The recent paper in PEC by Lee, Van Gelder and Cone, 'Early Cardiac Cath Lab Activation by Paramedics for Patients with ST_Segment Elevation MI' brings up several questions - directly and indirectly.
In order to make good clinical decisions are on the basis of the interpretation of the prehospital ECG, the false positive and false negative rates need to be within some sort of acceptable limits. What are those acceptable limits? Are those acceptable limits the same for all decisions? For example, does an ambulance decision decision to bypass the closest ED in favor of a hospital with 24/7 PCI need the same level of false positives and false negatives as the decision to activate the cath lab?
The answers to those questions may help frame the question of who, how and when the ECG is interpreted.
Let me begin this line of discussion by asking Drs. Lee, Van Gelder and Cone for their perspectives on the acceptable limits for false positives and negatives and if those limits vary with type of decision.
--- Mic
Mic
Gunderson
Editor/Moderator, NAEMSP Dialog;
President,
IPS
Thank you Mic since we all know that the National Standard Curriculum is developed by all stakeholders involved in EMS, not just fire organizations.
Gary Ludwig
----- Original Message -----
From: naemsp...@googlegroups.com <naemsp...@googlegroups.com>
To: NAEMSP Dialog <naemsp...@googlegroups.com>
Sent: Thu May 06 09:54:03 2010
Subject: [NAEMSP Dialog] Re: EMS Role in Reducing the Symptom to Reflow Interval for AMI
I would agree that about 20% of most ALS calls are for chest pain – but very, very few of these turn out to be STEMI. Even those that have STEMI-looking 12-lead ECGs often sometimes are not STEMI. I was the fourth person to lyse (remember thrombolysis for MI?) a guy who came to our ED outside Philly repeatedly with chest pain and a horrendous looking ECG – but that was his baseline ECG – he finally began carrying a photocopy with him, to avoid getting lysed again. (This was in the early 90’s, before we could retrieve old ECGs electronically.)
My point is that the percentage of chest pain patient transported by EMS who turn out to be true STEMI is quite low. 12-lead ECG can help sort that out (though there will be a small number of false positives, like the guy above), and can help allay the fears of small community hospitals that they will be losing large numbers of patients to regional STEMI/PCI centers.
Dave
--
David C. Cone, MD
EMS Section Chief
Yale Emergency Medicine
Editor-in-Chief
Academic Emergency Medicine
From:
naemsp...@googlegroups.com [mailto:naemsp...@googlegroups.com] On
Behalf Of Margaret Keavney
Sent: Friday, May 07, 2010 10:25 AM
To: naemsp...@googlegroups.com
Subject: Re: [NAEMSP Dialog] Re: EMS Role in Reducing the Symptom to
Reflow Interval for AMI
Our incidence of STEMIs identified with 12 leads in the field is much higher than your example. About 20% of our ALS calls are cardiac/chest pain. I don't have the exact numbers, be we see more like 120 a year, with an annual ALS volume of less than 100,000. I can get the actual numbers if it would help this group.
We ask our medics to leave 12 leads in place during transport for all cases in which we suspect potential myocardial ischemia (already known STEMI or not) and to do frequent repeat 12 leads for the purpose of tracking changes. We are also encouraging 12 lead acquisition as an early task when we have ROSC from SCA. We don’t yet have designated SCA centers or therapeutic hypothermia, although some of our hospitals are headed in that direction.
Laurie A. Romig, MD, FACEP
Medical Director
Pinellas County EMS
In my opinion, biometric testing is still in its infancy and portability. We now have high specificity troponin I test that are opening new doors. My question is what is the next test that will apply to out of hospital care. Keep in mind EMS arrives very early in the event. The myoglobin may not have elevated when we arrive.... let alone the troponin....
David Carter RN MBA
Site Administrator
Sarasota Memorial Health Care System
North Port Medical Plaza
Tom's comment caught my attention.I am interested to hear if the group thinks that using POC biomarkers (such as iStat), used in conjunction with prehospital 12 leads would significant improve the sensitivity and specificity of STEMI (or NSTEMI) alerts?Is anybody already doing this?Craig McMillanClifton Park AmbulanceAlbany NY
I think that there are two separate and related issues here:
1) Obtaining a pre-hospital 12 lead ECG, which should have a low threshold (as for BP or CBG) such as the list below (a – n) from Dr. Romig (most of whom do not have ACS or at least do not need to go to the cath lab emergently)
2) Using the information from the field 12 lead ECG for EMS to bypass some hospitals, which will be very system dependent
In our system, we have chosen to have fairly limited clinical criteria (cardiac chest discomfort or Vfib/Vtach converted to a spontaneous rhythm) and ECG ST elevation criteria that are highly correlated with STEMI for direct EMS cath lab activation. All other patients, some of whom may truly have ACS, are evaluated at the hospital of their choice by a physician and then, if appropriate, may be transferred to a cardiologist. Most of the non-STEMI ACS patients in our area are not taken emergently to the cath lab. The cath team and cardiologists are happy that only about 5% of our EMS STEMI Activation patients do not go emergently to the cath lab. By expanding our clinical criteria, we would very likely have more cath team/cardiologists standdowns, and thus less support for our STEMI program. Additionally, if more patients without STEMI (or ACS) were diverted away from their usual hospital of care and taken to the cath lab hospital, we would very likely lose local hospital and physician support for our program.
