Tipranavir, or tipranavir disodium, is a nonpeptidic protease
inhibitor (PI) manufactured by Boehringer-Ingelheim under the trade
name Aptivus. It is administered with ritonavir in combination therapy
to treat HIV infection.
Tipranavir has the ability to inhibit the replication of viruses that
are resistant to other protease inhibitors and it recommended for
patients who are resistant to other treatments. Resistance to
tipranavir itself seems to require multiple mutations.
http://bioinformations.info/?p=460