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QFTCISG Game 6, Rounds 9-10: drugs, devil's challenge
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Mark Brader
Dec 4, 2017, 5:16:24 AM12/4/17
to
These questions were written to be asked in Toronto on 2017-10-30,
and should be interpreted accordingly.
On each question you may give up to two answers, but if you give
both a right answer and a wrong answer, there is a small penalty.
Please post all your answers to the newsgroup in a single followup,
based only on your own knowledge. (In your answer posting, quote
the questions and place your answer below each one.) I will reveal
the correct answers in about 3 days.
All questions were written by members of Smith & Guessin' and are
used here by permission, but have been reformatted and may have
been retyped and/or edited by me. For further information see
my 2017-09-25 companion posting on "Questions from the Canadian
Inquisition (QFTCI*)".
** Game 6, Round 9 - Science - Drugs
The following is a round on the science and study of drugs.
All answers can be found on the handout:
ACE Inhibitor | Leukotrienes
Agonist | Liver
Alzheimer | Lungs
Antagonist | Multiple Sclerosis
Antihistamines | Non-depolarizing Muscarinic Blocker
Anti-Inflammatories | Parkinson's
Beta-Blocker | Pharmacoeconomics
Bioavailability | Pharmacogenomics
Cancer | Pharmacokinetics
Concentration | Positive Allosteric Modulator
Depolarizing Muscarinic Blocker | Schizophrenia
Glucocorticoids | Spleen
Heart | Teratogen
Huntingtons | Therapeutic Index
Intestines | Tolerance
Intravenous | Vasodilator
Kidneys | Vasopressin
1. Pharmacology is the study of drugs, and is generally broken
into two areas of study. Pharmacodynamics is the study of the
action of drugs in the body. The other studies the rates of drug
distribution and concentration in the body -- what is it called?
2. When we take a drug, it first must be absorbed into the
bloodstream and distributed to its target location. What is
the term for the proportion of drug that enters circulation
and so is able to have an effect?
3. A large factor that affects <answer 2> is the first-pass effect.
This describes the loss of drug after due to filtering that
takes place after it is digested, which in some cases can
greatly reduce drug concentration. This filtering takes place
in which organ(s)?
4. The majority of drugs work by binding to and altering the
normal activity receptors in the human body. Some will increase
the receptor's normal activity; others will block or decrease it.
Thus they are classified into two groups: name either one.
5. This neurodegenerative disease is based on a breakdown of
dopaminergic neurons in the brain causing a lack of control of
movement in the sufferer. Drugs used to treat this disease act
to increase dopamine in the system, such as L-Dopa or Carbidopa.
What is the disease?
6. Anti-neoplastics are drugs are targeted to impede cell growth,
usually by killing the cell and stopping replication. They
employ a wide range of mechanisms, such as the antimetabolite
methotrexate, or using antibodies such as traztuzumab to target
specific cells. What condition are anti-neoplastics used for?
7. This drug group acts directly by blocking receptors to prevent
allergy symptoms. The first generation of drugs would enter
the central nervous system and so made the user sleepier.
The second generation's structures were far more selective in
their target and so are termed non-drowsy. What is this class
of drugs known as?
8. Adrenergic receptors in the heart greatly effect rates and force
of contractions in the heart. By inhibiting certain receptors
using drugs such as propranolol or metoprolol, you can reduce
heart rate and oxygen demand; this is used to treat those with
arrhythmias or coronary artery disease. What are these drugs
known as?
9. Diuretics such as furosemide, torasemide, and mannitol are
used for the treatment of hypertension. By decreasing the
sodium concentrations in the bloodstream the total amount of
volume in the bloodstream is decreased, relieving pressure in
the peripheral arteries. Where in the body do diuretics act?
10. A special topic in pharmacology is looking at how drugs affect
embryos in development. While most drugs are safe for fetuses
at certain concentrations, some are not: a famous example was
the drug thalidomide, used during the 1960s. What is the name
for a drug that causes congenital defects in embryos?
** Game 6, Round 10 - Challenge - Devil's Night
For some of us as a kid, Devil's Night was the night before
Halloween, when we used to go out and throw eggs at homes, soap
car windows, and do bad things with firecrackers and dog doodoo.
What little devils we were!
Here, some questions that vaguely reference devils.
* A. Entertainment: Devil Movies
In each case, give the title of the movie.
A1. This 1997 movie follows Keanu Reeves as a lawyer who gets
hired by a large firm run by Al Pacino, who turns out to
be Satan himself.
A2. This 1987 movie follows Mickey Rourke as a private
investigator hired by Robert De Niro to track down crooner
Johnny Favorite, who has disappeared. Turns out De Niro
is Satan.
* B. Literature: See You in Hell
B1. In Dante's "Inferno", Dante voyages through the nine circles
of Hell. Who acts as his guide?
B2. And who is Dante's guide in "Paradiso", the closing epic
of the trilogy?
* C. History: Witch-Hunts
C1. The largest-scale witch-hunt ever recorded occurred during
the Spanish Inquisition in the 17th century. Over 7,000
people were examined by the Inquisition in which Spanish
region?
C2. The British Witchcraft Act of 1735 was largely responsible
for laying the groundwork of how to persecute witches and
other spiritual mediums. What was the last year a person was
convicted under this act in the UK -- give or take 15 years?
* D. Geography: Hotter than Hell
D1. Now that a record once claimed by Libya has been discredited,
the hottest temperature ever legitimately recorded happened
in the United States in 1917. The record temperature was
134°F (56.7°C). Where did that happen? Be sufficiently
specific -- not just the state.
D2. The above record has also been disputed as inaccurate.
The next hottest claim is 54°C in the city of Mitribah --
in which Persian Gulf country?
* E. Sports: New Jersey Devils
E1. In 1982 John McCullen bought an existing NHL franchise and
moved it to Newark, renaming it the New Jersey Devils.
What was the team called when he bought it? Full name
required, like "New Jersey Devils". Hint: a current MLB
franchise has the same name.
E2. This player wound up on the New Jersey Devils in 1991 as
trade compensation from the St. Louis Blues. He would
captain the team from 1992 to 2004, during which time they
would win three Stanley Cups. He was elected into the hall
of fame in 2007. Name him.
* F. Miscellaneous: The Devil You Know
In 1589 German theologian Peter Binsfeld classified the greatest
devils and demons as the "Seven Princes of Hell", and associated
them each to one of the Seven Deadly Sins.
F1. Pride was associated with this devil. His name is rendered
from the name "Isaiah" in Hebrew, and means "Light-Bringer"
in Latin. Name that devil!
F2. Gluttony was associated with this devil, whose name is a
literal translation of "Lord of the Flies". He is named
in the several books of the Bible. Name that devil!
--
Mark Brader, Toronto | "Here I sit, ego the size of a planet..."
m...@vex.net | --Steve Summit (after Douglas Adams)
My text in this article is in the public domain.
and should be interpreted accordingly.
On each question you may give up to two answers, but if you give
both a right answer and a wrong answer, there is a small penalty.
Please post all your answers to the newsgroup in a single followup,
based only on your own knowledge. (In your answer posting, quote
the questions and place your answer below each one.) I will reveal
the correct answers in about 3 days.
All questions were written by members of Smith & Guessin' and are
used here by permission, but have been reformatted and may have
been retyped and/or edited by me. For further information see
my 2017-09-25 companion posting on "Questions from the Canadian
Inquisition (QFTCI*)".
** Game 6, Round 9 - Science - Drugs
The following is a round on the science and study of drugs.
All answers can be found on the handout:
ACE Inhibitor | Leukotrienes
Agonist | Liver
Alzheimer | Lungs
Antagonist | Multiple Sclerosis
Antihistamines | Non-depolarizing Muscarinic Blocker
Anti-Inflammatories | Parkinson's
Beta-Blocker | Pharmacoeconomics
Bioavailability | Pharmacogenomics
Cancer | Pharmacokinetics
Concentration | Positive Allosteric Modulator
Depolarizing Muscarinic Blocker | Schizophrenia
Glucocorticoids | Spleen
Heart | Teratogen
Huntingtons | Therapeutic Index
Intestines | Tolerance
Intravenous | Vasodilator
Kidneys | Vasopressin
1. Pharmacology is the study of drugs, and is generally broken
into two areas of study. Pharmacodynamics is the study of the
action of drugs in the body. The other studies the rates of drug
distribution and concentration in the body -- what is it called?
2. When we take a drug, it first must be absorbed into the
bloodstream and distributed to its target location. What is
the term for the proportion of drug that enters circulation
and so is able to have an effect?
3. A large factor that affects <answer 2> is the first-pass effect.
This describes the loss of drug after due to filtering that
takes place after it is digested, which in some cases can
greatly reduce drug concentration. This filtering takes place
in which organ(s)?
4. The majority of drugs work by binding to and altering the
normal activity receptors in the human body. Some will increase
the receptor's normal activity; others will block or decrease it.
Thus they are classified into two groups: name either one.
5. This neurodegenerative disease is based on a breakdown of
dopaminergic neurons in the brain causing a lack of control of
movement in the sufferer. Drugs used to treat this disease act
to increase dopamine in the system, such as L-Dopa or Carbidopa.
What is the disease?
6. Anti-neoplastics are drugs are targeted to impede cell growth,
usually by killing the cell and stopping replication. They
employ a wide range of mechanisms, such as the antimetabolite
methotrexate, or using antibodies such as traztuzumab to target
specific cells. What condition are anti-neoplastics used for?
7. This drug group acts directly by blocking receptors to prevent
allergy symptoms. The first generation of drugs would enter
the central nervous system and so made the user sleepier.
The second generation's structures were far more selective in
their target and so are termed non-drowsy. What is this class
of drugs known as?
8. Adrenergic receptors in the heart greatly effect rates and force
of contractions in the heart. By inhibiting certain receptors
using drugs such as propranolol or metoprolol, you can reduce
heart rate and oxygen demand; this is used to treat those with
arrhythmias or coronary artery disease. What are these drugs
known as?
9. Diuretics such as furosemide, torasemide, and mannitol are
used for the treatment of hypertension. By decreasing the
sodium concentrations in the bloodstream the total amount of
volume in the bloodstream is decreased, relieving pressure in
the peripheral arteries. Where in the body do diuretics act?
