A 50 Hz magnetic field blocks melatonin-induced enhancement of junctional transfer in normal C3H/10T1/2 cells

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Oct 31, 2009, 3:35:36 AM10/31/09

Lest we forget about how much the EPA really is withholding from the
public!

Subject: EMF's & Melatonin....controller/neoplastic processes....US
EPA 1995

http://oas.oxfordjournals.org/5c/carcin.oxfordjournals.org/cgi/content/abstract/16/12/2945/1792401924/Top/default/empty.gif/51696c6a3245726e532b634141387549?x
<http://oas.oxfordjournals.org/5c/carcin.oxfordjournals.org/cgi/content/abstract/16/12/2945/1792401924/Top/default/empty.gif/51696c6a3245726e532b634141387549?x>
Subject: Melatonin....controller of neoplastic processes....EPA
# 1995...Blackman et al
#

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------------------------------------------------------------------------

research-article

A 50 Hz magnetic field blocks melatonin-induced enhancement of
junctional transfer in normal C3H/10T1/2 cells

*Alejandro Ubeda^ 1 ^ 3 , M. Angeles Trillo^ 1 , Dennis E. House^ 2
and Carl F. Blackman^ 2 *

^1 Hospital Ramón y Cajal, Dept Investigation, 28034 Madrid, Spain
^2 * US Environmental Protection Agency, Research Triangle Park, NC
27711, USA *

^3 To whom correspondence should be addressed

There is strong evidence that pineal melatonin is involved in^
controlling neoplastic processes. We have reported that
physiological,^ but not pharmacological or sub physiological,
concentrations^ of melatonin enhance intercellular communication in
normal C3H/10T1/2^ fibroblasts. Gap junctional intercellular
communication intervenes^ in the control of cell proliferation and
differentiation, and^ seems to play a crucial role in suppression of
tumor promotion.^ A number of /in vivo/ studies have shown that
extremely low frequency^ (ELF) magnetic fields (MF) can act as
cancer promoters or co-promoters.^ /In vitro/, 60 Hz MF have been
reported to block melatonin-induced^ inhibition of cell
proliferation in human breast cancer cells.^ The mechanisms
responsible for the observed interactions of^ MF at the cellular
level remain unknown. In the present study^ melatonin was added to
confluent fibroblasts at a concentration^ of 10^–10 M. Twenty-seven
hours later, a fluorescent dye^ was scrapeloaded into groups of
cells and the transfer of the^ dye to adjacent cells through gap
junctions was quantified.^ Under these conditions melatonin induced
a significant increase^ of dye transfer; this increase was not
observed when the cultures^ were exposed to the MF for 30 min before
the scrape-load assay^ was performed. This finding reinforces
previously reported results^ suggesting that the /in vivo/
oncostatic action of melatonin could^ be exerted, in part, through
modulation of the levels of gap^ junctional intercellular
communication. Also, the data indicate^ that ELF-MF could counteract
the melatonin-induced enhancement^ of junctional transfer.^

http://carcin.oxfordjournals.org/cgi/content/abstract/16/12/2945

--------

Chick embryo development can be irreversibly altered by early
exposure to weak extremely-low-frequency magnetic fields

If you click on this page on: Similar articles in PubMed

Its really impressive to read all that !

Ubeda and All have shown in 1994 a terrific study with only 1
microTesla !
See: http://www.ncbi.nlm.nih.gov/pubmed/7802707

Mayday, mayday, mayday...

Philippe Hug
Chairman of ARA
Switzerland

[ http://omega.twoday.net/search?q=magnetic+field
http://omega.twoday.net/search?q=exposure
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http://omega.twoday.net/search?q=C3H
http://omega.twoday.net/search?q=chick+embryo
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http://omega.twoday.net/search?q=neoplastic
http://omega.twoday.net/search?q=Carl+Blackman
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