converted into glucose whatever the source
except fructose which is metabolised differently in the liver. The body
can use either for energy and either can glycate proteins and lipids.
In past fructose was suggested for diabetics because it did not raise
blood glucose levels. But this was misleading because the damage was
being done by fructose also but is not measured by standard glucose
testing and requires a seperate test. The meters diabetics use do not
measure fructose levels so the true amount of simple sugars in the blood
is not indicated. Later it was learned that fructose can also cause
damage as it also contributes to glycation and like glucose the more of
it at longer periods the greater the damage.
The amount of fructose in the usa is included in nutrition labels as
part of the total sugar amount. Foods containing fructose and lactose,
such as fruit and milk products, can have nutritional value to a
diabetic but the amount of sugars and how much it affects blood levels
should be taken into consideration when deciding how much to consume.
The sugars in fruit contains about 1/2 fructose and 1/2 glucose but only
the glucose appears with a meter test so one can about double the real
blood level from fruits when deciding how much to eat. Also as you
mentioned before, fructose has a much highr level of contribution to
glycation as does glucose so all in all a diabetic should be eating
fruit in moderate amounts and then only those fruits with naturally low
glucose levels.
Kumar
anon...@nowhere.you.know wrote:
> "In view of my quote, I want to understand, if fruits(fructose) &
> milk/diary(glactose) can be responsible for getting glycation in
> diabetics? These foods are taken in lowt of quantity--sometimes
> indicated as good and sometimes bad. The above quote indicated these
> can be much more responsible for glycation in diabetics. It is also
> indicatibe that these are converted to glucose immediately after
> absorption but these can be some disorder in such conversion in
> diabetics?"
>
> Adigested carbohydrates are converted into glucose whatever the source
> except fructose which is metabolised differently in the liver. The body
> can use either for energy and either can glycate proteins and lipids.
>
> In past fructose was suggested for diabetics because it did not raise
> blood glucose levels. But this was misleading because the damage was
> being done by fructose also but is not measured by standard glucose
> testing and requires a seperate test. The meters diabetics use do not
> measure fructose levels so the true amount of simple sugars in the blood
> is not indicated. Later it was learned that fructose can also cause
> damage as it also contributes to glycation and like glucose the more of
> it at longer periods the greater the damage.
It is bit horrible. Fruits and milk are commonly taken. Fruits are
quite natural. I don't understand, how these are so damaging. Have you
any idea, what happens if a diabetic2 with persistent hyperglycemia and
IR discontinue fruits,milk and other exogenous AGEs?
coon...@amestwp.com
quite natural. I don't understand, how these are so damaging. Have you
any idea, what happens if a diabetic2 with persistent hyperglycemia and
IR discontinue fruits,milk and other exogenous AGEs?"
All foods a diabetic consumes is a compromise between its nutritional
value and the amount of carbohydrates it contains. Fruit and milk
happen to contain high levels of carbohydrates. Therefore one must
choose carefully among fruits and milk products. Not only these foods
but any carb containing food can be judged by the speed by which it
enters the blood. The slower it enters the blood and the total amount
of carbs determines how high the glucose level after a meal.
Here is a page which has tables of hundreds of foods with a score for
each showing how fast it enters the blood. It has many indian foods.
Read the introductory information carefully to grasp how the score is
determined and how you can use it in making food choices..
http://www.mendosa.com/gi.htm.
This page is a directory that contains many many items with links to
topics about foods and their effect on diabetes treatment, the one above
is from it:
'Rick Mendosa's Diabetes Directory'
Kumar
Thanks. However, whether cycle or metabolism of other type of sugars
than glucose esp. fructose and glactose is effected due to diabetes2?
mont...@lycos.com
Diabetes 54:3103-3111, 2005
Glycation and Carboxymethyllysine Levels in Skin Collagen Predict the
Risk of Future 10-Year Progression of Diabetic Retinopathy and
Nephropathy in the Diabetes Control and Complications Trial and
Epidemiology of Diabetes Interventions and Complications Participants
With Type 1 Diabetes
Saul Genuth1, Wanjie Sun2, Patricia Cleary2, David R. Sell3, William
Dahms4, John Malone5, William Sivitz6, Vincent M. Monnier3,7, and for
the DCCT Skin Collagen Ancillary Study Group*
"...Although CML is in part a downstream product of furosine, thus
arising from hyperglycemia, CML is also a product of lipid peroxidation
and glycoxidation (30) and of metal and peroxynitrite catalyzed
oxidative stress (31); overproduction of reactive oxygen species in
mitochondria exposed to excessive cellular flux of glucose contributes
to CML formation..."
Online at:
http://diabetes.diabetesjournals.org/cgi/content/full/54/11/3103
Kumar
Thanks. It looks glycated substances can be related to getting
inflammatory responses(systemic), oxidative stress and diabetic
complications. However its magnitude is to be evalued esp. in comparisn
to VATs mediated systemic inflammation/inflammatory cytokines. Here one
question can be thought; whether metabolism or cycle of glycated
substances or its mediators(fructose,glactose etc.) is effected on
getting diabetes or not?
mat...@angelfire.com
An unpalatable truth for monty1945, no doubt. He'll label you as an
industry shill if you keep exposing his ignorance with scientific
facts, you know.
MattLB
mont...@lycos.com
Mainly, I have pointed out how experimental findings have been
misinterpreted. I present many of my conclusions at:
http://groups.msn.com/TheScientificDebateForum-
People like yourself, however, will not address obvious refutations,
which are the basis for "getting science right." For example, if rats
are fed a fat free diet, and live well and long, how can the claim of
"essential fatty acids" continue? And as I pointed out, this direct,
on point experiment was conducted in 1948 ! Yet people like MattLB do
not seem to understand that human reason and basic logic underly the
scientific method. People like him/her, instead, argue, implicitly or
explicity, that the textbook dogma must be correct, even though the
textbooks are filled with qualified statements. When on objectively
investigates the experiments upon which these claims are based, one
finds that they are hardly what one expects. I pointed this out to
him/her in may contexts, for example, I researched the literature on
"membranes," and the scientists make clear that their ideas are based
upon assumptions. One scientist who has conducted on point experiments
in this field is Gilbert Ling, who has also done excellent reviews of
the relevant literature. MattLB dismisses Ling's endeavors with a wave
of the proverbial hand.
Moreover, when asked, MattLB never cites, nor provides, a formal
hypothesis for any of his claims, something required of the scientific
method. I, on the other hand, have challenged him and others to do on
point experiments: the person who is wrong must pay for all expenses.
He has never shown any interest in such proposals. If MattLB thinks he
is so "scientific," why does he run from doing the actual experiments
that would determine who is correct? MattLB, please explain to the
readers why you speak loudly and carry such a small, fragile stick.
With regard to "essential fatty acids," "lipid bilayer membranes,"
"trans fat," and this "glycation" issue, the experiments would be
simple to do. One uses lab animals that have often been used in this
context in the past and one provides them with different diets to see
if there is a major difference. With glycation, if one claims that too
much sugar is the problem (or sugar in the presence of high protein
foods), then there is no problem doing the proper experients. However,
one must be willing to do the experiments so that the alternative ideas
are respresented. In this case, I would have a group of animals fed
the meat and sugar diet, but it would be prepared the way I would want
it to be. Then, another group would be fed this diet, but it would be
prepared differently, with the meat being fried in a highly unsaturated
oil. If the latter group was much less healthy and died at younger
ages, it would be clear that the lipid peroxidation was the problem,
not the sugar and protein food. Obviously, one could try several
different variations, but if one does not control for possibily
relevant factors, one is violating the scientific method. For some
reason, this simple point is unable to penetrate the mind of MattLB.
Kumar
Andrew B. Chung, MD/PhD wrote:
systemic inflammations?
Kumar
palpitated:
> Spindly woman of loose morals with horrid frothing gash and ruined
> gagas goes hungry for junior needle for torturing stuff-my-bunny fun
> times. Mail me at <lordsh...@rediffmail.com>
Andrew B. Chung, MD/PhD
Disseminated tuberculosis.
Kumar
> > > > > Reducing intake has been shown to double the lifespan of laboratory
> > > > > animals.
> >
> > Other than VAT & possibily glycated substances, what other can cause
> > systemic inflammations?
>
> Disseminated tuberculosis.
Can glycation also occur in extravascular comparments? If yes, which
conditions are related to it?
The Lord of Fair Punishments
"Andrew B. Chung, MD/PhD" <lo...@thetruth.com> wrote in message
news:1163051577.2...@k70g2000cwa.googlegroups.com...
I wish your answers to non-medical questions would have been so straight
forward.
Andrew B. Chung, MD/PhD
Disseminated malignancies.
> Can glycation also occur in extravascular comparments?
Yes.
> If yes, which
> conditions are related to it?
Hyperglycemia.
MattLB
> For example, if rats
> are fed a fat free diet, and live well and long, how can the claim of
> "essential fatty acids" continue? And as I pointed out, this direct,
> on point experiment was conducted in 1948 !
So you keep saying, but despite my asking you've never provided any
more information than this. I can say there was a paper in 1949 in the
Journal of Russian dietology which showed they were essential just as
easily.
> Yet people like MattLB do
> not seem to understand that human reason and basic logic underly the
> scientific method.
Look, you've shown already that your spoutings on the scientific method
aren't underpinned by any understanding of fundamentals like controls.
> People like him/her, instead, argue, implicitly
Implicitly - you mean it's all in your mind.
> explicity, that the textbook dogma must be correct, even though the
> textbooks are filled with qualified statements.
Of course they are. Science is about continuing evidence for something,
not absolute certainity.
>, for example, I researched the literature on
> "membranes," and the scientists make clear that their ideas are based
> upon assumptions.
That's very vague. Which scientists, which ideas, which assumptions?
So much for citing things.
> One scientist who has conducted on point experiments
> in this field is Gilbert Ling, who has also done excellent reviews of
> the relevant literature. MattLB dismisses Ling's endeavors with a wave
> of the proverbial hand.
After having looked and found them to be very out-of-date and not much
at odds with standard thought - apart from the "no bilayer" stance.
> Moreover, when asked, MattLB never cites,
I've cited the following seven or eight times, yet you always fail to
address them (for obvious reasons)
"Thirty years later, Hansen et al. [140] were the first to describe
EFAD in humans. They observed unsatisfactory growth rates and dryness
of the skin in many infants on low LA intakes. EFAD has been most
extensively described in subjects on fat-free total parenteral
nutrition (TPN)[141-147]. For example, O'Neill et al. [142] reported on
28 patients,ranging from newborns to 66 years old, who received
fat-free TPN.
LA levels fell rapidly, followed by AA. In most of the patients the
20:3n9/20:4n6 ratio (a biochemical marker for EFAD) had
increased after a few weeks above the 0.4 criterion [148], followed
approximately one week later by clinical signs of a scaly and thin
skin, and hair loss. In addition to these classical EFAD symptoms,
many other biological and behavioural changes have been documented
[149-151]"
Two of the refs:
Wene JD, Connor WE, DenBesten L. The development of essential fatty
acid deficiency in healthy men fed fat-free diets intravenously and
orally. J Clin Invest 1975;56:127-34
O'Neill JA, Caldwell MD, Meng HC. Essential fatty acid deficiency in
surgical patients. Ann Surg 1977;185:535-41"
> If MattLB thinks he
> is so "scientific," why does he run from doing the actual experiments
> that would determine who is correct? MattLB, please explain to the
> readers why you speak loudly and carry such a small, fragile stick.
I have no interest in indulging your fantasies, particularly as you'll
only twist or gripe about things when it doesn't turn out the way you
want. As you were told in this very thread, a diet in which coconut oil
is the only fat source is used experimentally to provide high sat fat
intake, leading to metabolic disorders. You'll claim it wasn't fresh
oil and that's why it was unhealthy, but you're always claiming
saturated fats can't go off or get oxidised so you're rather stuck
there.
I can speak with the advantage of direct research experience and an
ongoing biochemical education (my stick), whereas you, lacking such a
background, have to go on what persuasive individuals have said in
books you've read. The drawbacks of this are evident any time you're
asked to think beyond what has been spelt out in black and white - with
no foundations your position crumbles.
> With glycation, if one claims that too
> much sugar is the problem (or sugar in the presence of high protein
> foods), then there is no problem doing the proper experients.
Animal experiments have been done on glycation products in the diet.
> However,
> one must be willing to do the experiments so that the alternative ideas
> are respresented.
Rubbish. A formal hypothesis (which you seem to insist on) can't test
several things at once.
> Obviously, one could try several
> different variations, but if one does not control for possibily
> relevant factors, one is violating the scientific method. For some
> reason, this simple point is unable to penetrate the mind of MattLB.
You're completely missing what a control is again, and also trying to
confound things further by doing several experiements at once.
MattLB
Kumar
> > Can glycation also occur in extravascular comparments?
>
> Yes.
>
> > If yes, which
> > conditions are related to it?
>
> Hyperglycemia.
Hyperglycemia is not glycation but it is a reason to glycation? How
extravascular glycations can effect us?
kumar
Sorry may be an unrelated issue but I commonly experiance no gas & no
blotting in abdomen and no indigestion, when I take foods/fried ones in
pure ghee(cow/buffalo) and in palm oil(probably non-seed oil or fruit
oil). Gas,blotted abdomen, indigestion is somewhat thought may be
related to VAT? Can you evaulate it?
[Btw, it is VAT or greater visceral adiposity, more VAT or more store
of fats in VAT?]
mont...@lycos.com
It could be related to the free radical activity that the more
unsaturated oils will cause, as compared to something like ghee. Also,
are you using palm oil or palm kernel oil? Just curious about that
point.
When MattLB is willing to present formal scientific hypotheses, be a
participant in a formal, moderated debate, or take me up on an
experimental challenge, I will respond to him once more. My case is
made on my web site. The evidence is not mine, nor has been generated
by one group of researchers (as anyone can see by reading through just
a few of the essays). What I offer there is my interpretation of the
experimental findings, an interpretation that is comprehensive, whereas
most of what one reads or hears about in the mainstream media has been
conducted by those who only know a great deal about one very isolated
area of research.
Kumar
mont...@lycos.com wrote:
> Kumar:
>
> It could be related to the free radical activity that the more
> unsaturated oils will cause, as compared to something like ghee. Also,
> are you using palm oil or palm kernel oil? Just curious about that
> point.
It is to be seriously evalued. Can unsaturated oils cause more browning
and more AGEs resulting into increased systemic inflammatory response
or free radical activity?
I used palm oil(RBD) not palm kernal oil which can be alike seed oil. I
feel red palm oil can still be better. Many contradictive theories are
there about use of palm oil...may these be due to commercial interests
on either side. Anyway, fruits are gifts of nature to us whereas seeds
may not, so fruits oil can be alike fruit juice.
Andrew B. Chung, MD/PhD
> Some other?
Gum disease.
> > > Can glycation also occur in extravascular comparments?
> >
> > Yes.
> >
> > > If yes, which
> > > conditions are related to it?
> >
> > Hyperglycemia.
>
> Hyperglycemia is not glycation but it is a reason to glycation? How
> extravascular glycations can effect us?
As per earlier discussions.
Art Deco
Illogical.
>
>> > > Can glycation also occur in extravascular comparments?
>> >
>> > Yes.
>> >
>> > > If yes, which
>> > > conditions are related to it?
>> >
>> > Hyperglycemia.
>>
>> Hyperglycemia is not glycation but it is a reason to glycation? How
>> extravascular glycations can effect us?
>
>As per earlier discussions.
Non sequitur.
>
>
> May GOD continue to heal your heart by curing your diabetes, dear
> neighbor Kumar whom I love unconditionally.
You're erroneously presupposing that it's a fact.
Classic unsubstantiated and erroneous claim, laced with invective, as
expected from someone who lacks a logical argument.
[malformed sig flushed]
--
COOSN-266-06-39716
Official Overseer of Kooks and Saucerheads in alt.astronomy
Official Associate AFA-B Vote Rustler
Official "Usenet psychopath and born-again LLPOF minion",
as designated by Brad Guth
"Who is "David Tholen", Daedalus? Still suffering from
attribution problems?"
-- Dr. David Tholen
Kumar
local inflammation or a cause to it?
> > > > Can glycation also occur in extravascular comparments?
> > >
> > > Yes.
> > >
> > > > If yes, which
> > > > conditions are related to it?
> > >
> > > Hyperglycemia.
