Mitochondrial Antioxidant SkQ1 Doubles Median Lifespan in Mice.
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Mitochondria-Targeted Plastoquinone Derivatives as Tools to Interrupt
Execution of the Aging Program. 5. SkQ1 Prolongs Lifespan and Prevents
Development of Traits of Senescence.
Anisimov VN, Bakeeva LE, Egormin PA, Filenko OF, Isakova EF, Manskikh
VN, Mikhelson VM, Panteleeva AA, Pasyukova EG, Pilipenko DI, Piskunova
TS, Popovich IG, Roshchina NV, Rybina OY, Saprunova VB, Samoylova TA,
Semenchenko AV, Skulachev MV, Spivak IM, Tsybul'ko EA, Tyndyk ML,
Vyssokikh MY, Yurova MN, Zabezhinsky MA, Skulachev VP.
Petrov Institute of Oncology, St. Petersburg, 197758, Russia.
Very low (nano- and subnanomolar) concentrations of 10-(6'-
plastoquinonyl) decyltriphenylphosphonium (SkQ1) were found to prolong
lifespan of a fungus (Podospora anserina), a crustacean (Ceriodaphnia
affinis), an insect (Drosophila melanogaster), and a mammal (mouse).
In the latter case, median lifespan is doubled if animals live in a
non-sterile vivarium. The lifespan increase is accompanied by
rectangularization of the survival curves (an increase in survival is
much larger at early than at late ages) and disappearance of typical
traits of senescence or retardation of their development. Data
summarized here and in the preceding papers of this series suggest
that mitochondria-targeted antioxidant SkQ1 is competent in slowing
down execution of an aging program responsible for development of age-
related senescence.
PMID: 19120018 [PubMed - in process]
Taka
http://pmid.us/19120018+19120017+19120016+19120015+19120014
Brilliant Russians again ... Wouldn't this be a better approach to
counteract AA-mediated oxidative stress than supplementing the
doubtful fish oil, Matti?
Taka