Effect of dimethylaminoethanol on the life span of senile male A-J mice.
timo...@my-deja.com
Effect of dimethylaminoethanol on the life span of senile male A-J
mice.
Hochschild R.
PMID: 4729429 [PubMed - indexed for MEDLINE]
The results of this experiment are this. Richard Hochschild fed A/J
mice a fairly long-lived strain 86 mg of the acetamido benzoate salt of
DMAE to mice that were already beyond their mean expected lifespan.
Mean LS extended 49.5% over controls
Maximum LS extended 36.3% over controls.
timo...@my-deja.com
of centrophenoxine.when he started injections of centrophenoxine in
young mice he got a 30-40% increase in LS. This is about all the info.
I could glean from secondary sources. It appears that DMAE,
centrophenoxine, lucidryl etc. all increase methylation. High doses in
the range of 2.5-5.0 grams /kg food intaked increased mortality.
Michael C Price
is that an increase in total LS or remaining LS?
Cheers,
Michael C Price
----------------------------------------
http://mcp.longevity-report.com
http://www.hedweb.com/manworld.htm
<timo...@my-deja.com> wrote in message
news:1146700959.3...@v46g2000cwv.googlegroups.com...
timo...@my-deja.com
The first of course refers to both mean and maximum lifespan. I
forgot to add that the 86mg was per liter of water. Denham Harman did
the 2.5-5g/kg diet (I also saw reference to a study he did in which he
increased LS with ginseng, no other details though). The last I am not
sure of but it may refer to mean/max LS. If you really want to hunt for
the info as the abstracts of older papers aren't included on PubMed try
either Richard Hochschild or Kalidas Nandy. Nandy got similar results.
You might even try Zs-Nagy on Centrophenoxine to see if he did any LS
experiments.
Regards,
Tim
timo...@my-deja.com
DZ
> Here's a link to an LEF monograph of DMAE with stats.
> http://www.lef.org/anti-aging/chap7.html
Interesting results but the interpretation is a bit off.
"The last column P (0.018, 0.039, 0.077) is the statistical
significance: these correspond to probabilities of 96.1%, 2%, and
92.3%, that the lifespan increases were not a result of chance."
I suppose these were meant to be (1-P)*100% = 98.2%, 96.1%, 92.3%.
But 1-P are not "probabilities that the lifespan increases were not a
result of chance".
This would be the same as saying that if the probability of getting
pregnant given you're a human female is 80%, then the probability of
getting pregnant is 100%-80%=20% if you're NOT a female :-)
Kev
J Gerontol. 1977 Jan;32(1):38-45.
Related Articles, Links
Effects of dimethylaminoethanol upon life-span and behavior of aged
Japanese quail.
Cherkin A, Exkardt MJ.
The lysosome hypothesis of aging predicts that membrane stabilizers will
extend life-span. Stabilizers containing the dimethylaminoethanol moiety
(DMAE) have been reported to extend the life-span of drosophila and
mice. We tested the prediction in Japanese quail (N = 15) by
administering DMAE bitartrate (18.4 mg/kg/day) in the drinking water for
69 weeks, starting at 195 weeks of age. A matched control group (N = 14)
received tartaric acid (4.0 mg/kg/day) in the water. Contrary to the
prediction, the DMAE-treated group has a shorter life-span after start
of treatment (49 weeks) than the controls (69 weeks). No significant
differences between the groups were observed in body weight or daily
fluid intake. Three behavioral studies were carried out on survivors at
243-249 weeks of age, namely; activity response to light-flash; sexual
mounting response to a female quail; and classical conditioning of the
heart rate. Aged quail differed from young-adults in changes in motor
activity in response to light flashes. Aged quail appeared less
responsive initially to reinforced conditioning trials and demonstrated
extinction when light flash was not followed by electric shock. There
were no detectable differences in latency to mount or in basal heart
rate, either as a function of age or as a function of DMAE
In article <1146700959.3...@v46g2000cwv.googlegroups.com>,