I think that is the most likely, HV breakdown , perhaps 2x220K in series
would not have failed but 1x450K would.
The item was stored indoors , no damp involvement.
But it seems a bit odd that dozens of times tested in use and then fails
after an extended period of non-use.
Perhaps stressing while in use, cracking the casing , then a film of
mould or something organic can grow over the MO surface in storage.