University of California Los Angeles, Reed Neurologic Research Center. bdob...@mednet.ucla.edu.
INTRODUCTION: Myopathic syndromes induced by 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) include muscle complaints, myalgia, myositis, and rhabdomyolysis. No prospective study of statins, however, included tests of strength, so the incidence of weakness, with or without muscle symptoms and elevated enzymes, is unknown, and perhaps overlooked. METHODS: From a convenience sample of patients referred to an outpatient neurorehabilitation clinic over the course of 1 year, 8 patients with hemiparetic stroke and 10 patients with other presumed neurologic diseases presented with new difficulty walking by 3 to 12 months after starting one of 3 statins. They reported no myalgias, exercise-induced aches, or weakness. Examination revealed proximal paresis graded 4/5 on the unaffected side in the hemiparetic patients and symmetrical bilateral proximal limb and neck flexor weakness graded 4/5 in the others. They stood up with difficulty and walked with bilateral hip drop and imbalance on turns. RESULTS: Laboratory tests did not reveal myositis or other causes for paresis. No improvement in strength or mobility was found 6 weeks after initiating resistance exercises. The statin agent was stopped. By 3 months off statin, all recovered 5/5 proximal strength. Walking improved, and they arose from a chair without pushing off with their arms. DISCUSSION: Serial manual muscle testing after initiating a statin may detect a reversible cause of disability. A genetic predisposition to statin-induced myopathic proximal weakness with normal creatine kinase is consistent with a continuum of previously reported symptoms and signs but may be underappreciated.
> University of California Los Angeles, Reed Neurologic Research Center. > bdob...@mednet.ucla.edu.
> INTRODUCTION: Myopathic syndromes induced by > 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors > (statins) include muscle complaints, myalgia, myositis, and > rhabdomyolysis. No prospective study of statins, however, included > tests of strength, so the incidence of weakness, with or without > muscle symptoms and elevated enzymes, is unknown, and perhaps > overlooked. METHODS: From a convenience sample of patients referred > to an outpatient neurorehabilitation clinic over the course of 1 year, > 8 patients with hemiparetic stroke and 10 patients with other presumed > neurologic diseases presented with new difficulty walking by 3 to 12 > months after starting one of 3 statins. They reported no myalgias, > exercise-induced aches, or weakness. Examination revealed proximal > paresis graded 4/5 on the unaffected side in the hemiparetic patients > and symmetrical bilateral proximal limb and neck flexor weakness > graded 4/5 in the others. They stood up with difficulty and walked > with bilateral hip drop and imbalance on turns. RESULTS: Laboratory > tests did not reveal myositis or other causes for paresis. No > improvement in strength or mobility was found 6 weeks after initiating > resistance exercises. The statin agent was stopped. By 3 months off > statin, all recovered 5/5 proximal strength. Walking improved, and > they arose from a chair without pushing off with their arms. > DISCUSSION: Serial manual muscle testing after initiating a statin may > detect a reversible cause of disability. A genetic predisposition to > statin-induced myopathic proximal weakness with normal creatine kinase > is consistent with a continuum of previously reported symptoms and > signs but may be underappreciated.
> PMID: 16093417 [PubMed - in process]
Inotherwords, for the small subset with a genetic predisposition to statin-induced myopathy and other pre-exisiting neurologic diseases improvement was achieved shortly after cessation of the statin.
As long as you think experiencing PREVENTABLE DISABILITY is a good thing.
DISABILITY is a major change in lifestyle, and can induce loss of job, loss of home, and harm to the family unit, in addition to pain and suffering.
PREVENTABLE DISABILITY adds additional stress and loss of trust and anger, knowing there was no justifiable reason that the patient was subjected to it without warning and permitted to become disabled by a drug that is precautionary, not curative.
Somehow, most who have been through it as either family or patient, would strongly disagee with you that it has been a positive experience.
>> University of California Los Angeles, Reed Neurologic Research Center. >> bdob...@mednet.ucla.edu.
>> INTRODUCTION: Myopathic syndromes induced by >> 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors >> (statins) include muscle complaints, myalgia, myositis, and >> rhabdomyolysis. No prospective study of statins, however, included >> tests of strength, so the incidence of weakness, with or without >> muscle symptoms and elevated enzymes, is unknown, and perhaps >> overlooked. METHODS: From a convenience sample of patients referred >> to an outpatient neurorehabilitation clinic over the course of 1 year, >> 8 patients with hemiparetic stroke and 10 patients with other presumed >> neurologic diseases presented with new difficulty walking by 3 to 12 >> months after starting one of 3 statins. They reported no myalgias, >> exercise-induced aches, or weakness. Examination revealed proximal >> paresis graded 4/5 on the unaffected side in the hemiparetic patients >> and symmetrical bilateral proximal limb and neck flexor weakness >> graded 4/5 in the others. They stood up with difficulty and walked >> with bilateral hip drop and imbalance on turns. RESULTS: Laboratory >> tests did not reveal myositis or other causes for paresis. No >> improvement in strength or mobility was found 6 weeks after initiating >> resistance exercises. The statin agent was stopped. By 3 months off >> statin, all recovered 5/5 proximal strength. Walking improved, and >> they arose from a chair without pushing off with their arms. >> DISCUSSION: Serial manual muscle testing after initiating a statin may >> detect a reversible cause of disability. A genetic predisposition to >> statin-induced myopathic proximal weakness with normal creatine kinase >> is consistent with a continuum of previously reported symptoms and >> signs but may be underappreciated.
>> PMID: 16093417 [PubMed - in process]
> Inotherwords, for the small subset with a genetic predisposition to > statin-induced myopathy and other pre-exisiting neurologic diseases > improvement was achieved shortly after cessation of the statin.
> As long as you think experiencing PREVENTABLE DISABILITY is a good thing.
Preventable disability does not solely apply to drugs. Most drug reactions are in fact not preventable. There is no way of knowing who will experience AE. I haven't seen it written by UCSD or anywhere except the package insert involving contra indications.
> DISABILITY is a major change in lifestyle, and can induce loss of job, loss > of home, and harm to the family unit, in addition to pain and suffering.
> PREVENTABLE DISABILITY adds additional stress and loss of trust and anger, > knowing there was no justifiable reason that the patient was subjected to it > without warning and permitted to become disabled by a drug that is > precautionary, not curative.
Not is not a definition of preventable "precautionary not curative". You are trying to prevent disease which is why the person is doing something. That is the whole point of doing it. If somebody dies of a heart attack while exercising was that death preventable by telling everybody not to exercise? There is a displacement of reality in your world.
> Somehow, most who have been through it as either family or patient, would > strongly disagee with you that it has been a positive experience.
That's not what he said and I understand your distortion of reality.
"Robert" <Robertit...@hotmail.com> wrote: > "Sharon Hope" <sh...@anet.net> wrote in message > news:q-qdnZW8o5sjLGLfRVn-1g@comcast.com... > > As long as you think experiencing PREVENTABLE DISABILITY is a good thing.
> Preventable disability does not solely apply to drugs. Most drug reactions > are in fact not preventable. There is no way of knowing who will experience > AE. I haven't seen it written by UCSD or anywhere except the package insert > involving contra indications.
> > DISABILITY is a major change in lifestyle, and can induce loss of job, > loss > > of home, and harm to the family unit, in addition to pain and suffering.
> > PREVENTABLE DISABILITY adds additional stress and loss of trust and anger, > > knowing there was no justifiable reason that the patient was subjected to > it > > without warning and permitted to become disabled by a drug that is > > precautionary, not curative.
> Not is not a definition of preventable "precautionary not curative". > You are trying to prevent disease which is why the person is doing > something. That is the whole point of doing it. If somebody dies of a heart > attack while exercising was that death preventable by telling everybody not > to exercise? > There is a displacement of reality in your world.
> > Somehow, most who have been through it as either family or patient, would > > strongly disagee with you that it has been a positive experience.
> That's not what he said and I understand your distortion of reality.
Reality...That which goes on outside and inside at the same time. Interesting no?
Burn your arm with a match and the world really is nasty. Caress a love one an the world holds promise.
Bill
-- Garden Shade Zone 5 S Jersey USA in a Japanese Jungle Manner.39.6376 -75.0208 This article is posted under fair use rules in accordance with Title 17 U.S.C. Section 107, and is strictly for the educational and informative purposes. This material is distributed without profit.
> In article <NdudnZ2dnZ1Fr0DInZ2dnQInYt-dnZ2dRVn-052d...@got.net>, > "Robert" <Robertit...@hotmail.com> wrote:
> > "Sharon Hope" <sh...@anet.net> wrote in message > > news:q-qdnZW8o5sjLGLfRVn-1g@comcast.com... > > > As long as you think experiencing PREVENTABLE DISABILITY is a good thing.
> > Preventable disability does not solely apply to drugs. Most drug reactions > > are in fact not preventable. There is no way of knowing who will experience > > AE. I haven't seen it written by UCSD or anywhere except the package insert > > involving contra indications.
> > > DISABILITY is a major change in lifestyle, and can induce loss of job, > > loss > > > of home, and harm to the family unit, in addition to pain and suffering.
> > > PREVENTABLE DISABILITY adds additional stress and loss of trust and anger, > > > knowing there was no justifiable reason that the patient was subjected to > > it > > > without warning and permitted to become disabled by a drug that is > > > precautionary, not curative.
> > Not is not a definition of preventable "precautionary not curative". > > You are trying to prevent disease which is why the person is doing > > something. That is the whole point of doing it. If somebody dies of a heart > > attack while exercising was that death preventable by telling everybody not > > to exercise? > > There is a displacement of reality in your world.
> > > Somehow, most who have been through it as either family or patient, would > > > strongly disagee with you that it has been a positive experience.
> > That's not what he said and I understand your distortion of reality.
> Reality...That which goes on outside and inside at the same time. > Interesting no?
> Burn your arm with a match and the world really is nasty. Caress a > love one an the world holds promise.
Doesn't have to be. Christopher Reeves did not go out and shoot the horse that broke his neck. He did not go out and tell people not to ride horses. He was a proponent of nerve repair drugs and research. Everybody is different so I am not saying one is right or one is wrong only that there is distortion of reality when one is touched.
> Bill
> -- > Garden Shade Zone 5 S Jersey USA in a Japanese Jungle
> This article is posted under fair use rules in accordance with > Title 17 U.S.C. Section 107, and is strictly for the educational > and informative purposes. This material is distributed without profit.