10. A special topic in pharmacology is looking at how drugs affect
embryos in development. While most drugs are safe for fetuses
at certain concentrations, some are not: a famous example was
the drug thalidomide, used during the 1960s. What is the name
for a drug that causes congenital defects in embryos?
** Game 6, Round 10 - Challenge - Devil's Night
For some of us as a kid, Devil's Night was the night before
Halloween, when we used to go out and throw eggs at homes, soap
car windows, and do bad things with firecrackers and dog doodoo.
What little devils we were!
Here, some questions that vaguely reference devils.
* A. Entertainment: Devil Movies
In each case, give the title of the movie.
A1. This 1997 movie follows Keanu Reeves as a lawyer who gets
hired by a large firm run by Al Pacino, who turns out to
be Satan himself.
A2. This 1987 movie follows Mickey Rourke as a private
investigator hired by Robert De Niro to track down crooner
Johnny Favorite, who has disappeared. Turns out De Niro
is Satan.
* B. Literature: See You in Hell
B1. In Dante's "Inferno", Dante voyages through the nine circles
of Hell. Who acts as his guide?
B2. And who is Dante's guide in "Paradiso", the closing epic
of the trilogy?
* C. History: Witch-Hunts
C1. The largest-scale witch-hunt ever recorded occurred during
the Spanish Inquisition in the 17th century. Over 7,000
people were examined by the Inquisition in which Spanish
region?
C2. The British Witchcraft Act of 1735 was largely responsible
for laying the groundwork of how to persecute witches and
other spiritual mediums. What was the last year a person was
convicted under this act in the UK -- give or take 15 years?
* D. Geography: Hotter than Hell
D1. Now that a record once claimed by Libya has been discredited,
the hottest temperature ever legitimately recorded happened
in the United States in 1917. The record temperature was
134°F (56.7°C). Where did that happen? Be sufficiently
specific -- not just the state.
D2. The above record has also been disputed as inaccurate.
The next hottest claim is 54°C in the city of Mitribah --
in which Persian Gulf country?
* E. Sports: New Jersey Devils
E1. In 1982 John McCullen bought an existing NHL franchise and
moved it to Newark, renaming it the New Jersey Devils.
What was the team called when he bought it? Full name
required, like "New Jersey Devils". Hint: a current MLB
franchise has the same name.
E2. This player wound up on the New Jersey Devils in 1991 as
trade compensation from the St. Louis Blues. He would
captain the team from 1992 to 2004, during which time they
would win three Stanley Cups. He was elected into the hall
of fame in 2007. Name him.
* F. Miscellaneous: The Devil You Know
In 1589 German theologian Peter Binsfeld classified the greatest
devils and demons as the "Seven Princes of Hell", and associated
them each to one of the Seven Deadly Sins.
F1. Pride was associated with this devil. His name is rendered
from the name "Isaiah" in Hebrew, and means "Light-Bringer"
in Latin. Name that devil!
F2. Gluttony was associated with this devil, whose name is a
literal translation of "Lord of the Flies". He is named
in the several books of the Bible. Name that devil!
--
Mark Brader, Toronto | "Here I sit, ego the size of a planet..."
m...@vex.net | --Steve Summit (after Douglas Adams)
My text in this article is in the public domain.
Dan Blum
Dec 4, 2017, 9:51:13 AM12/4/17
to
> 1. Pharmacology is the study of drugs, and is generally broken
> into two areas of study. Pharmacodynamics is the study of the
> action of drugs in the body. The other studies the rates of drug
> distribution and concentration in the body -- what is it called?
pharmacokinetics
> into two areas of study. Pharmacodynamics is the study of the
> action of drugs in the body. The other studies the rates of drug
> distribution and concentration in the body -- what is it called?
> 2. When we take a drug, it first must be absorbed into the
> bloodstream and distributed to its target location. What is
> the term for the proportion of drug that enters circulation
> and so is able to have an effect?
> 3. A large factor that affects <answer 2> is the first-pass effect.
> This describes the loss of drug after due to filtering that
> takes place after it is digested, which in some cases can
> greatly reduce drug concentration. This filtering takes place
> in which organ(s)?
> 4. The majority of drugs work by binding to and altering the
> normal activity receptors in the human body. Some will increase
> the receptor's normal activity; others will block or decrease it.
> Thus they are classified into two groups: name either one.
> 5. This neurodegenerative disease is based on a breakdown of
> dopaminergic neurons in the brain causing a lack of control of
> movement in the sufferer. Drugs used to treat this disease act
> to increase dopamine in the system, such as L-Dopa or Carbidopa.
> What is the disease?
> 6. Anti-neoplastics are drugs are targeted to impede cell growth,
> usually by killing the cell and stopping replication. They
> employ a wide range of mechanisms, such as the antimetabolite
> methotrexate, or using antibodies such as traztuzumab to target
> specific cells. What condition are anti-neoplastics used for?
> 7. This drug group acts directly by blocking receptors to prevent
> allergy symptoms. The first generation of drugs would enter
> the central nervous system and so made the user sleepier.
> The second generation's structures were far more selective in
> their target and so are termed non-drowsy. What is this class
> of drugs known as?
> 8. Adrenergic receptors in the heart greatly effect rates and force
> of contractions in the heart. By inhibiting certain receptors
> using drugs such as propranolol or metoprolol, you can reduce
> heart rate and oxygen demand; this is used to treat those with
> arrhythmias or coronary artery disease. What are these drugs
> known as?
> 9. Diuretics such as furosemide, torasemide, and mannitol are
> used for the treatment of hypertension. By decreasing the
> sodium concentrations in the bloodstream the total amount of
> volume in the bloodstream is decreased, relieving pressure in
> the peripheral arteries. Where in the body do diuretics act?
> 10. A special topic in pharmacology is looking at how drugs affect
> embryos in development. While most drugs are safe for fetuses
> at certain concentrations, some are not: a famous example was
> the drug thalidomide, used during the 1960s. What is the name
> for a drug that causes congenital defects in embryos?
> ** Game 6, Round 10 - Challenge - Devil's Night
> * B. Literature: See You in Hell
> B1. In Dante's "Inferno", Dante voyages through the nine circles
> of Hell. Who acts as his guide?
Virgil
> B1. In Dante's "Inferno", Dante voyages through the nine circles
> of Hell. Who acts as his guide?
> B2. And who is Dante's guide in "Paradiso", the closing epic
> of the trilogy?
> * C. History: Witch-Hunts
> C1. The largest-scale witch-hunt ever recorded occurred during
> the Spanish Inquisition in the 17th century. Over 7,000
> people were examined by the Inquisition in which Spanish
> region?
> C2. The British Witchcraft Act of 1735 was largely responsible
> for laying the groundwork of how to persecute witches and
> other spiritual mediums. What was the last year a person was
> convicted under this act in the UK -- give or take 15 years?
> * D. Geography: Hotter than Hell
> D1. Now that a record once claimed by Libya has been discredited,
> the hottest temperature ever legitimately recorded happened
> in the United States in 1917. The record temperature was
> specific -- not just the state.
Death Valley
> D2. The above record has also been disputed as inaccurate.
> in which Persian Gulf country?
Oman; Qatar
> * F. Miscellaneous: The Devil You Know
> F1. Pride was associated with this devil. His name is rendered
> from the name "Isaiah" in Hebrew, and means "Light-Bringer"
> in Latin. Name that devil!
Lucifer
> from the name "Isaiah" in Hebrew, and means "Light-Bringer"
> in Latin. Name that devil!
> F2. Gluttony was associated with this devil, whose name is a
> literal translation of "Lord of the Flies". He is named
> in the several books of the Bible. Name that devil!
--
_______________________________________________________________________
Dan Blum to...@panix.com
"I wouldn't have believed it myself if I hadn't just made it up."
Peter Smyth
Dec 4, 2017, 10:35:53 AM12/4/17
to
> 2. When we take a drug, it first must be absorbed into the
> bloodstream and distributed to its target location. What is
> the term for the proportion of drug that enters circulation
> and so is able to have an effect?
Bioavailability
> bloodstream and distributed to its target location. What is
> the term for the proportion of drug that enters circulation
> and so is able to have an effect?
> 3. A large factor that affects <answer 2> is the first-pass effect.
> This describes the loss of drug after due to filtering that
> takes place after it is digested, which in some cases can
> greatly reduce drug concentration. This filtering takes place
> in which organ(s)?
Liver
> This describes the loss of drug after due to filtering that
> takes place after it is digested, which in some cases can
> greatly reduce drug concentration. This filtering takes place
> in which organ(s)?
> 4. The majority of drugs work by binding to and altering the
> normal activity receptors in the human body. Some will increase
> the receptor's normal activity; others will block or decrease it.
> Thus they are classified into two groups: name either one.
Antagonist
> normal activity receptors in the human body. Some will increase
> the receptor's normal activity; others will block or decrease it.
> Thus they are classified into two groups: name either one.
> 5. This neurodegenerative disease is based on a breakdown of
> dopaminergic neurons in the brain causing a lack of control of
> movement in the sufferer. Drugs used to treat this disease act
> to increase dopamine in the system, such as L-Dopa or Carbidopa.
> What is the disease?
Parkinson's
> dopaminergic neurons in the brain causing a lack of control of
> movement in the sufferer. Drugs used to treat this disease act
> to increase dopamine in the system, such as L-Dopa or Carbidopa.
> What is the disease?
> 6. Anti-neoplastics are drugs are targeted to impede cell growth,
> usually by killing the cell and stopping replication. They
> employ a wide range of mechanisms, such as the antimetabolite
> methotrexate, or using antibodies such as traztuzumab to target
> specific cells. What condition are anti-neoplastics used for?
Cancer
> usually by killing the cell and stopping replication. They
> employ a wide range of mechanisms, such as the antimetabolite
> methotrexate, or using antibodies such as traztuzumab to target
> specific cells. What condition are anti-neoplastics used for?
> 7. This drug group acts directly by blocking receptors to prevent
> allergy symptoms. The first generation of drugs would enter
> the central nervous system and so made the user sleepier.
