I'd be shocked if some of the CS niceties ever got added to Python. I am a big fan of Python, but certain types of sugar just don't fit into its philosophy. People have asked for better ways to write anonymous functions in Python for as long as I can remember. I also doubt that optional parentheses in function calls would ever fly.
Despite liking some CS features that aren't in Python, I couldn't imagine ever using a transcompiler for Python. Python doesn't have any major semantic gaps, and it has all the major syntax sugar that I want, such as indentation-based blocking, multi-line strings, etc.
To each his own, though. Python has a pretty long history--in general, if somebody's thought of it, I'm guessing somebody's done it.