Your ability to be selective is astonishing. Cognitive dissonance at work. I said nothing about the experience of statin-induced myopathy being "positive". What's wrong with you? Where did I even remotely say that?
Also, it's safe to say that the patients in the study were already disabled to some degree before taking a statin, which then caused a *new* disability:
"8 patients with hemiparetic stroke and 10 patients with other presumed neurologic diseases presented with new difficulty..."
I still say that the fact they recovered within a relatively short time period from the *new* (statin-induced) disability is hopeful, wonderful and positive. I know it contradicts your stated views that this sort of statin AE recovery is a long, horrible proccess where there's little hope, if any, for full recovery. Perhaps that's why you respond in such an angry, negative fashion.
> As long as you think experiencing PREVENTABLE DISABILITY is a good > thing.
> DISABILITY is a major change in lifestyle, and can induce loss of job, > loss of home, and harm to the family unit, in addition to pain and > suffering.
> PREVENTABLE DISABILITY adds additional stress and loss of trust and > anger, knowing there was no justifiable reason that the patient was > subjected to it without warning and permitted to become disabled by a > drug that is precautionary, not curative.
> Somehow, most who have been through it as either family or patient, > would strongly disagee with you that it has been a positive > experience.
>>> University of California Los Angeles, Reed Neurologic Research >>> Center. bdob...@mednet.ucla.edu.
>>> INTRODUCTION: Myopathic syndromes induced by >>> 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors >>> (statins) include muscle complaints, myalgia, myositis, and >>> rhabdomyolysis. No prospective study of statins, however, included >>> tests of strength, so the incidence of weakness, with or without >>> muscle symptoms and elevated enzymes, is unknown, and perhaps >>> overlooked. METHODS: From a convenience sample of patients referred >>> to an outpatient neurorehabilitation clinic over the course of 1 >>> year, 8 patients with hemiparetic stroke and 10 patients with other >>> presumed neurologic diseases presented with new difficulty walking >>> by 3 to 12 months after starting one of 3 statins. They reported no >>> myalgias, exercise-induced aches, or weakness. Examination revealed >>> proximal paresis graded 4/5 on the unaffected side in the >>> hemiparetic patients and symmetrical bilateral proximal limb and >>> neck flexor weakness graded 4/5 in the others. They stood up with >>> difficulty and walked with bilateral hip drop and imbalance on >>> turns. RESULTS: Laboratory tests did not reveal myositis or other >>> causes for paresis. No improvement in strength or mobility was found >>> 6 weeks after initiating resistance exercises. The statin agent was >>> stopped. By 3 months off statin, all recovered 5/5 proximal >>> strength. Walking improved, and they arose from a chair without >>> pushing off with their arms. DISCUSSION: Serial manual muscle >>> testing after initiating a statin may detect a reversible cause of >>> disability. A genetic predisposition to statin-induced myopathic >>> proximal weakness with normal creatine kinase is consistent with a >>> continuum of previously reported symptoms and signs but may be >>> underappreciated.
>>> PMID: 16093417 [PubMed - in process]
>> Inotherwords, for the small subset with a genetic predisposition to >> statin-induced myopathy and other pre-exisiting neurologic diseases >> improvement was achieved shortly after cessation of the statin.
> As long as you think experiencing PREVENTABLE DISABILITY is a good thing.
> DISABILITY is a major change in lifestyle, and can induce loss of job, loss > of home, and harm to the family unit, in addition to pain and suffering.
> PREVENTABLE DISABILITY adds additional stress and loss of trust and anger, > knowing there was no justifiable reason that the patient was subjected to it > without warning and permitted to become disabled by a drug that is > precautionary, not curative.
Within the context of this study, what actions should have been taken that were not taken to prevent the temporary disability in your view?
>>> University of California Los Angeles, Reed Neurologic Research Center. >>> bdob...@mednet.ucla.edu.
>>> INTRODUCTION: Myopathic syndromes induced by >>> 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors >>> (statins) include muscle complaints, myalgia, myositis, and >>> rhabdomyolysis. No prospective study of statins, however, included >>> tests of strength, so the incidence of weakness, with or without >>> muscle symptoms and elevated enzymes, is unknown, and perhaps >>> overlooked. METHODS: From a convenience sample of patients referred >>> to an outpatient neurorehabilitation clinic over the course of 1 year, >>> 8 patients with hemiparetic stroke and 10 patients with other presumed >>> neurologic diseases presented with new difficulty walking by 3 to 12 >>> months after starting one of 3 statins. They reported no myalgias, >>> exercise-induced aches, or weakness. Examination revealed proximal >>> paresis graded 4/5 on the unaffected side in the hemiparetic patients >>> and symmetrical bilateral proximal limb and neck flexor weakness >>> graded 4/5 in the others. They stood up with difficulty and walked >>> with bilateral hip drop and imbalance on turns. RESULTS: Laboratory >>> tests did not reveal myositis or other causes for paresis. No >>> improvement in strength or mobility was found 6 weeks after initiating >>> resistance exercises. The statin agent was stopped. By 3 months off >>> statin, all recovered 5/5 proximal strength. Walking improved, and >>> they arose from a chair without pushing off with their arms. >>> DISCUSSION: Serial manual muscle testing after initiating a statin may >>> detect a reversible cause of disability. A genetic predisposition to >>> statin-induced myopathic proximal weakness with normal creatine kinase >>> is consistent with a continuum of previously reported symptoms and >>> signs but may be underappreciated.
>>> PMID: 16093417 [PubMed - in process]
>> Inotherwords, for the small subset with a genetic predisposition to >> statin-induced myopathy and other pre-exisiting neurologic diseases >> improvement was achieved shortly after cessation of the statin.
> Your ability to be selective is astonishing. Cognitive dissonance at > work. I said nothing about the experience of statin-induced myopathy > being "positive". What's wrong with you? Where did I even remotely say > that?
> Also, it's safe to say that the patients in the study were already > disabled to some degree before taking a statin, which then caused a *new* > disability:
> "8 patients with hemiparetic stroke and 10 patients with other > presumed neurologic diseases presented with new difficulty..."
> I still say that the fact they recovered within a relatively short time > period from the *new* (statin-induced) disability is hopeful, wonderful > and positive. I know it contradicts your stated views
>that this sort of > statin AE recovery is a long, horrible proccess where there's little > hope, if any, for full recovery. Perhaps that's why you respond in such > an angry, negative fashion.
>> As long as you think experiencing PREVENTABLE DISABILITY is a good >> thing.
>> DISABILITY is a major change in lifestyle, and can induce loss of job, >> loss of home, and harm to the family unit, in addition to pain and >> suffering.
>> PREVENTABLE DISABILITY adds additional stress and loss of trust and >> anger, knowing there was no justifiable reason that the patient was >> subjected to it without warning and permitted to become disabled by a >> drug that is precautionary, not curative.
>> Somehow, most who have been through it as either family or patient, >> would strongly disagee with you that it has been a positive >> experience.
>>>> University of California Los Angeles, Reed Neurologic Research >>>> Center. bdob...@mednet.ucla.edu.
>>>> INTRODUCTION: Myopathic syndromes induced by >>>> 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors >>>> (statins) include muscle complaints, myalgia, myositis, and >>>> rhabdomyolysis. No prospective study of statins, however, included >>>> tests of strength, so the incidence of weakness, with or without >>>> muscle symptoms and elevated enzymes, is unknown, and perhaps >>>> overlooked. METHODS: From a convenience sample of patients referred >>>> to an outpatient neurorehabilitation clinic over the course of 1 >>>> year, 8 patients with hemiparetic stroke and 10 patients with other >>>> presumed neurologic diseases presented with new difficulty walking >>>> by 3 to 12 months after starting one of 3 statins. They reported no >>>> myalgias, exercise-induced aches, or weakness. Examination revealed >>>> proximal paresis graded 4/5 on the unaffected side in the >>>> hemiparetic patients and symmetrical bilateral proximal limb and >>>> neck flexor weakness graded 4/5 in the others. They stood up with >>>> difficulty and walked with bilateral hip drop and imbalance on >>>> turns. RESULTS: Laboratory tests did not reveal myositis or other >>>> causes for paresis. No improvement in strength or mobility was found >>>> 6 weeks after initiating resistance exercises. The statin agent was >>>> stopped. By 3 months off statin, all recovered 5/5 proximal >>>> strength. Walking improved, and they arose from a chair without >>>> pushing off with their arms. DISCUSSION: Serial manual muscle >>>> testing after initiating a statin may detect a reversible cause of >>>> disability. A genetic predisposition to statin-induced myopathic >>>> proximal weakness with normal creatine kinase is consistent with a >>>> continuum of previously reported symptoms and signs but may be >>>> underappreciated.
>>>> PMID: 16093417 [PubMed - in process]
>>> Inotherwords, for the small subset with a genetic predisposition to >>> statin-induced myopathy and other pre-exisiting neurologic diseases >>> improvement was achieved shortly after cessation of the statin.
> "Sharon Hope" <sh...@anet.net> wrote in message > news:q-qdnZW8o5sjLGLfRVn-1g@comcast.com... >> As long as you think experiencing PREVENTABLE DISABILITY is a good thing.
>> DISABILITY is a major change in lifestyle, and can induce loss of job, >> loss of home, and harm to the family unit, in addition to pain and >> suffering.
>> PREVENTABLE DISABILITY adds additional stress and loss of trust and >> anger, knowing there was no justifiable reason that the patient was >> subjected to it without warning and permitted to become disabled by a >> drug that is precautionary, not curative.
> Within the context of this study, what actions should have been taken that > were not taken to prevent the temporary disability in your view?
Your answer is within the context of the study: In the conclusion.
>>>> University of California Los Angeles, Reed Neurologic Research Center. >>>> bdob...@mednet.ucla.edu.
