Uga Nk 5.0

[Stop A.I.D.S-Fiocco Rosso]

THERMODYNAMIC ASPECTS OF HIV-HOST INTERACTION
by G. Marineo
E.B.E. Bioengineering Research Centre - Rome
e-mail MC9...@MCLINK.IT

RESEARCH OBJECTIVES

The aim of the research, which began in January '94, is to demonstrate the
link between degeneration of the cell's bioenergetic structures due to the
unrelieved biological stress produced by HIV infection, and an abnormal
increase in entropy at both local and general levels. This is viewed as a
metacause of AIDS insofar as it inhibits the endogenous capacity for
maintaining over time an immune response capable of effectively controlling
the infection. Mathematical models have been developed and applied with a
view to offsetting the effects of the degenerative processes through the
artificial variation of the host's entropy. This is achieved artificially
using a medical device of new conception designed to restore both a correct
HIV specific response as well as normal homeostatic processes, starting
from the stage of declared AIDS.

THEORETICAL PRINCIPLES, MATERIALS AND METHODS

The application of thermodynamic principles to the study of biophysics has
demonstrated the applicability of the concept of entropy to living
organisms. Biological entropy is determined as the variation due to the
conversion of food into energy (+/-) summed with the variation due to the
metabolism (+). It follows that the normal ageing process has a
corresponding entropy function that increases over time until death. One of
the biophysical aspects characterizing diseases tending towards chronicity
is an abnormal increase in entropy at the cellular level due to stressing
of the bioenergetic structure (particularly the mitochondria). This
increase in entropy progressively hinders the natural tendency for
homeostasis to be restored through appropriate compensatory endogenous
responses. Starting from these premises, and having identified the constant
immune stress due to the presence of HIV in the host as a significant
condition for the early super-ageing of many cell systems, a medical device
(UGA NK-5.0) has been developed that can satisfactorily modify the
variation in entropy by functionally bypassing the bioenergetic structures
of the cell. This is achieved by means of a (self-regulating)
query/response loop driven by suitable electromagnetic fields. These fields
are set up instant by instant according to the interaction between the
field and the biological system by means of a microprocessor array with a
parallel architecture regulated by an AI (expert) system. It has been
attempted experimentally to restore 'optimal' biophysical conditions
(artificial introduction of a negative delta-s) so as to restore optimal
biophysical conditions in order to reactivate a correct immune response to
HIV. The possibility of this occurring even in the total absence of CD4 T
helpers is theoretically linked to the feasibility of inducing the
phenomenon of 'plasticity' essentially by amplifying the cooperative
activities of the B lymphocytes. In this way it was deemed possible to
maintain the ideal viral growth terrain at a low level, at the same time
achieving an increase in HIV specific immune activity. This assumption was
verified systematically, particularly from the 6th month of treatment on by
means of monthly checks. The results are evident and may be summed up as
follows:
- Reduction or remission of symptoms (Candida, KS, CMV, HVZ, asthenia,
dermatitis etc.);
- Sharp reduction in viremia;
- stable and significant increase in white cells, B lymphocytes, cytolitic
T, NK;
- sporadic growth of CD4 T helpers;
- increase in W.B. bands from 2/4 to 8/9;
- no side effects.

SUMMARY OF SIGNIFICANT PEAK VARIATIONS

WBC: + 1600 ( > 9000 during infection even at zero CD4)
RBC: + 2.19
P24: FROM +++ ( or 140 pG ) TO NEGATIVE (FROM 50 pG WITH AZT TO
NEGATIVE WITHOUT AZT)
CD4: +300 (+33%)
B: +138 (+20.7%)
NK: +289 (+13.9%)
T4/T8 + 1.47 (FROM 0.14 TO 1.61)

CONCLUSIONS

The positive results suggest the utility of carrying out a further set of
trials on 15 cases, five of whom are seropositive above 500 CD4, 10 with
AIDS and having a life expectancy of at least six months. The subjects will
be further subdivided into two groups according to whether they use
antivirals or not. This further stage of investigation will enable clinical
and engineering know-how to be optimized and will allow the foundations to
be laid for the effective therapy of patients that do not tolerate the
impact of drugs or else to boost the immune response after a cycle of
antiviral therapy.

[Batie, Christopher]

>
>THERMODYNAMIC ASPECTS OF HIV-HOST INTERACTION
>by G. Marineo
>E.B.E. Bioengineering Research Centre - Rome

I sure hope no one gives these folks any of their hard-earned $$.
Grrr!!

(Brief delay for gnashing of teeth and for suiting up as a physical
biochemist)
Crackpots (and creationists .. flame away) often like to envoke entropy,
perhaps because it is poorly understood by the general public and often is
poorly taught.

I won't attempt a thorough critique of this mess, but even the definition of
entropy

>. Biological entropy is determined as the variation due to the
>conversion of food into energy (+/-) summed with the variation due to the
>metabolism (+).

is so strange it isn't close enough to real biochemistry to qualify as a
mistaken hypothesis, it is just wrong-headed.

Likewise, the description of the the magic box and its function is a slickly
presented batch of buzz words and jargon taken from biology, biochemistry &
computer sci/electronics. Unfortunately, it is meaningless.

It would take quite a while to dissect this critter & expose all its rotten
parts. That, probably, would be a waste of bandwidth.

I hope y'all will trust someone from the rational/linear-thinking/non-
alternative-therapy/science world. This guy doesn't know what s/he
is talking about.

I'd suggest buying that plane ticket to Rome, but instead treat yourself to
some
therapeutic Italian cuisine & Renaissance art.

Christopher J. Batie, Ph.D.
cba...@lsumc.edu
Dept. Biochemistry and Molecular Biology Box P7-2
Louisiana State University Medical Center
New Orleans, LA 70112
Phone 504-568-5132
FAX 504-568-3370