What I'm interested in is determining if there are relationships between various predictors. Some of these (e.g., weather related) fluctuate from year to year across the entire data set (which is essentially of a network of plots spread out across a single location). Other predictors (e.g., soil type) are fixed across years but vary between the plots. And other predictors differ between the plots in a given year and change from year to year for individual plots (e.g., fire history - only some plots have burned in specific years). There are spatial relationships between the plots involved here as well, but I'm not even attempting to deal with that in this model. I have a number of outcome variables, which for simplicity are considered one at a time. They are essentially independent outcomes, though many of them are likely to be correlated with each other.
I have run a few models and they seem to be working out, but they tend to be complex an difficult to interpret. [This is a topic for a separate thread, but a better way to look at the effects of individual variables would be a real boon. Using sliders that allow you to vary the input variable and see the effect on the curve is very handy, and is used by various analytical packages, e.g., SAS JMP]
The initial models I ran were based on year to year changes in outcome variables (outcome_year n - outcome_year n-1). For those, I treated each year as a separate set of 324 points. I wasn't sure whether that was the best way to do that analysis, but I did end up with some reasonable models.