> >
> > Hyperglycemia is not glycation but it is a reason to glycation? How
> > extravascular glycations can effect us?
>
> As per earlier discussions.
tissues or excessive fat store in VAT--greter visceral adiposity),
glycated substances and absorbed fats which may encourage inflammatory
responses( as per other topics) as causes to systemic inflammatory
responses in diabetics?
Btw, whether sugar, carbs, triglycirides(glyceral part)(other are Mg
and NaCl) attract and absorb water in intestines relieving from
constipation and resulting into clear motions and increase motility?
Andrew B. Chung, MD/PhD
> Which gum disease?
Gingivitis.
> Btw, wheher gum disease is a result of systemic or
> local inflammation or a cause to it?
Goes both ways.
> > > > > Can glycation also occur in extravascular comparments?
> > > >
> > > > Yes.
> > > >
> > > > > If yes, which
> > > > > conditions are related to it?
> > > >
> > > > Hyperglycemia.
> > >
> > > Hyperglycemia is not glycation but it is a reason to glycation? How
> > > extravascular glycations can effect us?
> >
> > As per earlier discussions.
>
> Can we combine VAT(please clear, is it VAT--excessive visceral adipose
> tissues or excessive fat store in VAT--greter visceral adiposity),
> glycated substances and absorbed fats which may encourage inflammatory
> responses( as per other topics) as causes to systemic inflammatory
> responses in diabetics?
It is the inflammatory cytokines produced by the visceral adipose
tissue (VAT) that promote vascular inflammation thereby causing
increased insulin resistance.
> Btw, whether sugar, carbs, triglycirides(glyceral part)(other are Mg
> and NaCl) attract and absorb water in intestines relieving from
> constipation and resulting into clear motions and increase motility?
Not clinically seen.
Kumar
Andrew B. Chung, MD/PhD wrote:
> Kumar wrote:
>
> > Which gum disease?
>
> Gingivitis.
Pyorria?
Which gum disease is more common in diabetics?
> > Btw, wheher gum disease is a result of systemic or
> > local inflammation or a cause to it?
>
> Goes both ways.
>
> > > > > > Can glycation also occur in extravascular comparments?
> > > > >
> > > > > Yes.
> > > > >
> > > > > > If yes, which
> > > > > > conditions are related to it?
> > > > >
> > > > > Hyperglycemia.
> > > >
> > > > Hyperglycemia is not glycation but it is a reason to glycation? How
> > > > extravascular glycations can effect us?
> > >
> > > As per earlier discussions.
I think those were for intravascular glycations?
> > Can we combine VAT(please clear, is it VAT--excessive visceral adipose
> > tissues or excessive fat store in VAT--greter visceral adiposity),
> > glycated substances and absorbed fats which may encourage inflammatory
> > responses( as per other topics) as causes to systemic inflammatory
> > responses in diabetics?
>
> It is the inflammatory cytokines produced by the visceral adipose
> tissue (VAT) that promote vascular inflammation thereby causing
> increased insulin resistance.
Can't above other conditions/factors add to such inflamation?
> > Btw, whether sugar, carbs, triglycirides(glyceral part)(other are Mg
> > and NaCl) attract and absorb water in intestines relieving from
> > constipation and resulting into clear motions and increase motility?
>
> Not clinically seen.
They are hygroscopic..somewhat may act as MOM acts?
Whether bile is hygroscopic? Can bile's abnormal secretion(less) in
intestine make a person constipated, lazy esp. in morning, sleeping
more, waking late etc.? Two aspects may be related, abnormal bile
comong from liver and abnormal secretion from gall bladder(can't say
about abnormal re-absorption)?
Andrew B. Chung, MD/PhD
> Andrew B. Chung, MD/PhD wrote:
> > Kumar wrote:
> >snip> > > Gum disease.
> >
> > > Which gum disease?
> >
> > Gingivitis.
>
> Pyorria?
>
> Which gum disease is more common in diabetics?
The following link should help you:
http://www.nlm.nih.gov/medlineplus/gumdisease.html
> > > Btw, wheher gum disease is a result of systemic or
> > > local inflammation or a cause to it?
> >
> > Goes both ways.
> >
> > > > > > > Can glycation also occur in extravascular comparments?
> > > > > >
> > > > > > Yes.
> > > > > >
> > > > > > > If yes, which
> > > > > > > conditions are related to it?
> > > > > >
> > > > > > Hyperglycemia.
> > > > >
> > > > > Hyperglycemia is not glycation but it is a reason to glycation? How
> > > > > extravascular glycations can effect us?
> > > >
> > > > As per earlier discussions.
> I think those were for intravascular glycations?
No.
> > > Can we combine VAT(please clear, is it VAT--excessive visceral adipose
> > > tissues or excessive fat store in VAT--greter visceral adiposity),
> > > glycated substances and absorbed fats which may encourage inflammatory
> > > responses( as per other topics) as causes to systemic inflammatory
> > > responses in diabetics?
> >
> > It is the inflammatory cytokines produced by the visceral adipose
> > tissue (VAT) that promote vascular inflammation thereby causing
> > increased insulin resistance.
> Can't above other conditions/factors add to such inflamation?
It starts with the VAT.
> > > Btw, whether sugar, carbs, triglycirides(glyceral part)(other are Mg
> > > and NaCl) attract and absorb water in intestines relieving from
> > > constipation and resulting into clear motions and increase motility?
> >
> > Not clinically seen.
>
> They are hygroscopic..somewhat may act as MOM acts?
Still not clinically seen.
> Whether bile is hygroscopic? Can bile's abnormal secretion(less) in
> intestine make a person constipated, lazy esp. in morning, sleeping
> more, waking late etc.? Two aspects may be related, abnormal bile
> comong from liver and abnormal secretion from gall bladder(can't say
> about abnormal re-absorption)?
Clinically not seen.
Kumar
Andrew B. Chung, MD/PhD wrote:
> Kumar wrote:
> > Andrew B. Chung, MD/PhD wrote:
> > > Kumar wrote:
> > >snip> > > Gum disease.
> > >
> > > > Which gum disease?
> > >
> > > Gingivitis.
> >
> > Pyorria?
> >
> > Which gum disease is more common in diabetics?
>
> The following link should help you:
>
> http://www.nlm.nih.gov/medlineplus/gumdisease.html
Thanks.
> > > > Btw, wheher gum disease is a result of systemic or
> > > > local inflammation or a cause to it?
> > >
> > > Goes both ways.
Can gum diseases in diabetic be due to cell's swelling interfering in
blood flow and supply resulting into necrosis?
> > > > > > > > Can glycation also occur in extravascular comparments?
> > > > > > >
> > > > > > > Yes.
> > > > > > >
> > > > > > > > If yes, which
> > > > > > > > conditions are related to it?
> > > > > > >
> > > > > > > Hyperglycemia.
> > > > > >
> > > > > > Hyperglycemia is not glycation but it is a reason to glycation? How
> > > > > > extravascular glycations can effect us?
> > > > >
> > > > > As per earlier discussions.
>
> > I think those were for intravascular glycations?
>
> No.
Soory but if you can tell me again?
> > > > Can we combine VAT(please clear, is it VAT--excessive visceral adipose
> > > > tissues or excessive fat store in VAT--greter visceral adiposity),
> > > > glycated substances and absorbed fats which may encourage inflammatory
> > > > responses( as per other topics) as causes to systemic inflammatory
> > > > responses in diabetics?
> > >
> > > It is the inflammatory cytokines produced by the visceral adipose
> > > tissue (VAT) that promote vascular inflammation thereby causing
> > > increased insulin resistance.
>
> > Can't above other conditions/factors add to such inflamation?
>
> It starts with the VAT.
Whether VAT as you mention, is increase of visceral adipose tissues or
greater adiposity/fat stores in visceral adipose tissues?
> > > > Btw, whether sugar, carbs, triglycirides(glyceral part)(other are Mg
> > > > and NaCl) attract and absorb water in intestines relieving from
> > > > constipation and resulting into clear motions and increase motility?
> > >
> > > Not clinically seen.
> >
> > They are hygroscopic..somewhat may act as MOM acts?
>
> Still not clinically seen.
Whether soluble or not solubles fibers are also hygroscopic or releases
some chemicals in intestines?
> > Whether bile is hygroscopic? Can bile's abnormal secretion(less) in
> > intestine make a person constipated, lazy esp. in morning, sleeping
> > more, waking late etc.? Two aspects may be related, abnormal bile
> > comong from liver and abnormal secretion from gall bladder(can't say
> > about abnormal re-absorption)?
>
> Clinically not seen.
Can abnormal or obstructed flow of bile from liver to intestine make a
person lazy, more sleepy, waking late etc.?
I feel abnormalities in bile flow are related to many conditions
couldn't yet evalued?
Which out of bile and gastric acid ir related to either unclear or
clear motions? Billary diahrria is thought?
Andrew B. Chung, MD/PhD
> Andrew B. Chung, MD/PhD wrote:
> > Kumar wrote:
> > > Andrew B. Chung, MD/PhD wrote:
> > > > Kumar wrote:
> > > >snip> > > Gum disease.
> > > >
> > > > > Which gum disease?
> > > >
> > > > Gingivitis.
> > >
> > > Pyorria?
> > >
> > > Which gum disease is more common in diabetics?
> >
> > The following link should help you:
> >
> > http://www.nlm.nih.gov/medlineplus/gumdisease.html
>
> Thanks.
All thanks and praises belong to GOD, Whom I love with all my heart,
soul, mind, and strength:
http://HeartMDPhD.com/HolySpirit/fear.asp
Fear GOD and dread nothing that is of this world:
http://MabletonGA.OurLittle.net/DreadNought
> > > > > Btw, wheher gum disease is a result of systemic or
> > > > > local inflammation or a cause to it?
> > > >
> > > > Goes both ways.
> Can gum diseases in diabetic be due to cell's swelling interfering in
> blood flow and supply resulting into necrosis?
In the type 2 diabetic, it is due in part to the inflammatory cytokines
from viseral adipose tissue (VAT).
> > > > > > > > > Can glycation also occur in extravascular comparments?
> > > > > > > >
> > > > > > > > Yes.
> > > > > > > >
> > > > > > > > > If yes, which
> > > > > > > > > conditions are related to it?
> > > > > > > >
> > > > > > > > Hyperglycemia.
> > > > > > >
> > > > > > > Hyperglycemia is not glycation but it is a reason to glycation? How
> > > > > > > extravascular glycations can effect us?
> > > > > >
> > > > > > As per earlier discussions.
> >
> > > I think those were for intravascular glycations?
> >
> > No.
> Soory but if you can tell me again?
The glycosylations are happening everywhere and not just
intravascularly.
> > > > > Can we combine VAT(please clear, is it VAT--excessive visceral adipose
> > > > > tissues or excessive fat store in VAT--greter visceral adiposity),
> > > > > glycated substances and absorbed fats which may encourage inflammatory
> > > > > responses( as per other topics) as causes to systemic inflammatory
> > > > > responses in diabetics?
> > > >
> > > > It is the inflammatory cytokines produced by the visceral adipose
> > > > tissue (VAT) that promote vascular inflammation thereby causing
> > > > increased insulin resistance.
> >
> > > Can't above other conditions/factors add to such inflamation?
> >
> > It starts with the VAT.
>
> Whether VAT as you mention, is increase of visceral adipose tissues or
> greater adiposity/fat stores in visceral adipose tissues?
VAT is simply visceral adipose tissue which can be quantified by
measuring waist circumference.
> > > > > Btw, whether sugar, carbs, triglycirides(glyceral part)(other are Mg
> > > > > and NaCl) attract and absorb water in intestines relieving from
> > > > > constipation and resulting into clear motions and increase motility?
> > > >
> > > > Not clinically seen.
> > >
> > > They are hygroscopic..somewhat may act as MOM acts?
> >
> > Still not clinically seen.
>
> Whether soluble or not solubles fibers are also hygroscopic or releases
> some chemicals in intestines?
Soluble fiber in the diet comes with its own water so that it is not
hygroscopic.
> > > Whether bile is hygroscopic? Can bile's abnormal secretion(less) in
> > > intestine make a person constipated, lazy esp. in morning, sleeping
> > > more, waking late etc.? Two aspects may be related, abnormal bile
> > > comong from liver and abnormal secretion from gall bladder(can't say
> > > about abnormal re-absorption)?
> >
> > Clinically not seen.
> Can abnormal or obstructed flow of bile from liver to intestine make a
> person lazy, more sleepy, waking late etc.?
Not clinically seen.
> I feel abnormalities in bile flow are related to many conditions
> couldn't yet evalued?
You would be wise to inform your doctor(s) about your symptoms rather
than attributing them to bile flow.
> Which out of bile and gastric acid ir related to either unclear or
> clear motions? Billary diahrria is thought?
No clinical association.
Kumar
Andrew B. Chung, MD/PhD wrote:
> Kumar wrote:
interfering in
> > blood flow and supply resulting into necrosis?
>
> In the type 2 diabetic, it is due in part to the inflammatory cytokines
> from viseral adipose tissue (VAT).
> > > > > > > > > > Can glycation also occur in extravascular comparments?
> > > > > > > > >
> > > > > > > > > Yes.
> > > > > > > > >
> > > > > > > > > > If yes, which
> > > > > > > > > > conditions are related to it?
> > > > > > > > >
> > > > > > > > > Hyperglycemia.
> > > > > > > >
> > > > > > > > Hyperglycemia is not glycation but it is a reason to glycation? How
> > > > > > > > extravascular glycations can effect us?
> > > > > > >
> > > > > > > As per earlier discussions.
> > >
> > > > I think those were for intravascular glycations?
> > >
> > > No.
>
> > Soory but if you can tell me again?
>
> The glycosylations are happening everywhere and not just
> intravascularly.
In case of vasoconstriction or reduced blood flow?
> > > > > > Can we combine VAT(please clear, is it VAT--excessive visceral adipose
> > > > > > tissues or excessive fat store in VAT--greter visceral adiposity),
> > > > > > glycated substances and absorbed fats which may encourage inflammatory
> > > > > > responses( as per other topics) as causes to systemic inflammatory
> > > > > > responses in diabetics?
> > > > >
> > > > > It is the inflammatory cytokines produced by the visceral adipose
> > > > > tissue (VAT) that promote vascular inflammation thereby causing
> > > > > increased insulin resistance.
> > >
> > > > Can't above other conditions/factors add to such inflamation?
> > >
> > > It starts with the VAT.
> >
> > Whether VAT as you mention, is increase of visceral adipose tissues or
> > greater adiposity/fat stores in visceral adipose tissues?
>
> VAT is simply visceral adipose tissue which can be quantified by
> measuring waist circumference.
Can't they store more or less fats? Whether such store is in form of
triglyciride or fatty acids?
> > > > > > Btw, whether sugar, carbs, triglycirides(glyceral part)(other are Mg
> > > > > > and NaCl) attract and absorb water in intestines relieving from
> > > > > > constipation and resulting into clear motions and increase motility?
> > > > >
> > > > > Not clinically seen.
> > > >
> > > > They are hygroscopic..somewhat may act as MOM acts?
> > >
> > > Still not clinically seen.
> >
> > Whether soluble or not solubles fibers are also hygroscopic or releases
> > some chemicals in intestines?
>
> Soluble fiber in the diet comes with its own water so that it is not
> hygroscopic.
>
> > > > Whether bile is hygroscopic? Can bile's abnormal secretion(less) in
> > > > intestine make a person constipated, lazy esp. in morning, sleeping
> > > > more, waking late etc.? Two aspects may be related, abnormal bile
> > > > comong from liver and abnormal secretion from gall bladder(can't say
> > > > about abnormal re-absorption)?
> > >
> > > Clinically not seen.
>
> > Can abnormal or obstructed flow of bile from liver to intestine make a
> > person lazy, more sleepy, waking late etc.?
>
> Not clinically seen.
How bile secretion is triggered? Can there be different type or
quantity of bile secreted in different conditions? > > I feel
abnormalities in bile flow are related to many conditions
> > couldn't yet evalued?
>
> You would be wise to inform your doctor(s) about your symptoms rather
> than attributing them to bile flow.
I was just evaulating. In ancient systems bile was of great importance,
constitutional(personality type), but I think it is not given much
importance?
> > Which out of bile and gastric acid ir related to either unclear or
> > clear motions? Billary diahrria is thought?
>
> No clinical association.
Diahrria can occur when medication for resisting bile absorption is
given?
