SOGA Protein -- Insulinitis

[Pro-Humanist FREELOVER]

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May 23, 2013
http://diabeteshealth.com/read/2013/05/23/7874/type-1-glucose-production-pill-on-the-horizon-/
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Excerpts [with inserts, not part of original
article, included in brackets]:

According to research out of a lab in North
Carolina, there's more to worry about for
... [persons who have Insulinitis (old name:
type 1 diabetes)] than a lack of insulin.

In addition to insulin, those with ... [Insulinitis]
do not produce the protein SOGA, which at
its core lowers the body's production of blood
glucose, according to Terry Combs of Combs
Lab in Chapel Hill.

Combs, an assistant professor at the University
of North Carolina at Chapel Hill, and a team of
researchers discovered the SOGA protein in
2010.

In those without [Insulinitis] ... SOGA is released
at the same time as insulin, and blocks the pro-
duction of glucose at mealtime. Because those
with ... [Insulinitis] do not produce SOGA, at
mealtime, blood glucose levels soar. [currently,
blood glucose levels are dealt with manually by
those of us who have Insulinitis, via exogenous
insulin, either via injection or pump]

"The body is really overproducing the amount
of glucose it needs," Combs said ... "The body
of a [person who has Insulinitis or Cellosis (old
name: type 2 diabetes) or Diminosis (old name:
Mature Onset Diabetes of the Young) or any
other High Glucose Condition] overproduces
glucose to different degrees. [obviously, the
implication is the loss of the SOGA protein is
a variable, with different degrees of loss based
on which High Glucose Condition one has].

So the reason blood sugar [glucose] goes so
high after a meal is that you're getting a double
infusion of blood sugar [glucose], one from your
own body's production and one coming from
the food in your GI tract."

In his lab, Combs is working on producing a
pill that would recreate the effects of SOGA,
and prevent the body from overproducing glu-
cose, with the potential of eliminating the need
for insulin entirely [?], or at least reduce the
amount required to maintain steady blood
glucose levels.

Combs is currently exploring the use of the
synthetic SOGA on mice, and expects to
begin human studies within two to three
years, contingent on available funding. The
lab is set to launch a campaign to raise a
needed $2.5 million for the research.

"We will figure it out as we go along," he
said. "You could take it without measuring
your blood sugar [glucose] because it
wouldn't cause low blood sugar [glucose].

[per the following website, the optimum
goal is to use an oral SOGA pill so that
exogenous insulin would not be required
to deal with glucose -- it's unclear whe-
ther or not SOGA would eliminate or
would just reduce the need for exogen-
ous insulin]. There might end up being
a fast-acting version and a slow-acting
one."

For more information, visit
http://www.combslab.com

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Pro-Humanist FREELOVER
C.ure I.nsulinitis A.ssociation
http://prohuman.net/cureinsulinitisassociation.htm
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