Yes. You could have a single computer set to forward to all your
users' computers, or (slightly harder to do but also harder for users
to defeat) create and install a client on each of your users' machines
that receives messages over a custom protocol you design and then
notifies with those messages locally on each machine.
Keep in mind that, no matter what, your users can turn off the messages
—either by turning off forwarding (if you do it that way), or by
disabling the client app in Growl's preferences, or by turning off
Growl itself. Don't bury them in messages they'll want to shut out, or
they will. :)
Also, you will be writing software one way or the other. Growl alone
is not an origin for notifications; it is a conduit. You'll need to
write an app to be that origin.
Or, as long as Growl supports UDP, broadcast a notification onto the
LAN: all installed/enabled growl clients will show the same
notification, without the need of an extra piece of software.
Manu