Anyway, what increased RBC Dist Width(MCV normal) indicates?
Andrew B. Chung, MD/PhD
> Andrew B. Chung, MD/PhD wrote:
> > Kumar wrote:
> snip> > Can gum diseases in diabetic be due to cell's swelling
> interfering in
> > > blood flow and supply resulting into necrosis?
> >
> > In the type 2 diabetic, it is due in part to the inflammatory cytokines
> > from viseral adipose tissue (VAT).
> How inflammatory cytokines causes gum diseases?
By promoting inflammation there.
> > > > > > > > > > > Can glycation also occur in extravascular comparments?
> > > > > > > > > >
> > > > > > > > > > Yes.
> > > > > > > > > >
> > > > > > > > > > > If yes, which
> > > > > > > > > > > conditions are related to it?
> > > > > > > > > >
> > > > > > > > > > Hyperglycemia.
> > > > > > > > >
> > > > > > > > > Hyperglycemia is not glycation but it is a reason to glycation? How
> > > > > > > > > extravascular glycations can effect us?
> > > > > > > >
> > > > > > > > As per earlier discussions.
> > > >
> > > > > I think those were for intravascular glycations?
> > > >
> > > > No.
> >
> > > Soory but if you can tell me again?
> >
> > The glycosylations are happening everywhere and not just
> > intravascularly.
>
> In case of vasoconstriction or reduced blood flow?
Yes.
> > > > > > > Can we combine VAT(please clear, is it VAT--excessive visceral adipose
> > > > > > > tissues or excessive fat store in VAT--greter visceral adiposity),
> > > > > > > glycated substances and absorbed fats which may encourage inflammatory
> > > > > > > responses( as per other topics) as causes to systemic inflammatory
> > > > > > > responses in diabetics?
> > > > > >
> > > > > > It is the inflammatory cytokines produced by the visceral adipose
> > > > > > tissue (VAT) that promote vascular inflammation thereby causing
> > > > > > increased insulin resistance.
> > > >
> > > > > Can't above other conditions/factors add to such inflamation?
> > > >
> > > > It starts with the VAT.
> > >
> > > Whether VAT as you mention, is increase of visceral adipose tissues or
> > > greater adiposity/fat stores in visceral adipose tissues?
> >
> > VAT is simply visceral adipose tissue which can be quantified by
> > measuring waist circumference.
> Can't they store more or less fats? Whether such store is in form of
> triglyciride or fatty acids?
They are present to store fat **and** to release inflammatory cytokines
to cause metabolic syndrome (MetS).
> > > > > > > Btw, whether sugar, carbs, triglycirides(glyceral part)(other are Mg
> > > > > > > and NaCl) attract and absorb water in intestines relieving from
> > > > > > > constipation and resulting into clear motions and increase motility?
> > > > > >
> > > > > > Not clinically seen.
> > > > >
> > > > > They are hygroscopic..somewhat may act as MOM acts?
> > > >
> > > > Still not clinically seen.
> > >
> > > Whether soluble or not solubles fibers are also hygroscopic or releases
> > > some chemicals in intestines?
> >
> > Soluble fiber in the diet comes with its own water so that it is not
> > hygroscopic.
> >
> > > > > Whether bile is hygroscopic? Can bile's abnormal secretion(less) in
> > > > > intestine make a person constipated, lazy esp. in morning, sleeping
> > > > > more, waking late etc.? Two aspects may be related, abnormal bile
> > > > > comong from liver and abnormal secretion from gall bladder(can't say
> > > > > about abnormal re-absorption)?
> > > >
> > > > Clinically not seen.
> >
> > > Can abnormal or obstructed flow of bile from liver to intestine make a
> > > person lazy, more sleepy, waking late etc.?
> >
> > Not clinically seen.
> How bile secretion is triggered?
By CCK released by the physical distension of the stomach.
> Can there be different type or
> quantity of bile secreted in different conditions? > > I feel
> abnormalities in bile flow are related to many conditions
Not clinically seen.
> > > couldn't yet evalued?
> >
> > You would be wise to inform your doctor(s) about your symptoms rather
> > than attributing them to bile flow.
> I was just evaulating. In ancient systems bile was of great importance,
> constitutional(personality type), but I think it is not given much
> importance?
It is not clinically important.
> > > Which out of bile and gastric acid ir related to either unclear or
> > > clear motions? Billary diahrria is thought?
> >
> > No clinical association.
> Diahrria can occur when medication for resisting bile absorption is
> given?
Not clinically seen except as an adverse effect for some.
> Anyway, what increased RBC Dist Width(MCV normal) indicates?
It suggests there may have been some blood loss.
Kumar
Andrew B. Chung, MD/PhD wrote:
> Kumar wrote:
> > Andrew B. Chung, MD/PhD wrote:
> > > Kumar wrote:
> > snip> > Can gum diseases in diabetic be due to cell's swelling
> > interfering in
> > > > blood flow and supply resulting into necrosis?
> > >
> > > In the type 2 diabetic, it is due in part to the inflammatory cytokines
> > > from viseral adipose tissue (VAT).
>
> > How inflammatory cytokines causes gum diseases?
>
> By promoting inflammation there.
brought at the site of inflammation making environment hypotonic and
swelling of cells in that area?
snip> > > The glycosylations are happening everywhere and not just
> > > intravascularly.
> >
> > In case of vasoconstriction or reduced blood flow?
>
> Yes.
intravascularily on vasoconstriction or on decreased blood flow?
Can above feature is valid for all substances including water which are
filtered from capillaries? I am not considering filtring capacity but
quantity of blood flow?
> > > > > > > > Can we combine VAT(please clear, is it VAT--excessive visceral adipose
> > > > > > > > tissues or excessive fat store in VAT--greter visceral adiposity),
> > > > > > > > glycated substances and absorbed fats which may encourage inflammatory
> > > > > > > > responses( as per other topics) as causes to systemic inflammatory
> > > > > > > > responses in diabetics?
> > > > > > >
> > > > > > > It is the inflammatory cytokines produced by the visceral adipose
> > > > > > > tissue (VAT) that promote vascular inflammation thereby causing
> > > > > > > increased insulin resistance.
> > > > >
> > > > > > Can't above other conditions/factors add to such inflamation?
> > > > >
> > > > > It starts with the VAT.
> > > >
> > > > Whether VAT as you mention, is increase of visceral adipose tissues or
> > > > greater adiposity/fat stores in visceral adipose tissues?
> > >
> > > VAT is simply visceral adipose tissue which can be quantified by
> > > measuring waist circumference.
>
> > Can't they store more or less fats? Whether such store is in form of
> > triglyciride or fatty acids?
>
> They are present to store fat **and** to release inflammatory cytokines
> to cause metabolic syndrome (MetS).
Sorry pls clear; "They are present to store fat"?
> > > > > > > > Btw, whether sugar, carbs, triglycirides(glyceral part)(other are Mg
> > > > > > > > and NaCl) attract and absorb water in intestines relieving from
> > > > > > > > constipation and resulting into clear motions and increase motility?
> > > > > > >
> > > > > > > Not clinically seen.
> > > > > >
> > > > > > They are hygroscopic..somewhat may act as MOM acts?
> > > > >
> > > > > Still not clinically seen.
> > > >
> > > > Whether soluble or not solubles fibers are also hygroscopic or releases
> > > > some chemicals in intestines?
> > >
> > > Soluble fiber in the diet comes with its own water so that it is not
> > > hygroscopic.
Whether Non-soluble fibers are hygroscopic? Can isabgol husk absorb
bile and cause more excretion of bile with stool?
> > > > > > Whether bile is hygroscopic? Can bile's abnormal secretion(less) in
> > > > > > intestine make a person constipated, lazy esp. in morning, sleeping
> > > > > > more, waking late etc.? Two aspects may be related, abnormal bile
> > > > > > comong from liver and abnormal secretion from gall bladder(can't say
> > > > > > about abnormal re-absorption)?
> > > > >
> > > > > Clinically not seen.
> > >
> > > > Can abnormal or obstructed flow of bile from liver to intestine make a
> > > > person lazy, more sleepy, waking late etc.?
> > >
> > > Not clinically seen.
>
> > How bile secretion is triggered?
>
> By CCK released by the physical distension of the stomach.
Caningested fats promote bile secretion from in intestine?
> > Can there be different type or
> > quantity of bile secreted in different conditions? > > I feel
> > abnormalities in bile flow are related to many conditions
>
> Not clinically seen.
>
> > > > couldn't yet evalued?
> > >
> > > You would be wise to inform your doctor(s) about your symptoms rather
> > > than attributing them to bile flow.
>
> > I was just evaulating. In ancient systems bile was of great importance,
> > constitutional(personality type), but I think it is not given much
> > importance?
>
> It is not clinically important.
Whether composition of bile can be changed in different conditions?
Whether bile detoxfy blood?
> > > > Which out of bile and gastric acid ir related to either unclear or
> > > > clear motions? Billary diahrria is thought?
> > >
> > > No clinical association.
>
> > Diahrria can occur when medication for resisting bile absorption is
> > given?
>
> Not clinically seen except as an adverse effect for some.
>
> > Anyway, what increase RBC Dist Width(MCV normal) indicates?
>
> It suggests there may have been some blood loss.
How? Is there any relation between increase in RBC dist width,
decreased hematocrit and increased neutrophills?
Whether blood loss is compensated by water to maintain blood volume?
Can you define RBC dist width for me pls?
Andrew B. Chung, MD/PhD
> Andrew B. Chung, MD/PhD wrote:
> > Kumar wrote:
> > > Andrew B. Chung, MD/PhD wrote:
> > > > Kumar wrote:
> > > snip> > Can gum diseases in diabetic be due to cell's swelling
> > > interfering in
> > > > > blood flow and supply resulting into necrosis?
> > > >
> > > > In the type 2 diabetic, it is due in part to the inflammatory cytokines
> > > > from viseral adipose tissue (VAT).
> >
> > > How inflammatory cytokines causes gum diseases?
> >
> > By promoting inflammation there.
> Swelling is one feature of inflammation. Whether more water/fluid is
> brought at the site of inflammation making environment hypotonic and
> swelling of cells in that area?
No.
> snip> > > The glycosylations are happening everywhere and not just
> > > > intravascularly.
> > >
> > > In case of vasoconstriction or reduced blood flow?
> >
> > Yes.
> Will such glycosylation be reduced extravascularily but increased
> intravascularily on vasoconstriction or on decreased blood flow?
No.
> Can above feature is valid for all substances including water which are
> filtered from capillaries? I am not considering filtring capacity but
> quantity of blood flow?
It is relevant to all substances that are able to freely cross through
the capillary basement membrane.
> > > > > > > > > Can we combine VAT(please clear, is it VAT--excessive visceral adipose
> > > > > > > > > tissues or excessive fat store in VAT--greter visceral adiposity),
> > > > > > > > > glycated substances and absorbed fats which may encourage inflammatory
> > > > > > > > > responses( as per other topics) as causes to systemic inflammatory
> > > > > > > > > responses in diabetics?
> > > > > > > >
> > > > > > > > It is the inflammatory cytokines produced by the visceral adipose
> > > > > > > > tissue (VAT) that promote vascular inflammation thereby causing
> > > > > > > > increased insulin resistance.
> > > > > >
> > > > > > > Can't above other conditions/factors add to such inflamation?
> > > > > >
> > > > > > It starts with the VAT.
> > > > >
> > > > > Whether VAT as you mention, is increase of visceral adipose tissues or
> > > > > greater adiposity/fat stores in visceral adipose tissues?
> > > >
> > > > VAT is simply visceral adipose tissue which can be quantified by
> > > > measuring waist circumference.
> >
> > > Can't they store more or less fats? Whether such store is in form of
> > > triglyciride or fatty acids?
> >
> > They are present to store fat **and** to release inflammatory cytokines
> > to cause metabolic syndrome (MetS).
> Sorry pls clear; "They are present to store fat"?
Yes. Such is the nature of adipose tissue even if pathological as in
the case of VAT.
> > > > > > > > > Btw, whether sugar, carbs, triglycirides(glyceral part)(other are Mg
> > > > > > > > > and NaCl) attract and absorb water in intestines relieving from
> > > > > > > > > constipation and resulting into clear motions and increase motility?
> > > > > > > >
> > > > > > > > Not clinically seen.
> > > > > > >
> > > > > > > They are hygroscopic..somewhat may act as MOM acts?
> > > > > >
> > > > > > Still not clinically seen.
> > > > >
> > > > > Whether soluble or not solubles fibers are also hygroscopic or releases
> > > > > some chemicals in intestines?
> > > >
> > > > Soluble fiber in the diet comes with its own water so that it is not
> > > > hygroscopic.
>
> Whether Non-soluble fibers are hygroscopic? Can isabgol husk absorb
> bile and cause more excretion of bile with stool?
Not familiar with isabgol husk.
> > > > > > > Whether bile is hygroscopic? Can bile's abnormal secretion(less) in
> > > > > > > intestine make a person constipated, lazy esp. in morning, sleeping
> > > > > > > more, waking late etc.? Two aspects may be related, abnormal bile
> > > > > > > comong from liver and abnormal secretion from gall bladder(can't say
> > > > > > > about abnormal re-absorption)?
> > > > > >
> > > > > > Clinically not seen.
> > > >
> > > > > Can abnormal or obstructed flow of bile from liver to intestine make a
> > > > > person lazy, more sleepy, waking late etc.?
> > > >
> > > > Not clinically seen.
> >
> > > How bile secretion is triggered?
> >
> > By CCK released by the physical distension of the stomach.
> Caningested fats promote bile secretion from in intestine?
Bile is not secreted from the intestine but rather comes from the
liver.
> > > Can there be different type or
> > > quantity of bile secreted in different conditions? > > I feel
> > > abnormalities in bile flow are related to many conditions
> >
> > Not clinically seen.
> >
> > > > > couldn't yet evalued?
> > > >
> > > > You would be wise to inform your doctor(s) about your symptoms rather
> > > > than attributing them to bile flow.
> >
> > > I was just evaulating. In ancient systems bile was of great importance,
> > > constitutional(personality type), but I think it is not given much
> > > importance?
> >
> > It is not clinically important.
>
> Whether composition of bile can be changed in different conditions?
> Whether bile detoxfy blood?
Bile is used to emulsify ingested fats to aid in their digestion.
> > > > > Which out of bile and gastric acid ir related to either unclear or
> > > > > clear motions? Billary diahrria is thought?
> > > >
> > > > No clinical association.
> >
> > > Diahrria can occur when medication for resisting bile absorption is
> > > given?
> >
> > Not clinically seen except as an adverse effect for some.
> >
> > > Anyway, what increase RBC Dist Width(MCV normal) indicates?
> >
> > It suggests there may have been some blood loss.
> How? Is there any relation between increase in RBC dist width,
> decreased hematocrit and increased neutrophills?
Would suggest that there is infection **and** blood loss.
> Whether blood loss is compensated by water to maintain blood volume?
It is if blood pressure remains normal even upon standing without
abnormally elevated heart rate.
> Can you define RBC dist width for me pls?
It is the range in RBC widths that would include 90% of all red bloods
cells (RBCs).
Kumar
Andrew B. Chung, MD/PhD wrote:
> Kumar wrote:
> > Andrew B. Chung, MD/PhD wrote:
> > > Kumar wrote:
> > > > Andrew B. Chung, MD/PhD wrote:
> > > > > Kumar wrote:
> > > > snip> > Can gum diseases in diabetic be due to cell's swelling
> > > > interfering in
> > > > > > blood flow and supply resulting into necrosis?
> > > > >
> > > > > In the type 2 diabetic, it is due in part to the inflammatory cytokines
> > > > > from viseral adipose tissue (VAT).
> > >
> > > > How inflammatory cytokines causes gum diseases?
> > >
> > > By promoting inflammation there.
>
> > Swelling is one feature of inflammation. Whether more water/fluid is
> > brought at the site of inflammation making environment hypotonic and
> > swelling of cells in that area?
>
> No.
Why it can't be possible?
> > snip> > > The glycosylations are happening everywhere and not just
> > > > > intravascularly.
> > > >
> > > > In case of vasoconstriction or reduced blood flow?
> > >
> > > Yes.
>
> > Will such glycosylation be reduced extravascularily but increased
> > intravascularily on vasoconstriction or on decreased blood flow?
>
> No.