Thanks.
Paul S. Rostykus, MD, MPH
Jackson County (OR) EMS Supervising Physician
From:
naemsp...@googlegroups.com [mailto:naemsp...@googlegroups.com] On
Behalf Of Laurie Romig
Sent: Tuesday, May 11, 2010 5:18 PM
To: naemsp...@googlegroups.com
Subject: Re: [NAEMSP Dialog] Re: EMS Role in Reducing the Symptom to
Reflow Interval for AMI
We try to take the subject of potential atypical presentations of ACS very seriously here in Pinellas County, and it's paid off well in very low missed STEMI rates. Quoted below is part of our 12 Lead ECG Procedure so that you can see our approach. It's relatively easy for us to do this because we are an all-ALS system and we do tend to do 12 leads at the drop of a hat, but with nearly 800 paramedics and about the same number of EMT's, I count this as a low cost risk management and skills competency approach.
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11:40:00
False Positive Issue
There is a difference between Inappropriate Activation and False
Positive Cath. A Inappropriate Activation is where the medic
incorrectly makes a STEMI interpretation when in fact there is no
diagnostic ST elevation. The most common cause of this is failure to
recognize a LBBB. It also depends on the criteria you use for ST
elevation. Most programs require >1mm in inferior leads and >2mm in
precordial leads. Some programs require >1mm in precordial leads and
this results in increased False Positive Caths since repolarization
and J point elevation (particularly in the younger patient) can
present with 1mm elevation in the precordial leads. Few programs
activate the cath lab based on suspected new LBBB and posterior MI
findings. In my system the Inappropriate activation is less than 3%
with bundle branch block leading the cause.
False Positive Cath is a patient with STEMI criteria who is found
to have no culprit artery and the JAMA article by Larson confirms that
this rate is 8-14%.
The bottom line is EMS can do nothing about the False Positive
Caths. We only have control over our interpretation and perhaps this
is where the risk assessment scores may help lower the False Positive
Caths however I doubt it. They will simply be seen in the ED, get a
cardiology consult and then get a cath (perhaps the next day)
I see your point Dudley, but when you do 180,000 plus responses a year and are as liberal as we already are with doing 12 leads (and have been for many years), practicality has to be considered. I think that your idea is great for services that are relatively new to doing 12 leads, where the percentage of patients with “obvious indications” (as previously defined by local protocol or as perceived by the medics) is low, and/or where call volume is low enough to absorb the extra time required (as relatively minimal as it may be). We don’t discourage our folks from doing 12 leads and we probably have higher expectations for when 12 leads should be done than many EMS systems do. In addition, we require all medics to have completed an 8 hour 12 lead course either prior to or within about 6 months of entry into our system, offer 12 lead courses monthly, and include 12 lead interpretation in our CME programs. Of course, this doesn’t mean that all of our folks are equally competent, but I think we have a decent balance between education, protocol, liberal practice, and keeping the system functioning.
Everybody else’s mileage is highly likely to vary!
Laurie
Laurie A. Romig, MD, FACEP
Medical Director
Pinellas County EMS
Hi Marc:
I definitely have to agree with your point that it is possible to go overboard with the triage to PCI facilities. We first officially started our PCI transport policy for STEMI patients in 2002 and have stuck pretty closely to classic 12 lead criteria for STEMI partly because of the concern from our non-PCI facilities about interrupting continuity of care for their patients and, frankly, loss of income. Their fear was that anyone who had chest pain would end up going to PCI because “they might need it”; that’s one reason that we require on-line medical control contact (ours is centralized, rather than hospital based) for STEMI Alert patients and other potential ACS patients for whom the crews believe that PCI transport may be indicated. Initially, we did get a significant number of “just to be safe” consults; we do still get them occasionally, but they tend to be centered around atypical presentations, STEMI mimics and “gut feelings”. Another reason for not wanting to overdo PCI triage is that many of our PCI facilities tend to be our higher volume ED’s and also have other limited resource capabilities. If we severely over-stress those facilities without sufficient cause, we may interrupt their abilities to provide some of those other services to other patients. Even in our system where 7 out of our 12 hospitals have PCI capability and all hospitals are within a 200 square mile area, that can become a significant system resource issue. I can only begin to imagine the implications for rural systems with much more limited resources.
