Hi Jasper, I have made a few laser cut enclosures and I still keep doing it, it's often very good mix of design, electronics and plain handcrafts, I love it.
I've learned that lasercutting is very similar to 3D printing in a way that the machines are a bit unique and there are few tips and tricks for all of them, ponoko's tutorials work well for their cutters and probably for the rest big expensive machines, but not so much for the 900$ chinese CO2 cutter (obviously) anyway, there are good basics which should get you going with all of them.
There's also quite many choices how you want to build your box together and how it affects your design and the strength of the joints.
the handcraft style:
The easiest path I often tend to follow is using acrylic glue, I make my design using very simple big box joint for the edges. This is a very fast and good way to get your project done, but it's very easy to get messy with glue. Acrylic glue is very strong when you let it cure properly. I would avoid this method with wood (the simple joints), finger joints or a mix of glue and bolts is better option.
Finger joints:
it's a bit easier with wood using glue, but with acrylic it's very easy to crack it, if you don't shape your joint's right, I couldn't find the tutorial for this right now, but basically you should do a little teeth inside the joints
here's a picture I draw to demonstrate, I don't remember if there should be a opposite for the teeth as well, but try to find this tutorial if you are interested about finger joints with acrylic
nut's and bolts:
I've never done this because I don't like the look, but maybe some day when I find it handy. It's a good way to join the edges very strong without glue, it's also a good way to crack your acryl if you don't do the fine tuning:
Hopefully this helps a bit, or at least to find the right path
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anacron