Will glucose or even water be filtered lesser in tatal quantity from
capalliries, if blood flow is reduced due to vasocontriction?
> > Can above feature is valid for all substances including water which are
> > filtered from capillaries? I am not considering filtring capacity but
> > quantity of blood flow?
>
> It is relevant to all substances that are able to freely cross through
> the capillary basement membrane.
Yes but total blood flow can be reduced due to vsoconstriction? Whether
total filteration can't be also dependant and proportionate to total
blood flow in any area?
snip> > > > Can't they store more or less fats? Whether such store is
in form of
> > > > triglyciride or fatty acids?
> > >
> > > They are present to store fat **and** to release inflammatory cytokines
> > > to cause metabolic syndrome (MetS).
>
> > Sorry pls clear; "They are present to store fat"?
>
> Yes. Such is the nature of adipose tissue even if pathological as in
> the case of VAT.
Can they store more or less fats in quantity? Can they be substancially
increased in numbers?
> > > > > > > > > > Btw, whether sugar, carbs, triglycirides(glyceral part)(other are Mg
> > > > > > > > > > and NaCl) attract and absorb water in intestines relieving from
> > > > > > > > > > constipation and resulting into clear motions and increase motility?
> > > > > > > > >
> > > > > > > > > Not clinically seen.
> > > > > > > >
> > > > > > > > They are hygroscopic..somewhat may act as MOM acts?
> > > > > > >
> > > > > > > Still not clinically seen.
> > > > > >
> > > > > > Whether soluble or not solubles fibers are also hygroscopic or releases
> > > > > > some chemicals in intestines?
> > > > >
> > > > > Soluble fiber in the diet comes with its own water so that it is not
> > > > > hygroscopic.
> >
> > Whether Non-soluble fibers are hygroscopic? Can isabgol husk absorb
> > bile and cause more excretion of bile with stool?
>
> Not familiar with isabgol husk.
It is well known. Anyway,
"Isabgol (also Sat-Isabgol or Isapgol), is the Indian term for psyllium
seed husks (not a trademark). Isabgol is used for constipation and
irritable bowel syndrome. A few brand names are "B. G. Telephone Brand
Sat-Isabgol", "Deer Brand Sat Isabgol" and "Dabur Sat Isabgol".
Isabgol is also avaiable internationally in Indian shops and markets,
but as it is typically sold as isabgol rather than psyllium, many
people are not aware of that. Being a generic product, it is
significantly cheaper than similar products sold in pharmacies. Isabgol
(psyllium) is the active ingredient of the American product Metamucil.
http://en.wikipedia.org/wiki/Isabgol "
> > > > > > > > Whether bile is hygroscopic? Can bile's abnormal secretion(less) in
> > > > > > > > intestine make a person constipated, lazy esp. in morning, sleeping
> > > > > > > > more, waking late etc.? Two aspects may be related, abnormal bile
> > > > > > > > comong from liver and abnormal secretion from gall bladder(can't say
> > > > > > > > about abnormal re-absorption)?
> > > > > > >
> > > > > > > Clinically not seen.
> > > > >
> > > > > > Can abnormal or obstructed flow of bile from liver to intestine make a
> > > > > > person lazy, more sleepy, waking late etc.?
> > > > >
> > > > > Not clinically seen.
> > >
> > > > How bile secretion is triggered?
> > >
> > > By CCK released by the physical distension of the stomach.
>
> > Can ingested fats promote bile secretion [from] in intestine?
>
> Bile is not secreted from the intestine but rather comes from the
> liver.
Sorry, I meant; Can ingested fats promote bile secretion in intestine?
> > > > Can there be different type or
> > > > quantity of bile secreted in different conditions? > > I feel
> > > > abnormalities in bile flow are related to many conditions
> > >
> > > Not clinically seen.
> > >
> > > > > > couldn't yet evalued?
> > > > >
> > > > > You would be wise to inform your doctor(s) about your symptoms rather
> > > > > than attributing them to bile flow.
> > >
> > > > I was just evaulating. In ancient systems bile was of great importance,
> > > > constitutional(personality type), but I think it is not given much
> > > > importance?
> > >
> > > It is not clinically important.
> >
> > Whether composition of bile can be changed in different conditions?
> > Whether bile detoxfy blood?
>
> Bile is used to emulsify ingested fats to aid in their digestion.
Yes but if its composition and secreted quantity can be variable due to
different type of fats/foods?
> > > > > > Which out of bile and gastric acid ir related to either unclear or
> > > > > > clear motions? Billary diahrria is thought?
> > > > >
> > > > > No clinical association.
> > >
> > > > Diahrria can occur when medication for resisting bile absorption is
> > > > given?
> > >
> > > Not clinically seen except as an adverse effect for some.
> > >
> > > > Anyway, what increase RBC Dist Width(MCV normal) indicates?
> > >
> > > It suggests there may have been some blood loss.
>
> > How? Is there any relation between increase in RBC dist width,
> > decreased hematocrit and increased neutrophills?
>
> Would suggest that there is infection **and** blood loss.
>
> > Whether blood loss is compensated by water to maintain blood volume?
>
> It is if blood pressure remains normal even upon standing without
> abnormally elevated heart rate.
>
> > Can you define RBC dist width for me pls?
>
> It is the range in RBC widths that would include 90% of all red bloods
> cells (RBCs).
Whether its higher reading tells abnormal macrocytic size and shape of
RBCs?
Whether some higher reading of RDW, low Hct and some higher neutrophils
readin(may be subclinically higher but still within commonly indicated
normal range)gs can be common in people with persisting hyperglycemia
and IR?
Andrew B. Chung, MD/PhD
> Andrew B. Chung, MD/PhD wrote:
> > Kumar wrote:
> > > Andrew B. Chung, MD/PhD wrote:
> > > > Kumar wrote:
> > > > > Andrew B. Chung, MD/PhD wrote:
> > > > > > Kumar wrote:
> > > > > snip> > Can gum diseases in diabetic be due to cell's swelling
> > > > > interfering in
> > > > > > > blood flow and supply resulting into necrosis?
> > > > > >
> > > > > > In the type 2 diabetic, it is due in part to the inflammatory cytokines
> > > > > > from viseral adipose tissue (VAT).
> > > >
> > > > > How inflammatory cytokines causes gum diseases?
> > > >
> > > > By promoting inflammation there.
> >
> > > Swelling is one feature of inflammation. Whether more water/fluid is
> > > brought at the site of inflammation making environment hypotonic and
> > > swelling of cells in that area?
> >
> > No.
>
> Why it can't be possible?
It simply is not seen.
> > > snip> > > The glycosylations are happening everywhere and not just
> > > > > > intravascularly.
> > > > >
> > > > > In case of vasoconstriction or reduced blood flow?
> > > >
> > > > Yes.
> >
> > > Will such glycosylation be reduced extravascularily but increased
> > > intravascularily on vasoconstriction or on decreased blood flow?
> >
> > No.
> Will glucose or even water be filtered lesser in tatal quantity from
> capalliries, if blood flow is reduced due to vasocontriction?
Not to any clinically meaningful extent.
> > > Can above feature is valid for all substances including water which are
> > > filtered from capillaries? I am not considering filtring capacity but
> > > quantity of blood flow?
> >
> > It is relevant to all substances that are able to freely cross through
> > the capillary basement membrane.
>
> Yes but total blood flow can be reduced due to vsoconstriction? Whether
> total filteration can't be also dependant and proportionate to total
> blood flow in any area?
Transient events are not clinically meaningful in chronic disease such
as type-2 diabetes.
> snip> > > > Can't they store more or less fats? Whether such store is
> in form of
> > > > > triglyciride or fatty acids?
> > > >
> > > > They are present to store fat **and** to release inflammatory cytokines
> > > > to cause metabolic syndrome (MetS).
> >
> > > Sorry pls clear; "They are present to store fat"?
> >
> > Yes. Such is the nature of adipose tissue even if pathological as in
> > the case of VAT.
>
> Can they store more or less fats in quantity? Can they be substancially
> increased in numbers?
Wiser to get rid of the VAT rather than dwell on it.
> > > > > > > > > > > Btw, whether sugar, carbs, triglycirides(glyceral part)(other are Mg
> > > > > > > > > > > and NaCl) attract and absorb water in intestines relieving from
> > > > > > > > > > > constipation and resulting into clear motions and increase motility?
> > > > > > > > > >
> > > > > > > > > > Not clinically seen.
> > > > > > > > >
> > > > > > > > > They are hygroscopic..somewhat may act as MOM acts?
> > > > > > > >
> > > > > > > > Still not clinically seen.
> > > > > > >
> > > > > > > Whether soluble or not solubles fibers are also hygroscopic or releases
> > > > > > > some chemicals in intestines?
> > > > > >
> > > > > > Soluble fiber in the diet comes with its own water so that it is not
> > > > > > hygroscopic.
> > >
> > > Whether Non-soluble fibers are hygroscopic? Can isabgol husk absorb
> > > bile and cause more excretion of bile with stool?
> >
> > Not familiar with isabgol husk.
>
> It is well known. Anyway,
>
> "Isabgol (also Sat-Isabgol or Isapgol), is the Indian term for psyllium
> seed husks (not a trademark). Isabgol is used for constipation and
> irritable bowel syndrome. A few brand names are "B. G. Telephone Brand
> Sat-Isabgol", "Deer Brand Sat Isabgol" and "Dabur Sat Isabgol".
>
> Isabgol is also avaiable internationally in Indian shops and markets,
> but as it is typically sold as isabgol rather than psyllium, many
> people are not aware of that. Being a generic product, it is
> significantly cheaper than similar products sold in pharmacies. Isabgol
> (psyllium) is the active ingredient of the American product Metamucil.
> http://en.wikipedia.org/wiki/Isabgol "
Am familiar with psyllium. And, yes, it can help to lower cholesterol
by slowing down recovery of bile salts increasing losses in stool.
> > > > > > > > > Whether bile is hygroscopic? Can bile's abnormal secretion(less) in
> > > > > > > > > intestine make a person constipated, lazy esp. in morning, sleeping
> > > > > > > > > more, waking late etc.? Two aspects may be related, abnormal bile
> > > > > > > > > comong from liver and abnormal secretion from gall bladder(can't say
> > > > > > > > > about abnormal re-absorption)?
> > > > > > > >
> > > > > > > > Clinically not seen.
> > > > > >
> > > > > > > Can abnormal or obstructed flow of bile from liver to intestine make a
> > > > > > > person lazy, more sleepy, waking late etc.?
> > > > > >
> > > > > > Not clinically seen.
> > > >
> > > > > How bile secretion is triggered?
> > > >
> > > > By CCK released by the physical distension of the stomach.
> >
> > > Can ingested fats promote bile secretion [from] in intestine?
> >
> > Bile is not secreted from the intestine but rather comes from the
> > liver.
>
> Sorry, I meant; Can ingested fats promote bile secretion in intestine?
Bile production and release into the intestine is stimulated by
ingested fats.
> > > > > Can there be different type or
> > > > > quantity of bile secreted in different conditions? > > I feel
> > > > > abnormalities in bile flow are related to many conditions
> > > >
> > > > Not clinically seen.
> > > >
> > > > > > > couldn't yet evalued?
> > > > > >
> > > > > > You would be wise to inform your doctor(s) about your symptoms rather
> > > > > > than attributing them to bile flow.
> > > >
> > > > > I was just evaulating. In ancient systems bile was of great importance,
> > > > > constitutional(personality type), but I think it is not given much
> > > > > importance?
> > > >
> > > > It is not clinically important.
> > >
> > > Whether composition of bile can be changed in different conditions?
> > > Whether bile detoxfy blood?
> >
> > Bile is used to emulsify ingested fats to aid in their digestion.
>
> Yes but if its composition and secreted quantity can be variable due to
> different type of fats/foods?
Compostion, no. Quantity, yes.
> > > > > > > Which out of bile and gastric acid ir related to either unclear or
> > > > > > > clear motions? Billary diahrria is thought?
> > > > > >
> > > > > > No clinical association.
> > > >
> > > > > Diahrria can occur when medication for resisting bile absorption is
> > > > > given?
> > > >
> > > > Not clinically seen except as an adverse effect for some.
> > > >
> > > > > Anyway, what increase RBC Dist Width(MCV normal) indicates?
> > > >
> > > > It suggests there may have been some blood loss.
> >
> > > How? Is there any relation between increase in RBC dist width,
> > > decreased hematocrit and increased neutrophills?
> >
> > Would suggest that there is infection **and** blood loss.
> >
> > > Whether blood loss is compensated by water to maintain blood volume?
> >
> > It is if blood pressure remains normal even upon standing without
> > abnormally elevated heart rate.
> >
> > > Can you define RBC dist width for me pls?
> >
> > It is the range in RBC widths that would include 90% of all red bloods
> > cells (RBCs).
>
> Whether its higher reading tells abnormal macrocytic size and shape of
> RBCs?
Higher RDWs can be associated with abnormal forms/shapes.
> Whether some higher reading of RDW, low Hct and some higher neutrophils
> readin(may be subclinically higher but still within commonly indicated
> normal range)gs can be common in people with persisting hyperglycemia
> and IR?
Not clinically seen.
Kumar
Andrew B. Chung, MD/PhD wrote:
> Kumar wrote:
> > Andrew B. Chung, MD/PhD wrote:
> > > Kumar wrote:
> > > > Andrew B. Chung, MD/PhD wrote:
> > > > > Kumar wrote:
> > > > > > Andrew B. Chung, MD/PhD wrote:
> > > > > > > Kumar wrote:
> > > > > > snip> > Can gum diseases in diabetic be due to cell's swelling
> > > > > > interfering in
> > > > > > > > blood flow and supply resulting into necrosis?
> > > > > > >
> > > > > > > In the type 2 diabetic, it is due in part to the inflammatory cytokines
> > > > > > > from viseral adipose tissue (VAT).
> > > > >
> > > > > > How inflammatory cytokines causes gum diseases?
> > > > >
> > > > > By promoting inflammation there.
> > >
> > > > Swelling is one feature of inflammation. Whether more water/fluid is
> > > > brought at the site of inflammation making environment hypotonic and
> > > > swelling of cells in that area?
> > >
> > > No.
> >
> > Why it can't be possible?
>
> It simply is not seen.
Can variation in osmotic pressure of capaliries effect trans-capillary
movements of insulin?
> > > > snip> > > The glycosylations are happening everywhere and not just
> > > > > > > intravascularly.
> > > > > >
> > > > > > In case of vasoconstriction or reduced blood flow?
> > > > >
> > > > > Yes.
> > >
> > > > Will such glycosylation be reduced extravascularily but increased
> > > > intravascularily on vasoconstriction or on decreased blood flow?
> > >
> > > No.
>
> > Will glucose or even water be filtered lesser in tatal quantity from
> > capalliries, if blood flow is reduced due to vasocontriction?
>
> Not to any clinically meaningful extent.
>
> > > > Can above feature is valid for all substances including water which are
> > > > filtered from capillaries? I am not considering filtring capacity but
> > > > quantity of blood flow?
> > >
> > > It is relevant to all substances that are able to freely cross through
> > > the capillary basement membrane.
> >
> > Yes but total blood flow can be reduced due to vsoconstriction? Whether
> > total filteration can't be also dependant and proportionate to total
> > blood flow in any area?
>
> Transient events are not clinically meaningful in chronic disease such
> as type-2 diabetes.
Yes, but can't there be persistance of such events due to persisting
hyperglycemia?
>> > > > > > > Soluble fiber in the diet comes with its own water so that it is not
> > > > > > > hygroscopic.
> > > >
> > > > Whether Non-soluble fibers are hygroscopic? Can isabgol husk absorb
> > > > bile and cause more excretion of bile with stool?
> > >
> > > Not familiar with isabgol husk.
> >
> > It is well known. Anyway,
> >
> > "Isabgol (also Sat-Isabgol or Isapgol), is the Indian term for psyllium
> > seed husks (not a trademark). Isabgol is used for constipation and
> > irritable bowel syndrome. A few brand names are "B. G. Telephone Brand
> > Sat-Isabgol", "Deer Brand Sat Isabgol" and "Dabur Sat Isabgol".
> >
> > Isabgol is also avaiable internationally in Indian shops and markets,
> > but as it is typically sold as isabgol rather than psyllium, many
> > people are not aware of that. Being a generic product, it is
> > significantly cheaper than similar products sold in pharmacies. Isabgol
> > (psyllium) is the active ingredient of the American product Metamucil.