> The second generation's structures were far more selective in
> their target and so are termed non-drowsy. What is this class
> of drugs known as?
Antihistamines
> allergy symptoms. The first generation of drugs would enter
> the central nervous system and so made the user sleepier.
> The second generation's structures were far more selective in
> their target and so are termed non-drowsy. What is this class
> of drugs known as?
> 8. Adrenergic receptors in the heart greatly effect rates and force
> of contractions in the heart. By inhibiting certain receptors
> using drugs such as propranolol or metoprolol, you can reduce
> heart rate and oxygen demand; this is used to treat those with
> arrhythmias or coronary artery disease. What are these drugs
> known as?
Beta Blocker
> of contractions in the heart. By inhibiting certain receptors
> using drugs such as propranolol or metoprolol, you can reduce
> heart rate and oxygen demand; this is used to treat those with
> arrhythmias or coronary artery disease. What are these drugs
> known as?
> 9. Diuretics such as furosemide, torasemide, and mannitol are
> used for the treatment of hypertension. By decreasing the
> sodium concentrations in the bloodstream the total amount of
> volume in the bloodstream is decreased, relieving pressure in
> the peripheral arteries. Where in the body do diuretics act?
Kidney
> used for the treatment of hypertension. By decreasing the
> sodium concentrations in the bloodstream the total amount of
> volume in the bloodstream is decreased, relieving pressure in
> the peripheral arteries. Where in the body do diuretics act?
> 10. A special topic in pharmacology is looking at how drugs affect
> embryos in development. While most drugs are safe for fetuses
> at certain concentrations, some are not: a famous example was
> the drug thalidomide, used during the 1960s. What is the name
> for a drug that causes congenital defects in embryos?
Teratogen
> embryos in development. While most drugs are safe for fetuses
> at certain concentrations, some are not: a famous example was
> the drug thalidomide, used during the 1960s. What is the name
> for a drug that causes congenital defects in embryos?
>
> * D. Geography: Hotter than Hell
>
> D1. Now that a record once claimed by Libya has been discredited,
> the hottest temperature ever legitimately recorded happened
> in the United States in 1917. The record temperature was
> 134蚌 (56.7蚓). Where did that happen? Be sufficiently
> * D. Geography: Hotter than Hell
>
> D1. Now that a record once claimed by Libya has been discredited,
> the hottest temperature ever legitimately recorded happened
> in the United States in 1917. The record temperature was
> specific -- not just the state.
Death Valley, CA
> D2. The above record has also been disputed as inaccurate.
> The next hottest claim is 54蚓 in the city of Mitribah --
> in which Persian Gulf country?
Saudi Arabia
>
> * E. Sports: New Jersey Devils
>
> E1. In 1982 John McCullen bought an existing NHL franchise and
> moved it to Newark, renaming it the New Jersey Devils.
> What was the team called when he bought it? Full name
> required, like "New Jersey Devils". Hint: a current MLB
> franchise has the same name.
>
> E2. This player wound up on the New Jersey Devils in 1991 as
> trade compensation from the St. Louis Blues. He would
> captain the team from 1992 to 2004, during which time they
> would win three Stanley Cups. He was elected into the hall
> of fame in 2007. Name him.
>
>
> * F. Miscellaneous: The Devil You Know
>
> In 1589 German theologian Peter Binsfeld classified the greatest
> devils and demons as the "Seven Princes of Hell", and associated
> them each to one of the Seven Deadly Sins.
>
> F1. Pride was associated with this devil. His name is rendered
> from the name "Isaiah" in Hebrew, and means "Light-Bringer"
> in Latin. Name that devil!
Lucifer, Beelzebub
> * E. Sports: New Jersey Devils
>
> E1. In 1982 John McCullen bought an existing NHL franchise and
> moved it to Newark, renaming it the New Jersey Devils.
> What was the team called when he bought it? Full name
> required, like "New Jersey Devils". Hint: a current MLB
> franchise has the same name.
>
> E2. This player wound up on the New Jersey Devils in 1991 as
> trade compensation from the St. Louis Blues. He would
> captain the team from 1992 to 2004, during which time they
> would win three Stanley Cups. He was elected into the hall
> of fame in 2007. Name him.
>
>
> * F. Miscellaneous: The Devil You Know
>
> In 1589 German theologian Peter Binsfeld classified the greatest
> devils and demons as the "Seven Princes of Hell", and associated
> them each to one of the Seven Deadly Sins.
>
> F1. Pride was associated with this devil. His name is rendered
> from the name "Isaiah" in Hebrew, and means "Light-Bringer"
> in Latin. Name that devil!
> F2. Gluttony was associated with this devil, whose name is a
> literal translation of "Lord of the Flies". He is named
> in the several books of the Bible. Name that devil!
Lucifer, Beelzebub
> literal translation of "Lord of the Flies". He is named
> in the several books of the Bible. Name that devil!
Peter Smyth
Dan Tilque
Dec 4, 2017, 11:30:15 AM12/4/17
to
>
> 2. When we take a drug, it first must be absorbed into the
> bloodstream and distributed to its target location. What is
> the term for the proportion of drug that enters circulation
> and so is able to have an effect?
>
> 3. A large factor that affects <answer 2> is the first-pass effect.
> This describes the loss of drug after due to filtering that
> takes place after it is digested, which in some cases can
> greatly reduce drug concentration. This filtering takes place
> in which organ(s)?
>
> 4. The majority of drugs work by binding to and altering the
> normal activity receptors in the human body. Some will increase
> the receptor's normal activity; others will block or decrease it.
> Thus they are classified into two groups: name either one.
>
> 5. This neurodegenerative disease is based on a breakdown of
> dopaminergic neurons in the brain causing a lack of control of
> movement in the sufferer. Drugs used to treat this disease act
> to increase dopamine in the system, such as L-Dopa or Carbidopa.
> What is the disease?
>
> 6. Anti-neoplastics are drugs are targeted to impede cell growth,
> usually by killing the cell and stopping replication. They
> employ a wide range of mechanisms, such as the antimetabolite
> methotrexate, or using antibodies such as traztuzumab to target
> specific cells. What condition are anti-neoplastics used for?
>
> 7. This drug group acts directly by blocking receptors to prevent
> allergy symptoms. The first generation of drugs would enter
> the central nervous system and so made the user sleepier.
> The second generation's structures were far more selective in
> their target and so are termed non-drowsy. What is this class
> of drugs known as?
>
> 8. Adrenergic receptors in the heart greatly effect rates and force
> of contractions in the heart. By inhibiting certain receptors
> using drugs such as propranolol or metoprolol, you can reduce
> heart rate and oxygen demand; this is used to treat those with
> arrhythmias or coronary artery disease. What are these drugs
> known as?
>
> 9. Diuretics such as furosemide, torasemide, and mannitol are
> used for the treatment of hypertension. By decreasing the
> sodium concentrations in the bloodstream the total amount of
> volume in the bloodstream is decreased, relieving pressure in
> the peripheral arteries. Where in the body do diuretics act?
>
> 10. A special topic in pharmacology is looking at how drugs affect
> embryos in development. While most drugs are safe for fetuses
> at certain concentrations, some are not: a famous example was
> the drug thalidomide, used during the 1960s. What is the name
> for a drug that causes congenital defects in embryos?
>
>
> ** Game 6, Round 10 - Challenge - Devil's Night
>
> For some of us as a kid, Devil's Night was the night before
> Halloween, when we used to go out and throw eggs at homes, soap
> car windows, and do bad things with firecrackers and dog doodoo.
> What little devils we were!
>
> Here, some questions that vaguely reference devils.
>
> * A. Entertainment: Devil Movies
>
> In each case, give the title of the movie.
>
> A1. This 1997 movie follows Keanu Reeves as a lawyer who gets
> hired by a large firm run by Al Pacino, who turns out to
> be Satan himself.
>
> A2. This 1987 movie follows Mickey Rourke as a private
> investigator hired by Robert De Niro to track down crooner
> Johnny Favorite, who has disappeared. Turns out De Niro
> is Satan.
>
>
> * B. Literature: See You in Hell
>
> B1. In Dante's "Inferno", Dante voyages through the nine circles
> of Hell. Who acts as his guide?
>
> B2. And who is Dante's guide in "Paradiso", the closing epic
> of the trilogy?
>
>
> * C. History: Witch-Hunts
>
> C1. The largest-scale witch-hunt ever recorded occurred during
> the Spanish Inquisition in the 17th century. Over 7,000
> people were examined by the Inquisition in which Spanish
> region?
(bet they weren't expecting it)
>
> C2. The British Witchcraft Act of 1735 was largely responsible
> for laying the groundwork of how to persecute witches and
> other spiritual mediums. What was the last year a person was
> convicted under this act in the UK -- give or take 15 years?
>
>
> * D. Geography: Hotter than Hell
>
> D1. Now that a record once claimed by Libya has been discredited,
> the hottest temperature ever legitimately recorded happened
> in the United States in 1917. The record temperature was
> specific -- not just the state.
Death Valley
>
> D2. The above record has also been disputed as inaccurate.
> in which Persian Gulf country?
Bahrain
>
>
> * E. Sports: New Jersey Devils
>
> E1. In 1982 John McCullen bought an existing NHL franchise and
> moved it to Newark, renaming it the New Jersey Devils.
> What was the team called when he bought it? Full name
> required, like "New Jersey Devils". Hint: a current MLB
> franchise has the same name.
>
> E2. This player wound up on the New Jersey Devils in 1991 as
> trade compensation from the St. Louis Blues. He would
> captain the team from 1992 to 2004, during which time they
> would win three Stanley Cups. He was elected into the hall
> of fame in 2007. Name him.
>
>
> * F. Miscellaneous: The Devil You Know
>
> In 1589 German theologian Peter Binsfeld classified the greatest
> devils and demons as the "Seven Princes of Hell", and associated
> them each to one of the Seven Deadly Sins.
>
> F1. Pride was associated with this devil. His name is rendered
> from the name "Isaiah" in Hebrew, and means "Light-Bringer"
> in Latin. Name that devil!
>
> F2. Gluttony was associated with this devil, whose name is a
> literal translation of "Lord of the Flies". He is named
> in the several books of the Bible. Name that devil!