>>>> INTRODUCTION: Myopathic syndromes induced by >>>> 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors >>>> (statins) include muscle complaints, myalgia, myositis, and >>>> rhabdomyolysis. No prospective study of statins, however, included >>>> tests of strength, so the incidence of weakness, with or without >>>> muscle symptoms and elevated enzymes, is unknown, and perhaps >>>> overlooked. METHODS: From a convenience sample of patients referred >>>> to an outpatient neurorehabilitation clinic over the course of 1 year, >>>> 8 patients with hemiparetic stroke and 10 patients with other presumed >>>> neurologic diseases presented with new difficulty walking by 3 to 12 >>>> months after starting one of 3 statins. They reported no myalgias, >>>> exercise-induced aches, or weakness. Examination revealed proximal >>>> paresis graded 4/5 on the unaffected side in the hemiparetic patients >>>> and symmetrical bilateral proximal limb and neck flexor weakness >>>> graded 4/5 in the others. They stood up with difficulty and walked >>>> with bilateral hip drop and imbalance on turns. RESULTS: Laboratory >>>> tests did not reveal myositis or other causes for paresis. No >>>> improvement in strength or mobility was found 6 weeks after initiating >>>> resistance exercises. The statin agent was stopped. By 3 months off >>>> statin, all recovered 5/5 proximal strength. Walking improved, and >>>> they arose from a chair without pushing off with their arms. >>>> DISCUSSION: Serial manual muscle testing after initiating a statin may >>>> detect a reversible cause of disability. A genetic predisposition to >>>> statin-induced myopathic proximal weakness with normal creatine kinase >>>> is consistent with a continuum of previously reported symptoms and >>>> signs but may be underappreciated.
>>>> PMID: 16093417 [PubMed - in process]
>>> Inotherwords, for the small subset with a genetic predisposition to >>> statin-induced myopathy and other pre-exisiting neurologic diseases >>> improvement was achieved shortly after cessation of the statin.
>> "Sharon Hope" <sh...@anet.net> wrote in message >> news:q-qdnZW8o5sjLGLfRVn-1g@comcast.com... >>> As long as you think experiencing PREVENTABLE DISABILITY is a good thing.
>>> DISABILITY is a major change in lifestyle, and can induce loss of job, >>> loss of home, and harm to the family unit, in addition to pain and >>> suffering.
>>> PREVENTABLE DISABILITY adds additional stress and loss of trust and anger, >>> knowing there was no justifiable reason that the patient was subjected to >>> it without warning and permitted to become disabled by a drug that is >>> precautionary, not curative.
>> Within the context of this study, what actions should have been taken that >> were not taken to prevent the temporary disability in your view?
> Your answer is within the context of the study: In the conclusion.
There is no area in the study that you posted that is labeled conclusion or that appears to recommend actions. By within the context of the study did you mean in your post? What should be done, in your view, to prevent these kinds of temporary disabilities?
Did you mean that "serial manual muscle testing after initating a statin" should be done? (I'm not sure what that is.)
>>>>> University of California Los Angeles, Reed Neurologic Research Center. >>>>> bdob...@mednet.ucla.edu.
>>>>> INTRODUCTION: Myopathic syndromes induced by >>>>> 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors >>>>> (statins) include muscle complaints, myalgia, myositis, and >>>>> rhabdomyolysis. No prospective study of statins, however, included >>>>> tests of strength, so the incidence of weakness, with or without >>>>> muscle symptoms and elevated enzymes, is unknown, and perhaps >>>>> overlooked. METHODS: From a convenience sample of patients referred >>>>> to an outpatient neurorehabilitation clinic over the course of 1 year, >>>>> 8 patients with hemiparetic stroke and 10 patients with other presumed >>>>> neurologic diseases presented with new difficulty walking by 3 to 12 >>>>> months after starting one of 3 statins. They reported no myalgias, >>>>> exercise-induced aches, or weakness. Examination revealed proximal >>>>> paresis graded 4/5 on the unaffected side in the hemiparetic patients >>>>> and symmetrical bilateral proximal limb and neck flexor weakness >>>>> graded 4/5 in the others. They stood up with difficulty and walked >>>>> with bilateral hip drop and imbalance on turns. RESULTS: Laboratory >>>>> tests did not reveal myositis or other causes for paresis. No >>>>> improvement in strength or mobility was found 6 weeks after initiating >>>>> resistance exercises. The statin agent was stopped. By 3 months off >>>>> statin, all recovered 5/5 proximal strength. Walking improved, and >>>>> they arose from a chair without pushing off with their arms. >>>>> DISCUSSION: Serial manual muscle testing after initiating a statin may >>>>> detect a reversible cause of disability. A genetic predisposition to >>>>> statin-induced myopathic proximal weakness with normal creatine kinase >>>>> is consistent with a continuum of previously reported symptoms and >>>>> signs but may be underappreciated.
>>>>> PMID: 16093417 [PubMed - in process]
>>>> Inotherwords, for the small subset with a genetic predisposition to >>>> statin-induced myopathy and other pre-exisiting neurologic diseases >>>> improvement was achieved shortly after cessation of the statin.
> "listener" <liste...@nospam.net> wrote in message > news:Xns96B2D5C12DBF0some1outthere@38.144.126.102... >> Your ability to be selective is astonishing. Cognitive dissonance at >> work. I said nothing about the experience of statin-induced myopathy >> being "positive". What's wrong with you? Where did I even remotely >> say that?
>> Also, it's safe to say that the patients in the study were already >> disabled to some degree before taking a statin, which then caused a >> *new* disability:
>> "8 patients with hemiparetic stroke and 10 patients with other >> presumed neurologic diseases presented with new difficulty..."
>> I still say that the fact they recovered within a relatively short >> time period from the *new* (statin-induced) disability is hopeful, >> wonderful and positive. I know it contradicts your stated views
> Experience
>>that this sort of >> statin AE recovery is a long, horrible proccess where there's little >> hope, if any, for full recovery. Perhaps that's why you respond in >> such an angry, negative fashion.
>>> As long as you think experiencing PREVENTABLE DISABILITY is a good >>> thing.
>>> DISABILITY is a major change in lifestyle, and can induce loss of >>> job, loss of home, and harm to the family unit, in addition to pain >>> and suffering.
>>> PREVENTABLE DISABILITY adds additional stress and loss of trust and >>> anger, knowing there was no justifiable reason that the patient was >>> subjected to it without warning and permitted to become disabled by >>> a drug that is precautionary, not curative.
>>> Somehow, most who have been through it as either family or patient, >>> would strongly disagee with you that it has been a positive >>> experience.
>>>>> University of California Los Angeles, Reed Neurologic Research >>>>> Center. bdob...@mednet.ucla.edu.
>>>>> INTRODUCTION: Myopathic syndromes induced by >>>>> 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase >>>>> inhibitors (statins) include muscle complaints, myalgia, myositis, >>>>> and rhabdomyolysis. No prospective study of statins, however, >>>>> included tests of strength, so the incidence of weakness, with or >>>>> without muscle symptoms and elevated enzymes, is unknown, and >>>>> perhaps overlooked. METHODS: From a convenience sample of patients >>>>> referred to an outpatient neurorehabilitation clinic over the >>>>> course of 1 year, 8 patients with hemiparetic stroke and 10 >>>>> patients with other presumed neurologic diseases presented with >>>>> new difficulty walking by 3 to 12 months after starting one of 3 >>>>> statins. They reported no myalgias, exercise-induced aches, or >>>>> weakness. Examination revealed proximal paresis graded 4/5 on the >>>>> unaffected side in the hemiparetic patients and symmetrical >>>>> bilateral proximal limb and neck flexor weakness graded 4/5 in the >>>>> others. They stood up with difficulty and walked with bilateral >>>>> hip drop and imbalance on turns. RESULTS: Laboratory tests did not >>>>> reveal myositis or other causes for paresis. No improvement in >>>>> strength or mobility was found 6 weeks after initiating resistance >>>>> exercises. The statin agent was stopped. By 3 months off statin, >>>>> all recovered 5/5 proximal strength. Walking improved, and they >>>>> arose from a chair without pushing off with their arms. >>>>> DISCUSSION: Serial manual muscle testing after initiating a statin >>>>> may detect a reversible cause of disability. A genetic >>>>> predisposition to statin-induced myopathic proximal weakness with >>>>> normal creatine kinase is consistent with a continuum of >>>>> previously reported symptoms and signs but may be >>>>> underappreciated.
>>>>> PMID: 16093417 [PubMed - in process]
>>>> Inotherwords, for the small subset with a genetic predisposition to >>>> statin-induced myopathy and other pre-exisiting neurologic diseases >>>> improvement was achieved shortly after cessation of the statin.
> Either show me where I stated or implied that having a statin-induced > myopathy is a "positive experience" as you claimed or apologize.
> Replying with one word "Experience" is such bullshit, Sharon. You should > be ashamed of yourself.
> L.
If she can continue to post as she does regarding statins, every bit as fervernt in her beliefs as those who opposed fluoridation of the water in the 1950's, how can you possibly think that she would be ashamed of any single post she writes, even one as illogical and insulting as her one word reply?
Steve -- The above posting is neither a legal opinion nor legal advice, because we do not have an attorney-client relationship, and should not be construed as either. This posting does not represent the opinion of my employer, but is merely my personal view. To reply, delete _spamout_ and replace with the numeral 3
>> "listener" <liste...@nospam.net> wrote in message >> news:Xns96B2D5C12DBF0some1outthere@38.144.126.102... >>> Your ability to be selective is astonishing. Cognitive dissonance at >>> work. I said nothing about the experience of statin-induced myopathy >>> being "positive". What's wrong with you? Where did I even remotely >>> say that?
>>> Also, it's safe to say that the patients in the study were already >>> disabled to some degree before taking a statin, which then caused a >>> *new* disability:
>>> "8 patients with hemiparetic stroke and 10 patients with other >>> presumed neurologic diseases presented with new difficulty..."
>>> I still say that the fact they recovered within a relatively short >>> time period from the *new* (statin-induced) disability is hopeful, >>> wonderful and positive. I know it contradicts your stated views
>> Experience
>>>that this sort of >>> statin AE recovery is a long, horrible proccess where there's little >>> hope, if any, for full recovery. Perhaps that's why you respond in >>> such an angry, negative fashion.
>>>> As long as you think experiencing PREVENTABLE DISABILITY is a good >>>> thing.
>>>> DISABILITY is a major change in lifestyle, and can induce loss of >>>> job, loss of home, and harm to the family unit, in addition to pain >>>> and suffering.
>>>> PREVENTABLE DISABILITY adds additional stress and loss of trust and >>>> anger, knowing there was no justifiable reason that the patient was >>>> subjected to it without warning and permitted to become disabled by >>>> a drug that is precautionary, not curative.
>>>> Somehow, most who have been through it as either family or patient, >>>> would strongly disagee with you that it has been a positive >>>> experience.
