Oral Insulin for Cellosis, and maybe for Insulinitis?

[Pro-Humanist FREELOVER]

- - -

Cellosis (old name: type 2 diabetes)

Insulinitis (old name: type 1 diabetes)

Diminosis (old name: Mature Onset Diabetes
of the Young), and in an unknown percent
of those with Diminosis who use exogenous
insulin, oral insulin is likely applicable

- - -

The following, most news is of interest
to those with Cellosis or Diminosis and
who currently use exogenous insulin
(that applies to a minority of those with
those conditions)

Not much news regarding oral insulin for
those of us with Insulinitis, but some inter-
esting perspectives of dissonance from
pro-pump and pro-prick views from an
individual who has Insulinitis and who is
on 4 injections per day/night.

- - -
May 23, 2013
http://www.in-pharmatechnologist.com/Drug-Delivery/Oral-Insulin-All-Mouth-or-an-Injection-of-Hope-for-Type-1-Diabetes
- - -

Excerpts [with inserts, not part of original
article, included in brackets]:

... the world’s first insulin treatment for
... [Insulinitis] some 90 years ago, syringes
were the only delivery technology with which
patients could administer the product. [glass
syringes, non-disposable needle, both of
which had to be boiled prior to usage]

Syringes continued to be the most widely-
used delivery method [although, at some
point in the 1960s, disposal syringes and
disposal needles became available] ...
until – in the mid-1980s – the first insulin
pens were launched

[I didn't use insulin pens until over 5 years
ago, after seeking medical help for hypo-
glycemic unawareness, which interesting
enough, is still a problem, but at least,
after switching to an intensive glucose-
testing regimen, I no longer have cops
finding my loss of cognizance behind the
wheel to be an issue]

...

The vast majority of people [who use exo-
genous insulin] now will use insulin pens ...
[from Sara Kirsch who still uses disposable
syringes] “On the whole, the injections are
fine by me for the time being. I have had
no issues relating to syringes/vial delivery
other than an occasional bruise.” [notably,
insulin pens are no less likely to cause
bruises or pain than are disposable syr-
inges / needles]
...

[the following, a rarely heard voice of
dissonance regarding the insulin pump]

“As for the pump,” she continued, “the
idea disgusts me. I like to be free from
having to eat at a specific hour because
there is insulin being pumped into me at
a certain hour, and the thought of having
something dug into your side and attached
under your clo[th]es sounds horrific.”

[not sure what she's referring to in terms
of "having to eat at a specific hour", and
as far as I'm aware, eating requirements
are no different for pumpers as they are
for those who inject insulin, although of
course, there's no need for an injection
other than the injection required when the
pump insertion is done]

[Inhaled Insulin]

[in their discertaion on inhaled insulin, they
failed to mention Afrezza, which currently
is MannKind's attempt to get FDA approval,
and as I vaguely recall, well, hold on while
I check, MannKind is aiming to submit a
new drug application (based on its latest
trials) in the 3rd quarter, 2013]

Oral insulin

... the drug industry has continued to plough
millions of dollars into developing alternative
delivery methods.

The current R&D focus of choice is oral
delivery which ... is being examined by
several of the ... [High Glucose Condi-
tions] sector’s major players.

Last week, Israeli firm Oramed Pharm-
aceuticals announced its ORMD-0801
candidate had received clearance from
the FDA (US Food and Drug Administra-
tion) to initiate oral insulin trials in the
US last week. Spokesperson for Israel-
based Oramed Pharmaceuticals ... said
that the
http://www.in-pharmatechnologist.com/Drug-Delivery/Further-Hope-for-Oral-Insulin-as-Israeli-Delivery-Tech-Gets-Patent
oral form of insulin it was developing
could theoretically be marketable within
five years, but for ... [individuals with
Insulinitis] it would "be in addition to
injections [or inhaled insulin, if Afrezza
is approved?], though with the hope of
decreased need for injections and an
overall more stable glucose state.”

[Unknown from this article, whether or
not oral delivery addresses long-acting
or short-acting insulin requirements for
those with Insulinitis]

She added Oramed’s oral insulin is being
developed primarily to serve ... [indivi-
duals who have Cellosis (old name: type 2
diabetes)] ... and is therefore a longer-act-
ing candidate than other oral developments,
such as those being undertaken by
http://www.in-pharmatechnologist.com/Ingredients/Biocon-close-to-finalising-partnership-for-development-of-oral-insulin
Biocon and
http://www.in-pharmatechnologist.com/Drug-Delivery/Tamarisk-Technologies-claims-to-have-solved-the-oral-insulin-puzzle
Tamarisk.

Further Hope for Oral Insulin as Israeli
Delivery Tech Gets Patent (Novo Nordisk)
http://www.in-pharmatechnologist.com/Drug-Delivery/Further-Hope-for-Oral-Insulin-as-Israeli-Delivery-Tech-Gets-Patent

Novo Nordisk’s latest candidate, too, is
focused on ... [Cellosis] though - like Ora-
med - the company has a hope that a
variant for ... [Insulinitis] could follow
initial regulatory approval.

[another comment of dissonance, this
time regarding finger bloodpricks, from
Sara Kirsch]

Finger-Pricking Good?

... For Sara and many with her condition
it seems it is not the delivery that is the
issue but rather the constant monitoring
of glucose levels. “It's actually the pin
pricking of the fingers ... that bothers
me most. ... my fingers are all calloused
from years of checking my blood sugar
[glucose], sometimes so much so that
no blood comes out at times.”

- - - end excerpts - - -

- - - - - - - - - - - - - - - - - - - -

- - -
Pro-Humanist FREELOVER
C.ure I.nsulinitis A.ssociation
http://prohuman.net/cureinsulinitisassociation.htm
- - -