--
Dan Tilque
Bruce Bowler
Dec 4, 2017, 4:05:22 PM12/4/17
to
> 2. When we take a drug, it first must be absorbed into the
> bloodstream and distributed to its target location. What is the term
> for the proportion of drug that enters circulation and so is able to
> have an effect?
> 3. A large factor that affects <answer 2> is the first-pass effect.
> This describes the loss of drug after due to filtering that takes
> place after it is digested, which in some cases can greatly reduce
> drug concentration. This filtering takes place in which organ(s)?
> 4. The majority of drugs work by binding to and altering the
> normal activity receptors in the human body. Some will increase the
> receptor's normal activity; others will block or decrease it.
> Thus they are classified into two groups: name either one.
> 5. This neurodegenerative disease is based on a breakdown of
> dopaminergic neurons in the brain causing a lack of control of
> movement in the sufferer. Drugs used to treat this disease act to
> increase dopamine in the system, such as L-Dopa or Carbidopa. What is
> the disease?
> 6. Anti-neoplastics are drugs are targeted to impede cell growth,
> usually by killing the cell and stopping replication. They employ a
> wide range of mechanisms, such as the antimetabolite methotrexate, or
> using antibodies such as traztuzumab to target specific cells. What
> condition are anti-neoplastics used for?
> 7. This drug group acts directly by blocking receptors to prevent
> allergy symptoms. The first generation of drugs would enter the
> central nervous system and so made the user sleepier.
> The second generation's structures were far more selective in their
> target and so are termed non-drowsy. What is this class of drugs
> known as?
> 8. Adrenergic receptors in the heart greatly effect rates and force
> of contractions in the heart. By inhibiting certain receptors using
> drugs such as propranolol or metoprolol, you can reduce heart rate
> and oxygen demand; this is used to treat those with arrhythmias or
> coronary artery disease. What are these drugs known as?
> 9. Diuretics such as furosemide, torasemide, and mannitol are
> used for the treatment of hypertension. By decreasing the sodium
> concentrations in the bloodstream the total amount of volume in the
> bloodstream is decreased, relieving pressure in the peripheral
> arteries. Where in the body do diuretics act?
> 10. A special topic in pharmacology is looking at how drugs affect
> embryos in development. While most drugs are safe for fetuses at
> certain concentrations, some are not: a famous example was the drug
> thalidomide, used during the 1960s. What is the name for a drug that
> causes congenital defects in embryos?
> D2. The above record has also been disputed as inaccurate.
> The next hottest claim is 54°C in the city of Mitribah -- in
> which Persian Gulf country?
>
>
> * E. Sports: New Jersey Devils
>
> E1. In 1982 John McCullen bought an existing NHL franchise and
> moved it to Newark, renaming it the New Jersey Devils.
> What was the team called when he bought it? Full name required,
> like "New Jersey Devils". Hint: a current MLB franchise has the
> same name.
>
> E2. This player wound up on the New Jersey Devils in 1991 as
> trade compensation from the St. Louis Blues. He would captain
> the team from 1992 to 2004, during which time they would win
> three Stanley Cups. He was elected into the hall of fame in
> 2007. Name him.
>
>
> * F. Miscellaneous: The Devil You Know
>
> In 1589 German theologian Peter Binsfeld classified the greatest devils
> and demons as the "Seven Princes of Hell", and associated them each to
> one of the Seven Deadly Sins.
>
> F1. Pride was associated with this devil. His name is rendered
> from the name "Isaiah" in Hebrew, and means "Light-Bringer" in
> Latin. Name that devil!
>
> F2. Gluttony was associated with this devil, whose name is a
> literal translation of "Lord of the Flies". He is named in the
> several books of the Bible. Name that devil!
Pete Gayde
Dec 4, 2017, 11:03:30 PM12/4/17
to
m...@vex.net (Mark Brader) wrote in news:SsmdnazuN8bvvbjHnZ2dnUU7-
InN...@giganews.com:
Pharmacokinetics
>
> 2. When we take a drug, it first must be absorbed into the
> bloodstream and distributed to its target location. What is
> the term for the proportion of drug that enters circulation
> and so is able to have an effect?
Therapeutic Index; Bioavailability
>
> 3. A large factor that affects <answer 2> is the first-pass effect.
> This describes the loss of drug after due to filtering that
> takes place after it is digested, which in some cases can
> greatly reduce drug concentration. This filtering takes place
> in which organ(s)?
Kidneys; Liver
>
> 4. The majority of drugs work by binding to and altering the
> normal activity receptors in the human body. Some will increase
> the receptor's normal activity; others will block or decrease it.
> Thus they are classified into two groups: name either one.
Leukotrienes
>
> 5. This neurodegenerative disease is based on a breakdown of
> dopaminergic neurons in the brain causing a lack of control of
> movement in the sufferer. Drugs used to treat this disease act
> to increase dopamine in the system, such as L-Dopa or Carbidopa.
> What is the disease?
Parkinson's
>
> 6. Anti-neoplastics are drugs are targeted to impede cell growth,
> usually by killing the cell and stopping replication. They
> employ a wide range of mechanisms, such as the antimetabolite
> methotrexate, or using antibodies such as traztuzumab to target
> specific cells. What condition are anti-neoplastics used for?
Cancer
>
> 7. This drug group acts directly by blocking receptors to prevent
> allergy symptoms. The first generation of drugs would enter
> the central nervous system and so made the user sleepier.
> The second generation's structures were far more selective in
> their target and so are termed non-drowsy. What is this class
> of drugs known as?
Antihistamines
>
> 8. Adrenergic receptors in the heart greatly effect rates and force
> of contractions in the heart. By inhibiting certain receptors
> using drugs such as propranolol or metoprolol, you can reduce
> heart rate and oxygen demand; this is used to treat those with
> arrhythmias or coronary artery disease. What are these drugs
> known as?
Vasodilator
>
> 9. Diuretics such as furosemide, torasemide, and mannitol are
> used for the treatment of hypertension. By decreasing the
> sodium concentrations in the bloodstream the total amount of
> volume in the bloodstream is decreased, relieving pressure in
> the peripheral arteries. Where in the body do diuretics act?
Kidneys; Liver
>
> 10. A special topic in pharmacology is looking at how drugs affect
> embryos in development. While most drugs are safe for fetuses
> at certain concentrations, some are not: a famous example was
> the drug thalidomide, used during the 1960s. What is the name
> for a drug that causes congenital defects in embryos?
Vasopressin
Basque; Catalonia
>
> C2. The British Witchcraft Act of 1735 was largely responsible
> for laying the groundwork of how to persecute witches and
> other spiritual mediums. What was the last year a person was
> convicted under this act in the UK -- give or take 15 years?
1810; 1841
>
>
> * D. Geography: Hotter than Hell
>
> D1. Now that a record once claimed by Libya has been discredited,
> the hottest temperature ever legitimately recorded happened
> in the United States in 1917. The record temperature was
> 134°F (56.7°C). Where did that happen? Be sufficiently
> specific -- not just the state.
Death Valley
>
> D2. The above record has also been disputed as inaccurate.
> The next hottest claim is 54°C in the city of Mitribah --
> in which Persian Gulf country?
Qatar; Bahrain
>
>
> * E. Sports: New Jersey Devils
>
> E1. In 1982 John McCullen bought an existing NHL franchise and
> moved it to Newark, renaming it the New Jersey Devils.
> What was the team called when he bought it? Full name
> required, like "New Jersey Devils". Hint: a current MLB
> franchise has the same name.
Colorado Rockies
>
> E2. This player wound up on the New Jersey Devils in 1991 as
> trade compensation from the St. Louis Blues. He would
> captain the team from 1992 to 2004, during which time they
> would win three Stanley Cups. He was elected into the hall
> of fame in 2007. Name him.
Niedermayer
>
>
> * F. Miscellaneous: The Devil You Know
>
> In 1589 German theologian Peter Binsfeld classified the greatest
> devils and demons as the "Seven Princes of Hell", and associated
> them each to one of the Seven Deadly Sins.
>
> F1. Pride was associated with this devil. His name is rendered
> from the name "Isaiah" in Hebrew, and means "Light-Bringer"
> in Latin. Name that devil!
Beelzebub
>
> F2. Gluttony was associated with this devil, whose name is a
> literal translation of "Lord of the Flies". He is named
> in the several books of the Bible. Name that devil!
Beelzebub
>
Pete Gayde
InN...@giganews.com:
>
> 2. When we take a drug, it first must be absorbed into the
> bloodstream and distributed to its target location. What is
> the term for the proportion of drug that enters circulation
> and so is able to have an effect?
>
> 3. A large factor that affects <answer 2> is the first-pass effect.
> This describes the loss of drug after due to filtering that
> takes place after it is digested, which in some cases can
> greatly reduce drug concentration. This filtering takes place
> in which organ(s)?
>
> 4. The majority of drugs work by binding to and altering the
> normal activity receptors in the human body. Some will increase
> the receptor's normal activity; others will block or decrease it.
> Thus they are classified into two groups: name either one.
>
> 5. This neurodegenerative disease is based on a breakdown of
> dopaminergic neurons in the brain causing a lack of control of
> movement in the sufferer. Drugs used to treat this disease act
> to increase dopamine in the system, such as L-Dopa or Carbidopa.
> What is the disease?
>
> 6. Anti-neoplastics are drugs are targeted to impede cell growth,
> usually by killing the cell and stopping replication. They
> employ a wide range of mechanisms, such as the antimetabolite
> methotrexate, or using antibodies such as traztuzumab to target
> specific cells. What condition are anti-neoplastics used for?
>
> 7. This drug group acts directly by blocking receptors to prevent
> allergy symptoms. The first generation of drugs would enter
> the central nervous system and so made the user sleepier.
> The second generation's structures were far more selective in
> their target and so are termed non-drowsy. What is this class
> of drugs known as?
>
> 8. Adrenergic receptors in the heart greatly effect rates and force
> of contractions in the heart. By inhibiting certain receptors
> using drugs such as propranolol or metoprolol, you can reduce
> heart rate and oxygen demand; this is used to treat those with
> arrhythmias or coronary artery disease. What are these drugs
> known as?