> > http://en.wikipedia.org/wiki/Isabgol "
>
> Am familiar with psyllium. And, yes, it can help to lower cholesterol
> by slowing down recovery of bile salts increasing losses in stool.
It is indicative that butter fat/pure ghee attract more bile, so while
increasing cholestreol it also excrete more bile resulting into
cholestreol's beneficial roles as well controlling their levels?
> > > > > > > > > > Whether bile is hygroscopic? Can bile's abnormal secretion(less) in
> > > > > > > > > > intestine make a person constipated, lazy esp. in morning, sleeping
> > > > > > > > > > more, waking late etc.? Two aspects may be related, abnormal bile
> > > > > > > > > > comong from liver and abnormal secretion from gall bladder(can't say
> > > > > > > > > > about abnormal re-absorption)?
> > > > > > > > >
> > > > > > > > > Clinically not seen.
> > > > > > >
> > > > > > > > Can abnormal or obstructed flow of bile from liver to intestine make a
> > > > > > > > person lazy, more sleepy, waking late etc.?
> > > > > > >
> > > > > > > Not clinically seen.
> > > > >
> > > > > > How bile secretion is triggered?
> > > > >
> > > > > By CCK released by the physical distension of the stomach.
> > >
> > > > Can ingested fats promote bile secretion [from] in intestine?
> > >
> > > Bile is not secreted from the intestine but rather comes from the
> > > liver.
> >
> > Sorry, I meant; Can ingested fats promote bile secretion in intestine?
>
> Bile production and release into the intestine is stimulated by
> ingested fats.
Whether butterfat/pure ghee stimulate comparatively more bile than
begetable oils?
> > > > > > Can there be different type or
> > > > > > quantity of bile secreted in different conditions? > > I feel
> > > > > > abnormalities in bile flow are related to many conditions
> > > > >
> > > > > Not clinically seen.
> > > > >
> > > > > > > > couldn't yet evalued?
> > > > > > >
> > > > > > > You would be wise to inform your doctor(s) about your symptoms rather
> > > > > > > than attributing them to bile flow.
> > > > >
> > > > > > I was just evaulating. In ancient systems bile was of great importance,
> > > > > > constitutional(personality type), but I think it is not given much
> > > > > > importance?
> > > > >
> > > > > It is not clinically important.
> > > >
> > > > Whether composition of bile can be changed in different conditions?
> > > > Whether bile detoxfy blood?
> > >
> > > Bile is used to emulsify ingested fats to aid in their digestion.
> >
> > Yes but if its composition and secreted quantity can be variable due to
> > different type of fats/foods?
>
> Compostion, no. Quantity, yes.
Can it be secretated in intestine less or more concentrated?
> > > > > > > > Which out of bile and gastric acid ir related to either unclear or
> > > > > > > > clear motions? Billary diahrria is thought?
> > > > > > >
> > > > > > > No clinical association.
> > > > >
> > > > > > Diahrria can occur when medication for resisting bile absorption is
> > > > > > given?
> > > > >
> > > > > Not clinically seen except as an adverse effect for some.
> > > > >
> > > > > > Anyway, what increase RBC Dist Width(MCV normal) indicates?
> > > > >
> > > > > It suggests there may have been some blood loss.
> > >
> > > > How? Is there any relation between increase in RBC dist width,
> > > > decreased hematocrit and increased neutrophills?
> > >
> > > Would suggest that there is infection **and** blood loss.
> > >
> > > > Whether blood loss is compensated by water to maintain blood volume?
> > >
> > > It is if blood pressure remains normal even upon standing without
> > > abnormally elevated heart rate.
> > >
> > > > Can you define RBC dist width for me pls?
> > >
> > > It is the range in RBC widths that would include 90% of all red bloods
> > > cells (RBCs).
> >
> > Whether its higher reading tells abnormal macrocytic size and shape of
> > RBCs?
>
> Higher RDWs can be associated with abnormal forms/shapes.
Will such RBCs be macrocytic/megablastic?
> > Whether some higher reading of RDW, low Hct and some higher neutrophils
> > reading (may be subclinically higher but still within commonly indicated
> > normal range)gs can be common in people with persisting hyperglycemia
> > and IR?
>
> Not clinically seen.
Can low Hct or hypotonicity of blood increase RTWs?
Whether swelled cells in vascular wall or circulating attracts
inflammatory response or oxidative mechanism?
> > > > > May GOD continue to heal your heart by curing your diabetes, dear
> > > > > neighbor Kumar whom I love unconditionally.
Oblized.
Andrew B. Chung, MD/PhD
> Andrew B. Chung, MD/PhD wrote:
> > Kumar wrote:
> > > Andrew B. Chung, MD/PhD wrote:
> > > > Kumar wrote:
> > > > > Andrew B. Chung, MD/PhD wrote:
> > > > > > Kumar wrote:
> > > > > > > Andrew B. Chung, MD/PhD wrote:
> > > > > > > > Kumar wrote:
> > > > > > > snip> > Can gum diseases in diabetic be due to cell's swelling
> > > > > > > interfering in
> > > > > > > > > blood flow and supply resulting into necrosis?
> > > > > > > >
> > > > > > > > In the type 2 diabetic, it is due in part to the inflammatory cytokines
> > > > > > > > from viseral adipose tissue (VAT).
> > > > > >
> > > > > > > How inflammatory cytokines causes gum diseases?
> > > > > >
> > > > > > By promoting inflammation there.
> > > >
> > > > > Swelling is one feature of inflammation. Whether more water/fluid is
> > > > > brought at the site of inflammation making environment hypotonic and
> > > > > swelling of cells in that area?
> > > >
> > > > No.
> > >
> > > Why it can't be possible?
> >
> > It simply is not seen.
>
> Can variation in osmotic pressure of capaliries effect trans-capillary
> movements of insulin?
Not clinically seen.
> > > > > snip> > > The glycosylations are happening everywhere and not just
> > > > > > > > intravascularly.
> > > > > > >
> > > > > > > In case of vasoconstriction or reduced blood flow?
> > > > > >
> > > > > > Yes.
> > > >
> > > > > Will such glycosylation be reduced extravascularily but increased
> > > > > intravascularily on vasoconstriction or on decreased blood flow?
> > > >
> > > > No.
> >
> > > Will glucose or even water be filtered lesser in tatal quantity from
> > > capalliries, if blood flow is reduced due to vasocontriction?
> >
> > Not to any clinically meaningful extent.
> >
> > > > > Can above feature is valid for all substances including water which are
> > > > > filtered from capillaries? I am not considering filtring capacity but
> > > > > quantity of blood flow?
> > > >
> > > > It is relevant to all substances that are able to freely cross through
> > > > the capillary basement membrane.
> > >
> > > Yes but total blood flow can be reduced due to vsoconstriction? Whether
> > > total filteration can't be also dependant and proportionate to total
> > > blood flow in any area?
> >
> > Transient events are not clinically meaningful in chronic disease such
> > as type-2 diabetes.
>
> Yes, but can't there be persistance of such events due to persisting
> hyperglycemia?
Hyperglycemia does not cause vasoconstriction.
> >> > > > > > > Soluble fiber in the diet comes with its own water so that it is not
> > > > > > > > hygroscopic.
> > > > >
> > > > > Whether Non-soluble fibers are hygroscopic? Can isabgol husk absorb
> > > > > bile and cause more excretion of bile with stool?
> > > >
> > > > Not familiar with isabgol husk.
> > >
> > > It is well known. Anyway,
> > >
> > > "Isabgol (also Sat-Isabgol or Isapgol), is the Indian term for psyllium
> > > seed husks (not a trademark). Isabgol is used for constipation and
> > > irritable bowel syndrome. A few brand names are "B. G. Telephone Brand
> > > Sat-Isabgol", "Deer Brand Sat Isabgol" and "Dabur Sat Isabgol".
> > >
> > > Isabgol is also avaiable internationally in Indian shops and markets,
> > > but as it is typically sold as isabgol rather than psyllium, many
> > > people are not aware of that. Being a generic product, it is
> > > significantly cheaper than similar products sold in pharmacies. Isabgol
> > > (psyllium) is the active ingredient of the American product Metamucil.
> > > http://en.wikipedia.org/wiki/Isabgol "
> >
> > Am familiar with psyllium. And, yes, it can help to lower cholesterol
> > by slowing down recovery of bile salts increasing losses in stool.
>
> It is indicative that butter fat/pure ghee attract more bile, so while
> increasing cholestreol it also excrete more bile resulting into
> cholestreol's beneficial roles as well controlling their levels?
Not clinically seen.
> > > > > > > > > > > Whether bile is hygroscopic? Can bile's abnormal secretion(less) in
> > > > > > > > > > > intestine make a person constipated, lazy esp. in morning, sleeping
> > > > > > > > > > > more, waking late etc.? Two aspects may be related, abnormal bile
> > > > > > > > > > > comong from liver and abnormal secretion from gall bladder(can't say
> > > > > > > > > > > about abnormal re-absorption)?
> > > > > > > > > >
> > > > > > > > > > Clinically not seen.
> > > > > > > >
> > > > > > > > > Can abnormal or obstructed flow of bile from liver to intestine make a
> > > > > > > > > person lazy, more sleepy, waking late etc.?
> > > > > > > >
> > > > > > > > Not clinically seen.
> > > > > >
> > > > > > > How bile secretion is triggered?
> > > > > >
> > > > > > By CCK released by the physical distension of the stomach.
> > > >
> > > > > Can ingested fats promote bile secretion [from] in intestine?
> > > >
> > > > Bile is not secreted from the intestine but rather comes from the
> > > > liver.
> > >
> > > Sorry, I meant; Can ingested fats promote bile secretion in intestine?
> >
> > Bile production and release into the intestine is stimulated by
> > ingested fats.
> Whether butterfat/pure ghee stimulate comparatively more bile than
> begetable oils?
Not clinically seen.
> > > > > > > Can there be different type or
> > > > > > > quantity of bile secreted in different conditions? > > I feel
> > > > > > > abnormalities in bile flow are related to many conditions
> > > > > >
> > > > > > Not clinically seen.
> > > > > >
> > > > > > > > > couldn't yet evalued?
> > > > > > > >
> > > > > > > > You would be wise to inform your doctor(s) about your symptoms rather
> > > > > > > > than attributing them to bile flow.
> > > > > >
> > > > > > > I was just evaulating. In ancient systems bile was of great importance,
> > > > > > > constitutional(personality type), but I think it is not given much
> > > > > > > importance?
> > > > > >
> > > > > > It is not clinically important.
> > > > >
> > > > > Whether composition of bile can be changed in different conditions?
> > > > > Whether bile detoxfy blood?
> > > >
> > > > Bile is used to emulsify ingested fats to aid in their digestion.
> > >
> > > Yes but if its composition and secreted quantity can be variable due to
> > > different type of fats/foods?
> >
> > Composition, no. Quantity, yes.
>
> Can it be secretated in intestine less or more concentrated?
The latter would be the purpose of the gall bladder.
> > > > > > > > > Which out of bile and gastric acid ir related to either unclear or
> > > > > > > > > clear motions? Billary diahrria is thought?
> > > > > > > >
> > > > > > > > No clinical association.
> > > > > >
> > > > > > > Diahrria can occur when medication for resisting bile absorption is
> > > > > > > given?
> > > > > >
> > > > > > Not clinically seen except as an adverse effect for some.
> > > > > >
> > > > > > > Anyway, what increase RBC Dist Width(MCV normal) indicates?
> > > > > >
> > > > > > It suggests there may have been some blood loss.
> > > >
> > > > > How? Is there any relation between increase in RBC dist width,
> > > > > decreased hematocrit and increased neutrophills?
> > > >
> > > > Would suggest that there is infection **and** blood loss.
> > > >
> > > > > Whether blood loss is compensated by water to maintain blood volume?
> > > >
> > > > It is if blood pressure remains normal even upon standing without
> > > > abnormally elevated heart rate.
> > > >
> > > > > Can you define RBC dist width for me pls?
> > > >
> > > > It is the range in RBC widths that would include 90% of all red bloods
> > > > cells (RBCs).
> > >
> > > Whether its higher reading tells abnormal macrocytic size and shape of
> > > RBCs?
> >
> > Higher RDWs can be associated with abnormal forms/shapes.
>
> Will such RBCs be macrocytic/megablastic?
They are often known as schizocytes.
> > > Whether some higher reading of RDW, low Hct and some higher neutrophils
> > > reading (may be subclinically higher but still within commonly indicated
> > > normal range)gs can be common in people with persisting hyperglycemia
> > > and IR?
> >
> > Not clinically seen.
> Can low Hct or hypotonicity of blood increase RTWs?
Blood loss with normal production of red cells by the bone marrow to
bring the Hct back up would typically increase RDW.
> Whether swelled cells in vascular wall or circulating attracts
> inflammatory response or oxidative mechanism?
Not clinically seen.
> > > > > > May GOD continue to heal your heart by curing your diabetes, dear
> > > > > > neighbor Kumar whom I love unconditionally.
Prayerfully in Christ's amazing love,
kumar
trans-capillary
movements of insulin?
> > > > > > snip> > > The glycosylations are happening everywhere and not just
> > > > > > > > > intravascularly.
> > > > > > > >
> > > > > > > > In case of vasoconstriction or reduced blood flow?
> > > > > > >
> > > > > > > Yes.
> > > > >
> > > > > > Will such glycosylation be reduced extravascularily but increased
> > > > > > intravascularily on vasoconstriction or on decreased blood flow?
> > > > >
> > > > > No.
> > >
> > > > Will glucose or even water be filtered lesser in tatal quantity from
> > > > capalliries, if blood flow is reduced due to vasocontriction?
> > >
> > > Not to any clinically meaningful extent.
> > >
> > > > > > Can above feature is valid for all substances including water which are
> > > > > > filtered from capillaries? I am not considering filtring capacity but
> > > > > > quantity of blood flow?
> > > > >
> > > > > It is relevant to all substances that are able to freely cross through
> > > > > the capillary basement membrane.
> > > >
> > > > Yes but total blood flow can be reduced due to vsoconstriction? Whether
> > > > total filteration can't be also dependant and proportionate to total
> > > > blood flow in any area?
> > >
> > > Transient events are not clinically meaningful in chronic disease such
> > > as type-2 diabetes.
> >
> > Yes, but can't there be persistance of such events due to persisting
> > hyperglycemia?
>
> Hyperglycemia does not cause vasoconstriction.
When increased O2 levels can effect size and numbers of blood vessels
supplying to tissues as local blood flow control, hyperglycemia may
also do that--by reduced blood flow?
> > >> > > > > > > Soluble fiber in the diet comes with its own water so that it is not
> > > > > > > > > hygroscopic.
> > > > > >
> > > > > > Whether Non-soluble fibers are hygroscopic? Can isabgol husk absorb
> > > > > > bile and cause more excretion of bile with stool?
> > > > >
> > > > > Not familiar with isabgol husk.
> > > >
> > > > It is well known. Anyway,
> > > >
> > > > "Isabgol (also Sat-Isabgol or Isapgol), is the Indian term for psyllium
> > > > seed husks (not a trademark). Isabgol is used for constipation and
> > > > irritable bowel syndrome. A few brand names are "B. G. Telephone Brand
> > > > Sat-Isabgol", "Deer Brand Sat Isabgol" and "Dabur Sat Isabgol".
> > > >
> > > > Isabgol is also avaiable internationally in Indian shops and markets,
> > > > but as it is typically sold as isabgol rather than psyllium, many
> > > > people are not aware of that. Being a generic product, it is
> > > > significantly cheaper than similar products sold in pharmacies. Isabgol
> > > > (psyllium) is the active ingredient of the American product Metamucil.
> > > > http://en.wikipedia.org/wiki/Isabgol "
> > >
> > > Am familiar with psyllium. And, yes, it can help to lower cholesterol
> > > by slowing down recovery of bile salts increasing losses in stool.
> >
> > It is indicative that butter fat/pure ghee attract more bile, so while
> > increasing cholestreol it also excrete more bile resulting into
> > cholestreol's beneficial roles as well controlling their levels?
>
> Not clinically seen.
Can't any fiber, which can absorb bile and enable more of its excretion
do that?
