321 W. Grand Av., #307
Alhambra, CA 91801
(818) 458-0457
E-mail:  ak...@hsc.usc.edu
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OBJECTIVES

A challenging research position involving drug development in
preclinical and clinical setting.

EDUCATIONAL BACKGROUND

Candidate for Ph.D.  University of Southern California, Los Angeles, CA
(Pharmaceutics)      Expected graduation November 1993.

Master of Science     Banaras Hindu University, India. Graduated in
(Medicinal Chemistry) May 1988.

Bachelor of Science)  Banaras Hindu University, India. Graduated in
(Pharmacy             May 1986.

RESEARCH EXPERIENCE

Preclinical and clinical Phase I studies with 13-cis-retinoic acid.
Extensive pharmacokinetic analysis using PCNONLIN and ADAPT II.
Cell culture and sterile techniques (Worked with Leukemia and
Neuroblastoma cell lines).
Photomicrography of the cells through phase-contrast microscope.
Worked with rats, mice and nude (athymic) mice.
Solid-phase and liquid-liquid phase extractions.
Computer controlled HPLC systems.
Synthesis of organic compounds.
Pharmacological testing for anticonvulsant, analgesic and
anticancer activities.
Quantitative Structure Activity Relationship (QSAR) studies using
computer modelling.
Radioisotopes.

COMPUTER LITERACY

 - DOS, Windows, OS/2, UNIX operating systems and Mackintosh computers.
 - Wordprocessing, Graphics, Spreadsheet etc.
 - Pharmacokinetic analysis softwares: PCNONLIN, JANA, BMDP and ADAPT-II.
 - Working with NONMEM.
 - Computer programming in Quick Basic.

INDUSTRIAL TRAINING

A six week summer training in "East India Pharmaceuticals Ltd.",
Calcutta, India (June 1985).
A four week summer training in "Rallis India Ltd.", Bombay, India
(June 1986).

SOCIETY MEMBERSHIPS

American Association of Pharmaceutical Scientists (AAPS)
American Association for Cancer Research (AACR)-Associate member
Southern Medical Association-Associate member
Indian Pharmaceutical Association

PUBLICATIONS

Nema S and Khan AA. Recent Advances in the Chemotherapy of AIDS.
Pharmatimes. issue 9, 47-49, 1986.

Pandeya SN and Khan AA, Anticonvulsant and Analgesic Activities of
1,2,4-Thiadiazoles. II. Indian J. Physiol. Pharmacol. 32(2): 164-7,
1988.

Anis A. Khan. Synthesis and Biological Activities of 1, 2, 4-
Thiadiazole Derivatives. Masters thesis. Banaras Hindu University,
Varanasi, UP India 1988.

Khan AA, Kwock R, Ray M, Leichman L and Avramis VI. Pre-Clinical
and Clinical Pharmacology Studies of Mitomycin C (MMC). J. Cancer
Res. & Clin. Oncol., Proc. 15th Intl. Cancer Congress, Hamburg, W.
Germany (Suppl.) 116: 578, 1990.

A. A. Khan, J. G. Villablanca, C. P. Reynolds, K. K. Matthay, N. K.
C. Ramsay, R. Seeger and V. I. Avramis. Pharmacokinetics of 13-cis-
Retinoic Acid in Children with Neuroblastoma Following Bone Marrow
Transplantation. J. Clin. Oncol., Proc. ASCO 11: 135, 1992.

Villablanca, J.G., Avramis, V.I., Khan, A.A., Matthay, K.K.,
Ramsay, N.K.C., Seeger, R.C., Reynolds, C.P. Phase I Trial of 13-
cis Retinoic Acid (cis-RA) in Neuroblastoma Patients Following Bone
Marrow Transplantation (BMT).  J.Clin. Oncol., Proc. ASCO 11: 366,
1992.

Eric J. Lien, Samitendu Banerjee, Anis Khan, Hua Gao and Fengzhen
Wang.  Dipolar, Hydrogen Bonding and van der Waals Forces and Their
Contributions to the Partition Coefficients and Solubilities of
Chemical and Drugs. Proc. 9th European Symposium on Structure-
Activity Relationships: QSAR and Molecular Modelling, P-14.
Strasbourg, France. September 1992.

J. G. Villablanca, V.I. Avramis, A. A. Khan, K. K. Matthay, N. K.
C. Ramsay, R. C. Seeger, and C. P. Reynolds.  Phase I trial of 13-
cis-Retinoic Acid in Neuroblastoma Patients Following Bone Marrow
Transplantation (BMT).  Proc. of Advances in Neuroblastoma
Research, No 6: 147, 1993.

Mayumi Takamura, Hideo Mugishima, Toshihito Nagata, Toshiaki
Shimada, Motoaki Chin, Takashi Suzuki, Takahito Fujisawa, Masahiko
Okuni, Kazuo Uchikura, Anis Khan, and Vassilios Avramis.  13-cis-
Retinoic Acid in Advanced Neuroblastoma Patients Following
Autologous Bone Marrow Transplantation.  Proc. of Advances in
Neuroblastoma Research, No 6: 136, 1993.

Khan, A.A., Villablanca, J.G., Reynolds, C.P. and Avramis, V.I.
Pharmacokinetic Analysis of 13-cis-Retinoic Acid in Children With
Neuroblastoma.  Proc. of Amer. Assoc. Cancer Res. 34: 395, 1993.

Judith G. Villablanca, Anis A. Khan, Vassilios I. Avramis and C.
Patrick Reynolds. Hypercalcemia: A Dose Limiting Toxicity
Associated with 13-cis-Retinoic Acid. American Journal of Pediatric
hematology/Oncology. (In press).

SUBMITTED

Anis A. Khan, Judith G. Villablanca, C. Patrick Reynolds, and
Vassilios I. Avramis.  Pharmacokinetics of 13-cis Retinoic Acid
(cis-RA) in Pediatric Patients with Neuroblastoma Following Bone
Marrow Transplantation (BMT). Submitted to Cancer Research 1993.

Khan AA, Leichman L, Ray M., and Avramis VI. Pharmacokinetics of
Mitomycin C (MMC) During a Phase I Trial by Continuous Infusion in
Patients with Metastatic Solid Tumors.  Manuscript submitted to
Cancer Chemotherapy and Pharmacology journal.

Eric J. Lien, Samitendu Banerjee, Anis Khan, Hua Gao and Fengzen
Wang. Contributions of Dipolar, H-bond and van der Waals Forces to
Partition Coefficients and Solubilities.  Manuscript submitted to
QSAR journal.  

IN PREPARATION

Judith G. Villablanca, Anis A. Khan, Vassilios I. Avramis,
Katherine K. Matthay, Robert Seeger, Norma K C Ramsay and C.
Patrick Reynolds. Phase I trial of 13-cis-retinoic acid in
pediatric patients with neuroblastoma following bone marrow
transplantation.

PERSONAL

I am single, 28 years old, willing to relocate, hard working and
competitive, enjoy photography and working with computers.        

REFERENCES
References will be provided upon request.

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Dear Sir/Madam:

If the above interests you, to talk about my reasearch background, I request
to have an interview at a convenient time for both.

Thanks for your interest.  Look forward to hearing from you.

Sincerely,

Anis Khan

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