>
> 9. Diuretics such as furosemide, torasemide, and mannitol are
> used for the treatment of hypertension. By decreasing the
> sodium concentrations in the bloodstream the total amount of
> volume in the bloodstream is decreased, relieving pressure in
> the peripheral arteries. Where in the body do diuretics act?
>
> 10. A special topic in pharmacology is looking at how drugs affect
> embryos in development. While most drugs are safe for fetuses
> at certain concentrations, some are not: a famous example was
> the drug thalidomide, used during the 1960s. What is the name
> for a drug that causes congenital defects in embryos?
>
> C2. The British Witchcraft Act of 1735 was largely responsible
> for laying the groundwork of how to persecute witches and
> other spiritual mediums. What was the last year a person was
> convicted under this act in the UK -- give or take 15 years?
>
>
> * D. Geography: Hotter than Hell
>
> D1. Now that a record once claimed by Libya has been discredited,
> the hottest temperature ever legitimately recorded happened
> in the United States in 1917. The record temperature was
> 134°F (56.7°C). Where did that happen? Be sufficiently
> specific -- not just the state.
>
> D2. The above record has also been disputed as inaccurate.
> The next hottest claim is 54°C in the city of Mitribah --
> in which Persian Gulf country?
>
>
> * E. Sports: New Jersey Devils
>
> E1. In 1982 John McCullen bought an existing NHL franchise and
> moved it to Newark, renaming it the New Jersey Devils.
> What was the team called when he bought it? Full name
> required, like "New Jersey Devils". Hint: a current MLB
> franchise has the same name.
>
> E2. This player wound up on the New Jersey Devils in 1991 as
> trade compensation from the St. Louis Blues. He would
> captain the team from 1992 to 2004, during which time they
> would win three Stanley Cups. He was elected into the hall
> of fame in 2007. Name him.
>
>
> * F. Miscellaneous: The Devil You Know
>
> In 1589 German theologian Peter Binsfeld classified the greatest
> devils and demons as the "Seven Princes of Hell", and associated
> them each to one of the Seven Deadly Sins.
>
> F1. Pride was associated with this devil. His name is rendered
> from the name "Isaiah" in Hebrew, and means "Light-Bringer"
> in Latin. Name that devil!
>
> F2. Gluttony was associated with this devil, whose name is a
> literal translation of "Lord of the Flies". He is named
> in the several books of the Bible. Name that devil!
>
Pete Gayde
Joshua Kreitzer
Dec 5, 2017, 12:56:37 AM12/5/17
to
> ** Game 6, Round 9 - Science - Drugs
>
> The following is a round on the science and study of drugs.
>
>
> The following is a round on the science and study of drugs.
>
> 1. Pharmacology is the study of drugs, and is generally broken
> into two areas of study. Pharmacodynamics is the study of the
> action of drugs in the body. The other studies the rates of drug
> distribution and concentration in the body -- what is it called?
pharmacokinetics
> into two areas of study. Pharmacodynamics is the study of the
> action of drugs in the body. The other studies the rates of drug
> distribution and concentration in the body -- what is it called?
> 2. When we take a drug, it first must be absorbed into the
> bloodstream and distributed to its target location. What is
> the term for the proportion of drug that enters circulation
> and so is able to have an effect?
> 3. A large factor that affects <answer 2> is the first-pass effect.
> This describes the loss of drug after due to filtering that
> takes place after it is digested, which in some cases can
> greatly reduce drug concentration. This filtering takes place
> in which organ(s)?
> 4. The majority of drugs work by binding to and altering the
> normal activity receptors in the human body. Some will increase
> the receptor's normal activity; others will block or decrease it.
> Thus they are classified into two groups: name either one.
> 5. This neurodegenerative disease is based on a breakdown of
> dopaminergic neurons in the brain causing a lack of control of
> movement in the sufferer. Drugs used to treat this disease act
> to increase dopamine in the system, such as L-Dopa or Carbidopa.
> What is the disease?
> 6. Anti-neoplastics are drugs are targeted to impede cell growth,
> usually by killing the cell and stopping replication. They
> employ a wide range of mechanisms, such as the antimetabolite
> methotrexate, or using antibodies such as traztuzumab to target
> specific cells. What condition are anti-neoplastics used for?
> 7. This drug group acts directly by blocking receptors to prevent
> allergy symptoms. The first generation of drugs would enter
> the central nervous system and so made the user sleepier.
> The second generation's structures were far more selective in
> their target and so are termed non-drowsy. What is this class
> of drugs known as?
> 8. Adrenergic receptors in the heart greatly effect rates and force
> of contractions in the heart. By inhibiting certain receptors
> using drugs such as propranolol or metoprolol, you can reduce
> heart rate and oxygen demand; this is used to treat those with
> arrhythmias or coronary artery disease. What are these drugs
> known as?
> 9. Diuretics such as furosemide, torasemide, and mannitol are
> used for the treatment of hypertension. By decreasing the
> sodium concentrations in the bloodstream the total amount of
> volume in the bloodstream is decreased, relieving pressure in
> the peripheral arteries. Where in the body do diuretics act?
> 10. A special topic in pharmacology is looking at how drugs affect
> embryos in development. While most drugs are safe for fetuses
> at certain concentrations, some are not: a famous example was
> the drug thalidomide, used during the 1960s. What is the name
> for a drug that causes congenital defects in embryos?
> ** Game 6, Round 10 - Challenge - Devil's Night
>
> Here, some questions that vaguely reference devils.
>
> * A. Entertainment: Devil Movies
>
> In each case, give the title of the movie.
>
> A1. This 1997 movie follows Keanu Reeves as a lawyer who gets
> hired by a large firm run by Al Pacino, who turns out to
> be Satan himself.
"The Devil's Advocate"
>
> * A. Entertainment: Devil Movies
>
> In each case, give the title of the movie.
>
> A1. This 1997 movie follows Keanu Reeves as a lawyer who gets
> hired by a large firm run by Al Pacino, who turns out to
> be Satan himself.
> A2. This 1987 movie follows Mickey Rourke as a private
> investigator hired by Robert De Niro to track down crooner
> Johnny Favorite, who has disappeared. Turns out De Niro
> is Satan.
> * B. Literature: See You in Hell
>
> B1. In Dante's "Inferno", Dante voyages through the nine circles
> of Hell. Who acts as his guide?
> B2. And who is Dante's guide in "Paradiso", the closing epic
> of the trilogy?
> * C. History: Witch-Hunts
>
> C1. The largest-scale witch-hunt ever recorded occurred during
> the Spanish Inquisition in the 17th century. Over 7,000
> people were examined by the Inquisition in which Spanish
> region?
> C2. The British Witchcraft Act of 1735 was largely responsible
> for laying the groundwork of how to persecute witches and
> other spiritual mediums. What was the last year a person was
> convicted under this act in the UK -- give or take 15 years?
> * D. Geography: Hotter than Hell
>
> D1. Now that a record once claimed by Libya has been discredited,
> the hottest temperature ever legitimately recorded happened
> in the United States in 1917. The record temperature was
> specific -- not just the state.
Death Valley (in California)
> D2. The above record has also been disputed as inaccurate.
> in which Persian Gulf country?
Saudi Arabia; Oman
> * E. Sports: New Jersey Devils
>
> E1. In 1982 John McCullen bought an existing NHL franchise and
> moved it to Newark, renaming it the New Jersey Devils.
> What was the team called when he bought it? Full name
> required, like "New Jersey Devils". Hint: a current MLB
> franchise has the same name.
> * F. Miscellaneous: The Devil You Know
>
> In 1589 German theologian Peter Binsfeld classified the greatest
> devils and demons as the "Seven Princes of Hell", and associated
> them each to one of the Seven Deadly Sins.
>
> F1. Pride was associated with this devil. His name is rendered
> from the name "Isaiah" in Hebrew, and means "Light-Bringer"
> in Latin. Name that devil!
> F2. Gluttony was associated with this devil, whose name is a
> literal translation of "Lord of the Flies". He is named
> in the several books of the Bible. Name that devil!
--
Joshua Kreitzer
grom...@hotmail.com
Erland Sommarskog
Dec 5, 2017, 3:12:00 PM12/5/17
to
Mark Brader (m...@vex.net) writes:
> 1. Pharmacology is the study of drugs, and is generally broken
> into two areas of study. Pharmacodynamics is the study of the
> action of drugs in the body. The other studies the rates of drug
> distribution and concentration in the body -- what is it called?
Pharmacokinetics
> 1. Pharmacology is the study of drugs, and is generally broken
> into two areas of study. Pharmacodynamics is the study of the
> action of drugs in the body. The other studies the rates of drug
> distribution and concentration in the body -- what is it called?
> 2. When we take a drug, it first must be absorbed into the
> bloodstream and distributed to its target location. What is
> the term for the proportion of drug that enters circulation
> and so is able to have an effect?
> 3. A large factor that affects <answer 2> is the first-pass effect.
> This describes the loss of drug after due to filtering that
> takes place after it is digested, which in some cases can
> greatly reduce drug concentration. This filtering takes place
> in which organ(s)?
> 4. The majority of drugs work by binding to and altering the
> normal activity receptors in the human body. Some will increase
> the receptor's normal activity; others will block or decrease it.
> Thus they are classified into two groups: name either one.
> 5. This neurodegenerative disease is based on a breakdown of
> dopaminergic neurons in the brain causing a lack of control of
> movement in the sufferer. Drugs used to treat this disease act
> to increase dopamine in the system, such as L-Dopa or Carbidopa.
> What is the disease?
> 6. Anti-neoplastics are drugs are targeted to impede cell growth,
> usually by killing the cell and stopping replication. They
> employ a wide range of mechanisms, such as the antimetabolite
> methotrexate, or using antibodies such as traztuzumab to target
> specific cells. What condition are anti-neoplastics used for?
> 7. This drug group acts directly by blocking receptors to prevent
> allergy symptoms. The first generation of drugs would enter
> the central nervous system and so made the user sleepier.
> The second generation's structures were far more selective in
> their target and so are termed non-drowsy. What is this class
> of drugs known as?
>
> 8. Adrenergic receptors in the heart greatly effect rates and force
> of contractions in the heart. By inhibiting certain receptors
> using drugs such as propranolol or metoprolol, you can reduce
> heart rate and oxygen demand; this is used to treat those with
> arrhythmias or coronary artery disease. What are these drugs
> known as?
