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TABLE OF CONTENTS
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December 2007 Volume 39, Issue 12 |
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 Editorial
Obituary
Book Review
News and Views
Brief Communications
Articles
Letters
Technical Report
Erratum
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February 2-6, 2008 * Miami Beach, FL
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Editorial |
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Risky business p1415
Recent discoveries and improvements in technology have boosted the profile of 'personalized genomics'. But the demonstrated complexities of the genetics of common disease suggest caution—and an urgent need for more data, both in and out of the lab.
doi:10.1038/ng1207-1415
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Obituary |
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John Hilton Edwards 1928-2007 p1417
Victor A McKusick
doi:10.1038/ng1207-1417
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Book Review |
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Hairs and heirs p1419
Philip R. Reilly reviews The Genetic Strand: Exploring a Family History Through DNA by Edward Ball
doi:10.1038/ng1207-1419
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News and Views |
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Stalled polymerases and transcriptional regulation pp1421 - 1422
After initiating transcription, RNA polymerase II often stalls a short distance downstream of promoters. The recent discovery of stalled polymerases at a large number of eukaryotic promoters suggests that the regulation of stalling plays a more important role in gene expression and development than previously suspected.
John W Tamkun
doi:10.1038/ng1207-1421
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See also: Letter by Muse et al. | Letter by Zeitlinger et al.
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Sudden and unexpected pp1422 - 1423
Infections have been implicated in sudden and unexpected deaths, but evidence of causality and insights into underlying mechanisms are lacking. Now, a new study in mice identifies a homeostatic mechanism that seems critical for stabilizing the host response after microbial infection.
Rudi Balling
doi:10.1038/ng1207-1422
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See also: Article by Croker et al.
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High-maintenance proteins and hypertriglyceridemia pp1424 - 1425
Lipoprotein lipase, the enzyme that hydrolyzes fatty acids from triglycerides carried by circulating lipoproteins, resides on the surface of the capillary endothelium. Analysis of a hypertriglyceridemic mutant mouse has now identified a protein, LMF1, that is critical for the transport of active lipoprotein lipase through the secretory pathway.
Alan D Attie
doi:10.1038/ng1207-1424
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See also: Letter by Péterfy et al.
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Two sides of the same coin pp1425 - 1426
Dramatically different mutant phenotypes usually reflect mutations in different genes, but this is not necessarily so, especially when microRNA regulation is involved. A beautiful example of this now comes from the discovery of the maize microRNA tasselseed4 and its target ids1/Tasselseed6, which uncovers a new facet in the control of inflorescence branching and sex determination in flowers.
Andrea Gallavotti and Robert J Schmidt
doi:10.1038/ng1207-1425
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See also: Letter by Chuck et al.
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Touching base p1427
doi:10.1038/ng1207-1427
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Research highlights p1429
doi:10.1038/ng1207-1429
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With 100 publications, researchers have used the GS FLX to shorten the time from hypothesis to answer. Long reads and high accuracy enabled easy-to-interpret, high quality results. Combined with the GS FLX's ultra-high throughput, studies are completed fast, speeding publication.
