Cardio Capers PON1...& Other P Thingamabob's
randall
Hi,
Since psoriasis does have cardio risks associated with it we should be
aware
of any and all things we can work in our favor.
And that includes WHAT goes in OUR mouths.
As the psoriatic liver is impaired to some degree no doubt related to
severity and liver enzymes are so important. Consider the benefits
from eating foods rich in Quercetin.
First what are these phase II enzymes?
http://en.wikipedia.org/wiki/Hepatotoxicity
http://en.wikipedia.org/wiki/Drug_metabolism
to
http://en.wikipedia.org/wiki/Drug_metabolism#Phase_II
And the secret enzyme of the day:
paraoxonase 1 (PON1) 1552 hits on pubmed
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=DetailsSearch&term=paraoxonase+1&log$=activity
See this one: PMID: 19141295
Fourth one down in the above search.
What is PON1?
http://en.wikipedia.org/wiki/PON1
Paraoxonase 1 (PON1) is a protein-coding gene.[1] The protein encoded
by this gene has esterase activity.[2]
Function
[...]
PON1 (paraoxonase 1) is also a major anti-atherosclerotic component of
high-density lipoprotein (HDL).[3][4]
<sniP>
---------------
http://en.wikipedia.org/wiki/Quercitin
Eat those CAPER's. LOL
[...]
Drug interactions
Quercetin is contraindicated with some antibiotics; it may interact
with fluoroquinolones (a type of medicinal antibiotic), as quercetin
competitively binds to bacterial DNA gyrase. Whether this inhibits or
enhances the effect of fluoroquinolones is not entirely clear.[12]
Quercetin is also a potent inhibitor of CYP3A4, an enzyme that breaks
down most drugs in the body.[13] As such, quercetin would be expected
to increase serum levels, and therefore effects, of drugs metabolized
by this enzyme.
[...]
Foods rich in quercetin include capers (1800mg/kg)[1], lovage (1700mg/
kg), apples (440mg/kg), tea (Camellia sinensis), onion, especially red
onion (higher concentrations of quercetin occur in the outermost rings
[2]), red grapes, citrus fruit, tomato, broccoli and other leafy green
vegetables, and a number of berries including cherry, raspberry, bog
whortleberry (158 mg/kg, fresh weight), lingonberry (cultivated 74mg/
kg, wild 146 mg/kg), cranberry (cultivated 83 mg/kg, wild 121 mg/kg),
chokeberry (89 mg/kg), sweet rowan (85 mg/kg), rowanberry (63 mg/kg),
sea buckthorn berry (62 mg/kg), crowberry (cultivated 53mg/kg, wild 56
mg/kg),[3] and the fruit of the prickly pear cactus. A recent study
found that organically grown tomatoes had 79% more quercetin than
"conventionally grown".[4]
A study[5] by the University of Queensland, Australia, has also
indicated the presence of quercetin in varieties of honey, including
honey derived from eucalyptus and tea tree flowers.[6]
<sniP>
========================
Let's find some online news items for PON1.
http://7thspace.com/headlines/301859/paraoxonase_1_is_related_to_inflammation_fibrosis_and_ppar_delta_in_experimental_liver_disease.html
Paraoxonase-1 is related to inflammation, fibrosis and PPAR delta in
experimental liver disease
Paraoxonase-1 (PON1) is an antioxidant enzyme synthesized by the
liver. It protects against liver impairment and attenuates the
production of the pro-inflammatory monocyte chemoattractant protein-1
(MCP-1).
We investigated the relationships between hepatic PON1 and MCP-1
expression in rats with liver disease and explored the possible
molecular mechanisms involved.
Methods: CCl4 was administered for up to 12 weeks to induce liver
damage.
Serum and hepatic levels of PON1 and MCP-1, their gene and protein
expression, nuclear transcription factors, and histological and
biochemical markers of liver impairment were measured.
Results: High levels of PON1 and MCP-1 expression were observed at
12th week in the hepatocytes surrounding the fibrous septa and
inflammatory areas.