Beta-Blocker
> 8. Adrenergic receptors in the heart greatly effect rates and force
> of contractions in the heart. By inhibiting certain receptors
> using drugs such as propranolol or metoprolol, you can reduce
> heart rate and oxygen demand; this is used to treat those with
> arrhythmias or coronary artery disease. What are these drugs
> known as?
> 9. Diuretics such as furosemide, torasemide, and mannitol are
> used for the treatment of hypertension. By decreasing the
> sodium concentrations in the bloodstream the total amount of
> volume in the bloodstream is decreased, relieving pressure in
> the peripheral arteries. Where in the body do diuretics act?
> 10. A special topic in pharmacology is looking at how drugs affect
> embryos in development. While most drugs are safe for fetuses
> at certain concentrations, some are not: a famous example was
> the drug thalidomide, used during the 1960s. What is the name
> for a drug that causes congenital defects in embryos?
> ** Game 6, Round 10 - Challenge - Devil's Night
>
>
> C1. The largest-scale witch-hunt ever recorded occurred during
> the Spanish Inquisition in the 17th century. Over 7,000
> people were examined by the Inquisition in which Spanish
> region?
Castille
> the Spanish Inquisition in the 17th century. Over 7,000
> people were examined by the Inquisition in which Spanish
> region?
> C2. The British Witchcraft Act of 1735 was largely responsible
> for laying the groundwork of how to persecute witches and
> other spiritual mediums. What was the last year a person was
> convicted under this act in the UK -- give or take 15 years?
> * D. Geography: Hotter than Hell
>
> D1. Now that a record once claimed by Libya has been discredited,
> the hottest temperature ever legitimately recorded happened
> in the United States in 1917. The record temperature was
> 134°F (56.7°C). Where did that happen? Be sufficiently
> specific -- not just the state.
> D2. The above record has also been disputed as inaccurate.
> The next hottest claim is 54°C in the city of Mitribah --
> in which Persian Gulf country?
> E1. In 1982 John McCullen bought an existing NHL franchise and
> moved it to Newark, renaming it the New Jersey Devils.
> What was the team called when he bought it? Full name
> required, like "New Jersey Devils". Hint: a current MLB
> franchise has the same name.
Jason Kreitzer
Dec 6, 2017, 10:48:44 PM12/6/17
to
> 2. When we take a drug, it first must be absorbed into the
> bloodstream and distributed to its target location. What is
> the term for the proportion of drug that enters circulation
> and so is able to have an effect?
Bioavailability?
> bloodstream and distributed to its target location. What is
> the term for the proportion of drug that enters circulation
> and so is able to have an effect?
> 3. A large factor that affects <answer 2> is the first-pass effect.
> This describes the loss of drug after due to filtering that
> takes place after it is digested, which in some cases can
> greatly reduce drug concentration. This filtering takes place
> in which organ(s)?
Liver?
> This describes the loss of drug after due to filtering that
> takes place after it is digested, which in some cases can
> greatly reduce drug concentration. This filtering takes place
> in which organ(s)?
> 4. The majority of drugs work by binding to and altering the
> normal activity receptors in the human body. Some will increase
> the receptor's normal activity; others will block or decrease it.
> Thus they are classified into two groups: name either one.
Agonist?
> normal activity receptors in the human body. Some will increase
> the receptor's normal activity; others will block or decrease it.
> Thus they are classified into two groups: name either one.
> 5. This neurodegenerative disease is based on a breakdown of
> dopaminergic neurons in the brain causing a lack of control of
> movement in the sufferer. Drugs used to treat this disease act
> to increase dopamine in the system, such as L-Dopa or Carbidopa.
> What is the disease?
Parkinson's
> dopaminergic neurons in the brain causing a lack of control of
> movement in the sufferer. Drugs used to treat this disease act
> to increase dopamine in the system, such as L-Dopa or Carbidopa.
> What is the disease?
> 6. Anti-neoplastics are drugs are targeted to impede cell growth,
> usually by killing the cell and stopping replication. They
> employ a wide range of mechanisms, such as the antimetabolite
> methotrexate, or using antibodies such as traztuzumab to target
> specific cells. What condition are anti-neoplastics used for?
Huntington's?
> usually by killing the cell and stopping replication. They
> employ a wide range of mechanisms, such as the antimetabolite
> methotrexate, or using antibodies such as traztuzumab to target
> specific cells. What condition are anti-neoplastics used for?
> 7. This drug group acts directly by blocking receptors to prevent
> allergy symptoms. The first generation of drugs would enter
> the central nervous system and so made the user sleepier.
> The second generation's structures were far more selective in
> their target and so are termed non-drowsy. What is this class
> of drugs known as?
Antihistamines?
> allergy symptoms. The first generation of drugs would enter
> the central nervous system and so made the user sleepier.
> The second generation's structures were far more selective in
> their target and so are termed non-drowsy. What is this class
> of drugs known as?
> 8. Adrenergic receptors in the heart greatly effect rates and force
> of contractions in the heart. By inhibiting certain receptors
> using drugs such as propranolol or metoprolol, you can reduce
> heart rate and oxygen demand; this is used to treat those with
> arrhythmias or coronary artery disease. What are these drugs
> known as?
Beta Blockers?
> of contractions in the heart. By inhibiting certain receptors
> using drugs such as propranolol or metoprolol, you can reduce
> heart rate and oxygen demand; this is used to treat those with
> arrhythmias or coronary artery disease. What are these drugs
> known as?
> 9. Diuretics such as furosemide, torasemide, and mannitol are
> used for the treatment of hypertension. By decreasing the
> sodium concentrations in the bloodstream the total amount of
> volume in the bloodstream is decreased, relieving pressure in
> the peripheral arteries. Where in the body do diuretics act?
Heart?
> used for the treatment of hypertension. By decreasing the
> sodium concentrations in the bloodstream the total amount of
> volume in the bloodstream is decreased, relieving pressure in
> the peripheral arteries. Where in the body do diuretics act?
> 10. A special topic in pharmacology is looking at how drugs affect
> embryos in development. While most drugs are safe for fetuses
> at certain concentrations, some are not: a famous example was
> the drug thalidomide, used during the 1960s. What is the name
> for a drug that causes congenital defects in embryos?
Thalidomide
> embryos in development. While most drugs are safe for fetuses
> at certain concentrations, some are not: a famous example was
> the drug thalidomide, used during the 1960s. What is the name
> for a drug that causes congenital defects in embryos?
>
> ** Game 6, Round 10 - Challenge - Devil's Night
>
> For some of us as a kid, Devil's Night was the night before
> Halloween, when we used to go out and throw eggs at homes, soap
> car windows, and do bad things with firecrackers and dog doodoo.
> What little devils we were!
>
> Here, some questions that vaguely reference devils.
>
> * A. Entertainment: Devil Movies
>
> In each case, give the title of the movie.
>
> A1. This 1997 movie follows Keanu Reeves as a lawyer who gets
> hired by a large firm run by Al Pacino, who turns out to
> be Satan himself.
"The Devil's Advocate"
> ** Game 6, Round 10 - Challenge - Devil's Night
>
> For some of us as a kid, Devil's Night was the night before
> Halloween, when we used to go out and throw eggs at homes, soap
> car windows, and do bad things with firecrackers and dog doodoo.
> What little devils we were!
>
> Here, some questions that vaguely reference devils.
>
> * A. Entertainment: Devil Movies
>
> In each case, give the title of the movie.
>
> A1. This 1997 movie follows Keanu Reeves as a lawyer who gets
> hired by a large firm run by Al Pacino, who turns out to
> be Satan himself.
> A2. This 1987 movie follows Mickey Rourke as a private
> investigator hired by Robert De Niro to track down crooner
> Johnny Favorite, who has disappeared. Turns out De Niro
> is Satan.
"Angel Heart"
> investigator hired by Robert De Niro to track down crooner
> Johnny Favorite, who has disappeared. Turns out De Niro
> is Satan.
>
> * B. Literature: See You in Hell
>
> B1. In Dante's "Inferno", Dante voyages through the nine circles
> of Hell. Who acts as his guide?
>
> B2. And who is Dante's guide in "Paradiso", the closing epic
> of the trilogy?
>
>
> * C. History: Witch-Hunts
>
> C1. The largest-scale witch-hunt ever recorded occurred during
> the Spanish Inquisition in the 17th century. Over 7,000
> people were examined by the Inquisition in which Spanish
> region?
>
> C2. The British Witchcraft Act of 1735 was largely responsible
> for laying the groundwork of how to persecute witches and
> other spiritual mediums. What was the last year a person was
> convicted under this act in the UK -- give or take 15 years?
>
>
> * D. Geography: Hotter than Hell
>
> D1. Now that a record once claimed by Libya has been discredited,
> the hottest temperature ever legitimately recorded happened
> in the United States in 1917. The record temperature was
> 134°F (56.7°C). Where did that happen? Be sufficiently
> specific -- not just the state.
Death Valley, California
> * B. Literature: See You in Hell
>
> B1. In Dante's "Inferno", Dante voyages through the nine circles
> of Hell. Who acts as his guide?
>
> B2. And who is Dante's guide in "Paradiso", the closing epic
> of the trilogy?
>
>
> * C. History: Witch-Hunts
>
> C1. The largest-scale witch-hunt ever recorded occurred during
> the Spanish Inquisition in the 17th century. Over 7,000
> people were examined by the Inquisition in which Spanish
> region?
>
> C2. The British Witchcraft Act of 1735 was largely responsible
> for laying the groundwork of how to persecute witches and
> other spiritual mediums. What was the last year a person was
> convicted under this act in the UK -- give or take 15 years?
>
>
> * D. Geography: Hotter than Hell
>
> D1. Now that a record once claimed by Libya has been discredited,
> the hottest temperature ever legitimately recorded happened
> in the United States in 1917. The record temperature was
> 134°F (56.7°C). Where did that happen? Be sufficiently
> specific -- not just the state.
> D2. The above record has also been disputed as inaccurate.
> The next hottest claim is 54°C in the city of Mitribah --
> in which Persian Gulf country?