>>>>>> University of California Los Angeles, Reed Neurologic Research >>>>>> Center. bdob...@mednet.ucla.edu.
>>>>>> INTRODUCTION: Myopathic syndromes induced by >>>>>> 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase >>>>>> inhibitors (statins) include muscle complaints, myalgia, myositis, >>>>>> and rhabdomyolysis. No prospective study of statins, however, >>>>>> included tests of strength, so the incidence of weakness, with or >>>>>> without muscle symptoms and elevated enzymes, is unknown, and >>>>>> perhaps overlooked. METHODS: From a convenience sample of patients >>>>>> referred to an outpatient neurorehabilitation clinic over the >>>>>> course of 1 year, 8 patients with hemiparetic stroke and 10 >>>>>> patients with other presumed neurologic diseases presented with >>>>>> new difficulty walking by 3 to 12 months after starting one of 3 >>>>>> statins. They reported no myalgias, exercise-induced aches, or >>>>>> weakness. Examination revealed proximal paresis graded 4/5 on the >>>>>> unaffected side in the hemiparetic patients and symmetrical >>>>>> bilateral proximal limb and neck flexor weakness graded 4/5 in the >>>>>> others. They stood up with difficulty and walked with bilateral >>>>>> hip drop and imbalance on turns. RESULTS: Laboratory tests did not >>>>>> reveal myositis or other causes for paresis. No improvement in >>>>>> strength or mobility was found 6 weeks after initiating resistance >>>>>> exercises. The statin agent was stopped. By 3 months off statin, >>>>>> all recovered 5/5 proximal strength. Walking improved, and they >>>>>> arose from a chair without pushing off with their arms. >>>>>> DISCUSSION: Serial manual muscle testing after initiating a statin >>>>>> may detect a reversible cause of disability. A genetic >>>>>> predisposition to statin-induced myopathic proximal weakness with >>>>>> normal creatine kinase is consistent with a continuum of >>>>>> previously reported symptoms and signs but may be >>>>>> underappreciated.
>>>>>> PMID: 16093417 [PubMed - in process]
>>>>> Inotherwords, for the small subset with a genetic predisposition to >>>>> statin-induced myopathy and other pre-exisiting neurologic diseases >>>>> improvement was achieved shortly after cessation of the statin.
In article <b59Me.11425$Co1.10536@lakeread01>, "Steve Marcus" <smarcus_spamo...@cox.net> wrote:
> If she can continue to post as she does regarding statins, every bit as > fervernt in her beliefs as those who opposed fluoridation of the water in > the 1950's, how can you possibly think that she would be ashamed of any > single post she writes, even one as illogical and insulting as her one word > reply?
> Steve
Thank you Steve for a wonderful example of a run on sentence.
Here is a rehash of your words . Slanted by me.
She can continue to post as she does regarding statins. Her belief is similar to those who opposed fluoridation of water in
> the 1950's. How can you possibly think that she would be ashamed of any > single post she writes. Her one word repley is illogical and insulting.
Take a few deep breathes .
It is all in the context Steve. If she can continue...Get real!
Bill
-- Garden Shade Zone 5 S Jersey USA in a Japanese Jungle Manner.39.6376 -75.0208 This article is posted under fair use rules in accordance with Title 17 U.S.C. Section 107, and is strictly for the educational and informative purposes. This material is distributed without profit.
> In article <b59Me.11425$Co1.10536@lakeread01>, > "Steve Marcus" <smarcus_spamo...@cox.net> wrote:
>> If she can continue to post as she does regarding statins, every bit >> as fervernt in her beliefs as those who opposed fluoridation of the >> water in the 1950's, how can you possibly think that she would be >> ashamed of any single post she writes, even one as illogical and >> insulting as her one word reply?
>> Steve
> Thank you Steve for a wonderful example of a run on sentence.
> Here is a rehash of your words . Slanted by me.
> She can continue to post as she does regarding statins. Her belief > is > similar to those who opposed fluoridation of water in >> the 1950's. How can you possibly think that she would be ashamed of >> any single post she writes. Her one word repley is illogical and >> insulting.
> Take a few deep breathes .
> It is all in the context Steve. If she can continue...Get real!
> Bill
Hmmmm. I understood what he meant. No grammer lesson was needed.
>>> "Sharon Hope" <sh...@anet.net> wrote in message >>> news:q-qdnZW8o5sjLGLfRVn-1g@comcast.com... >>>> As long as you think experiencing PREVENTABLE DISABILITY is a good >>>> thing.
>>>> DISABILITY is a major change in lifestyle, and can induce loss of job, >>>> loss of home, and harm to the family unit, in addition to pain and >>>> suffering.
>>>> PREVENTABLE DISABILITY adds additional stress and loss of trust and >>>> anger, knowing there was no justifiable reason that the patient was >>>> subjected to it without warning and permitted to become disabled by a >>>> drug that is precautionary, not curative.
>>> Within the context of this study, what actions should have been taken >>> that were not taken to prevent the temporary disability in your view?
>> Your answer is within the context of the study: In the conclusion.
> There is no area in the study that you posted that is labeled conclusion > or that appears to recommend actions. By within the context of the study > did you mean in your post? What should be done, in your view, to prevent > these kinds of temporary disabilities?
> Did you mean that "serial manual muscle testing after initating a statin" > should be done? (I'm not sure what that is.)
> Bill
>>> Bill
>>>> Somehow, most who have been through it as either family or patient, >>>> would strongly disagee with you that it has been a positive experience.
>>>>>> University of California Los Angeles, Reed Neurologic Research >>>>>> Center. >>>>>> bdob...@mednet.ucla.edu.
>>>>>> INTRODUCTION: Myopathic syndromes induced by >>>>>> 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors >>>>>> (statins) include muscle complaints, myalgia, myositis, and >>>>>> rhabdomyolysis. No prospective study of statins, however, included >>>>>> tests of strength, so the incidence of weakness, with or without >>>>>> muscle symptoms and elevated enzymes, is unknown, and perhaps >>>>>> overlooked. METHODS: From a convenience sample of patients referred >>>>>> to an outpatient neurorehabilitation clinic over the course of 1 >>>>>> year, >>>>>> 8 patients with hemiparetic stroke and 10 patients with other >>>>>> presumed >>>>>> neurologic diseases presented with new difficulty walking by 3 to 12 >>>>>> months after starting one of 3 statins. They reported no myalgias, >>>>>> exercise-induced aches, or weakness. Examination revealed proximal >>>>>> paresis graded 4/5 on the unaffected side in the hemiparetic patients >>>>>> and symmetrical bilateral proximal limb and neck flexor weakness >>>>>> graded 4/5 in the others. They stood up with difficulty and walked >>>>>> with bilateral hip drop and imbalance on turns. RESULTS: Laboratory >>>>>> tests did not reveal myositis or other causes for paresis. No >>>>>> improvement in strength or mobility was found 6 weeks after >>>>>> initiating >>>>>> resistance exercises. The statin agent was stopped. By 3 months off >>>>>> statin, all recovered 5/5 proximal strength. Walking improved, and >>>>>> they arose from a chair without pushing off with their arms. >>>>>> DISCUSSION: Serial manual muscle testing after initiating a statin >>>>>> may >>>>>> detect a reversible cause of disability. A genetic predisposition to >>>>>> statin-induced myopathic proximal weakness with normal creatine >>>>>> kinase >>>>>> is consistent with a continuum of previously reported symptoms and >>>>>> signs but may be underappreciated.
>>>>>> PMID: 16093417 [PubMed - in process]
>>>>> Inotherwords, for the small subset with a genetic predisposition to >>>>> statin-induced myopathy and other pre-exisiting neurologic diseases >>>>> improvement was achieved shortly after cessation of the statin.
>> "listener" <liste...@nospam.net> wrote in message >> news:Xns96B2D5C12DBF0some1outthere@38.144.126.102... >>> Your ability to be selective is astonishing. Cognitive dissonance at >>> work. I said nothing about the experience of statin-induced myopathy >>> being "positive". What's wrong with you? Where did I even remotely >>> say that?
>>> Also, it's safe to say that the patients in the study were already >>> disabled to some degree before taking a statin, which then caused a >>> *new* disability:
>>> "8 patients with hemiparetic stroke and 10 patients with other >>> presumed neurologic diseases presented with new difficulty..."
>>> I still say that the fact they recovered within a relatively short >>> time period from the *new* (statin-induced) disability is hopeful, >>> wonderful and positive. I know it contradicts your stated views
>> Experience
>>>that this sort of >>> statin AE recovery is a long, horrible proccess where there's little >>> hope, if any, for full recovery. Perhaps that's why you respond in >>> such an angry, negative fashion.
>>>> As long as you think experiencing PREVENTABLE DISABILITY is a good >>>> thing.
>>>> DISABILITY is a major change in lifestyle, and can induce loss of >>>> job, loss of home, and harm to the family unit, in addition to pain >>>> and suffering.
>>>> PREVENTABLE DISABILITY adds additional stress and loss of trust and >>>> anger, knowing there was no justifiable reason that the patient was >>>> subjected to it without warning and permitted to become disabled by >>>> a drug that is precautionary, not curative.
>>>> Somehow, most who have been through it as either family or patient, >>>> would strongly disagee with you that it has been a positive >>>> experience.
>>>>>> University of California Los Angeles, Reed Neurologic Research >>>>>> Center. bdob...@mednet.ucla.edu.
>>>>>> INTRODUCTION: Myopathic syndromes induced by >>>>>> 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase >>>>>> inhibitors (statins) include muscle complaints, myalgia, myositis, >>>>>> and rhabdomyolysis. No prospective study of statins, however, >>>>>> included tests of strength, so the incidence of weakness, with or >>>>>> without muscle symptoms and elevated enzymes, is unknown, and >>>>>> perhaps overlooked. METHODS: From a convenience sample of patients >>>>>> referred to an outpatient neurorehabilitation clinic over the >>>>>> course of 1 year, 8 patients with hemiparetic stroke and 10 >>>>>> patients with other presumed neurologic diseases presented with >>>>>> new difficulty walking by 3 to 12 months after starting one of 3 >>>>>> statins. They reported no myalgias, exercise-induced aches, or >>>>>> weakness. Examination revealed proximal paresis graded 4/5 on the >>>>>> unaffected side in the hemiparetic patients and symmetrical >>>>>> bilateral proximal limb and neck flexor weakness graded 4/5 in the >>>>>> others. They stood up with difficulty and walked with bilateral >>>>>> hip drop and imbalance on turns. RESULTS: Laboratory tests did not >>>>>> reveal myositis or other causes for paresis. No improvement in >>>>>> strength or mobility was found 6 weeks after initiating resistance >>>>>> exercises. The statin agent was stopped. By 3 months off statin, >>>>>> all recovered 5/5 proximal strength. Walking improved, and they >>>>>> arose from a chair without pushing off with their arms. >>>>>> DISCUSSION: Serial manual muscle testing after initiating a statin >>>>>> may detect a reversible cause of disability. A genetic >>>>>> predisposition to statin-induced myopathic proximal weakness with >>>>>> normal creatine kinase is consistent with a continuum of >>>>>> previously reported symptoms and signs but may be >>>>>> underappreciated.
