The API calls look fairly similar, but you pass strings instead of
c_whatever_p(), they return tuples, and they throw exceptions instead
of returning HRESULT h s.t. FAILED(h).  The resulting code feels much
more Pythonic.  For example, my first test looked like this:

    def testread(self):
        """Read all data currently in pipe."""
        while True:
            try:
                (nRead, nAvail, nMessage) =
win32pipe.PeekNamedPipe(self.hFile, 0)
                if nAvail:
                    (hr, data) = win32file.ReadFile(self.hFile, nAvail)
                    return data
            except pywintypes.error, e:
                errno = e.args[0]
                if errno == 109:  # other end disconnected
                    self.disconnect()
                    self.connect()
                else:
                    raise

It's kind of cool that you can directly port C code to Python, but the
end result is IMO nigh-unreadable.