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Immunosenescence of human natural killer cells.
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Immanuel kant
May 23, 2012, 5:57:12 PM5/23/12
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Immunotherapy may be a way to rid senecent cells. Thymic hormones?
J Innate Immun. 2011;3(4):337-43. Epub 2011 May 11.
Immunosenescence of human natural killer cells.
Gayoso I, Sanchez-Correa B, Campos C, Alonso C, Pera A, Casado JG,
Morgado S, Tarazona R, Solana R.
SourceDepartment of Immunology, IMIBIC - Reina Sofia University
Hospital, University of Cordoba, Cordoba, Spain.
Abstract
Natural killer (NK) cells are a key component of innate immunity
involved not only in the elimination of virus-infected or tumor cells
but also in the regulation of the immuneresponse by producing
cytokines and chemokines that can activate other cellular components
of innate and adaptive immunity. NKcell subsets are differentially
affected by aging. Whereas CD56(bright) cells are decreased in healthy
elderly individuals, the CD56(dim) subset is expanded. The expression
of CD57, a marker of highly differentiated NK cells, is increased in
the elderly; this supports the notion that a remodeling process of
NKcell subsets occurs in aging with a gradual decrease in more
immature CD56(bright) NK cells and an increase in highly
differentiated CD56(dim) CD57+ NK cells. This NKcell redistribution
can explain many of the phenotypic and functional changes in NK cells
associated with healthy agingsuch as decreased proliferation and the
maintenance of CD16-dependent cytotoxicity.
Copyright © 2011 S. Karger AG, Basel.
PMID: 21576928
J Innate Immun. 2011;3(4):337-43. Epub 2011 May 11.
Immunosenescence of human natural killer cells.
Gayoso I, Sanchez-Correa B, Campos C, Alonso C, Pera A, Casado JG,
Morgado S, Tarazona R, Solana R.
SourceDepartment of Immunology, IMIBIC - Reina Sofia University
Hospital, University of Cordoba, Cordoba, Spain.
Abstract
Natural killer (NK) cells are a key component of innate immunity
involved not only in the elimination of virus-infected or tumor cells
but also in the regulation of the immuneresponse by producing
cytokines and chemokines that can activate other cellular components
of innate and adaptive immunity. NKcell subsets are differentially
affected by aging. Whereas CD56(bright) cells are decreased in healthy
elderly individuals, the CD56(dim) subset is expanded. The expression
of CD57, a marker of highly differentiated NK cells, is increased in
the elderly; this supports the notion that a remodeling process of
NKcell subsets occurs in aging with a gradual decrease in more
immature CD56(bright) NK cells and an increase in highly
differentiated CD56(dim) CD57+ NK cells. This NKcell redistribution
can explain many of the phenotypic and functional changes in NK cells
associated with healthy agingsuch as decreased proliferation and the
maintenance of CD16-dependent cytotoxicity.
Copyright © 2011 S. Karger AG, Basel.
PMID: 21576928
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