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DNA origami that fits into a PDMS socket?
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Nathan McCorkle  
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 More options Feb 29 2012, 12:36 am
From: Nathan McCorkle <nmz...@gmail.com>
Date: Wed, 29 Feb 2012 00:36:37 -0500
Local: Wed, Feb 29 2012 12:36 am
Subject: DNA origami that fits into a PDMS socket?
If you could make a nanofluidic 'tunnel' out of DNA origami that when
washed over an open microfluidic channel, stuck into a certain cut-out
section and was sealed around the edges... I think you'd have a cheap
source of nanofluidic reaction centers for something like
single-molecule DNA synthesis, which maybe could be measured with
capacitance or UV Raman spectroscopy to feedback info about whether
extension occurred or not.

--
Nathan McCorkle
Rochester Institute of Technology
College of Science, Biotechnology/Bioinformatics


 
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Nathan McCorkle  
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 More options Feb 29 2012, 3:46 am
From: Nathan McCorkle <nmz...@gmail.com>
Date: Wed, 29 Feb 2012 00:46:34 -0800 (PST)
Local: Wed, Feb 29 2012 3:46 am
Subject: Re: DNA origami that fits into a PDMS socket?

rOn Wednesday, February 29, 2012 12:36:37 AM UTC-5, Nathan McCorkle wrote:

> If you could make a nanofluidic 'tunnel' out of DNA origami that when
> washed over an open microfluidic channel, stuck into a certain cut-out
> section and was sealed around the edges...

Note that I'm talking about using PDMS as the microfluidic channel, which
is an elastomer so will have some flex to it. Maybe the cutout is a
rectangle, and the DNA origami is cuboid shaped with the tunnel going
through lengthwise... for that matter, maybe you make it a T shape, so you
get specificity for the entrance of the tube.    


 
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