Resveratrol: Is There Any Effect on Healthy Subjects?

[rs1...@yahoo.com]

Biol Trace Elem Res. 2007 Sep;118(3):250-254.

Resveratrol: Is There Any Effect on Healthy Subject?

Kavas GO, Aribal-Kocatürk P, Büyükkağnici DI.

Faculty of Medicine, Department of Pathophysiology, Ankara University,
Sıhhiye, Ankara, 06100, Turkey.

This preliminary study was planned to investigate the effects of
resveratrol on oxidative-nitrosative stress markers and on trace
element concentrations in blood and on circulatory system parameters
in rats. Twenty-five Sprague-Dawley male rats, 10-12 weeks old, with
mean body weight of 295 g were used in the study. Administration of
resveratrol (0.5 ml/day) was performed in experimental group in 10
days. In control (n = 10) and in experimental groups (n = 15), after 1
week training period, systolic arterial blood pressures and heart
rates were recorded daily. At the end of the tenth day, blood samples
of control and experimental groups were drawn. Total nitrite, nitrite,
nitrate, malondialdehyde, copper, zinc concentrations in plasma,
superoxide dismutase, and catalase activities and copper, zinc
concentrations in red cell were determined both in control and
experimental groups. Alterations in oxidative and nitrosative stress
markers, trace element concentrations, and circulatory system
parameters in experimental group compared to controls were observed.
The results of this study were discussed according to the effect of
resveratrol.

PMID: 17916928 [PubMed - as supplied by publisher]

[rs1...@yahoo.com]

>From full text:

"In this study, systolic arterial blood pressure was decreased, and
heart rate was increased
(p=0.042, p=0,049). It was reported that polyphenols may participate
in the regulation of
vascular tone; also, polyphenols have been attributed to the release
of endothelial NO, a
pivotal vasoprotective molecule. Hence, increased total nitrite
concentration in our
study suggested that there appears an augmentation in NO production
after resveratrol
treatment leading to a decrease in systolic arterial blood pressure.
The increase in heart rate
is considered as the consequence of the decrease in systolic arterial
blood pressure.
In conclusion, resveratrol treatment led [to] a decrease in lipid
peroxidation and also an
enhancement of plasma antioxidant capacity and bioavailability of NO
in healthy rats. With
resveratrol treatment, significant increase in plasma and red cell
copper and plasma zinc
concentrations were also detected."