>>>>>> PMID: 16093417 [PubMed - in process]
>>>>> Inotherwords, for the small subset with a genetic predisposition to >>>>> statin-induced myopathy and other pre-exisiting neurologic diseases >>>>> improvement was achieved shortly after cessation of the statin.
So you're saying that improvement from myopathy after stopping statins is a bad thing? I think you are really an incredibly disillusioned, angry person. Seek professional help.
> Apologies should be directed to the statin disabled.
> Your second sentence in your initial conclusion was offensive to > anyone who has had their loved one disabled needlessly.
> "listener" <liste...@nospam.net> wrote in message > news:Xns96B375FB3C319some1outthere@38.144.126.103... >> Either show me where I stated or implied that having a statin-induced >> myopathy is a "positive experience" as you claimed or apologize.
>> Replying with one word "Experience" is such bullshit, Sharon. You >> should be ashamed of yourself.
>>> "listener" <liste...@nospam.net> wrote in message >>> news:Xns96B2D5C12DBF0some1outthere@38.144.126.102... >>>> Your ability to be selective is astonishing. Cognitive dissonance >>>> at work. I said nothing about the experience of statin-induced >>>> myopathy being "positive". What's wrong with you? Where did I even >>>> remotely say that?
>>>> Also, it's safe to say that the patients in the study were already >>>> disabled to some degree before taking a statin, which then caused a >>>> *new* disability:
>>>> "8 patients with hemiparetic stroke and 10 patients with other >>>> presumed neurologic diseases presented with new difficulty..."
>>>> I still say that the fact they recovered within a relatively short >>>> time period from the *new* (statin-induced) disability is hopeful, >>>> wonderful and positive. I know it contradicts your stated views
>>> Experience
>>>>that this sort of >>>> statin AE recovery is a long, horrible proccess where there's >>>> little hope, if any, for full recovery. Perhaps that's why you >>>> respond in such an angry, negative fashion.
>>>>> As long as you think experiencing PREVENTABLE DISABILITY is a good >>>>> thing.
>>>>> DISABILITY is a major change in lifestyle, and can induce loss of >>>>> job, loss of home, and harm to the family unit, in addition to >>>>> pain and suffering.
>>>>> PREVENTABLE DISABILITY adds additional stress and loss of trust >>>>> and anger, knowing there was no justifiable reason that the >>>>> patient was subjected to it without warning and permitted to >>>>> become disabled by a drug that is precautionary, not curative.
>>>>> Somehow, most who have been through it as either family or >>>>> patient, would strongly disagee with you that it has been a >>>>> positive experience.
>>>>>>> University of California Los Angeles, Reed Neurologic Research >>>>>>> Center. bdob...@mednet.ucla.edu.
>>>>>>> INTRODUCTION: Myopathic syndromes induced by >>>>>>> 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase >>>>>>> inhibitors (statins) include muscle complaints, myalgia, >>>>>>> myositis, and rhabdomyolysis. No prospective study of statins, >>>>>>> however, included tests of strength, so the incidence of >>>>>>> weakness, with or without muscle symptoms and elevated enzymes, >>>>>>> is unknown, and perhaps overlooked. METHODS: From a convenience >>>>>>> sample of patients referred to an outpatient neurorehabilitation >>>>>>> clinic over the course of 1 year, 8 patients with hemiparetic >>>>>>> stroke and 10 patients with other presumed neurologic diseases >>>>>>> presented with new difficulty walking by 3 to 12 months after >>>>>>> starting one of 3 statins. They reported no myalgias, >>>>>>> exercise-induced aches, or weakness. Examination revealed >>>>>>> proximal paresis graded 4/5 on the unaffected side in the >>>>>>> hemiparetic patients and symmetrical bilateral proximal limb and >>>>>>> neck flexor weakness graded 4/5 in the others. They stood up >>>>>>> with difficulty and walked with bilateral hip drop and imbalance >>>>>>> on turns. RESULTS: Laboratory tests did not reveal myositis or >>>>>>> other causes for paresis. No improvement in strength or mobility >>>>>>> was found 6 weeks after initiating resistance exercises. The >>>>>>> statin agent was stopped. By 3 months off statin, all recovered >>>>>>> 5/5 proximal strength. Walking improved, and they arose from a >>>>>>> chair without pushing off with their arms. DISCUSSION: Serial >>>>>>> manual muscle testing after initiating a statin may detect a >>>>>>> reversible cause of disability. A genetic predisposition to >>>>>>> statin-induced myopathic proximal weakness with normal creatine >>>>>>> kinase is consistent with a continuum of previously reported >>>>>>> symptoms and signs but may be underappreciated.
>>>>>>> PMID: 16093417 [PubMed - in process]
>>>>>> Inotherwords, for the small subset with a genetic predisposition >>>>>> to statin-induced myopathy and other pre-exisiting neurologic >>>>>> diseases improvement was achieved shortly after cessation of the >>>>>> statin.
> You should contact the POC for the study with that question.
What does POC mean? (Google lists Prosche Owners Club, Ports of Call, etc.) And I am asking you what you meant by Preventable Disability when you referred to this study.
It is a serious question worthy of discussion. What should be done to help prevent serious reactions from statins.
I'll give you my thoughts. I think part of it is an education issue both to the provider and the patient. For the patient, perhaps a better, standard information brochure should be given out telling him what symptoms to watch out for, what to do when they occur, and what tests should be done - to double check the Dr. For the Dr. better guidelines on instructing the patient and on when to despense the statin - assuming there is enough out there to take a better stab at it than they have done.
>>>> "Sharon Hope" <sh...@anet.net> wrote in message >>>> news:q-qdnZW8o5sjLGLfRVn-1g@comcast.com... >>>>> As long as you think experiencing PREVENTABLE DISABILITY is a good >>>>> thing.
>>>>> DISABILITY is a major change in lifestyle, and can induce loss of job, >>>>> loss of home, and harm to the family unit, in addition to pain and >>>>> suffering.
>>>>> PREVENTABLE DISABILITY adds additional stress and loss of trust and >>>>> anger, knowing there was no justifiable reason that the patient was >>>>> subjected to it without warning and permitted to become disabled by a >>>>> drug that is precautionary, not curative.
>>>> Within the context of this study, what actions should have been taken >>>> that were not taken to prevent the temporary disability in your view?
>>> Your answer is within the context of the study: In the conclusion.
>> There is no area in the study that you posted that is labeled conclusion or >> that appears to recommend actions. By within the context of the study did >> you mean in your post? What should be done, in your view, to prevent these >> kinds of temporary disabilities?
>> Did you mean that "serial manual muscle testing after initating a statin" >> should be done? (I'm not sure what that is.)
>> Bill
>>>> Bill
>>>>> Somehow, most who have been through it as either family or patient, >>>>> would strongly disagee with you that it has been a positive experience.
>>>>>>> University of California Los Angeles, Reed Neurologic Research Center. >>>>>>> bdob...@mednet.ucla.edu.
>>>>>>> INTRODUCTION: Myopathic syndromes induced by >>>>>>> 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors >>>>>>> (statins) include muscle complaints, myalgia, myositis, and >>>>>>> rhabdomyolysis. No prospective study of statins, however, included >>>>>>> tests of strength, so the incidence of weakness, with or without >>>>>>> muscle symptoms and elevated enzymes, is unknown, and perhaps >>>>>>> overlooked. METHODS: From a convenience sample of patients referred >>>>>>> to an outpatient neurorehabilitation clinic over the course of 1 year, >>>>>>> 8 patients with hemiparetic stroke and 10 patients with other presumed >>>>>>> neurologic diseases presented with new difficulty walking by 3 to 12 >>>>>>> months after starting one of 3 statins. They reported no myalgias, >>>>>>> exercise-induced aches, or weakness. Examination revealed proximal >>>>>>> paresis graded 4/5 on the unaffected side in the hemiparetic patients >>>>>>> and symmetrical bilateral proximal limb and neck flexor weakness >>>>>>> graded 4/5 in the others. They stood up with difficulty and walked >>>>>>> with bilateral hip drop and imbalance on turns. RESULTS: Laboratory >>>>>>> tests did not reveal myositis or other causes for paresis. No >>>>>>> improvement in strength or mobility was found 6 weeks after initiating >>>>>>> resistance exercises. The statin agent was stopped. By 3 months off >>>>>>> statin, all recovered 5/5 proximal strength. Walking improved, and >>>>>>> they arose from a chair without pushing off with their arms. >>>>>>> DISCUSSION: Serial manual muscle testing after initiating a statin may >>>>>>> detect a reversible cause of disability. A genetic predisposition to >>>>>>> statin-induced myopathic proximal weakness with normal creatine kinase >>>>>>> is consistent with a continuum of previously reported symptoms and >>>>>>> signs but may be underappreciated.
>>>>>>> PMID: 16093417 [PubMed - in process]
>>>>>> Inotherwords, for the small subset with a genetic predisposition to >>>>>> statin-induced myopathy and other pre-exisiting neurologic diseases >>>>>> improvement was achieved shortly after cessation of the statin.
As long as you think experiencing PREVENTABLE DISABILITY is a good thing.
DISABILITY is a major change in lifestyle, and can induce loss of job, loss of home, and harm to the family unit, in addition to pain and suffering.
PREVENTABLE DISABILITY adds additional stress and loss of trust and anger, knowing there was no justifiable reason that the patient was subjected to it without warning and permitted to become disabled by a drug that is precautionary, not curative.
Somehow, most who have been through it as either family or patient, would strongly disagee with you that it has been a positive experience.