> > > > > > > > > > > > Whether bile is hygroscopic? Can bile's abnormal secretion(less) in
> > > > > > > > > > > > intestine make a person constipated, lazy esp. in morning, sleeping
> > > > > > > > > > > > more, waking late etc.? Two aspects may be related, abnormal bile
> > > > > > > > > > > > comong from liver and abnormal secretion from gall bladder(can't say
> > > > > > > > > > > > about abnormal re-absorption)?
> > > > > > > > > > >
> > > > > > > > > > > Clinically not seen.
> > > > > > > > >
> > > > > > > > > > Can abnormal or obstructed flow of bile from liver to intestine make a
> > > > > > > > > > person lazy, more sleepy, waking late etc.?
> > > > > > > > >
> > > > > > > > > Not clinically seen.
> > > > > > >
> > > > > > > > How bile secretion is triggered?
> > > > > > >
> > > > > > > By CCK released by the physical distension of the stomach.
> > > > >
> > > > > > Can ingested fats promote bile secretion [from] in intestine?
> > > > >
> > > > > Bile is not secreted from the intestine but rather comes from the
> > > > > liver.
> > > >
> > > > Sorry, I meant; Can ingested fats promote bile secretion in intestine?
> > >
> > > Bile production and release into the intestine is stimulated by
> > > ingested fats.
>
> > Whether butterfat/pure ghee stimulate comparatively more bile than
> > begetable oils?
>
> Not clinically seen.
How cholestrol stimulate bile secretion in intestines?
> > > > > > > > Can there be different type or
> > > > > > > > quantity of bile secreted in different conditions? > > I feel
> > > > > > > > abnormalities in bile flow are related to many conditions
> > > > > > >
> > > > > > > Not clinically seen.
> > > > > > >
> > > > > > > > > > couldn't yet evalued?
> > > > > > > > >
> > > > > > > > > You would be wise to inform your doctor(s) about your symptoms rather
> > > > > > > > > than attributing them to bile flow.
> > > > > > >
> > > > > > > > I was just evaulating. In ancient systems bile was of great importance,
> > > > > > > > constitutional(personality type), but I think it is not given much
> > > > > > > > importance?
> > > > > > >
> > > > > > > It is not clinically important.
> > > > > >
> > > > > > Whether composition of bile can be changed in different conditions?
> > > > > > Whether bile detoxfy blood?
> > > > >
> > > > > Bile is used to emulsify ingested fats to aid in their digestion.
> > > >
> > > > Yes but if its composition and secreted quantity can be variable due to
> > > > different type of fats/foods?
> > >
> > > Composition, no. Quantity, yes.
> >
> > Can it be secretated in intestine less or more concentrated?
>
> The latter would be the purpose of the gall bladder.
What is the purpose of more or less bile's concentration secretions?
> > > > > > > > > > Which out of bile and gastric acid ir related to either unclear or
> > > > > > > > > > clear motions? Billary diahrria is thought?
> > > > > > > > >
> > > > > > > > > No clinical association.
> > > > > > >
> > > > > > > > Diahrria can occur when medication for resisting bile absorption is
> > > > > > > > given?
> > > > > > >
> > > > > > > Not clinically seen except as an adverse effect for some.
> > > > > > >
> > > > > > > > Anyway, what increase RBC Dist Width(MCV normal) indicates?
> > > > > > >
> > > > > > > It suggests there may have been some blood loss.
> > > > >
> > > > > > How? Is there any relation between increase in RBC dist width,
> > > > > > decreased hematocrit and increased neutrophills?
> > > > >
> > > > > Would suggest that there is infection **and** blood loss.
> > > > >
> > > > > > Whether blood loss is compensated by water to maintain blood volume?
> > > > >
> > > > > It is if blood pressure remains normal even upon standing without
> > > > > abnormally elevated heart rate.
> > > > >
> > > > > > Can you define RBC dist width for me pls?
> > > > >
> > > > > It is the range in RBC widths that would include 90% of all red bloods
> > > > > cells (RBCs).
> > > >
> > > > Whether its higher reading tells abnormal macrocytic size and shape of
> > > > RBCs?
> > >
> > > Higher RDWs can be associated with abnormal forms/shapes.
> >
> > Will such RBCs be macrocytic/megablastic?
>
> They are often known as schizocytes.
A fat/puffy person can look of different shape?
Btw, can you tell differenciating factors between puffy,flaby and obese
person?
> > > > Whether some higher reading of RDW, low Hct and some higher neutrophils
> > > > reading (may be subclinically higher but still within commonly indicated
> > > > normal range)gs can be common in people with persisting hyperglycemia
> > > > and IR?
> > >
> > > Not clinically seen.
>
> > Can low Hct or hypotonicity of blood increase RTWs?
>
> Blood loss with normal production of red cells by the bone marrow to
> bring the Hct back up would typically increase RDW.
Wether RDW and Hct's variations(may be sub-clinical but near to
abnormal) are common in diabetics?
> > Whether swelled cells in vascular wall or circulating attracts
> > inflammatory response or oxidative mechanism?
>
> Not clinically seen.
Whether glysylated hemoglobin and elevated circulating lipid levels can
attract inflammatory responses?
Whether alkalizers can oppose inflammatory responses in view of acidity
is linked to control bacterias as in intestines?
Andrew B. Chung, MD/PhD
Not clinically seen.
Not clinically seen.
> > > >> > > > > > > Soluble fiber in the diet comes with its own water so that it is not
> > > > > > > > > > hygroscopic.
> > > > > > >
> > > > > > > Whether Non-soluble fibers are hygroscopic? Can isabgol husk absorb
> > > > > > > bile and cause more excretion of bile with stool?
> > > > > >
> > > > > > Not familiar with isabgol husk.
> > > > >
> > > > > It is well known. Anyway,
> > > > >
> > > > > "Isabgol (also Sat-Isabgol or Isapgol), is the Indian term for psyllium
> > > > > seed husks (not a trademark). Isabgol is used for constipation and
> > > > > irritable bowel syndrome. A few brand names are "B. G. Telephone Brand
> > > > > Sat-Isabgol", "Deer Brand Sat Isabgol" and "Dabur Sat Isabgol".
> > > > >
> > > > > Isabgol is also avaiable internationally in Indian shops and markets,
> > > > > but as it is typically sold as isabgol rather than psyllium, many
> > > > > people are not aware of that. Being a generic product, it is
> > > > > significantly cheaper than similar products sold in pharmacies. Isabgol
> > > > > (psyllium) is the active ingredient of the American product Metamucil.
> > > > > http://en.wikipedia.org/wiki/Isabgol "
> > > >
> > > > Am familiar with psyllium. And, yes, it can help to lower cholesterol
> > > > by slowing down recovery of bile salts increasing losses in stool.
> > >
> > > It is indicative that butter fat/pure ghee attract more bile, so while
> > > increasing cholestreol it also excrete more bile resulting into
> > > cholestreol's beneficial roles as well controlling their levels?
> >
> > Not clinically seen.
> Can't any fiber, which can absorb bile and enable more of its excretion
> do that?
Butter fat is not fiber.
> > > > > > > > > > > > > Whether bile is hygroscopic? Can bile's abnormal secretion(less) in
> > > > > > > > > > > > > intestine make a person constipated, lazy esp. in morning, sleeping
> > > > > > > > > > > > > more, waking late etc.? Two aspects may be related, abnormal bile
> > > > > > > > > > > > > comong from liver and abnormal secretion from gall bladder(can't say
> > > > > > > > > > > > > about abnormal re-absorption)?
> > > > > > > > > > > >
> > > > > > > > > > > > Clinically not seen.
> > > > > > > > > >
> > > > > > > > > > > Can abnormal or obstructed flow of bile from liver to intestine make a
> > > > > > > > > > > person lazy, more sleepy, waking late etc.?
> > > > > > > > > >
> > > > > > > > > > Not clinically seen.
> > > > > > > >
> > > > > > > > > How bile secretion is triggered?
> > > > > > > >
> > > > > > > > By CCK released by the physical distension of the stomach.
> > > > > >
> > > > > > > Can ingested fats promote bile secretion [from] in intestine?
> > > > > >
> > > > > > Bile is not secreted from the intestine but rather comes from the
> > > > > > liver.
> > > > >
> > > > > Sorry, I meant; Can ingested fats promote bile secretion in intestine?
> > > >
> > > > Bile production and release into the intestine is stimulated by
> > > > ingested fats.
> >
> > > Whether butterfat/pure ghee stimulate comparatively more bile than
> > > begetable oils?
> >
> > Not clinically seen.
>
> How cholestrol stimulate bile secretion in intestines?
It does not directly. Indeed, bile is largely comprised of
cholesterol.
> > > > > > > > > Can there be different type or
> > > > > > > > > quantity of bile secreted in different conditions? > > I feel
> > > > > > > > > abnormalities in bile flow are related to many conditions
> > > > > > > >
> > > > > > > > Not clinically seen.
> > > > > > > >
> > > > > > > > > > > couldn't yet evalued?
> > > > > > > > > >
> > > > > > > > > > You would be wise to inform your doctor(s) about your symptoms rather
> > > > > > > > > > than attributing them to bile flow.
> > > > > > > >
> > > > > > > > > I was just evaulating. In ancient systems bile was of great importance,
> > > > > > > > > constitutional(personality type), but I think it is not given much
> > > > > > > > > importance?
> > > > > > > >
> > > > > > > > It is not clinically important.
> > > > > > >
> > > > > > > Whether composition of bile can be changed in different conditions?
> > > > > > > Whether bile detoxfy blood?
> > > > > >
> > > > > > Bile is used to emulsify ingested fats to aid in their digestion.
> > > > >
> > > > > Yes but if its composition and secreted quantity can be variable due to
> > > > > different type of fats/foods?
> > > >
> > > > Composition, no. Quantity, yes.
> > >
> > > Can it be secretated in intestine less or more concentrated?
> >
> > The latter would be the purpose of the gall bladder.
>
> What is the purpose of more or less bile's concentration secretions?
To aid in the emulsification and digestion of fats.
> > > > > > > > > > > Which out of bile and gastric acid ir related to either unclear or
> > > > > > > > > > > clear motions? Billary diahrria is thought?
> > > > > > > > > >
> > > > > > > > > > No clinical association.
> > > > > > > >
> > > > > > > > > Diahrria can occur when medication for resisting bile absorption is
> > > > > > > > > given?
> > > > > > > >
> > > > > > > > Not clinically seen except as an adverse effect for some.
> > > > > > > >
> > > > > > > > > Anyway, what increase RBC Dist Width(MCV normal) indicates?
> > > > > > > >
> > > > > > > > It suggests there may have been some blood loss.
> > > > > >
> > > > > > > How? Is there any relation between increase in RBC dist width,
> > > > > > > decreased hematocrit and increased neutrophills?
> > > > > >
> > > > > > Would suggest that there is infection **and** blood loss.
> > > > > >
> > > > > > > Whether blood loss is compensated by water to maintain blood volume?
> > > > > >
> > > > > > It is if blood pressure remains normal even upon standing without
> > > > > > abnormally elevated heart rate.
> > > > > >
> > > > > > > Can you define RBC dist width for me pls?
> > > > > >
> > > > > > It is the range in RBC widths that would include 90% of all red bloods
> > > > > > cells (RBCs).
> > > > >
> > > > > Whether its higher reading tells abnormal macrocytic size and shape of
> > > > > RBCs?
> > > >
> > > > Higher RDWs can be associated with abnormal forms/shapes.
> > >
> > > Will such RBCs be macrocytic/megablastic?
> >
> > They are often known as schizocytes.
>
> A fat/puffy person can look of different shape?
Not clinically seen.
> Btw, can you tell differenciating factors between puffy,flaby and obese
> person?
They are heavier than optimal.
> > > > > Whether some higher reading of RDW, low Hct and some higher neutrophils
> > > > > reading (may be subclinically higher but still within commonly indicated
> > > > > normal range)gs can be common in people with persisting hyperglycemia
> > > > > and IR?
> > > >
> > > > Not clinically seen.
> >
> > > Can low Hct or hypotonicity of blood increase RTWs?
> >
> > Blood loss with normal production of red cells by the bone marrow to
> > bring the Hct back up would typically increase RDW.
>
> Wether RDW and Hct's variations(may be sub-clinical but near to
> abnormal) are common in diabetics?
Not clinically seen.
> > > Whether swelled cells in vascular wall or circulating attracts
> > > inflammatory response or oxidative mechanism?
> >
> > Not clinically seen.
>
> Whether glysylated hemoglobin and elevated circulating lipid levels can
> attract inflammatory responses?
Not clinically seen.
> Whether alkalizers can oppose inflammatory responses in view of acidity
> is linked to control bacterias as in intestines?
Not clinically seen.
Art Deco
>Not clinically seen.
>Not clinically seen.
>> > Not clinically seen.
>> > > > > > > > Not clinically seen.
>> > > > > > > > It is not clinically important.
>> > > > > > > > > > No clinical association.
>Not clinically seen.
>Not clinically seen.
>> > Not clinically seen.
>Not clinically seen.
>Not clinically seen.
>Prayerfully in Christ's amazing love,
Get a new schtick, Chunk.
Kumar
Yes, but I asked about fiber.
> > > > > > > > > > > > > > Whether bile is hygroscopic? Can bile's abnormal secretion(less) in
> > > > > > > > > > > > > > intestine make a person constipated, lazy esp. in morning, sleeping
> > > > > > > > > > > > > > more, waking late etc.? Two aspects may be related, abnormal bile
> > > > > > > > > > > > > > comong from liver and abnormal secretion from gall bladder(can't say
> > > > > > > > > > > > > > about abnormal re-absorption)?
> > > > > > > > > > > > >
> > > > > > > > > > > > > Clinically not seen.
> > > > > > > > > > >
> > > > > > > > > > > > Can abnormal or obstructed flow of bile from liver to intestine make a
> > > > > > > > > > > > person lazy, more sleepy, waking late etc.?
> > > > > > > > > > >
> > > > > > > > > > > Not clinically seen.
> > > > > > > > >
> > > > > > > > > > How bile secretion is triggered?
> > > > > > > > >
> > > > > > > > > By CCK released by the physical distension of the stomach.
> > > > > > >
> > > > > > > > Can ingested fats promote bile secretion [from] in intestine?
> > > > > > >
> > > > > > > Bile is not secreted from the intestine but rather comes from the
> > > > > > > liver.
> > > > > >
> > > > > > Sorry, I meant; Can ingested fats promote bile secretion in intestine?
> > > > >
> > > > > Bile production and release into the intestine is stimulated by
> > > > > ingested fats.
> > >
> > > > Whether butterfat/pure ghee stimulate comparatively more bile than
> > > > begetable oils?
> > >
> > > Not clinically seen.
> >
> > How cholestrol stimulate bile secretion in intestines?
>
> It does not directly. Indeed, bile is largely comprised of
> cholesterol.
http://groups.google.com/group/sci.med.cardiology/browse_frm/thread/f0d692953b7eb961/#
What is the fate of cholesterol in bile?
What causes a person to look either puffy or flaby or obese?
> > > > > > Whether some higher reading of RDW, low Hct and some higher neutrophils
> > > > > > reading (may be subclinically higher but still within commonly indicated
> > > > > > normal range)gs can be common in people with persisting hyperglycemia
> > > > > > and IR?
> > > > >
> > > > > Not clinically seen.
> > >
> > > > Can low Hct or hypotonicity of blood increase RTWs?
> > >
> > > Blood loss with normal production of red cells by the bone marrow to
> > > bring the Hct back up would typically increase RDW.
> >
> > Wether RDW and Hct's variations(may be sub-clinical but near to
> > abnormal) are common in diabetics?
>
> Not clinically seen.
>
> > > > Whether swelled cells in vascular wall or circulating attracts
> > > > inflammatory response or oxidative mechanism?
> > >
> > > Not clinically seen.
> >
> > Whether glysylated hemoglobin and elevated circulating lipid levels can
> > attract inflammatory responses?
>
> Not clinically seen.
>
> > Whether alkalizers can oppose inflammatory responses in view of acidity
> > is linked to control bacterias as in intestines?
>
> Not clinically seen.
Other than its tissue damaging effects, Whether inflammatory responses
can keep infections under control?
Andrew B. Chung, MD/PhD
> > > > > increasing cholestreol it also excrete more bile resulting into
> > > > > cholestreol's beneficial roles as well controlling their levels?
**emphasis** added.
> > > >
> > > > Not clinically seen.
> >
> > > Can't any fiber, which can absorb bile and enable more of its excretion
> > > do that?
> >
> > Butter fat is not fiber.