www.genome-sequencing.com |
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Brief Communications |
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Rheumatoid arthritis association at 6q23 pp1431 - 1433
Wendy Thomson, Anne Barton, Xiayi Ke, Steve Eyre, Anne Hinks, John Bowes, Rachelle Donn, Deborah Symmons, Samantha Hider, Ian N Bruce, Wellcome Trust Case Control Consortium: Anthony G Wilson, Ioanna Marinou, Ann Morgan, Paul Emery, YEAR Consortium: Angela Carter, Sophia Steer, Lynne Hocking, David M Reid, Paul Wordsworth, Pille Harrison, David Strachan and Jane Worthington
doi:10.1038/ng.2007.32
First paragraph | Full Text | PDF
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Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11 pp1434 - 1436
Henry Houlden, Janel Johnson, Christopher Gardner-Thorpe, Tammaryn Lashley, Dena Hernandez, Paul Worth, Andrew B Singleton, David A Hilton, Janice Holton, Tamas Revesz, Mary B Davis, Paolo Giunti and Nicholas W Wood
doi:10.1038/ng.2007.43
First paragraph | Full Text | PDF
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Cystatin C modulates cerebral β-amyloidosis pp1437 - 1439
Stephan A Kaeser, Martin C Herzig, Janaky Coomaraswamy, Ellen Kilger, Maj-Linda Selenica, David T Winkler, Matthias Staufenbiel, Efrat Levy, Anders Grubb and Mathias Jucker
doi:10.1038/ng.2007.23
First paragraph | Full Text | PDF
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Cystatin C inhibits amyloid-β deposition in Alzheimer's disease mouse models pp1440 - 1442
Weiqian Mi, Monika Pawlik, Magdalena Sastre, Sonia S Jung, David S Radvinsky, Andrew M Klein, John Sommer, Stephen D Schmidt, Ralph A Nixon, Paul M Mathews and Efrat Levy
doi:10.1038/ng.2007.29
First paragraph | Full Text | PDF
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Articles |
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Genetic determinants of hair, eye and skin pigmentation in Europeans pp1443 - 1452
Patrick Sulem, Daniel F Gudbjartsson, Simon N Stacey, Agnar Helgason, Thorunn Rafnar, Kristinn P Magnusson, Andrei Manolescu, Ari Karason, Arnar Palsson, Gudmar Thorleifsson, Margret Jakobsdottir, Stacy Steinberg, Snæbjörn Pálsson, Fridbert Jonasson, Bardur Sigurgeirsson, Kristin Thorisdottir, Rafn Ragnarsson, Kristrun R Benediktsdottir, Katja K Aben, Lambertus A Kiemeney, Jon H Olafsson, Jeffrey Gulcher, Augie Kong, Unnur Thorsteinsdottir and Kari Stefansson
doi:10.1038/ng.2007.13
Abstract | Full Text | PDF
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ATP-sensitive potassium channels mediate survival during infection in mammals and insects pp1453 - 1460
Ben Croker, Karine Crozat, Michael Berger, Yu Xia, Sosathya Sovath, Lana Schaffer, Ioannis Eleftherianos, Jean-Luc Imler and Bruce Beutler
doi:10.1038/ng.2007.25
Abstract | Full Text | PDF
See also: News and Views by Balling
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Dynamic evolution of the innate immune system in Drosophila pp1461 - 1468
Timothy B Sackton, Brian P Lazzaro, Todd A Schlenke, Jay D Evans, Dan Hultmark and Andrew G Clark
doi:10.1038/ng.2007.60
Abstract | Full Text | PDF
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Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors pp1469 - 1476
Henri L Saenz, Philipp Engel, Michele C Stoeckli, Christa Lanz, Günter Raddatz, Muriel Vayssier-Taussat, Richard Birtles, Stephan C Schuster and Christoph Dehio
doi:10.1038/ng.2007.38
Abstract | Full Text | PDF
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Letters |
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Two independent alleles at 6q23 associated with risk of rheumatoid arthritis pp1477 - 1482
Robert M Plenge, Chris Cotsapas, Leela Davies, Alkes L Price, Paul I W de Bakker, Julian Maller, Itsik Pe'er, Noel P Burtt, Brendan Blumenstiel, Matt DeFelice, Melissa Parkin, Rachel Barry, Wendy Winslow, Claire Healy, Robert R Graham, Benjamin M Neale, Elena Izmailova, Ronenn Roubenoff, Alexander N Parker, Roberta Glass, Elizabeth W Karlson, Nancy Maher, David A Hafler, David M Lee, Michael F Seldin, Elaine F Remmers, Annette T Lee, Leonid Padyukov, Lars Alfredsson, Jonathan Coblyn, Michael E Weinblatt, Stacey B Gabriel, Shaun Purcell,
Lars Klareskog, Peter K Gregersen, Nancy A Shadick, Mark J Daly and David Altshuler
doi:10.1038/ng.2007.27
First paragraph | Full Text | PDF
