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MeDIP-SEQ assay
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Alan Ruttenberg  
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 More options Jun 28 2010, 1:42 pm
From: Alan Ruttenberg <alanruttenb...@gmail.com>
Date: Mon, 28 Jun 2010 13:42:42 -0400
Local: Mon, Jun 28 2010 1:42 pm
Subject: [Obi-devel] MeDIP-SEQ assay
Changing primary structure of macromolecule to GDC made the following
unsatisfiable, but I think exposes a true error.
The definition:

has_specified_output some
    ('measurement datum'
     and ('is about' some
        ('primary structure of DNA macromolecule'
         and 'DNA residue methylation')))

has the conjunction ('primary structure of DNA macromolecule'  and
'DNA residue methylation')

Which should be empty - these were distinct qualities - just no
disjoint asserted. I'm changing it to.

has_specified_output some
    ('measurement datum'
     and ('is about' some 'primary structure of DNA macromolecule')
     and ('is about' some 'DNA residue methylation'))

However comments on what it should be are welcome.

-Alan

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Chris Stoeckert  
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 More options Jun 28 2010, 2:10 pm
From: Chris Stoeckert <stoec...@pcbi.upenn.edu>
Date: Mon, 28 Jun 2010 14:10:13 -0400
Local: Mon, Jun 28 2010 2:10 pm
Subject: Re: [Obi-devel] MeDIP-SEQ assay
Alan,
The output of MeDIP-Seq is sequence data on DNA fragments containing methylated residues so how about:

has_specified_output some ('sequence data'
    'is about' some primary structure of DNA macromolecule' (inheres_in some 'deoxyribonucleic acids (has_quality DNA residue methylation'))

<if this is the way to go theres a separate discussion point on domain of inheres_in>
Chris

On Jun 28, 2010, at 1:42 PM, Alan Ruttenberg wrote:

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Philippe Rocca-Serra  
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 More options Jul 2 2010, 12:04 pm
From: Philippe Rocca-Serra <ro...@ebi.ac.uk>
Date: Fri, 02 Jul 2010 17:04:56 +0100
Local: Fri, Jul 2 2010 12:04 pm
Subject: Re: [Obi-devel] MeDIP-SEQ assay
Hi Chris, Alan,

'DNA residue methylation' sounds like a process to me, appending it with
'status' is probably more inline with a quality.

Alternately, we could possibly play with the notion of "methylated
nucleobase residue"  located_in 'deoxyribonucleic acids'.

We could also be more specific about the type of output data by
specifying the position of the methylated nucleobase residue.

Cheers

Philippe

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