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Korean Mistletoe (Viscum album coloratum) Extract Improves Endurance Capacity in Mice by Stimulating Mitochondrial Activity.
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Olafur Pall Olafsson
May 23, 2012, 4:59:34 PM5/23/12
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J Med Food. 2012 May 21. [Epub ahead of print]
Korean Mistletoe (Viscum album coloratum) Extract Improves Endurance
Capacity in Mice by Stimulating Mitochondrial Activity.
Jung HY, Lee AN, Song TJ, An HS, Kim YH, Kim KD, Kim IB, Kim KS, Han
BS, Kim CH, Kim KS, Kim JB.
Source
1 School of Life and Food Sciences, Handong Global University ,
Pohang, Gyungbuk, South Korea .
Abstract
Abstract The beneficial effects of exercise on overall health make it
desirable to identify the orally active agents that enhance the
effects of exercise in an effort to cure metabolic diseases. Natural
compounds such as resveratrol (RSV) are known to increase endurance by
potentiating mitochondrial function. Korean mistletoe (Viscum album
coloratum) extract (KME) has characteristics similar to those of RSV.
In the present study, we determined whether KME could increase
mitochondrial activity and exert an anti-fatigue effect. We found that
KME treatment significantly increased the mitochondrial oxygen
consumption rate (OCR) in L6 cells and increased the expression of
peroxisome proliferator-activated receptor γ coactivator (PGC)-1α and
silent mating type information regulation 2 homolog 1 (SIRT1), two
major regulators of mitochondria function, in C2C12 cells. In the
treadmill test, KME-treated mice could run 2.5-times longer than chow-
fed control mice. Additionally, plasma lactate levels of exhausted
mice were significantly lower in the KME-treated group. In addition,
the swimming time to exhaustion of mice treated with KME was prolonged
by as much as 212% in the forced-swim test. Liver and kidney histology
was similar between the KME-treated and phosphate-buffered saline-
treated animals, indicating that KME was nontoxic. Taken together, our
data show that KME induces mitochondrial activity, possibly by
activating PGC-1α and SIRT1, and improves the endurance of mice,
strongly suggesting that KME has great potential as a novel
mitochondria-activating agent.
PMID: 22612297
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Korean Mistletoe (Viscum album coloratum) Extract Improves Endurance
Capacity in Mice by Stimulating Mitochondrial Activity.
Jung HY, Lee AN, Song TJ, An HS, Kim YH, Kim KD, Kim IB, Kim KS, Han
BS, Kim CH, Kim KS, Kim JB.
Source
1 School of Life and Food Sciences, Handong Global University ,
Pohang, Gyungbuk, South Korea .
Abstract
Abstract The beneficial effects of exercise on overall health make it
desirable to identify the orally active agents that enhance the
effects of exercise in an effort to cure metabolic diseases. Natural
compounds such as resveratrol (RSV) are known to increase endurance by
potentiating mitochondrial function. Korean mistletoe (Viscum album
coloratum) extract (KME) has characteristics similar to those of RSV.
In the present study, we determined whether KME could increase
mitochondrial activity and exert an anti-fatigue effect. We found that
KME treatment significantly increased the mitochondrial oxygen
consumption rate (OCR) in L6 cells and increased the expression of
peroxisome proliferator-activated receptor γ coactivator (PGC)-1α and
silent mating type information regulation 2 homolog 1 (SIRT1), two
major regulators of mitochondria function, in C2C12 cells. In the
treadmill test, KME-treated mice could run 2.5-times longer than chow-
fed control mice. Additionally, plasma lactate levels of exhausted
mice were significantly lower in the KME-treated group. In addition,
the swimming time to exhaustion of mice treated with KME was prolonged
by as much as 212% in the forced-swim test. Liver and kidney histology
was similar between the KME-treated and phosphate-buffered saline-
treated animals, indicating that KME was nontoxic. Taken together, our
data show that KME induces mitochondrial activity, possibly by
activating PGC-1α and SIRT1, and improves the endurance of mice,
strongly suggesting that KME has great potential as a novel
mitochondria-activating agent.
PMID: 22612297
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mitochondrial biogenesis or peroxisome proliferator-activated receptor-
gamma coactivator-1alpha (PGC-1alpha) deacetylation following
endurance exercise.
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receptor-γ coactivator-1α (PGC-1α) deacetylation by physical activity:
intact adipocytokine signaling is required.
[Diabetes. 2011]
Endurance exercise increases the SIRT1 and peroxisome proliferator-
activated receptor gamma coactivator-1alpha protein expressions in rat
skeletal muscle.
[Metabolism. 2008]
Review Deacetylation of PGC-1α by SIRT1: importance for skeletal
muscle function and exercise-induced mitochondrial biogenesis.
[Appl Physiol Nutr Metab. 2011]
Review Regulation by exercise of skeletal muscle content of
mitochondria and GLUT4.
[J Physiol Pharmacol. 2008]
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