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Description:
A discussion group for anyone with an interest in Medical Statistics.
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Estimating test retest and inter rater reliability
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Dear All
Is it possible to obtain estimates of test retest reliability and
inter rater reliability using the following design?
Time 1 Time 2
S1 rated by R1 S1 rated by R1
S2 rated by R1 S2 rated by R2
S3 rated by R2 S3 rated by R2... more »
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Sample size for Repeated Measures
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Dear all I am working on a Cohort study with Repeated Measures. I want to calculate sample size. How do I calculate the sample size? Thanks in advance
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sample size for sensitivity/specificity
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I have a clinical test (positive/negative) and surgery (disease/not-
diseased) and plan to calculate sensitivity/specificity. How do I
estimate the sample size? Any advice would be greatly appreciated.
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Confidence interval for ratio of independent binomial proportions
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Can anyone give advice on the state of the art for estimating the
confidence interval for the ratio of two independent binomial
proportions (e.g., CI for a likelihood ratio)?
An FDA guidance seems to be recommending 'exact' confidence intervals
here, though I'm not sure what they mean -- maybe something available... more »
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Simulation for sample size calculation
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Dear all,
I often get asked for simple sample size calculations, e.g. for a
difference between two independent means or two independent
proportions, however in the pursuit of greater accuracy I'd like to be
able to run simulations to get my figures instead of relying on the
standard formula. The trouble is I'm not sure of a (gentle) source of... more »
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Bland-Altman-Plots in case of duplicates/replicates
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Dear community,
I'm wondering if there are specials aspects to consider if Bland-
Altman plots are drawn for experiments when measurements are performed
in duplicates (or more replicates) per method.
One could use means, of course, but in that case information about
precision is lost, and differences could become smaller in average.... more »
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Population Attributable Risk (PAR) from Cross Sectional Studies?
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Hello Forumers:
I have a question. I am trying to wrap my head around the calculation
and use of Population Attributable Risk based on a cross sectional
study.
From my basic epidemiology courses, I have come to understand that
such an estimate is only reasonable when one can make plausible
assumptions of causality. Given that cross sectional studies are... more »
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{MEDSTATS} Trajectory modelling, useful with only two timepoints?
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Thomas Fröjd <tfr...@gmail.com> wrote ...I've never used PROC TRAJ (never even heard of it) but I'd hesitate to call something with only two timepoints a trajectory. Patterns in recovery are too complex to be captured with only two time points. I am also leery of classifying number of symptoms into "low" and "high" unless there is a clear separation.... more »
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