Penicillin: A Paradigm for Biotechnology
Richard Mateles
Richard I. Mateles, Editor
Reprints The History of Penicillin Production, the classic publication
of the American Institute of Chemical Engineers, originally published in
1970 and long out-of-print. It is updated by the inclusion of two new
chapters dealing with scientific advances in penicillin biochemistry,
microbiology, and genetics made since 1970; and the current commercial and
industrial status of penicillin and its derivatives.
This book tells the remarkable story of penicillin's progress from a
laboratory curiosity to being the first antibiotic available for regular
use, and still a very important product today. The contributors to this book
are the scientists and engineers who played the major role in that
enterprise, which has served as a model for fermentation development for the
last fifty years.
Among the penicillin program's "firsts," which continue to be important
in biotechnology today, were:
a.. mutation and selection for microbial strain improvement
b.. scale-up of fermentors for aerobic processes
c.. countercurrent liquid-liquid extraction
d.. industrial-scale lyophilization of sterile pharmaceuticals
e.. Published: December, 1998 xi + 114 pp. ISBN 1-891545-01-9
To order a copy, mail this form (or fax to 312-346-3345) to: Candida
Corporation, Suite 1616, 77 West Washington Street, , Chicago, IL 60602.
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