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Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia pp1483 - 1487
Miklós Péterfy, Osnat Ben-Zeev, Hui Z Mao, Daphna Weissglas-Volkov, Bradley E Aouizerat, Clive R Pullinger, Philip H Frost, John P Kane, Mary J Malloy, Karen Reue, Paivi Pajukanta and Mark H Doolittle
doi:10.1038/ng.2007.24
First paragraph | Full Text | PDF
See also: News and Views by Attie
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Mutations in smooth muscle α-actin (ACTA2) lead to thoracic aortic aneurysms and dissections pp1488 - 1493
Dong-Chuan Guo, Hariyadarshi Pannu, Van Tran-Fadulu, Christina L Papke, Robert K Yu, Nili Avidan, Scott Bourgeois, Anthony L Estrera, Hazim J Safi, Elizabeth Sparks, David Amor, Lesley Ades, Vivienne McConnell, Colin E Willoughby, Dianne Abuelo, Marcia Willing, Richard A Lewis, Dong H Kim, Steve Scherer, Poyee P Tung, Chul Ahn, L Maximilian Buja, C S Raman, Sanjay S Shete and Dianna M Milewicz
doi:10.1038/ng.2007.6
First paragraph | Full Text | PDF
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A survey of genetic human cortical gene expression pp1494 - 1499
Amanda J Myers, J Raphael Gibbs, Jennifer A Webster, Kristen Rohrer, Alice Zhao, Lauren Marlowe, Mona Kaleem, Doris Leung, Leslie Bryden, Priti Nath, Victoria L Zismann, Keta Joshipura, Matthew J Huentelman, Diane Hu-Lince, Keith D Coon, David W Craig, John V Pearson, Peter Holmans, Christopher B Heward, Eric M Reiman, Dietrich Stephan and John Hardy
doi:10.1038/ng.2007.16
First paragraph | Full Text | PDF
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Loss of Trim24 (Tif1α) gene function confers oncogenic activity to retinoic acid receptor alpha pp1500 - 1506
Konstantin Khetchoumian, Marius Teletin, Johan Tisserand, Manuel Mark, Benjamin Herquel, Mihaela Ignat, Jessica Zucman-Rossi, Florence Cammas, Thierry Lerouge, Christelle Thibault, Daniel Metzger, Pierre Chambon and Régine Losson
doi:10.1038/ng.2007.15
First paragraph | Full Text | PDF
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RNA polymerase is poised for activation across the genome pp1507 - 1511
Ginger W Muse, Daniel A Gilchrist, Sergei Nechaev, Ruchir Shah, Joel S Parker, Sherry F Grissom, Julia Zeitlinger and Karen Adelman
doi:10.1038/ng.2007.21
First paragraph | Full Text | PDF
See also: News and Views by Tamkun
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RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo pp1512 - 1516
Julia Zeitlinger, Alexander Stark, Manolis Kellis, Joung-Woo Hong, Sergei Nechaev, Karen Adelman, Michael Levine and Richard A Young
doi:10.1038/ng.2007.26
First paragraph | Full Text | PDF
See also: News and Views by Tamkun
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The maize tasselseed4 microRNA controls sex determination and meristem cell fate by targeting Tasselseed6/indeterminate spikelet1 pp1517 - 1521
George Chuck, Robert Meeley, Erin Irish, Hajime Sakai and Sarah Hake
doi:10.1038/ng.2007.20
First paragraph | Full Text | PDF
See also: News and Views by Gallavotti & Schmidt
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Technical Report |
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Genome-wide in situ exon capture for selective resequencing pp1522 - 1527
Emily Hodges, Zhenyu Xuan, Vivekanand Balija, Melissa Kramer, Michael N Molla, Steven W Smith, Christina M Middle, Matthew J Rodesch, Thomas J Albert, Gregory J Hannon and W Richard McCombie
doi:10.1038/ng.2007.42
First paragraph | Full Text | PDF
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Erratum |
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Erratum: Splinkerette PCR for more efficient characterization of gene trap events p1528
Carsten Horn, Jens Hansen, Frank Schnutgen, Claudia Seisenberger, Thomas Floss, Markus Irgang, Silke De-Zolt, Wolfgang Wurst, Harald von Melchner and Patricia Ruiz Noppinger
doi:10.1038/ng1207-1528
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Nature Reviews Molecular Cell Biology
Poster - Readout of chromatin marks by histone-binding modules
The poster illustrates well-known histone marks and the 3D structures of representative histone-binding modules, and outlines emerging themes in the molecular recognition of modified histones.
Visit www.nature.com/nrm/posters/histonemarks for free online access.
Produced with support from:
abcam |
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