>
> Yes, but I asked about fiber.
See **emphasis** above.
It is reabsorbed.
Overeating.
> > > > > > > Whether some higher reading of RDW, low Hct and some higher neutrophils
> > > > > > > reading (may be subclinically higher but still within commonly indicated
> > > > > > > normal range)gs can be common in people with persisting hyperglycemia
> > > > > > > and IR?
> > > > > >
> > > > > > Not clinically seen.
> > > >
> > > > > Can low Hct or hypotonicity of blood increase RTWs?
> > > >
> > > > Blood loss with normal production of red cells by the bone marrow to
> > > > bring the Hct back up would typically increase RDW.
> > >
> > > Wether RDW and Hct's variations(may be sub-clinical but near to
> > > abnormal) are common in diabetics?
> >
> > Not clinically seen.
> >
> > > > > Whether swelled cells in vascular wall or circulating attracts
> > > > > inflammatory response or oxidative mechanism?
> > > >
> > > > Not clinically seen.
> > >
> > > Whether glysylated hemoglobin and elevated circulating lipid levels can
> > > attract inflammatory responses?
> >
> > Not clinically seen.
> >
> > > Whether alkalizers can oppose inflammatory responses in view of acidity
> > > is linked to control bacterias as in intestines?
> >
> > Not clinically seen.
>
> Other than its tissue damaging effects, Whether inflammatory responses
> can keep infections under control?
Without a specific immune response, the answer would be "no."
Kumar
Andrew B. Chung, MD/PhD wrote:
> Kumar wrote:
> > Andrew B. Chung, MD/PhD wrote:
> > > > > > > Am familiar with psyllium. And, yes, it can help to lower cholesterol
> > > > > > > by slowing down recovery of bile salts increasing losses in stool.
> > > > > >
> > > > > > It is indicative that **butter fat/pure ghee** attract more bile, so while
> > > > > > increasing cholestreol it also excrete more bile resulting into
> > > > > > cholestreol's beneficial roles as well controlling their levels?
>
> **emphasis** added.
Sorry, your awnser is not clear to me. I meant buuer fat/pure ghee
attract more bile secretions in intestines not bile absorption?
Possibily, more the bile synthesis in liver and secretion in
intestines, comparatively more can be its excretion esp. when blood
cholesterol levels are higher?
>snip> > > > How cholestrol stimulate bile secretion in intestines?
> > >
> > > It does not directly. Indeed, bile is largely comprised of
> > > cholesterol.
> >
> > http://groups.google.com/group/sci.med.cardiology/browse_frm/thread/f0d692953b7eb961/#
> >
> > What is the fate of cholesterol in bile?
>
> It is reabsorbed.
All or as per blood levels?
snip> > > > A fat/puffy person can look of different shape?
> > >
> > > Not clinically seen.
> > >
> > > > Btw, can you tell differenciating factors between puffy,flaby and obese
> > > > person?
> > >
> > > They are heavier than optimal.
Pls tell differenciating factors in between puffy,flaby and obese
people
> > What causes a person to look either puffy or flaby or obese?
>
> Overeating.
Can one be swelled with water other with fats?
> > > > > > > > Whether some higher reading of RDW, low Hct and some higher neutrophils
> > > > > > > > reading (may be subclinically higher but still within commonly indicated
> > > > > > > > normal range)gs can be common in people with persisting hyperglycemia
> > > > > > > > and IR?
> > > > > > >
> > > > > > > Not clinically seen.
> > > > >
> > > > > > Can low Hct or hypotonicity of blood increase RTWs?
> > > > >
> > > > > Blood loss with normal production of red cells by the bone marrow to
> > > > > bring the Hct back up would typically increase RDW.
> > > >
> > > > Wether RDW and Hct's variations(may be sub-clinical but near to
> > > > abnormal) are common in diabetics?
> > >
> > > Not clinically seen.
> > >
> > > > > > Whether swelled cells in vascular wall or circulating attracts
> > > > > > inflammatory response or oxidative mechanism?
> > > > >
> > > > > Not clinically seen.
> > > >
> > > > Whether glysylated hemoglobin and elevated circulating lipid levels can
> > > > attract inflammatory responses?
> > >
> > > Not clinically seen.
> > >
> > > > Whether alkalizers can oppose inflammatory responses in view of acidity
> > > > is linked to control bacterias as in intestines?
> > >
> > > Not clinically seen.
> >
> > Other than its tissue damaging effects, Whether inflammatory responses
> > can keep infections under control?
>
> Without a specific immune response, the answer would be "no."
Whether inflammatory responces preceed infectious immune response?
Btw whether occasional or excessive eaters in other species as
honeu-bees are diabetic?
Andrew B. Chung, MD/PhD
> Andrew B. Chung, MD/PhD wrote:
> > Kumar wrote:
> > > Andrew B. Chung, MD/PhD wrote:
> > > > > > > > Am familiar with psyllium. And, yes, it can help to lower cholesterol
> > > > > > > > by slowing down recovery of bile salts increasing losses in stool.
> > > > > > >
> > > > > > > It is indicative that **butter fat/pure ghee** attract more bile, so while
> > > > > > > increasing cholestreol it also excrete more bile resulting into
> > > > > > > cholestreol's beneficial roles as well controlling their levels?
> >
> > **emphasis** added.
>
> Sorry, your awnser is not clear to me.
It served to help you understand why I wrote to comment how you had
confused butter fat with dietary fiber. The former does not result in
the excretion of more cholesterol for any cholesterol-lower benefit as
compared to the latter.
Kumar
Andrew B. Chung, MD/PhD wrote:
> Kumar wrote:
> > Andrew B. Chung, MD/PhD wrote:
> > > Kumar wrote:
> > > > Andrew B. Chung, MD/PhD wrote:
> > > > > > > > > Am familiar with psyllium. And, yes, it can help to lower cholesterol
> > > > > > > > > by slowing down recovery of bile salts increasing losses in stool.
> > > > > > > >
> > > > > > > > It is indicative that **butter fat/pure ghee** attract more bile, so while
> > > > > > > > increasing cholestreol it also excrete more bile resulting into
> > > > > > > > cholestreol's beneficial roles as well controlling their levels?
> > >
> > > **emphasis** added.
> >
> > Sorry, your awnser is not clear to me.
>
> It served to help you understand why I wrote to comment how you had
> confused butter fat with dietary fiber. The former does not result in
> the excretion of more cholesterol for any cholesterol-lower benefit as
> compared to the latter.
I have not confused about butter with fibers. These are two different
things. I thought, Butter may promote more bile secretion in intestines
so more of its excretion whereas fiber can absorb more bile resulting
more of its excretion in stool.
Andrew B. Chung, MD/PhD
> Andrew B. Chung, MD/PhD wrote:
> > Kumar wrote:
> > > Andrew B. Chung, MD/PhD wrote:
> > > > Kumar wrote:
> > > > > Andrew B. Chung, MD/PhD wrote:
> > > > > > > > > > Am familiar with psyllium. And, yes, it can help to lower cholesterol
> > > > > > > > > > by slowing down recovery of bile salts increasing losses in stool.
> > > > > > > > >
> > > > > > > > > It is indicative that **butter fat/pure ghee** attract more bile, so while
> > > > > > > > > increasing cholestreol it also excrete more bile resulting into
> > > > > > > > > cholestreol's beneficial roles as well controlling their levels?
> > > >
> > > > **emphasis** added.
> > >
> > > Sorry, your awnser is not clear to me.
> >
> > It served to help you understand why I wrote to comment how you had
> > confused butter fat with dietary fiber. The former does not result in
> > compared to the latter.
>
> I have not confused about butter with fibers. These are two different
> things. I thought, Butter may promote more bile secretion in intestines
> so more of its excretion whereas fiber can absorb more bile resulting
> more of its excretion in stool.
Bile secretion occurs **before** digestion and absorption of fats such
as butter.
Kumar
Andrew B. Chung, MD/PhD wrote:
> Kumar wrote:
> > Andrew B. Chung, MD/PhD wrote:
> > > Kumar wrote:
> > > > Andrew B. Chung, MD/PhD wrote:
> > > > > Kumar wrote:
> > > > > > Andrew B. Chung, MD/PhD wrote:
> > > > > > > > > > > Am familiar with psyllium. And, yes, it can help to lower cholesterol
> > > > > > > > > > > by slowing down recovery of bile salts increasing losses in stool.
> > > > > > > > > >
> > > > > > > > > > It is indicative that **butter fat/pure ghee** attract more bile, so while
> > > > > > > > > > increasing cholestreol it also excrete more bile resulting into
> > > > > > > > > > cholestreol's beneficial roles as well controlling their levels?
> > > > >
> > > > > **emphasis** added.
> > > >
> > > > Sorry, your awnser is not clear to me.
> > >
> > > It served to help you understand why I wrote to comment how you had
> > > confused butter fat with dietary fiber. The former does not result in
> > > the excretion of more cholesterol for any cholesterol-lowering benefit as
> > > compared to the latter.
> >
> > I have not confused about butter with fibers. These are two different
> > things. I thought, Butter may promote more bile secretion in intestines
> > so more of its excretion whereas fiber can absorb more bile resulting
> > more of its excretion in stool.
>
> Bile secretion occurs **before** digestion and absorption of fats such
> as butter.
cholesterol intake or on their intake?
Do our body benefits from natural cycle of cholesterol or any other
food form intake to excretion or by less intake oand lesser
excretion/reabsorption?
To deviate from naturally followed practices may be sometimes improper
as we are not understanding everything absolutely, clearly and
completely. As noone can thing any such deviations--right or wrong?
Andrew B. Chung, MD/PhD
The trigger is simply food reaching the gut.
> Do our body benefits from natural cycle of cholesterol or any other
> food form intake to excretion or by less intake oand lesser
> excretion/reabsorption?
Our body benefits from an optimal intake amount which is by GOD's
design and which HE calls an omer:
http://HeartMDPhD.com/HolySpirit/overweight.asp
> To deviate from naturally followed practices may be sometimes improper
> as we are not understanding everything absolutely, clearly and
> completely. As noone can thing any such deviations--right or wrong?
It remains wise to look to LORD GOD Almighty, Creator of heaven and
earth, for knowledge and wisdom.
Kumar
Whether type of food trigger different type of secretions?
> > Do our body benefits from natural cycle of cholesterol or any other
> > food form intake to excretion or by less intake oand lesser
> > excretion/reabsorption?
>
> Our body benefits from an optimal intake amount which is by GOD's
> design and which HE calls an omer:
>
> http://HeartMDPhD.com/HolySpirit/overweight.asp
Yes, but we may be now attuned/brainased to eat less or no
cholesterols?
> > To deviate from naturally followed practices may be sometimes improper
> > as we are not understanding everything absolutely, clearly and
> > completely. As no one can think any such deviations--right or wrong?
>
> It remains wise to look to LORD GOD Almighty, Creator of heaven and
> earth, for knowledge and wisdom.
The other thought;
Can excess glucose in blood cause any blood substances sticky,
aggregate, or club, resuting into some restriction in transcapillary
movement of insulin etc.?
Can hyprglycemia effect changes in endothelliul cells junctution in
capillaries which may restrict normal movement of insulin into tissues?
Andrew B. Chung, MD/PhD
Not clinically seen.
> > > Do our body benefits from natural cycle of cholesterol or any other
> > > food form intake to excretion or by less intake oand lesser
> > > excretion/reabsorption?
> >
> > Our body benefits from an optimal intake amount which is by GOD's
> > design and which HE calls an omer:
> >
> > http://HeartMDPhD.com/HolySpirit/overweight.asp
>
> Yes, but we may be now attuned/brainased to eat less or no
> cholesterols?
Cholesterol is not an essential nutrient.
> > > To deviate from naturally followed practices may be sometimes improper
> > > as we are not understanding everything absolutely, clearly and
> > > completely. As no one can think any such deviations--right or wrong?
> >
> > It remains wise to look to LORD GOD Almighty, Creator of heaven and
> > earth, for knowledge and wisdom.
>
> The other thought;
>
> Can excess glucose in blood cause any blood substances sticky,
> aggregate, or club, resuting into some restriction in transcapillary
> movement of insulin etc.?
Not clinically seen.
> Can hyprglycemia effect changes in endothelliul cells junctution in
> capillaries which may restrict normal movement of insulin into tissues?
Not clinically seen.
Kumar
> > > > Do our body benefits from natural cycle of cholesterol or any other
> > > > food form intake to excretion or by less intake oand lesser
> > > > excretion/reabsorption?
> > >
> > > Our body benefits from an optimal intake amount which is by GOD's
> > > design and which HE calls an omer:
> > >
> > > http://HeartMDPhD.com/HolySpirit/overweight.asp
> >
> > Yes, but we may be now attuned/brainwashed to eat less or no
> > cholesterols?
>
> Cholesterol is not an essential nutrient.
Is it not essential to body?
"Function
Cholesterol is required to build and maintain cell membranes; it makes
the membrane's fluidity - degree of viscosity - stable over wider
temperature intervals (the hydroxyl group on cholesterol interacts with
the phosphate head of the membrane, and the bulky steroid and the
hydrocarbon chain is embedded in the membrane). Some research indicates
that cholesterol may act as an antioxidant.[1] Cholesterol also aids in
the manufacture of bile (which helps digest fats), and is also
important for the metabolism of fat-soluble vitamins, including
vitamins A, D, E and K. It is the major precursor for the synthesis of
vitamin D and of the various steroid hormones (which include cortisol
and aldosterone in the adrenal glands, and the sex hormones
progesterone, the various estrogens, testosterone, and derivatives ).
Recently, cholesterol has also been implicated in cell signalling
processes, where it has been suggested that it forms lipid rafts in the
plasma membrane. It also reduces the permeability of the plasma
membrane to hydrogen ions (protons) and sodium ions.[2]
http://en.wikipedia.org/wiki/Cholesterol "
Kumar
> > > > Do our body benefits from natural cycle of cholesterol or any other
> > > > food form intake to excretion or by less intake oand lesser
> > > > excretion/reabsorption?
> > >
> > > Our body benefits from an optimal intake amount which is by GOD's
> > > design and which HE calls an omer:
> > >
> > > http://HeartMDPhD.com/HolySpirit/overweight.asp
> >
> > Yes, but we may be now attuned/brainwashed to eat less or no
> > cholesterols?
>
> Cholesterol is not an essential nutrient.
Is it not essential to body?
"Function
Cholesterol is required to build and maintain cell membranes; it makes
the membrane's fluidity - degree of viscosity - stable over wider
temperature intervals (the hydroxyl group on cholesterol interacts with
the phosphate head of the membrane, and the bulky steroid and the
hydrocarbon chain is embedded in the membrane). Some research indicates
that cholesterol may act as an antioxidant.[1] Cholesterol also aids in
the manufacture of bile (which helps digest fats), and is also
important for the metabolism of fat-soluble vitamins, including
vitamins A, D, E and K. It is the major precursor for the synthesis of
vitamin D and of the various steroid hormones (which include cortisol
and aldosterone in the adrenal glands, and the sex hormones
progesterone, the various estrogens, testosterone, and derivatives ).
Recently, cholesterol has also been implicated in cell signalling
processes, where it has been suggested that it forms lipid rafts in the
plasma membrane. It also reduces the permeability of the plasma
membrane to hydrogen ions (protons) and sodium ions.[2]
http://en.wikipedia.org/wiki/Cholesterol "
> > > > To deviate from naturally followed practices may be sometimes improper
> > > > as we are not understanding everything absolutely, clearly and
> > > > completely. As no one can think any such deviations--right or wrong?
> > >
> > > It remains wise to look to LORD GOD Almighty, Creator of heaven and
> > > earth, for knowledge and wisdom.
> >
> > The other thought;
> >
> > Can excess glucose in blood cause any blood substances sticky,
> > aggregate, or club, resuting into some restriction in transcapillary
> > movement of insulin etc.?
>
> Not clinically seen.
"Glycosylation Purpose
The polysaccharide chains attached to the target proteins serve various
functions. For instance, some proteins do not fold correctly unless
they are glycosylated first. Also, polysaccharides linked at the amide
nitrogen of asparagine in the protein confer stability on some secreted
glycoproteins. Experiments have shown that glycosylation in this case
is not a strict requirement for proper folding, but the unglycosylated
protein degrades quickly. Glycosylation may play a role in *cell-cell
adhesion* (a mechanism employed by cells of the immune system), as
well.
http://en.wikipedia.org/wiki/Glycosylation "
Whether above quote indicate something as I thought?