CCl4-administered rats had an increased hepatic PON1 concentration
that was related to decreased gene transcription and inhibited protein
degradation. Decreased PON1 gene transcription was associated with
PPARd expression.
These changes were accompanied by increased hepatic MCP-1
concentration and gene expression. There were significant direct
relationships between hepatic PON1 and MCP-1 concentrations (P =
0.005) and between PON1 and the amount of activated stellate cells (P
= 0.001).
Conclusion: Our results from this experimental model suggest a hepato-
protective role for PON1 against inflammation, fibrosis and liver
disease mediated by MCP-1.
Author: Judit Marsillach, Jordi Camps, Natalia Ferre, Raul Beltran,
Anna Rull, Bharti Mackness, Michael Mackness and Jorge Joven
Credits/Source: BMC Gastroenterology 2009, 9:3
<sniP>
---------------------------
Quercetin Improves Heart Health
Breaking News
By VRP Staff
The bioflavonoid quercetin is involved in regulating a gene that
protects against LDL cholesterol oxidation, a new study has revealed.
The gene paraoxonase 1 (PON1) protects low-density lipoprotein (LDL)
cholesterol from undergoing the oxidation process. PON1 therefore
plays a role in heart health because it is the oxidation process that
is linked to LDL cholesterol’s heart damaging effects. PON1 also is a
major anti-atherosclerotic protein component of the “good”
cholesterol, high-density lipoprotein (HDL) cholesterol.
In a new study, researchers explored the role that quercetin plays in
regulating PON1 expression in rats. The scientists found that compared
to the control group, the rats fed quercetin for four weeks
experienced a 35 percent increase in PON1 expression in the liver.
Serum PON1 activities also increased by 29 percent. In the quercetin
group, the activity of homocysteine thiolactonase (HCTL), an enzyme
associated with breaking down homocysteine, an amino acid implicated
in heart disease, increased by 23 percent.
Furthermore, quercetin appeared to assist HDL in offsetting the
negative effects of LDL in that it took longer for the LDL to oxidize
when it was exposed to the plasma HDL from the quercetin-fed group
compared to the HDL from the control group.
The study authors concluded, “Our data suggest that quercetin has
antiatherogenic effect by up regulating PON1 gene expression and its
protective capacity against LDL oxidation.”
<sniP>
http://www.nature.com/nature/journal/v449/n7162/fig_tab/nature05893_F1.html
In response to microbial infection or tissue injury, LL37 is produced
locally in the skin, where its normal functions include antimicrobial
activity and aiding in wound-healing. Lande et al.1 show that LL37
also forms complexes with self DNA that is released from dying cells.
In normal skin, these DNA–LL37 complexes probably remain undetected
and inconsequential. But in the presence of plasmacytoid dendritic
cells (pDCs), which accumulate in the skin lesions of patients with
psoriasis, these complexes trigger strong interferon-α (IFN-α)
production, which is known to perpetuate the disease10.
<sniP>
Bevins et al call self-DNA, HOST DNA. LOL
http://www.nature.com/nature/journal/v449/n7162/full/nature05893.html
Why read the article when the pictures tell the whole story? LOL
-----------------
How funny is that one?
YOUR HOST DNA is the problem when cathelicidin mixes with LL-37 (LL37)
<w>
------------
You can read all about LL37 here:
http://www.phoenixpeptide.com/catalog/pnxfoget.php?id=pnxnews_000000087&title=Compound&sum=Function
You might need to re-enter USofA for country to obtain the page.
=========================
This goes with that connected health site from yesterday.
The Role of Online Support Communities: Benefits of Expanded Social
Networks to Patients With Psoriasis.
Idriss SZ, Kvedar JC, Watson AJ.
MBChB, MRCP, 25 New Chardon St, Suite 400D, Boston, MA 02114.
AJWa...@partners.org.
OBJECTIVE: To determine the demographics, usage patterns, attitudes,
and experiences of online support site users. DESIGN: Online survey.
Patients A total of 260 subjects recruited from 5 online psoriasis
support groups. MAIN OUTCOME MEASURES: An exploratory analysis was
performed to determine demographic and disease characteristics of
online support site users. Perceived benefits were also documented.
