St. John'swort
Hypericum perforatum
St. John'swort contains numerous
compounds that possess documented biological actions, and are the focus of much
study. Those constituents that have generated the most interest thus far,
include the naphthodianthrones, hypericin and pseudohypericin, a wide range of
flavonoids, including quercetin, quercitrin, amentoflavone and hyperin, and the
phloroglucinols, hyperforin and adhyperforin. Also of interest to researchers
are the essential oils, and xanthones.
Wise herbalists have always used
the whole herb, and researchers agree, that it is an interaction between the
many constituents in St. John's wort, rather than any one active ingredient,
that is responsible for the wide range of beneficial actions this healing herb
offers.
All parts of the herb are used medicinally, with hypericin
content concentrated in the buds and flowers, and also present in top and bottom
leaves, as well as the stem, though to a lesser degree.
Activity of
Constituents:
Amentoflavone is antiinflammatory and
antiulcer.
GABA is a sedative.
Hyperforin is an antibacterial
agent active against gram-positive bacteria, is wound healing, a potential
anticarcinogenic, and a neurotransmitter inhibitor.
Hypericin is strongly
antiviral
Proanthocyanidins are antioxidant, antimicrobial, antiviral,
and vasorelaxant.
Pseudohypericin is antiviral and
Quercitrin is a
MAO inhibitor, as are the Xanthones.
Xanthones are antidepressant,
antimicrobial, antiviral, diuretic, and cardiotonic.
St. John'swort is an
excellent wound healer. It possesses strong antimicrobial properties, is a
significant antifungal and antibacterial agent, and is especially effective
against gram-positive bacteria. It inactivates Escherichia coli at dilutions of
1:400 or 1:200, and is also active against Staphloccus aureus.
Two
constituents of the herb, hyperforin and adhyperforin possess antibiotic effects
stronger than that of sulfonilamide.
Burns heal rapidly with the
application of St. John'swort. In one study using St. Johns'wort oil, first,
second, and third degree burns healed at least three times as rapidly than those
treated with conventional treatments, and scaring was minimal. Orally
administered St. John'swort tincture demonstrated a remarkable healing of
incisions, excision and dead space wounds, and has also been shown to inhibit
keloid formation.
Studies indicate St. John'swort may enhance coronary
blood flow as well as hawthorne, due to the activity of the procyanidins. It
significantly increases the production of nocturnal melatonin, which means
taking it will help you sleep better, and feel better.
St. John's wort
has also shown promise in the treatment of chronic tension headaches, and also
appears to be liver-protective. It is a proven antidepressant, best used by
those who are mildly to moderately depressed. It is also historically used to
treat neurological conditions such as anxiety, insomnia, restlessness,
irritability, neuralgia, trigeminal neuralgia. neuroses, migraines, fibrosis,
dyspepsia, and sciatica.
St. John’swort is an ally when dealing with any
fungal problem, such as candida (infusion as sitz bath), thrush (infusion as
mouth wash), or an infection on the skin or nails(frequent soaks in infusion).
Frequent applications of St. John’swort oil will also help in healing these
infections.
Use the oil to rub on to tired, sore, achey, painful,
overworked muscles. St. John’swort oil is legendary for relieving the pain and
inflammation of back-ache, stiff neck, sore shoulders, bad knees, tennis elbow,
and anything else that hurts.
St. Johns'wort has shown to be of
considerable benefit to patients with Acquired Immune Deficiency Syndrome.
(AIDS)
In one study, 16 out of 18 patients stabilized or improved during
a 40 month period during which they were treated with St. John'swort. Only 2 of
the 16 experienced an opportunistic infection during the time they took the
herb.
Many studies have proven that St. John'swort inhibits a variety of
viruses, including herpes simplex types 1 and 2, and HIV-1 viruses associated
with AIDS. Researchers have concluded that both hypericin and pseudohypericin
are uncommonly effective antiviral agents.
St. John's wort is also active
against murine cytomegalovirus, para-influenza 3 virus, Sindbis virus, vesicular
stomatitis virus, and equine infectious anemia virus.
The antiviral
activity of St. John's wort appears to be somewhat photodynamic, involving a
photoactivation process to become more intensely effective. Internal use of St.
John'swort is not recommended if you are currently taking a pharmaceutical
antidepressant.