> > Can hyprglycemia effect changes in endothelliul cells junctution in
> > capillaries which may restrict normal movement of insulin into tissues?
>
> Not clinically seen.
What can effect Capillaries endothelliul cells junctions to make them
ess or more leaky?
Andrew B. Chung, MD/PhD
No. Simply a conditioned response.
> > > > > Do our body benefits from natural cycle of cholesterol or any other
> > > > > food form intake to excretion or by less intake oand lesser
> > > > > excretion/reabsorption?
> > > >
> > > > Our body benefits from an optimal intake amount which is by GOD's
> > > > design and which HE calls an omer:
> > > >
> > > > http://HeartMDPhD.com/HolySpirit/overweight.asp
> > >
> > > Yes, but we may be now attuned/brainwashed to eat less or no
> > > cholesterols?
> >
> > Cholesterol is not an essential nutrient.
>
> Is it not essential to body?
That which is readily made in the body far more in excess than is
needed for vital functions is not an essential nutrient.
> "Function
> Cholesterol is required to build and maintain cell membranes; it makes
> the membrane's fluidity - degree of viscosity - stable over wider
> temperature intervals (the hydroxyl group on cholesterol interacts with
> the phosphate head of the membrane, and the bulky steroid and the
> hydrocarbon chain is embedded in the membrane). Some research indicates
> that cholesterol may act as an antioxidant.[1] Cholesterol also aids in
> the manufacture of bile (which helps digest fats), and is also
> important for the metabolism of fat-soluble vitamins, including
> vitamins A, D, E and K. It is the major precursor for the synthesis of
> vitamin D and of the various steroid hormones (which include cortisol
> and aldosterone in the adrenal glands, and the sex hormones
> progesterone, the various estrogens, testosterone, and derivatives ).
>
> Recently, cholesterol has also been implicated in cell signalling
> processes, where it has been suggested that it forms lipid rafts in the
> plasma membrane. It also reduces the permeability of the plasma
> membrane to hydrogen ions (protons) and sodium ions.[2]
> http://en.wikipedia.org/wiki/Cholesterol "
See above.
P.S.
Simply here on this blessed LORD's day doing the work that GOD has
prepared in advance for me to do.
"These who do the will of MY Father are MY family." -- LORD Jesus
Christ
Amen !
Laus Deo ! !
Marana tha ! ! !
Kumar
>
> No. Simply a conditioned response.
Fats triggering bile secretion in intestines?
Can prolonged reduced fats intake cause some impairement in bile
synthesis, travel from liver and secretion from GB?
> > > > > > Do our body benefits from natural cycle of cholesterol or any other
> > > > > > food form intake to excretion or by less intake oand lesser
> > > > > > excretion/reabsorption?
> > > > >
> > > > > Our body benefits from an optimal intake amount which is by GOD's
> > > > > design and which HE calls an omer:
> > > > >
> > > > > http://HeartMDPhD.com/HolySpirit/overweight.asp
> > > >
> > > > Yes, but we may be now attuned/brainwashed to eat less or no
> > > > cholesterols?
> > >
> > > Cholesterol is not an essential nutrient.
> >
> > Is it not essential to body?
>
> That which is readily made in the body far more in excess than is
> needed for vital functions is not an essential nutrient.
Can we maintain normally without intake of Cholesterols with food?
> > "Function
> > Cholesterol is required to build and maintain cell membranes; it makes
> > the membrane's fluidity - degree of viscosity - stable over wider
> > temperature intervals (the hydroxyl group on cholesterol interacts with
> > the phosphate head of the membrane, and the bulky steroid and the
> > hydrocarbon chain is embedded in the membrane). Some research indicates
> > that cholesterol may act as an antioxidant.[1] Cholesterol also aids in
> > the manufacture of bile (which helps digest fats), and is also
> > important for the metabolism of fat-soluble vitamins, including
> > vitamins A, D, E and K. It is the major precursor for the synthesis of
> > vitamin D and of the various steroid hormones (which include cortisol
> > and aldosterone in the adrenal glands, and the sex hormones
> > progesterone, the various estrogens, testosterone, and derivatives ).
> >
> > Recently, cholesterol has also been implicated in cell signalling
> > processes, where it has been suggested that it forms lipid rafts in the
> > plasma membrane. It also reduces the permeability of the plasma
> > membrane to hydrogen ions (protons) and sodium ions.[2]
> > http://en.wikipedia.org/wiki/Cholesterol "
>
> See above.
> > > > Can excess glucose in blood cause any blood substances sticky,
> > > > aggregate, or club, resuting into some restriction in transcapillary
> > > > movement of insulin etc.?
> > >
> > > Not clinically seen.
> > >
> > > > Can hyprglycemia effect changes in endothelliul cells junctution in
> > > > capillaries which may restrict normal movement of insulin into tissues?
> > >
> > > Not clinically seen.
How persisted hyperglycemia causes diabetic nephropathy?
Whether DN is just either leaky kidneys or their decreased
performance--filteration and reabsorption?
Andrew B. Chung, MD/PhD
Occurs with the stretching of the stomach.
> Can prolonged reduced fats intake cause some impairement in bile
> synthesis, travel from liver and secretion from GB?
Not clinically seen.
> > > > > > > Do our body benefits from natural cycle of cholesterol or any other
> > > > > > > food form intake to excretion or by less intake oand lesser
> > > > > > > excretion/reabsorption?
> > > > > >
> > > > > > Our body benefits from an optimal intake amount which is by GOD's
> > > > > > design and which HE calls an omer:
> > > > > >
> > > > > > http://HeartMDPhD.com/HolySpirit/overweight.asp
> > > > >
> > > > > Yes, but we may be now attuned/brainwashed to eat less or no
> > > > > cholesterols?
> > > >
> > > > Cholesterol is not an essential nutrient.
> > >
> > > Is it not essential to body?
> >
> > That which is readily made in the body far more in excess than is
> > needed for vital functions is not an essential nutrient.
>
> Can we maintain normally without intake of Cholesterols with food?
Yes.
Persistent hyperglycemia is deleterious.
> Whether DN is just either leaky kidneys or their decreased
> performance--filteration and reabsorption?
Dying kidneys.
May GOD continue to heal our hearts with HIS living water curing our
diabetes, depression, anxiety, and panic so that we can love our
neighbors a little more and LORD Jesus Christ a lot more, dear neighbor
Kumar
of foods including non-fat foods?
> > Can prolonged reduced fats intake cause some impairement in bile
> > synthesis, travel from liver and secretion from GB?
>
> Not clinically seen.
> > > > > > > > Do our body benefits from natural cycle of cholesterol or any other
> > > > > > > > food form intake to excretion or by less intake oand lesser
> > > > > > > > excretion/reabsorption?
> > > > > > >
> > > > > > > Our body benefits from an optimal intake amount which is by GOD's
> > > > > > > design and which HE calls an omer:
> > > > > > >
> > > > > > > http://HeartMDPhD.com/HolySpirit/overweight.asp
> > > > > >
> > > > > > Yes, but we may be now attuned/brainwashed to eat less or no
> > > > > > cholesterols?
> > > > >
> > > > > Cholesterol is not an essential nutrient.
> > > >
> > > > Is it not essential to body?
> > >
> > > That which is readily made in the body far more in excess than is
> > > needed for vital functions is not an essential nutrient.
> >
> > Can we maintain normally without intake of Cholesterols with food?
>
> Yes.
Yes but how it specifically effect kidneys?
> > Whether DN is just either leaky kidneys or their decreased
> > performance--filteration and reabsorption?
>
> Dying kidneys.
Pls tell me types of kindney impairements?
How one can get protienuria still creatnine and BUN level normal?
Stephen Knight
<lo...@thetruth.com> wrote:
>May GOD continue to heal our hearts with HIS living water curing our
>diabetes, depression, anxiety, and panic so that we can love our
>neighbors a little more and LORD Jesus Christ a lot more
That is so sweet and christian. The feeling of the LORD is
overwhelming! I'm ready to join Fred Phelps congregation, and hold a
'Jesus Hates Faggots' banner at a funeral for a gay AIDS person.
I'm floating! I now feel the purest, wonderful LOVE of JESUS.
No more 666 on MY forehead.
Now... if I can find my crayons, I can be a marcher, no.. a soldier
for the LORD.
HOWLAYLOOYA!
MA RANTA HOY! YA! YA! GIDDIUP!
Warlord Steve
BAAWA
Ma¢k
<woo...@comcast.net> Giggled into the madness of usenet:
>On 12 Dec 2006 10:11:34 -0800, "Andrew B. Chung, MD/PhD"
><lo...@thetruth.com> wrote:
>
>
>>May GOD continue to heal our hearts with HIS living water curing our
>>diabetes, depression, anxiety, and panic so that we can love our
>>neighbors a little more and LORD Jesus Christ a lot more
>
> That is so sweet and christian. The feeling of the LORD is
>overwhelming! I'm ready to join Fred Phelps congregation, and hold a
>'Jesus Hates Faggots' banner at a funeral for a gay AIDS person.
not exactly correct, you would picketing the funerals of infants and
other children who died of AIDS no matter how they got the disease,
from their mother, from a blood transfusion, it makes no difference.
Andrew B. Chung, MD/PhD
It is the same.
> > > Can prolonged reduced fats intake cause some impairement in bile
> > > synthesis, travel from liver and secretion from GB?
> >
> > Not clinically seen.
>
> Do you mean fats have no particular role in promoting bile secretions?
No.
By causing glomerulosclerosis.
> > > Whether DN is just either leaky kidneys or their decreased
> > > performance--filteration and reabsorption?
> >
> > Dying kidneys.
>
> Pls tell me types of kindney impairements?
Glomerulosclerosis.
> How one can get protienuria still creatnine and BUN level normal?
Early glomerular basement membrane problems are isolated to the
glomerulus and not the rest of the nephron.
kumar
> > How one can get protienuria still creatnine and BUN level normal?
>
> Early glomerular basement membrane problems are isolated to the
> glomerulus and not the rest of the nephron.
intake or improper metabolism or vasodialation/relaxed vessels or
increased p[ressure or otherwise?
Andrew B. Chung, MD/PhD
Persistently high glucose concentrations is toxic for kidney cells.
> > > How one can get protienuria still creatnine and BUN level normal?
> >
> > Early glomerular basement membrane problems are isolated to the
> > glomerulus and not the rest of the nephron.
>
> Can proteinuria be due to any non damaging reason, say high protien
> intake or improper metabolism or vasodialation/relaxed vessels or
> increased p[ressure or otherwise?
Not clinically seen.
Father Haskell
> Kumar wrote:
> > Do you mean fats have no particular role in promoting bile secretions?
>
> No.
Of course not. That's what religion is for.
kumar
Why then persistently high glucose concentrations can't be toxic to
other target cells?
Andrew B. Chung, MD/PhD
Persistently high glucose concentrations are toxic to target cells as a
rule simply by definition.
May GOD continue to heal our hearts with HIS living water curing our
diabetes, depression, anxiety or panic so that we can love our
Art Deco
>so that we can love our
>neighbors a little more
Like those on your "demons" hate lits, hypocrite?
Kumar
Andrew B. Chung, MD/PhD wrote:
> kumar wrote:
> > > > > > > > > > > > Can hyprglycemia effect changes in endothelliul cells junctution in
> > > > > > > > > > > > capillaries which may restrict normal movement of insulin into tissues?
> > > > > > > > > > >
> > > > > > > > > > > Not clinically seen.
> > > > > > > >
> > > > > > > > How persisted hyperglycemia causes diabetic nephropathy?
> > > > > > >
> > > > > > > Persistent hyperglycemia is deleterious.
> > > > > >
> > > > > > Yes but how it specifically effect kidneys?
> > > > >
> > > > > By causing glomerulosclerosis.
> > > > >
> > > > > > > > Whether DN is just either leaky kidneys or their decreased
> > > > > > > > performance--filteration and reabsorption?
> > > > > > >
> > > > > > > Dying kidneys.
> > > > > >
> > > > > > Pls tell me types of kindney impairements?
> > > > >
> > > > > Glomerulosclerosis.
> > >
> > > > How high glucose levels causes it?
> > >
> > > Persistently high glucose concentrations is toxic for kidney cells.
> >
> > Why then persistently high glucose concentrations can't be toxic to
> > other target cells?
>
> Persistently high glucose concentrations are toxic to target cells as a
> rule simply by definition.
concentrations to target cells and succeed in it?
ah
Dr. Chung seems to be infected with the dreaded RCI disease.
Andrew B. Chung, MD/PhD
> Andrew, in the Holy Spirit, boldly wrote:
> > Convicted neighbor kumar wrote:
http://HeartMDPhD.com/Convicts
> > > > > > > > > > > > > Can hyprglycemia effect changes in endothelliul cells junctution in
> > > > > > > > > > > > > capillaries which may restrict normal movement of insulin into tissues?
> > > > > > > > > > > >
> > > > > > > > > > > > Not clinically seen.
> > > > > > > > >
> > > > > > > > > How persisted hyperglycemia causes diabetic nephropathy?
> > > > > > > >
> > > > > > > > Persistent hyperglycemia is deleterious.
> > > > > > >
> > > > > > > Yes but how it specifically effect kidneys?
> > > > > >
> > > > > > By causing glomerulosclerosis.
> > > > > >
> > > > > > > > > Whether DN is just either leaky kidneys or their decreased
> > > > > > > > > performance--filteration and reabsorption?
> > > > > > > >
> > > > > > > > Dying kidneys.
> > > > > > >
> > > > > > > Pls tell me types of kindney impairements?
> > > > > >
> > > > > > Glomerulosclerosis.
> > > >
> > > > > How high glucose levels causes it?
> > > >
> > > > Persistently high glucose concentrations is toxic for kidney cells.
> > >
> > > Why then persistently high glucose concentrations can't be toxic to
> > > other target cells?
> >
> > Persistently high glucose concentrations are toxic to target cells as a
> > rule simply by definition.
> Whether body systems try to avoid such high/toxic glucose
> concentrations to target cells and succeed in it?
Until there is the continued choice to overeat leading to the formation
of visceral adipose tissue (VAT) which is the source of inflammatory
cytokines that fuel the cascading systemic inflammation that leads to
metabolic syndrome (MetS) that is the prerequisite for the development
of type-2 diabetes:
http://HeartMDPhD.com/HolySpirit/overweight.asp
Here is the way to reverse the process:
http://HeartMDPhD.com/wtloss.asp
Which now includes a million dollar guarantee:
http://MabletonGA.OurLittle.net/Guarantee
The existence of VAT concurrently with the existence of subcutaneous
adipose tissue (SAT) can not be explained by Darwin's defunct theory of
evolution but only by GOD, Creator of heaven and earth.
May GOD continue to heal our hearts with HIS living water curing our
diabetes, depression, anxiety or panic so that we can love our
neighbors a little more and LORD Jesus Christ a lot more, dear neighbor
Kumar whom I love unconditionally.
Prayerfully in Christ's amazing love,
Andrew <><
--
Andrew B. Chung
Cardiologist, Atlanta, Georgia, USA
http://HeartMDPhD.com/HolySpirit
As for knowing who are the very elect, these you will know by the
unconditional love they have for everyone including their enemies
(Matthew 5:44-45, 1 Corinthians 13:3, James 2:14-17).
http://HeartMDPhD.com/Love
Happy Birthday Jesus ! ! ! ! ! ! ! !
(((( hugs )))))
Art Deco
>Convicted neighbor Kumar wrote:
You're losing it, Chunk. Your only fan has now attained "convicted"
status.
Kumar
Andrew B. Chung, MD/PhD wrote:
Whether such systemic inflammation is meant to trigger IR to avoid
high/toxic glucose
concentrations to target cells?
Andrew B. Chung, MD/PhD
IR ultimately causes the high levels of blood glucose that damages
target cells.
Kumar
How high levels of blood glucose damages target cells extravascularily?
Whether damages due to diabetes is related to damages due to
hyperglycemia within blood or/and due to toxicity of glucose to target
extravasular cells?
Andrew B. Chung, MD/PhD
By the post-translational modification (glycosylation) of structural
proteins.
> Whether damages due to diabetes is related to damages due to
> hyperglycemia within blood or/and due to toxicity of glucose to target
> extravasular cells?
Target cells include leukocytes which are intravascular and endothelial
cells which are vascular.