The following study shows clearly .. due to previous studies which left

isotopes in the study group .. 1.46 mg/d for males and 1.15 mg/d for
females to be the loss / required intake for a growing adolescent.

This is about 5-10 times less than what is currently  recommended .. ?

Recommended Dietary Allowances for Iron for Infants (7 to 12 months),
Children, and Adults
Ages Male (mg) Female (mg)
9-13 years 8mg/d 8mg/d
14-18 years 111mg/d  15 mg/d

<<snip>>
the requirement for absorbed iron was estimated to be 1.46 mg/d for
males and 1.15 mg/d for females.
<<snip>>

Which seems even at the low of 8 to be MUCH higher than required .. ?

http://www.beefinfo.org/bh_iron.cfm

And since a growing adolescent is the SAME .. basically .. as an adult
in REQUIRED iron .. according to the same .. researchers .. then one
might .. presume .. the calculations for REQUIRED iron in an adult ..
may ALSO .. be .. skewed / wrong .. ?
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Inevitable iron loss by human adolescents, with calculations of the
requirement for absorbed iron.

Fomon SJ, Drulis JM, Nelson SE, Serfass RE, Woodhead JC, Ziegler EE
Department of Pediatrics, University of Iowa, Iowa City, IA and.
Department of Preventive Medicine and Community Health, University of
Texas Medical Branch, Galveston, TX.

[Medline record in process]

In growing individuals, the requirement for absorbed iron consists of
iron needed for growth and iron needed to replace inevitable iron loss.

We were able to estimate inevitable iron loss by adolescents because
total body iron of the adolescents had been enriched with the stable
isotope, (58)Fe, as the result of earlier studies of iron absorption.
During an interval beginning at least 1.56 y after isotope
administration (a time sufficient for complete mixing of the isotope
with total body iron) and extending for no less than 3.29 y, we
determined the isotopic enrichment of circulating iron. On the basis of

several assumptions, we calculated total body (58)Fe and total body
iron at the beginning and end of the interval. Because of complete
mixing of the isotope with total body iron, fractional total (58)Fe
loss was the same as fractional loss of total iron. In males, the
fractional loss of iron was 9.70%/y and the quantitative loss was 256
mg/y or 0.70 mg/d. In females, the fractional loss of iron was 14.60%/y

and the quantitative loss was 306 mg/y or 0.84 mg/d. Using several
assumptions, we then calculated that the iron requirement for growth
during this interval was 0.76 mg/d for males and 0.31 mg/d for females.

Adding the iron loss to the iron requirement for growth, the
requirement for absorbed iron was estimated to be 1.46 mg/d for males
and 1.15 mg/d for females.

PMID: 12514285, UI: 22401955

-------------------------------------------------

And NOW with the newly revised intake / requirement .. would this NEW
marker put the intake of iron INTO this point .. ? .. restricted iron
.. ? ..

-------------------------------------------------
<<snip>>
severe dietary iron restriction impairs hookworm development
<<snip>>

1: Infect Immun. 2006 Jan;74(1):289-95. Related Articles, Links

Dietary iron content mediates hookworm pathogenesis in vivo.

Held MR, Bungiro RD, Harrison LM, Hamza I, Cappello M.

Program in International Child Health, Department of Pediatrics, Yale
University School of Medicine, New Haven, CT 06520.
michael.cappe...@yale.edu.

Hookworm infection is associated with growth delay and iron deficiency
anemia in developing countries. A series of experiments were designed
in order to test the hypothesis that host dietary iron restriction
mediates susceptibility to hookworm infection using the hamster model
of Ancylostoma ceylanicum. Animals were maintained on diets containing
either 10 ppm iron (iron restricted) or 200 ppm iron (standard/high
iron), followed by infection with A. ceylanicum third-stage larvae.
Infected animals fed the standard diet exhibited statistically
significant growth delay and reduced blood hemoglobin levels compared
to uninfected controls on day 20 postinfection. In contrast, no
statistically significant differences in weight or hemoglobin
concentration were observed between infected and uninfected animals fed

the iron-restricted diet. Moreover, iron-restricted animals were
observed to have reduced intestinal worm burdens on day 10 and day 20
postinfection compared to those of animals maintained on the
standard/high-iron diet. In a subsequent study, animals equilibrated on

diets containing a range of iron levels (10 ppm, 40 ppm, 100 ppm, or
200 ppm) were infected with A. ceylanicum and followed for evidence of
hookworm disease. Infected animals from the intermediate-dietary iron
(40- and 100-ppm) groups exhibited greater weight loss and anemia than
those in the low (10-ppm)- or high (200-ppm)-iron diet groups.
Mortality was also significantly higher in the
intermediate-dietary-iron groups. These data suggest that severe
dietary iron restriction impairs hookworm development in vivo but that
moderate iron restriction enhances host susceptibility to severe
disease.

PMID: 16368983 [PubMed - in process]

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