And yes, the size of my EMS brood (can you tell that I’m a bit motherly about it?) presents a constant challenge, and one that has to factor into everything we do. Fortunately, I’m blessed with strong support for medical direction and have the data to show that we’re doing a really good job in this particular arena, so something’s working!
Laurie
Laurie A. Romig, MD, FACEP
Medical Director
Pinellas County EMS
From:
naemsp...@googlegroups.com [mailto:naemsp...@googlegroups.com] On
Behalf Of Marc Berenson
Sent: Wednesday, May 12, 2010 2:55 AM
To: naemsp...@googlegroups.com
Subject: Re: [NAEMSP Dialog] Re: EMS Role in Reducing the Symptom to
Reflow Interval for AMI
**Devil's Advocate Warning** :)
Great points by Tom Bouthillet. We must keep in mind that while there are obvious ECG's (postivie s-t elev and neg s-t elev) there are many in between. This is one reason why we often consult with cardiologists during our management of the patient with suspected MI.
We can provide the education to paramedics to understand and interpret the most difficult and challenging ECG's and to evaluate and manage the most complext airways. How much time are we willing to put into the education program, or what are you willing to give up?
Jerry Allison, MD, MS, EMT-P (ret) |
Funny, I have seen ED and Cardiologist disagree on ECG's. We don't need or want 100% . I would be comfortable with 85% or higher accuracy in recognizing STEMI. I see the NSTEMI as the next challenge. We do not have a star trek device to wave over the patient (yet) to give us a diagnosis. I also disagree with pushing transmission. To me that is saying Paramedics can not be taught. They can and do quite well. Let along the ability to transmit is spotty at best.
David Carter RN MBA
Administrator
Sarasota Memorial Health Care System
North Port Medical Plaza
Tom does make some excellent points.
Jerry,
I am not advocating the instruction of every possible ECG
presentation. We may not even have to change the paramedic
curriculum, which I do feel is lacking in many other areas as well. A
possible solution in my opinion would be an adjunct course. As
paramedics we cary CPR, BTLS, PHTLS, ACLS, PALS cards in many areas.
Some of these are required by our governing agencies, and some are
required by our places of employment. ACLS is currently aimed at
advanced care, mostly for patients in cardiac arrest. The best thing
about these classes is the fact that you need to refresh them every so
often. Would a similar course, directed only at 12-lead ECG
interpretation be feasible?
Paramedicine...@gmail.com
-
Adam Thompson, EMT-P
Lee County (FL) EMS;
EMS Educator, Edison State College
Paramedicine101.blogspot.com
@Paramedicine101
Initial Clinical Results Using Intracardiac Electrogram Monitoring to Detect and Alert Patients During Coronary Plaque Rupture and Ischemia
Tim A. Fischell, MD, David R. Fischell, PhD, Alvaro Avezum, MD, M. Sasha John, PhD, David Holmes, MD, Malcolm Foster III, MD, Richard Kovach, MD, Paulo Medeiros, MD, Leopoldo Piegas, MD, Helio Guimaraes, MD, and C. Michael Gibson, MS, MD
ABSTRACT
Objective:
We report the first clinical studies of intracardiac ST-segment monitoring in ambulatory humans to alert them to significant ST-segment shifts associated with thrombotic occlusion.Background:
Despite improvements in door-to-balloon times, delays in symptom-to-door times of 2-3 hours remain. Early alerting of the presence of acute myocardial infarction (MI) could prompt patients to seek immediate medical evaluation.Methods:
Intracardiac monitoring was performed in 37 patients at high risk for acute coronary syndromes. The implanted monitor continuously evaluated the patients’ STsegments sensed from a conventional pacemaker RV apical lead, and alerted patients to detected ischemic events.Results:
During follow-up (median 1.52 years, range 126-974 days) 4 patients developed STsegment changes of > 3 standard deviations of their normal daily range, in the absence of an elevated heart-rate. This in combination with immediate hospital monitoring led to angiogram and/or IVUS which confirmed thrombotic coronary occlusion/ruptured plaque. The median alarm-to-door time was 19.5 minutes (6, 18, 21, and 60 minutes). Alerting for demand related ischemia, at elevated heart-rates, reflective of flow-limiting coronary obstructions, occurred in 4 patients. There were 2 false-positive ischemia alarms related to arrhythmias and 1 due to a programming error that did not prompt cardiac catheterization.Conclusions
: Shifts exceeding 3 standard deviations from a patient's daily intracardiac STrange may be a sensitive/specific marker for thrombotic coronary occlusion. Patient alerting was associated with a median alert-to-door time of 19.5 minutes in patients at highrisk of recurrent coronary syndromes who typically present with 2-3 hour delays.