Your problem description (minus the fact that it is specific to mod_wsgi, which sounds like a significant Clue) is reminiscent of this old thread:
http://groups.google.com/group/django-users/browse_thread/thread/6ef7622e8e7aa6a5/eb2d54fad5a8385f?
I believe I also had another person email me privately saying they were seeing this error message, but no one was ever able to provide a small test project that demonstrated the error (and the original poster on that thread stopped hitting the error after updating & splitting out the admin definitions into admin.py).
It sounds like there is likely a bug hidden somewhere here, but we need a reliable way of recreating it in order to figure out what is going on. If you can help out with providing a small testcase that demonstrates the problem I'm sure it would be appreciated.
Karen