[Heaven] Watchers To The Antediluvians: We'll Mix Natural With Unnatural In Biotech Hack To Make You Stronger, Better

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Apr 29, 2010, 2:35:05 PM4/29/10
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Watchers To The Antediluvians: We'll Mix Natural With Unnatural In Biotech Hack To Make You Stronger, Better
Mice healed three times faster than normal after their broken bones were flooded by proteins naturally used to regrow new tissues. The discovery raises the possibility of a stem cell–free route to regeneration.
The Wnt family of proteins used in the mice are involved in healing many other types of tissue; the researchers hope they will find many other uses for them. “Gut, skin, brain, muscle, cardiac muscle, corneas, retinas — people have studied the role of Wnt signals in all those tissues,” said Stanford University reconstructive surgeon and study co-author Jill Helms. “Maybe there could be a therapeutic approach to all this.” The experiment, published April 28 in Science Translational Medicine, is rooted in two decades of research on Wnt genes and proteins, which play a variety of regenerative roles. They help embryonic stem cells make copies of themselves, keeping a body’s supply fresh, and guide the maturation of stem cells into specific cell types. Wnt proteins are found throughout the animal kingdom, from sponges and flatworms to mice and humans, and their function seems to be consistent. When tissues are injured, Wnt genes in surrounding cells become more active, pumping out extra Wnt proteins. Arriving repair cells divide faster and grow more rapidly.

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