We disagree, and will continue to disagree, that it is a GOOD THING to disable patients so that, when they recover, they can consider the recovery a GOOD THING.
To me, NOT CAUSING THE DISABILITY IS A GOOD THING.
> So you're saying that improvement from myopathy after stopping statins is > a bad thing? I think you are really an incredibly disillusioned, angry > person. Seek professional help.
>> Apologies should be directed to the statin disabled.
>> Your second sentence in your initial conclusion was offensive to >> anyone who has had their loved one disabled needlessly.
>> "listener" <liste...@nospam.net> wrote in message >> news:Xns96B375FB3C319some1outthere@38.144.126.103... >>> Either show me where I stated or implied that having a statin-induced >>> myopathy is a "positive experience" as you claimed or apologize.
>>> Replying with one word "Experience" is such bullshit, Sharon. You >>> should be ashamed of yourself.
>>>> "listener" <liste...@nospam.net> wrote in message >>>> news:Xns96B2D5C12DBF0some1outthere@38.144.126.102... >>>>> Your ability to be selective is astonishing. Cognitive dissonance >>>>> at work. I said nothing about the experience of statin-induced >>>>> myopathy being "positive". What's wrong with you? Where did I even >>>>> remotely say that?
>>>>> Also, it's safe to say that the patients in the study were already >>>>> disabled to some degree before taking a statin, which then caused a >>>>> *new* disability:
>>>>> "8 patients with hemiparetic stroke and 10 patients with other >>>>> presumed neurologic diseases presented with new difficulty..."
>>>>> I still say that the fact they recovered within a relatively short >>>>> time period from the *new* (statin-induced) disability is hopeful, >>>>> wonderful and positive. I know it contradicts your stated views
>>>> Experience
>>>>>that this sort of >>>>> statin AE recovery is a long, horrible proccess where there's >>>>> little hope, if any, for full recovery. Perhaps that's why you >>>>> respond in such an angry, negative fashion.
>>>>>> As long as you think experiencing PREVENTABLE DISABILITY is a good >>>>>> thing.
>>>>>> DISABILITY is a major change in lifestyle, and can induce loss of >>>>>> job, loss of home, and harm to the family unit, in addition to >>>>>> pain and suffering.
>>>>>> PREVENTABLE DISABILITY adds additional stress and loss of trust >>>>>> and anger, knowing there was no justifiable reason that the >>>>>> patient was subjected to it without warning and permitted to >>>>>> become disabled by a drug that is precautionary, not curative.
>>>>>> Somehow, most who have been through it as either family or >>>>>> patient, would strongly disagee with you that it has been a >>>>>> positive experience.
>>>>>>>> University of California Los Angeles, Reed Neurologic Research >>>>>>>> Center. bdob...@mednet.ucla.edu.
>>>>>>>> INTRODUCTION: Myopathic syndromes induced by >>>>>>>> 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase >>>>>>>> inhibitors (statins) include muscle complaints, myalgia, >>>>>>>> myositis, and rhabdomyolysis. No prospective study of statins, >>>>>>>> however, included tests of strength, so the incidence of >>>>>>>> weakness, with or without muscle symptoms and elevated enzymes, >>>>>>>> is unknown, and perhaps overlooked. METHODS: From a convenience >>>>>>>> sample of patients referred to an outpatient neurorehabilitation >>>>>>>> clinic over the course of 1 year, 8 patients with hemiparetic >>>>>>>> stroke and 10 patients with other presumed neurologic diseases >>>>>>>> presented with new difficulty walking by 3 to 12 months after >>>>>>>> starting one of 3 statins. They reported no myalgias, >>>>>>>> exercise-induced aches, or weakness. Examination revealed >>>>>>>> proximal paresis graded 4/5 on the unaffected side in the >>>>>>>> hemiparetic patients and symmetrical bilateral proximal limb and >>>>>>>> neck flexor weakness graded 4/5 in the others. They stood up >>>>>>>> with difficulty and walked with bilateral hip drop and imbalance >>>>>>>> on turns. RESULTS: Laboratory tests did not reveal myositis or >>>>>>>> other causes for paresis. No improvement in strength or mobility >>>>>>>> was found 6 weeks after initiating resistance exercises. The >>>>>>>> statin agent was stopped. By 3 months off statin, all recovered >>>>>>>> 5/5 proximal strength. Walking improved, and they arose from a >>>>>>>> chair without pushing off with their arms. DISCUSSION: Serial >>>>>>>> manual muscle testing after initiating a statin may detect a >>>>>>>> reversible cause of disability. A genetic predisposition to >>>>>>>> statin-induced myopathic proximal weakness with normal creatine >>>>>>>> kinase is consistent with a continuum of previously reported >>>>>>>> symptoms and signs but may be underappreciated.
>>>>>>>> PMID: 16093417 [PubMed - in process]
>>>>>>> Inotherwords, for the small subset with a genetic predisposition >>>>>>> to statin-induced myopathy and other pre-exisiting neurologic >>>>>>> diseases improvement was achieved shortly after cessation of the >>>>>>> statin.
> Apologies should be directed to the statin disabled.
> Your second sentence in your initial conclusion was offensive to anyone > who has had their loved one disabled needlessly.
Virtually everything that *you* write on the topic of statins is offensive to people who understand anything about drug research and peer reviewed studies. More importantly, virtually everything that *you* write is both offensive and dangerous to people who are being aided, or could potentially be aided, by statin therapy.
Your loved one was disabled needlessly due to an unusual adverse reaction to a prescription drug combined with what may well have been an insensitivity to that reaction on the part of his physician(s). Adverse reactions to common beneficial drugs such as aspirin and penicillin have killed people before, and will continue to do so. It's called "bad luck." Your reaction to your loved one's bad luck is to mount a campaign of propaganda and disinformation against statin drugs akin to the opposition to fluoridation of water; the chief difference being that bad teeth have the potential for killing far fewer people than coronary artery disease.
You truly need to engage in some serious self-examination.
Steve -- The above posting is neither a legal opinion nor legal advice, because we do not have an attorney-client relationship, and should not be construed as either. This posting does not represent the opinion of my employer, but is merely my personal view. To reply, delete _spamout_ and replace with the numeral 3
> "listener" <liste...@nospam.net> wrote in message > news:Xns96B375FB3C319some1outthere@38.144.126.103... >> Either show me where I stated or implied that having a statin-induced >> myopathy is a "positive experience" as you claimed or apologize.
>> Replying with one word "Experience" is such bullshit, Sharon. You should >> be ashamed of yourself.
>>> "listener" <liste...@nospam.net> wrote in message >>> news:Xns96B2D5C12DBF0some1outthere@38.144.126.102... >>>> Your ability to be selective is astonishing. Cognitive dissonance at >>>> work. I said nothing about the experience of statin-induced myopathy >>>> being "positive". What's wrong with you? Where did I even remotely >>>> say that?
>>>> Also, it's safe to say that the patients in the study were already >>>> disabled to some degree before taking a statin, which then caused a >>>> *new* disability:
>>>> "8 patients with hemiparetic stroke and 10 patients with other >>>> presumed neurologic diseases presented with new difficulty..."
>>>> I still say that the fact they recovered within a relatively short >>>> time period from the *new* (statin-induced) disability is hopeful, >>>> wonderful and positive. I know it contradicts your stated views
>>> Experience
>>>>that this sort of >>>> statin AE recovery is a long, horrible proccess where there's little >>>> hope, if any, for full recovery. Perhaps that's why you respond in >>>> such an angry, negative fashion.
>>>>> As long as you think experiencing PREVENTABLE DISABILITY is a good >>>>> thing.
>>>>> DISABILITY is a major change in lifestyle, and can induce loss of >>>>> job, loss of home, and harm to the family unit, in addition to pain >>>>> and suffering.
>>>>> PREVENTABLE DISABILITY adds additional stress and loss of trust and >>>>> anger, knowing there was no justifiable reason that the patient was >>>>> subjected to it without warning and permitted to become disabled by >>>>> a drug that is precautionary, not curative.
>>>>> Somehow, most who have been through it as either family or patient, >>>>> would strongly disagee with you that it has been a positive >>>>> experience.
>>>>>>> University of California Los Angeles, Reed Neurologic Research >>>>>>> Center. bdob...@mednet.ucla.edu.
>>>>>>> INTRODUCTION: Myopathic syndromes induced by >>>>>>> 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase >>>>>>> inhibitors (statins) include muscle complaints, myalgia, myositis, >>>>>>> and rhabdomyolysis. No prospective study of statins, however, >>>>>>> included tests of strength, so the incidence of weakness, with or >>>>>>> without muscle symptoms and elevated enzymes, is unknown, and >>>>>>> perhaps overlooked. METHODS: From a convenience sample of patients >>>>>>> referred to an outpatient neurorehabilitation clinic over the >>>>>>> course of 1 year, 8 patients with hemiparetic stroke and 10 >>>>>>> patients with other presumed neurologic diseases presented with >>>>>>> new difficulty walking by 3 to 12 months after starting one of 3 >>>>>>> statins. They reported no myalgias, exercise-induced aches, or >>>>>>> weakness. Examination revealed proximal paresis graded 4/5 on the >>>>>>> unaffected side in the hemiparetic patients and symmetrical >>>>>>> bilateral proximal limb and neck flexor weakness graded 4/5 in the >>>>>>> others. They stood up with difficulty and walked with bilateral >>>>>>> hip drop and imbalance on turns. RESULTS: Laboratory tests did not >>>>>>> reveal myositis or other causes for paresis. No improvement in >>>>>>> strength or mobility was found 6 weeks after initiating resistance >>>>>>> exercises. The statin agent was stopped. By 3 months off statin, >>>>>>> all recovered 5/5 proximal strength. Walking improved, and they >>>>>>> arose from a chair without pushing off with their arms. >>>>>>> DISCUSSION: Serial manual muscle testing after initiating a statin >>>>>>> may detect a reversible cause of disability. A genetic >>>>>>> predisposition to statin-induced myopathic proximal weakness with >>>>>>> normal creatine kinase is consistent with a continuum of >>>>>>> previously reported symptoms and signs but may be >>>>>>> underappreciated.
>>>>>>> PMID: 16093417 [PubMed - in process]
>>>>>> Inotherwords, for the small subset with a genetic predisposition to >>>>>> statin-induced myopathy and other pre-exisiting neurologic diseases >>>>>> improvement was achieved shortly after cessation of the statin.
