Effects of centrophenoxine on lipofuscin in the retinal pigment epithelium of old mice.
timo...@my-deja.com
Effects of centrophenoxine on lipofuscin in the retinal pigment
epithelium of old mice.
Dylewski DP, Nandy S, Nandy K.
The effects of centrophenoxine on the retinal pigment epithelium (RPE)
of 17 month old female mice have been studied. Animals were injected
subcutaneously for 3 months (60 injections) with the drug (0.1 mg/g of
body wt) daily in 0.1 M phosphate buffered saline at pH 7.0. The
morphological changes in the pigment layers of the retina of both eyes
were studied by light and electron microscopy and the lipofuscin
pigment was demonstrated by its autofluorescence and ultrastructural
characteristics. There was a significant reduction of the lipofuscin
pigment in the treated animals, but the melanin pigment remained
unchanged. The lipofuscin granules also appeared less osmiophilic and
showed a greater preponderance of membranes and vacuoles. Although the
precise mechanism of action of the drug is not clear, an increased
protective function of the pigment epithelium by the drug has been
suggested.
PMID: 6410295 [PubMed - indexed for MEDLINE]
timo...@my-deja.com
Lipofuscinogenesis in mice early treated with centrophenoxine.
Nandy K.
Previous studies in our and other laboratories indicated that there is
a reduction in the neuronal lipofuscin in old rodents after several
weeks of treatment with centrophenoxine. The present study investigates
whether this chemical can prevent pigment formation if given early in
life before the onset of pigmentogenesis. The study shows that the drug
did not stop lipofuscin formation in 1 month old mice. But there was a
consistent decrease in the pigment in the neurons of cerebral cortex
and hippocampus of the treated animals compared to the age-matched
controls. The degree of reduction was largely dependent on the duration
of the treatment and a significant diminution was noted after treatment
for five months or more.
PMID: 357853 [PubMed - indexed for MEDLINE]
timo...@my-deja.com
Centrophenoxine: effects on aging mammalian brain.
Nandy K.
A study was made of the effects of centrophenoxine on the learning and
memory of old mice. The results were correlated with changes in
neuronal lipofuscin in the cerebral cortex and hippocampus. Old female
mice (11-12 months) were treated with centropheoxine for three months
and their learning and memory were tested in a T-maze. The number of
trials required to attain the criterion in the 20 treated old mice were
compared with those for 20 untreated mice of the same age and for 20
younger untreated mice. The treated animals learned the task with
significantly fewer trials, and also exhibited a reduction of neuronal
lipofuscin pigment in both the cerebral cortex and the hippocampus. The
changes in lipofuscin were demonstrated by study of the characteristic
autofluorescence, and by histolchemical and ultrastructural (electron
microscope) observations.
PMID: 342588 [PubMed - indexed for MEDLINE]
iftik...@gmail.com
centrophenoxine. What is new ?, that is what many on this board would
like to know.