>
>
> * E. Sports: New Jersey Devils
>
> E1. In 1982 John McCullen bought an existing NHL franchise and
> moved it to Newark, renaming it the New Jersey Devils.
> What was the team called when he bought it? Full name
> required, like "New Jersey Devils". Hint: a current MLB
> franchise has the same name.
>
> E2. This player wound up on the New Jersey Devils in 1991 as
> trade compensation from the St. Louis Blues. He would
> captain the team from 1992 to 2004, during which time they
> would win three Stanley Cups. He was elected into the hall
> of fame in 2007. Name him.
>
>
> * F. Miscellaneous: The Devil You Know
>
> In 1589 German theologian Peter Binsfeld classified the greatest
> devils and demons as the "Seven Princes of Hell", and associated
> them each to one of the Seven Deadly Sins.
>
> F1. Pride was associated with this devil. His name is rendered
> from the name "Isaiah" in Hebrew, and means "Light-Bringer"
> in Latin. Name that devil!
>
> F2. Gluttony was associated with this devil, whose name is a
> literal translation of "Lord of the Flies". He is named
> in the several books of the Bible. Name that devil!
Beelzebub
> The next hottest claim is 54°C in the city of Mitribah --
> in which Persian Gulf country?
>
>
> * E. Sports: New Jersey Devils
>
> E1. In 1982 John McCullen bought an existing NHL franchise and
> moved it to Newark, renaming it the New Jersey Devils.
> What was the team called when he bought it? Full name
> required, like "New Jersey Devils". Hint: a current MLB
> franchise has the same name.
>
> E2. This player wound up on the New Jersey Devils in 1991 as
> trade compensation from the St. Louis Blues. He would
> captain the team from 1992 to 2004, during which time they
> would win three Stanley Cups. He was elected into the hall
> of fame in 2007. Name him.
>
>
> * F. Miscellaneous: The Devil You Know
>
> In 1589 German theologian Peter Binsfeld classified the greatest
> devils and demons as the "Seven Princes of Hell", and associated
> them each to one of the Seven Deadly Sins.
>
> F1. Pride was associated with this devil. His name is rendered
> from the name "Isaiah" in Hebrew, and means "Light-Bringer"
> in Latin. Name that devil!
>
> F2. Gluttony was associated with this devil, whose name is a
> literal translation of "Lord of the Flies". He is named
> in the several books of the Bible. Name that devil!
Mark Brader
Dec 7, 2017, 5:53:51 AM12/7/17
to
Mark Brader:
JOSHUA KREITZER. Hearty congratulations, sir!
> ** Game 6, Round 9 - Science - Drugs
> The following is a round on the science and study of drugs.
> All answers can be found on the handout:
> ACE Inhibitor | Leukotrienes
> Agonist | Liver
> Alzheimer | Lungs
> Antagonist | Multiple Sclerosis
> Antihistamines | Non-depolarizing Muscarinic Blocker
> Anti-Inflammatories | Parkinson's
> Beta-Blocker | Pharmacoeconomics
> Bioavailability | Pharmacogenomics
> Cancer | Pharmacokinetics
> Concentration | Positive Allosteric Modulator
> Depolarizing Muscarinic Blocker | Schizophrenia
> Glucocorticoids | Spleen
> Heart | Teratogen
> Huntingtons | Therapeutic Index
> Intestines | Tolerance
> Intravenous | Vasodilator
> Kidneys | Vasopressin
This was the easiest round in the original game.
> 1. Pharmacology is the study of drugs, and is generally broken
> into two areas of study. Pharmacodynamics is the study of the
> action of drugs in the body. The other studies the rates of drug
> distribution and concentration in the body -- what is it called?
Pharmacokinetics. 4 for everyone -- Dan Blum, Peter, Dan Tilque,
Bruce, Pete, Joshua, Erland, and Jason.
> 2. When we take a drug, it first must be absorbed into the
> bloodstream and distributed to its target location. What is
> the term for the proportion of drug that enters circulation
> and so is able to have an effect?
Bioavailability. 4 for Dan Blum, Peter, Dan Tilque, Bruce, Joshua,
and Jason. 2 for Pete.
> 3. A large factor that affects <answer 2> is the first-pass effect.
> This describes the loss of drug after due to filtering that
> takes place after it is digested, which in some cases can
> greatly reduce drug concentration. This filtering takes place
> in which organ(s)?
Liver. 4 for Peter, Bruce, Erland, and Jason. 3 for Dan Blum.
2 for Pete and Joshua.
> 4. The majority of drugs work by binding to and altering the
> normal activity receptors in the human body. Some will increase
> the receptor's normal activity; others will block or decrease it.
> Thus they are classified into two groups: name either one.
Agonists, antagonists. 4 for Dan Blum, Peter, Dan Tilque, Bruce,
Joshua, and Jason.
> 5. This neurodegenerative disease is based on a breakdown of
> dopaminergic neurons in the brain causing a lack of control of
> movement in the sufferer. Drugs used to treat this disease act
> to increase dopamine in the system, such as L-Dopa or Carbidopa.
> What is the disease?
Parkinson's. 4 for Dan Blum, Peter, Dan Tilque, Bruce, Pete,
Joshua, and Jason.
> 6. Anti-neoplastics are drugs are targeted to impede cell growth,
> usually by killing the cell and stopping replication. They
> employ a wide range of mechanisms, such as the antimetabolite
> methotrexate, or using antibodies such as traztuzumab to target
> specific cells. What condition are anti-neoplastics used for?
Cancer. 4 for Dan Blum, Peter, Dan Tilque, Bruce, Pete, Joshua,
and Erland.
> 7. This drug group acts directly by blocking receptors to prevent
> allergy symptoms. The first generation of drugs would enter
> the central nervous system and so made the user sleepier.
> The second generation's structures were far more selective in
> their target and so are termed non-drowsy. What is this class
> of drugs known as?
Antihistamines. 4 for everyone.
> 8. Adrenergic receptors in the heart greatly effect rates and force
> of contractions in the heart. By inhibiting certain receptors
> using drugs such as propranolol or metoprolol, you can reduce
> heart rate and oxygen demand; this is used to treat those with
> arrhythmias or coronary artery disease. What are these drugs
> known as?
Beta-blockers. 4 for Peter, Dan Tilque, Joshua, Erland, and Jason.
2 for Bruce.
> 9. Diuretics such as furosemide, torasemide, and mannitol are
> used for the treatment of hypertension. By decreasing the
> sodium concentrations in the bloodstream the total amount of
> volume in the bloodstream is decreased, relieving pressure in
> the peripheral arteries. Where in the body do diuretics act?
Kidneys. 4 for Dan Blum, Peter, Dan Tilque, Bruce, and Joshua.
3 for Pete.
> 10. A special topic in pharmacology is looking at how drugs affect
> embryos in development. While most drugs are safe for fetuses
> at certain concentrations, some are not: a famous example was
> the drug thalidomide, used during the 1960s. What is the name
> for a drug that causes congenital defects in embryos?
Teratogen. 4 for Dan Blum, Peter, Dan Tilque, Bruce, and Joshua.
> ** Game 6, Round 10 - Challenge - Devil's Night
> For some of us as a kid, Devil's Night was the night before
> Halloween, when we used to go out and throw eggs at homes, soap
> car windows, and do bad things with firecrackers and dog doodoo.
> What little devils we were!
> Here, some questions that vaguely reference devils.
> * A. Entertainment: Devil Movies
> In each case, give the title of the movie.
> A1. This 1997 movie follows Keanu Reeves as a lawyer who gets
> hired by a large firm run by Al Pacino, who turns out to
> be Satan himself.
"The Devil's Advocate". 4 for Joshua and Jason.
> A2. This 1987 movie follows Mickey Rourke as a private
> investigator hired by Robert De Niro to track down crooner
> Johnny Favorite, who has disappeared. Turns out De Niro
> is Satan.
"Angel Heart". 4 for Joshua and Jason.
> * B. Literature: See You in Hell
> B1. In Dante's "Inferno", Dante voyages through the nine circles
> of Hell. Who acts as his guide?
Virgil. 4 for Dan Blum and Joshua.
> B2. And who is Dante's guide in "Paradiso", the closing epic
> of the trilogy?
Beatrice. 4 for Dan Blum and Joshua.
The whole trilogy is of course "The Divine Comedy", and the middle
part is "Purgatorio", in which Virgil is also the guide.
> * C. History: Witch-Hunts
> C1. The largest-scale witch-hunt ever recorded occurred during
> the Spanish Inquisition in the 17th century. Over 7,000
> people were examined by the Inquisition in which Spanish
> region?
Basque country. 3 for Pete.
> C2. The British Witchcraft Act of 1735 was largely responsible
> for laying the groundwork of how to persecute witches and
> other spiritual mediums. What was the last year a person was
> convicted under this act in the UK -- give or take 15 years?
1944 (accepting 1929-59)! 3 for Dan Blum and Joshua.
It's not as silly as it sounds. The act provided for prosecution
of people who *claimed* supernatural powers, so it could be used
against those who knew there was no such thing but were committing
fraud. The replacement act passed in 1951 was called the Fraudulent
Mediums Act. Also, one of the prosecutions in 1944 was of someone
who had allegedly revealed a military secret, so maybe in that case
it was also a convenient way to put her out of circulation.
> * D. Geography: Hotter than Hell
> D1. Now that a record once claimed by Libya has been discredited,
> the hottest temperature ever legitimately recorded happened
> in the United States in 1917. The record temperature was
> 134蚌 (56.7蚓). Where did that happen? Be sufficiently
> D2. The above record has also been disputed as inaccurate.
> The next hottest claim is 54蚓 in the city of Mitribah --
> * E. Sports: New Jersey Devils
> E1. In 1982 John McCullen bought an existing NHL franchise and
> moved it to Newark, renaming it the New Jersey Devils.
> What was the team called when he bought it? Full name
> required, like "New Jersey Devils". Hint: a current MLB
> franchise has the same name.
Colorado Rockies. (Still earlier they were the Kansas City Scouts,
but that's irrelevant here.) 4 for Pete and Joshua.