I don't think it could be any clearer how, in just our short exchange, you take something and twist it around and then continue to insist that your distortion is the truth. You really are out of touch with reality. Nothing you say or post is to be trusted. I sincerely hope that some day you find relief from your stress, loss of trust and anger and can move on from this offensive, misguided crusade.
> As long as you think experiencing PREVENTABLE DISABILITY is a good > thing.
> DISABILITY is a major change in lifestyle, and can induce loss of > job, loss of home, and harm to the family unit, in addition to > pain and suffering.
> PREVENTABLE DISABILITY adds additional stress and loss of trust > and anger, knowing there was no justifiable reason that the > patient was subjected to it without warning and permitted to > become disabled by a drug that is precautionary, not curative.
> Somehow, most who have been through it as either family or > patient, would strongly disagee with you that it has been a > positive experience.
> We disagree, and will continue to disagree, that it is a GOOD THING to > disable patients so that, when they recover, they can consider the > recovery a GOOD THING.
> To me, NOT CAUSING THE DISABILITY IS A GOOD THING.
>> So you're saying that improvement from myopathy after stopping >> statins is a bad thing? I think you are really an incredibly >> disillusioned, angry person. Seek professional help.
>>> Apologies should be directed to the statin disabled.
>>> Your second sentence in your initial conclusion was offensive to >>> anyone who has had their loved one disabled needlessly.
>>> "listener" <liste...@nospam.net> wrote in message >>> news:Xns96B375FB3C319some1outthere@38.144.126.103... >>>> Either show me where I stated or implied that having a >>>> statin-induced myopathy is a "positive experience" as you claimed >>>> or apologize.
>>>> Replying with one word "Experience" is such bullshit, Sharon. You >>>> should be ashamed of yourself.
>>>>> "listener" <liste...@nospam.net> wrote in message >>>>> news:Xns96B2D5C12DBF0some1outthere@38.144.126.102... >>>>>> Your ability to be selective is astonishing. Cognitive dissonance >>>>>> at work. I said nothing about the experience of statin-induced >>>>>> myopathy being "positive". What's wrong with you? Where did I >>>>>> even remotely say that?
>>>>>> Also, it's safe to say that the patients in the study were >>>>>> already disabled to some degree before taking a statin, which >>>>>> then caused a *new* disability:
>>>>>> "8 patients with hemiparetic stroke and 10 patients with other >>>>>> presumed neurologic diseases presented with new difficulty..."
>>>>>> I still say that the fact they recovered within a relatively >>>>>> short time period from the *new* (statin-induced) disability is >>>>>> hopeful, wonderful and positive. I know it contradicts your >>>>>> stated views
>>>>> Experience
>>>>>>that this sort of >>>>>> statin AE recovery is a long, horrible proccess where there's >>>>>> little hope, if any, for full recovery. Perhaps that's why you >>>>>> respond in such an angry, negative fashion.
>>>>>>> As long as you think experiencing PREVENTABLE DISABILITY is a >>>>>>> good thing.
>>>>>>> DISABILITY is a major change in lifestyle, and can induce loss >>>>>>> of job, loss of home, and harm to the family unit, in addition >>>>>>> to pain and suffering.
>>>>>>> PREVENTABLE DISABILITY adds additional stress and loss of trust >>>>>>> and anger, knowing there was no justifiable reason that the >>>>>>> patient was subjected to it without warning and permitted to >>>>>>> become disabled by a drug that is precautionary, not curative.
>>>>>>> Somehow, most who have been through it as either family or >>>>>>> patient, would strongly disagee with you that it has been a >>>>>>> positive experience.
>>>>>>>>> University of California Los Angeles, Reed Neurologic Research >>>>>>>>> Center. bdob...@mednet.ucla.edu.
>>>>>>>>> INTRODUCTION: Myopathic syndromes induced by >>>>>>>>> 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase >>>>>>>>> inhibitors (statins) include muscle complaints, myalgia, >>>>>>>>> myositis, and rhabdomyolysis. No prospective study of statins, >>>>>>>>> however, included tests of strength, so the incidence of >>>>>>>>> weakness, with or without muscle symptoms and elevated >>>>>>>>> enzymes, is unknown, and perhaps overlooked. METHODS: From a >>>>>>>>> convenience sample of patients referred to an outpatient >>>>>>>>> neurorehabilitation clinic over the course of 1 year, 8 >>>>>>>>> patients with hemiparetic stroke and 10 patients with other >>>>>>>>> presumed neurologic diseases presented with new difficulty >>>>>>>>> walking by 3 to 12 months after starting one of 3 statins. >>>>>>>>> They reported no myalgias, exercise-induced aches, or >>>>>>>>> weakness. Examination revealed proximal paresis graded 4/5 on >>>>>>>>> the unaffected side in the hemiparetic patients and >>>>>>>>> symmetrical bilateral proximal limb and neck flexor weakness >>>>>>>>> graded 4/5 in the others. They stood up with difficulty and >>>>>>>>> walked with bilateral hip drop and imbalance on turns. >>>>>>>>> RESULTS: Laboratory tests did not reveal myositis or >>>>>>>>> other causes for paresis. No improvement in strength or >>>>>>>>> mobility was found 6 weeks after initiating resistance >>>>>>>>> exercises. The statin agent was stopped. By 3 months off >>>>>>>>> statin, all recovered 5/5 proximal strength. Walking improved, >>>>>>>>> and they arose from a chair without pushing off with their >>>>>>>>> arms. DISCUSSION: Serial manual muscle testing after >>>>>>>>> initiating a statin may detect a reversible cause of >>>>>>>>> disability. A genetic predisposition to statin-induced >>>>>>>>> myopathic proximal weakness with normal creatine kinase is >>>>>>>>> consistent with a continuum of previously reported symptoms >>>>>>>>> and signs but may be underappreciated.
>>>>>>>>> PMID: 16093417 [PubMed - in process]
>>>>>>>> Inotherwords, for the small subset with a genetic >>>>>>>> predisposition to statin-induced myopathy and other >>>>>>>> pre-exisiting neurologic diseases improvement was achieved >>>>>>>> shortly after cessation of the statin.
>> Your second sentence in your initial conclusion was offensive to anyone >> who has had their loved one disabled needlessly.
> Virtually everything that *you* write on the topic of statins is offensive > to people who understand anything about drug research and peer reviewed > studies. More importantly, virtually everything that *you* write is both > offensive and dangerous to people who are being aided, or could > potentially be aided, by statin therapy.
> Your loved one was disabled needlessly due to an unusual adverse reaction > to a prescription drug combined with what may well have been an > insensitivity to that reaction on the part of his physician(s). Adverse > reactions to common beneficial drugs such as aspirin and penicillin have > killed people before, and will continue to do so. It's called "bad luck." > Your reaction to your loved one's bad luck is to mount a campaign of > propaganda and disinformation against statin drugs akin to the opposition > to fluoridation of water; the chief difference being that bad teeth have > the potential for killing far fewer people than coronary artery disease.
This is simply not true.
The adverse effects from the Lipitor began almost immediately, and were reported to his doctor immediately.
The doctor, lacking full disclosure of statin adverse effects and their dangers ( this was prior to the Baycol voluntary recall), told his patient repeatedly to ignore the adverse effects and keep taking the statin or he would die from a heart attack.
Pain? Keep taking Lipitor or you will die. Neuropathy? Tough it out, keep taking Lipitor or you will die. Memory loss? Haven't heard of it in relation to Lipitor, if it Alzheimer's there is no cure anyway, so FORGET IT, and keep taking Lipitor or you will die. CK over 10x normal at the threshold of rhabdomyolysis, ignore the pain and keep taking Lipitor or you will die. (no recognition that rhabdo can also make you die) Uh-oh, a specialist says the Lipitor may kill him? His memory now scores below the 1 percentile, this in a Corporate CEO? We have nothing to discuss, just hide the Lipitor pills from him.
Every month the degree of intensity and the number of adverse effects grew. Every single month for 48 months. At the end of that time he was fully disabled, physically and cognitively.
Because of the lack of disclosure about adverse effects at that time, the damage continued to grow.
This was not just bad luck, this was a direct result, not just of the drug's myotoxic, neurotoxic and brain-damaging propensities, but a direct result of a lack of available honest information on statin adverse effects.
This persists, as many of the statin trials simply withold information on adverse effects, others document known and acknowledged PI-listed adverse effects in the "unrelated" category.
My posts center on the awareness of adverse effects.
> You truly need to engage in some serious self-examination.
> Steve > -- > The above posting is neither a legal opinion nor legal advice, > because we do not have an attorney-client relationship, and > should not be construed as either. This posting does not > represent the opinion of my employer, but is merely my personal > view. To reply, delete _spamout_ and replace with the numeral 3
>> "listener" <liste...@nospam.net> wrote in message >> news:Xns96B375FB3C319some1outthere@38.144.126.103... >>> Either show me where I stated or implied that having a statin-induced >>> myopathy is a "positive experience" as you claimed or apologize.
>>> Replying with one word "Experience" is such bullshit, Sharon. You should >>> be ashamed of yourself.
>>>> "listener" <liste...@nospam.net> wrote in message >>>> news:Xns96B2D5C12DBF0some1outthere@38.144.126.102... >>>>> Your ability to be selective is astonishing. Cognitive dissonance at >>>>> work. I said nothing about the experience of statin-induced myopathy >>>>> being "positive". What's wrong with you? Where did I even remotely >>>>> say that?
>>>>> Also, it's safe to say that the patients in the study were already >>>>> disabled to some degree before taking a statin, which then caused a >>>>> *new* disability:
>>>>> "8 patients with hemiparetic stroke and 10 patients with other >>>>> presumed neurologic diseases presented with new difficulty..."
>>>>> I still say that the fact they recovered within a relatively short >>>>> time period from the *new* (statin-induced) disability is hopeful, >>>>> wonderful and positive. I know it contradicts your stated views
>>>> Experience
>>>>>that this sort of >>>>> statin AE recovery is a long, horrible proccess where there's little >>>>> hope, if any, for full recovery. Perhaps that's why you respond in >>>>> such an angry, negative fashion.
>>>>>> As long as you think experiencing PREVENTABLE DISABILITY is a good >>>>>> thing.