RESULTS: The mean (SD) age of respondents was 40.1 (11.5) years
(range, 18-75 years), most (75.7%) were white, female (60.4%), and
college educated (84.3%). Key factors associated with use of online
support sites included availability of resources (95.3%), convenience
(94.0%), access to good advice (91.0%), and the lack of embarrassment
when dealing with personal issues (90.8%). The most common activities
were posting messages (65.0%) and searching for information (63.1%).
Nearly half of all respondents perceived improvements in their quality
of life (49.5%) and psoriasis severity (41.0%) since joining the site.
Intensity of participation in online support activities was associated
with improved quality of life (P = .002), but not with improvements in
psoriasis severity. CONCLUSIONS: Our data demonstrate that psoriasis
virtual communities offer users both a valuable educational resource
and a source of psychological and social support. Such benefits could
be further enhanced by physician engagement within these communities.
PMID: 19153342
--------------------
More genes for the P theory of genetics.. <w> <w>
Methylation works for phase II detoxification.
http://www.ncbi.nlm.nih.gov/pubmed/19153068?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
Promoter methylation status of p15 and p21 genes in HPP-CFCs of bone
marrow of patients with psoriasis.
Zhang K, Zhang R, Li X, Yin G, Niu X.
Psoriasis is inflammatory disease related to dysfunctional immunity.
The dysfunctional immunity may influence the haematopoietic
microenvironment or haematopoiesis in psoriasis. However, direct
evidence is lacking. Our objective was to investigate the
proliferation of hematopoietic cells from psoriatic patients and any
link between the promoter methylation status of p15 and p21 genes and
the colony formation ability of high proliferative potential colony-
forming cells (HPP-CFCs). Marrow mononuclear cells were isolated from
the bone marrow of psoriatic patients and normal controls by density
gradient centrifugalization. Colony forming assays of HPP-CFCs were
performed in vitro in methylcellulose semi-solid culture medium. mRNA
expression and the promoter methylation status of p15 and p21 genes in
HPP-CFCs were studied by semi-quantitative RT-PCR and methylation-
specific PCR respectively. In methycellulose semi-solid culture
system, the colony count of HPP-CFCs in bone marrow of psoriatic
patients was significantly less than that of normal controls.
Moreover, significantly lower positive frequencies of promoter
methylation and higher transcription levels for p15 and p21 genes were
observed in psoriasis in comparison to normal volunteers. The lower
promoter methylation of p15 and p21 genes may be an important
mechanism for the dysfunctional growth regulation pathways in HPP-CFCs
in psoriasis.
PMID: 19153068
-------------------
Strep as a P PLAYER, all the time and what one can do is stop
http://www.ncbi.nlm.nih.gov/pubmed/19151963?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
[The role of streptococci in psoriasis.]
[Article in German]
Prinz JC.
Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-
Maximilians-Universität, Frauenlobstrasse 9-11, 80337, München,
Deutschland, joerg...@med.uni-muenchen.de.
Infections with Streptococcus pyogenes are highly relevant among the
environmental factors that contribute to first onset or relapses of
psoriasis in predisposed individuals. Streptococcal angina or
pharyngitis, but also perianal streptococcal dermatitis,
vulvovaginitis or balanoposthitis are potential causes. Several
mechanisms such as molecular mimicry or superantigens may be involved.
Many patients develop a chronic streptococcal infection or
colonization that may result from the ability of streptococci for
intracellular uptake and persistence in epithelial cells. Whether and
under what conditions a curative treatment of streptococcal infection
by tonsillectomy or antibiotic treatment may affect the course of
psoriasis, as proposed by several observations, needs to be determined
in more detail by clinical trials.