> E2. This player wound up on the New Jersey Devils in 1991 as
> trade compensation from the St. Louis Blues. He would
> captain the team from 1992 to 2004, during which time they
> would win three Stanley Cups. He was elected into the hall
> of fame in 2007. Name him.
Scott Stevens.
> * F. Miscellaneous: The Devil You Know
> In 1589 German theologian Peter Binsfeld classified the greatest
> devils and demons as the "Seven Princes of Hell", and associated
> them each to one of the Seven Deadly Sins.
> F1. Pride was associated with this devil. His name is rendered
> from the name "Isaiah" in Hebrew, and means "Light-Bringer"
> in Latin. Name that devil!
Lucifer. 4 for Dan Blum, Dan Tilque, and Joshua. 3 for Peter.
> F2. Gluttony was associated with this devil, whose name is a
> literal translation of "Lord of the Flies". He is named
> in the several books of the Bible. Name that devil!
Beelzebub. 4 for Dan Blum, Dan Tilque, Pete, Joshua, and Jason.
2 for Peter.
Scores, if there are no errors:
GAME 6 ROUNDS-> 2 3 4 6 7 8 9 10 BEST
TOPICS-> His Can Art Spo Ent Mis Sci Cha SIX
Joshua Kreitzer 19 16 4 32 24 8 38 35 164
Dan Blum 17 2 14 11 16 9 35 23 116
Pete Gayde 13 6 4 32 4 18 23 15 107
Jason Kreitzer -- -- 4 24 24 4 28 16 100
Bruce Bowler -- -- -- -- 0 40 38 4 82
Dan Tilque -- -- 4 16 4 4 36 12 76
Peter Smyth -- -- 0 20 -- -- 40 9 69
Erland Sommarskog -- -- 0 15 -- -- 20 4 39
Marc Dashevsky -- -- 0 28 -- -- -- -- 28
--
Mark Brader, Toronto | "The problem is that tax lawyers are
m...@vex.net | amazingly creative." -- David Sherman
> These questions were written to be asked in Toronto on 2017-10-30,
> and should be interpreted accordingly... For further information
> see my 2017-09-25 companion posting on "Questions from the Canadian
> Inquisition (QFTCI*)".
Game 6 is over and the winner by a considerable margin is
> Inquisition (QFTCI*)".
JOSHUA KREITZER. Hearty congratulations, sir!
> ** Game 6, Round 9 - Science - Drugs
> The following is a round on the science and study of drugs.
> All answers can be found on the handout:
> ACE Inhibitor | Leukotrienes
> Agonist | Liver
> Alzheimer | Lungs
> Antagonist | Multiple Sclerosis
> Antihistamines | Non-depolarizing Muscarinic Blocker
> Anti-Inflammatories | Parkinson's
> Beta-Blocker | Pharmacoeconomics
> Bioavailability | Pharmacogenomics
> Cancer | Pharmacokinetics
> Concentration | Positive Allosteric Modulator
> Depolarizing Muscarinic Blocker | Schizophrenia
> Glucocorticoids | Spleen
> Heart | Teratogen
> Huntingtons | Therapeutic Index
> Intestines | Tolerance
> Intravenous | Vasodilator
> Kidneys | Vasopressin
> 1. Pharmacology is the study of drugs, and is generally broken
> into two areas of study. Pharmacodynamics is the study of the
> action of drugs in the body. The other studies the rates of drug
> distribution and concentration in the body -- what is it called?
Bruce, Pete, Joshua, Erland, and Jason.
> 2. When we take a drug, it first must be absorbed into the
> bloodstream and distributed to its target location. What is
> the term for the proportion of drug that enters circulation
> and so is able to have an effect?
and Jason. 2 for Pete.
> 3. A large factor that affects <answer 2> is the first-pass effect.
> This describes the loss of drug after due to filtering that
> takes place after it is digested, which in some cases can
> greatly reduce drug concentration. This filtering takes place
> in which organ(s)?
2 for Pete and Joshua.
> 4. The majority of drugs work by binding to and altering the
> normal activity receptors in the human body. Some will increase
> the receptor's normal activity; others will block or decrease it.
> Thus they are classified into two groups: name either one.
Joshua, and Jason.
> 5. This neurodegenerative disease is based on a breakdown of
> dopaminergic neurons in the brain causing a lack of control of
> movement in the sufferer. Drugs used to treat this disease act
> to increase dopamine in the system, such as L-Dopa or Carbidopa.
> What is the disease?
Joshua, and Jason.
> 6. Anti-neoplastics are drugs are targeted to impede cell growth,
> usually by killing the cell and stopping replication. They
> employ a wide range of mechanisms, such as the antimetabolite
> methotrexate, or using antibodies such as traztuzumab to target
> specific cells. What condition are anti-neoplastics used for?
and Erland.
> 7. This drug group acts directly by blocking receptors to prevent
> allergy symptoms. The first generation of drugs would enter
> the central nervous system and so made the user sleepier.
> The second generation's structures were far more selective in
> their target and so are termed non-drowsy. What is this class
> of drugs known as?
> 8. Adrenergic receptors in the heart greatly effect rates and force
> of contractions in the heart. By inhibiting certain receptors
> using drugs such as propranolol or metoprolol, you can reduce
> heart rate and oxygen demand; this is used to treat those with
> arrhythmias or coronary artery disease. What are these drugs
> known as?
2 for Bruce.
> 9. Diuretics such as furosemide, torasemide, and mannitol are
> used for the treatment of hypertension. By decreasing the
> sodium concentrations in the bloodstream the total amount of
> volume in the bloodstream is decreased, relieving pressure in
> the peripheral arteries. Where in the body do diuretics act?
3 for Pete.
> 10. A special topic in pharmacology is looking at how drugs affect
> embryos in development. While most drugs are safe for fetuses
> at certain concentrations, some are not: a famous example was
> the drug thalidomide, used during the 1960s. What is the name
> for a drug that causes congenital defects in embryos?
> ** Game 6, Round 10 - Challenge - Devil's Night
> For some of us as a kid, Devil's Night was the night before
> Halloween, when we used to go out and throw eggs at homes, soap
> car windows, and do bad things with firecrackers and dog doodoo.
> What little devils we were!
> Here, some questions that vaguely reference devils.
> * A. Entertainment: Devil Movies
> In each case, give the title of the movie.
> A1. This 1997 movie follows Keanu Reeves as a lawyer who gets
> hired by a large firm run by Al Pacino, who turns out to
> be Satan himself.
> A2. This 1987 movie follows Mickey Rourke as a private
> investigator hired by Robert De Niro to track down crooner
> Johnny Favorite, who has disappeared. Turns out De Niro
> is Satan.
> * B. Literature: See You in Hell
> B1. In Dante's "Inferno", Dante voyages through the nine circles
> of Hell. Who acts as his guide?
> B2. And who is Dante's guide in "Paradiso", the closing epic
> of the trilogy?
The whole trilogy is of course "The Divine Comedy", and the middle
part is "Purgatorio", in which Virgil is also the guide.
> * C. History: Witch-Hunts
> C1. The largest-scale witch-hunt ever recorded occurred during
> the Spanish Inquisition in the 17th century. Over 7,000
> people were examined by the Inquisition in which Spanish
> region?
> C2. The British Witchcraft Act of 1735 was largely responsible
> for laying the groundwork of how to persecute witches and
> other spiritual mediums. What was the last year a person was
> convicted under this act in the UK -- give or take 15 years?
It's not as silly as it sounds. The act provided for prosecution
of people who *claimed* supernatural powers, so it could be used
against those who knew there was no such thing but were committing
fraud. The replacement act passed in 1951 was called the Fraudulent
Mediums Act. Also, one of the prosecutions in 1944 was of someone
who had allegedly revealed a military secret, so maybe in that case
it was also a convenient way to put her out of circulation.
> * D. Geography: Hotter than Hell
> D1. Now that a record once claimed by Libya has been discredited,
> the hottest temperature ever legitimately recorded happened
> in the United States in 1917. The record temperature was
> specific -- not just the state.
Furnace Creek, Death Valley, California. 4 for everyone.
> D2. The above record has also been disputed as inaccurate.
> in which Persian Gulf country?
Kuwait.
> * E. Sports: New Jersey Devils
> E1. In 1982 John McCullen bought an existing NHL franchise and
> moved it to Newark, renaming it the New Jersey Devils.
> What was the team called when he bought it? Full name
> required, like "New Jersey Devils". Hint: a current MLB
> franchise has the same name.
but that's irrelevant here.) 4 for Pete and Joshua.
> E2. This player wound up on the New Jersey Devils in 1991 as
> trade compensation from the St. Louis Blues. He would
> captain the team from 1992 to 2004, during which time they
> would win three Stanley Cups. He was elected into the hall
> of fame in 2007. Name him.
> * F. Miscellaneous: The Devil You Know
> In 1589 German theologian Peter Binsfeld classified the greatest
> devils and demons as the "Seven Princes of Hell", and associated
> them each to one of the Seven Deadly Sins.
> F1. Pride was associated with this devil. His name is rendered
> from the name "Isaiah" in Hebrew, and means "Light-Bringer"
> in Latin. Name that devil!
> F2. Gluttony was associated with this devil, whose name is a
> literal translation of "Lord of the Flies". He is named
> in the several books of the Bible. Name that devil!
2 for Peter.
Scores, if there are no errors:
GAME 6 ROUNDS-> 2 3 4 6 7 8 9 10 BEST
TOPICS-> His Can Art Spo Ent Mis Sci Cha SIX
Joshua Kreitzer 19 16 4 32 24 8 38 35 164
Dan Blum 17 2 14 11 16 9 35 23 116
Pete Gayde 13 6 4 32 4 18 23 15 107
Jason Kreitzer -- -- 4 24 24 4 28 16 100
Bruce Bowler -- -- -- -- 0 40 38 4 82
Dan Tilque -- -- 4 16 4 4 36 12 76
Peter Smyth -- -- 0 20 -- -- 40 9 69
Erland Sommarskog -- -- 0 15 -- -- 20 4 39
Marc Dashevsky -- -- 0 28 -- -- -- -- 28
--
Mark Brader, Toronto | "The problem is that tax lawyers are
m...@vex.net | amazingly creative." -- David Sherman
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