>>>>>> DISABILITY is a major change in lifestyle, and can induce loss of >>>>>> job, loss of home, and harm to the family unit, in addition to pain >>>>>> and suffering.
>>>>>> PREVENTABLE DISABILITY adds additional stress and loss of trust and >>>>>> anger, knowing there was no justifiable reason that the patient was >>>>>> subjected to it without warning and permitted to become disabled by >>>>>> a drug that is precautionary, not curative.
>>>>>> Somehow, most who have been through it as either family or patient, >>>>>> would strongly disagee with you that it has been a positive >>>>>> experience.
>>>>>>>> University of California Los Angeles, Reed Neurologic Research >>>>>>>> Center. bdob...@mednet.ucla.edu.
>>>>>>>> INTRODUCTION: Myopathic syndromes induced by >>>>>>>> 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase >>>>>>>> inhibitors (statins) include muscle complaints, myalgia, myositis, >>>>>>>> and rhabdomyolysis. No prospective study of statins, however, >>>>>>>> included tests of strength, so the incidence of weakness, with or >>>>>>>> without muscle symptoms and elevated enzymes, is unknown, and >>>>>>>> perhaps overlooked. METHODS: From a convenience sample of patients >>>>>>>> referred to an outpatient neurorehabilitation clinic over the >>>>>>>> course of 1 year, 8 patients with hemiparetic stroke and 10 >>>>>>>> patients with other presumed neurologic diseases presented with >>>>>>>> new difficulty walking by 3 to 12 months after starting one of 3 >>>>>>>> statins. They reported no myalgias, exercise-induced aches, or >>>>>>>> weakness. Examination revealed proximal paresis graded 4/5 on the >>>>>>>> unaffected side in the hemiparetic patients and symmetrical >>>>>>>> bilateral proximal limb and neck flexor weakness graded 4/5 in the >>>>>>>> others. They stood up with difficulty and walked with bilateral >>>>>>>> hip drop and imbalance on turns. RESULTS: Laboratory tests did not >>>>>>>> reveal myositis or other causes for paresis. No improvement in >>>>>>>> strength or mobility was found 6 weeks after initiating resistance >>>>>>>> exercises. The statin agent was stopped. By 3 months off statin, >>>>>>>> all recovered 5/5 proximal strength. Walking improved, and they >>>>>>>> arose from a chair without pushing off with their arms. >>>>>>>> DISCUSSION: Serial manual muscle testing after initiating a statin >>>>>>>> may detect a reversible cause of disability. A genetic >>>>>>>> predisposition to statin-induced myopathic proximal weakness with >>>>>>>> normal creatine kinase is consistent with a continuum of >>>>>>>> previously reported symptoms and signs but may be >>>>>>>> underappreciated.
>>>>>>>> PMID: 16093417 [PubMed - in process]
>>>>>>> Inotherwords, for the small subset with a genetic predisposition to >>>>>>> statin-induced myopathy and other pre-exisiting neurologic diseases >>>>>>> improvement was achieved shortly after cessation of the statin.
>>> Your second sentence in your initial conclusion was offensive to anyone >>> who has had their loved one disabled needlessly.
>> Virtually everything that *you* write on the topic of statins is >> offensive to people who understand anything about drug research and peer >> reviewed studies. More importantly, virtually everything that *you* >> write is both offensive and dangerous to people who are being aided, or >> could potentially be aided, by statin therapy.
>> Your loved one was disabled needlessly due to an unusual adverse reaction >> to a prescription drug combined with what may well have been an >> insensitivity to that reaction on the part of his physician(s). Adverse >> reactions to common beneficial drugs such as aspirin and penicillin have >> killed people before, and will continue to do so. It's called "bad >> luck." Your reaction to your loved one's bad luck is to mount a campaign >> of propaganda and disinformation against statin drugs akin to the >> opposition to fluoridation of water; the chief difference being that bad >> teeth have the potential for killing far fewer people than coronary >> artery disease.
> This is simply not true.
> The adverse effects from the Lipitor began almost immediately, and were > reported to his doctor immediately.
> The doctor, lacking full disclosure of statin adverse effects and their > dangers ( this was prior to the Baycol voluntary recall), told his patient > repeatedly to ignore the adverse effects and keep taking the statin or he > would die from a heart attack.
> Pain? Keep taking Lipitor or you will die. Neuropathy? Tough it out, > keep taking Lipitor or you will die. Memory loss? Haven't heard of it in > relation to Lipitor, if it Alzheimer's there is no cure anyway, so FORGET > IT, and keep taking Lipitor or you will die. CK over 10x normal at the > threshold of rhabdomyolysis, ignore the pain and keep taking Lipitor or > you will die. (no recognition that rhabdo can also make you die) Uh-oh, > a specialist says the Lipitor may kill him? His memory now scores below > the 1 percentile, this in a Corporate CEO? We have nothing to discuss, > just hide the Lipitor pills from him.
> Every month the degree of intensity and the number of adverse effects > grew. Every single month for 48 months. At the end of that time he was > fully disabled, physically and cognitively.
> Because of the lack of disclosure about adverse effects at that time, the > damage continued to grow.
> This was not just bad luck, this was a direct result, not just of the > drug's myotoxic, neurotoxic and brain-damaging propensities, but a direct > result of a lack of available honest information on statin adverse > effects.
> This persists, as many of the statin trials simply withold information on > adverse effects, others document known and acknowledged PI-listed adverse > effects in the "unrelated" category.
> My posts center on the awareness of adverse effects.
> The motivation is obvious.
> If they offend you, don't read them.
>> You truly need to engage in some serious self-examination.
>> Steve >> -- >> The above posting is neither a legal opinion nor legal advice, >> because we do not have an attorney-client relationship, and >> should not be construed as either. This posting does not >> represent the opinion of my employer, but is merely my personal >> view. To reply, delete _spamout_ and replace with the numeral 3
>>> "listener" <liste...@nospam.net> wrote in message >>> news:Xns96B375FB3C319some1outthere@38.144.126.103... >>>> Either show me where I stated or implied that having a statin-induced >>>> myopathy is a "positive experience" as you claimed or apologize.
>>>> Replying with one word "Experience" is such bullshit, Sharon. You >>>> should >>>> be ashamed of yourself.
>>>>> "listener" <liste...@nospam.net> wrote in message >>>>> news:Xns96B2D5C12DBF0some1outthere@38.144.126.102... >>>>>> Your ability to be selective is astonishing. Cognitive dissonance at >>>>>> work. I said nothing about the experience of statin-induced myopathy >>>>>> being "positive". What's wrong with you? Where did I even remotely >>>>>> say that?
>>>>>> Also, it's safe to say that the patients in the study were already >>>>>> disabled to some degree before taking a statin, which then caused a >>>>>> *new* disability:
>>>>>> "8 patients with hemiparetic stroke and 10 patients with other >>>>>> presumed neurologic diseases presented with new difficulty..."
>>>>>> I still say that the fact they recovered within a relatively short >>>>>> time period from the *new* (statin-induced) disability is hopeful, >>>>>> wonderful and positive. I know it contradicts your stated views
>>>>> Experience
>>>>>>that this sort of >>>>>> statin AE recovery is a long, horrible proccess where there's little >>>>>> hope, if any, for full recovery. Perhaps that's why you respond in >>>>>> such an angry, negative fashion.
>>>>>>> As long as you think experiencing PREVENTABLE DISABILITY is a good >>>>>>> thing.
>>>>>>> DISABILITY is a major change in lifestyle, and can induce loss of >>>>>>> job, loss of home, and harm to the family unit, in addition to pain >>>>>>> and suffering.
>>>>>>> PREVENTABLE DISABILITY adds additional stress and loss of trust and >>>>>>> anger, knowing there was no justifiable reason that the patient was >>>>>>> subjected to it without warning and permitted to become disabled by >>>>>>> a drug that is precautionary, not curative.
>>>>>>> Somehow, most who have been through it as either family or patient, >>>>>>> would strongly disagee with you that it has been a positive >>>>>>> experience.
>>>>>>>>> University of California Los Angeles, Reed Neurologic Research >>>>>>>>> Center. bdob...@mednet.ucla.edu.
>>>>>>>>> INTRODUCTION: Myopathic syndromes induced by >>>>>>>>> 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase >>>>>>>>> inhibitors (statins) include muscle complaints, myalgia, myositis, >>>>>>>>> and rhabdomyolysis. No prospective study of statins, however, >>>>>>>>> included tests of strength, so the incidence of weakness, with or >>>>>>>>> without muscle symptoms and elevated enzymes, is unknown, and >>>>>>>>> perhaps overlooked. METHODS: From a convenience sample of patients >>>>>>>>> referred to an outpatient neurorehabilitation clinic over the >>>>>>>>> course of 1 year, 8 patients with hemiparetic stroke and 10 >>>>>>>>> patients with other presumed neurologic diseases presented with >>>>>>>>> new difficulty walking by 3 to 12 months after starting one of 3 >>>>>>>>> statins. They reported no myalgias, exercise-induced aches, or >>>>>>>>> weakness. Examination revealed proximal paresis graded 4/5 on the >>>>>>>>> unaffected side in the hemiparetic patients and symmetrical >>>>>>>>> bilateral proximal limb and neck flexor weakness graded 4/5 in the >>>>>>>>> others. They stood up with difficulty and walked with bilateral >>>>>>>>> hip drop and imbalance on turns. RESULTS: Laboratory tests did not >>>>>>>>> reveal myositis or other causes for paresis. No improvement in >>>>>>>>> strength or mobility was found 6 weeks after initiating resistance >>>>>>>>> exercises. The statin agent was stopped. By 3 months off statin, >>>>>>>>> all recovered 5/5 proximal strength. Walking improved, and they >>>>>>>>> arose from a chair without pushing off with their arms. >>>>>>>>> DISCUSSION: Serial manual muscle testing after initiating a statin >>>>>>>>> may detect a reversible cause of disability. A genetic >>>>>>>>> predisposition to statin-induced myopathic proximal weakness with >>>>>>>>> normal creatine kinase is consistent with a continuum of >>>>>>>>> previously reported symptoms and signs but may be >>>>>>>>> underappreciated.
>>>>>>>>> PMID: 16093417 [PubMed - in process]
>>>>>>>> Inotherwords, for the small subset with a genetic predisposition to >>>>>>>> statin-induced myopathy and other pre-exisiting neurologic diseases >>>>>>>> improvement was achieved shortly after cessation of the statin.
