Dan's "Suprise For '96"
Bjyounger
about it in Goodman and Gillman's THE PHARMACOLOGICAL BASIS of
THERAPEUTICS (4th Edition).
METABOLIC EFFECTS: "After oral ingestion of 3 to 5mg/kg by man, the
metabolic rate rises within an hour by 20 to 30% and remains at this level
for about 24 hours. It gradually returns to normal within the following 48
hours. If aforementioned dose is repeated daily, the metabolic rate rises
to approximately +50% and remains at this level as long as medication is
continued,"
They then go on to state all the nice side effects of 2,4-DNP. But they
do state that "...had its long residence in the tissues been recognized
and appropriate doses used, it might have become a useful drug."
Bernie
Patrick Arnold
>From: Lyle McDonald <lyl...@delphi.com>
>Subject: Re: Dan's "Suprise For '96"
>Date: Sun, 17 Mar 96 00:34:15 -0500
>Is what you're saying here that at appropriate dosages (3-5mg/kg) that 2,4-DNP
>is a safe and effective metabolic booster. If so, break the silence
>and tell us where we can get a hold of some and how we can use it without
>killing ourselves.
>
My trusty Merck Index says that 2,4-DNP has an LD-50 of 30mg/Kg in rats. That
means half of a large group of rats die when given that particular dose. If
this is the same for humans than this stuff has a markedly small differential
between therapeutic and dangerous dosages. So one cannot overemphasize
caution when playing with this stuff, particularly due to the fact that it is
readily absorbed thru the skin and its vapors are absorbed when inhaled as
well.
Listed uses are in the manufacture of dyes, wood preservative, insectiside,
and as a pH indicator in analytical chemistry.
PA