PMID: 19151963
---------------
New Structural Motif In Key Enzymes Is Essential To Prevent Autoimmune
Disease
http://www.medicalnewstoday.com/articles/135857.php
or
http://news.biocompare.com/News/NewsStory/260000/NewsStory.html
Early Immune System Exposures Linked To Chronic Disease
http://www.medicalnewstoday.com/articles/135313.php
Type I Interferon Production In White Blood Cells Regulated By A New
Mechanism
http://www.medicalnewstoday.com/articles/135245.php
** DERMA -- News **
New Melanoma / Skin Cancer Channel On Medical News Today
http://www.medicalnewstoday.com/articles/135781.php
Pre-emptive Treatment Helped Curtail Skin Toxicity With Panitumumab
http://www.medicalnewstoday.com/articles/135796.php
Acculturation Of Latinos Influences Sun-safe Behaviors
http://www.medicalnewstoday.com/articles/135685.php
A Shot In The Arm To Fight Skin Cancer
http://www.medicalnewstoday.com/articles/135646.php
No Harm Done To Depressed Adolescents By Being Part Of Placebo Group
In Clinical
Trial, Researchers Find
http://www.medicalnewstoday.com/articles/135612.php
Skin Pigmentation Studies That Shed Light On The Evolution Of Race,
Published In
Zebrafish Journal
http://www.medicalnewstoday.com/articles/135556.php
UM Brings Top Dermatologist To Lead Melanoma Clinic
http://www.medicalnewstoday.com/articles/135192.php
http://www.medicalnewstoday.com/sections/melanoma
** MELANOMA / SKIN CANCER News **
Important Advance In The Treatment Of Cancer And Viral Infections
http://www.medicalnewstoday.com/articles/135866.php
-------------------
A disease no one has ever heard of caused by global warming
http://www.medicalnewstoday.com/articles/135750.php
=================================================
http://www.sciencedaily.com/releases/2009/01/090120213454.htm
Blocked Protein Prevents Lupus In Mouse Model
ScienceDaily (Jan. 20, 2009) — Mice from a strain that ordinarily
develops systemic lupus erythematosus (SLE), but bred with a
deficiency in receptor for the protein Interleukin 21, stayed healthy
and exhibited none of the symptoms of the disease, researchers at The
Jackson Laboratory and National Institutes of Health report.
SLE is an autoimmune disease, with symptoms of varying severity
including include painful or swollen joints, unexplained fever and
extreme fatigue. An estimated 2 million Americans—9 out of 10 of them
female—live with SLE.
The primary job of the immune system is to identify and vanquish
potentially dangerous infectious pathogens. Autoimmune diseases
develop when immune system instead unleashes this potent defense
system against the individual’s own tissues, with predictably severe
consequences.
Unlike other autoimmune diseases such as Type 1 diabetes, in which the
immune response is focused on certain tissues, SLE is a systemic
disease in which abnormal antibodies are produced that injure a
variety of tissues and organs, including the skin, heart, lungs and
kidneys.
The cause of SLE is not well understood, but recent work by a Jackson
Laboratory research team led by Professor Derry Roopenian is shedding
light on how the disease develops and offers hope for better
therapies.
Interleukin 21 (IL21) i s produced as part of the response by immune
cells known as T cells. The IL21 produced then affects a variety of
cells in the normal immune system response. However, IL21 produced in
overabundance by individuals susceptible to SLE can cause the defense
mechanism to misfire and produce antibodies that attack the
individual’s own tissues.
Dr. Roopenian and colleagues at the National Heart, Lung, and Blood
Institute and the National Institute of Allergy and Infectious
Diseases worked with a mouse model for SLE and demonstrated that IL21
signaling is essential for the SLE-like autoimmune disease to
progress. Mice deficient in the cellular receptor for IL21 that were
otherwise genetically identical remained healthy and exhibited none of
the disease symptoms.
“The findings provide strong clue towards understanding how SLE occurs
and a clear indication of the importance of Interleukin 21 signaling
in lupus like diseases”, Dr. Roopenian says. “They suggest that
interrupting Interleukin 21 signaling events may prove to be an
effective therapeutic option for human SLE.”
Journal reference:
1. . A critical role for IL-21 receptor signaling in the
pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice.
Proceedings of the National Academy of Sciences, Early Edition
publication Jan. 19-23, 2009
=========================
randall...