FLAKE GENEs --- TOPICALs - Stress -- Lithium -- EXERCISE vs Supplements...
randall
It's all haPPening in your GENEs.
http://www.ncbi.nlm.nih.gov/pubmed/19446472
Unraveling the genetics of complex diseases: Susceptibility genes for
rheumatoid arthritis and psoriasis.
Li Y, Begovich AB.
Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA.
Talk of numerous genetic risk factors for rheumatoid arthritis (RA)
and psoriasis has been percolating for years, but with the exception
of the human leukocyte antigen (HLA) region, none have been
definitively identified. Recently the results of multiple, well
powered, genetic case-control studies have begun to appear providing
convincing statistical evidence for at least ten non-HLA related risk
genes or loci (C5/TRAF1, CD40, CTLA4, KIF5A/PIP4K2C, MMEL1/TNFRSF14,
PADI4, PRKCQ, PTPN22, STAT4, and TNFAIP3/OLIG3) for RA and six (IL12B,
IL13, IL23R, STAT2/IL23A, TNFAIP3, and TNIP1) for psoriasis. These
initial, novel findings are beginning to shed light on the molecular
pathways pertinent to the individual diseases and highlight the
pleiotropic effects of several risk factors as well as the allelic
heterogeneity underlying susceptibility to these and other autoimmune
diseases.
PMID: 19446472
So when we hate ourselves it's really just these genes
IL12B, IL13, IL23R, STAT2/IL23A, TNFAIP3, and TNIP1, that we hate?
StoP hating YOU and hate these guys IL12B, IL13, IL23R, STAT2/IL23A,
TNFAIP3, and TNIP1, inside of you then?
Or you can hate all of those pesky viruses and fungi.
Just blast those fungi and virals right outa your life. :)
-------
We need some Obama hoPe and change.
YeP...
I hoPe i'm not left with small change when the Chinese take over the
world and we
end up on a tax plantation. LOL
Now, now... it's all bushes fault. he spent to much. LOL <w>
Let's try to understand OUR genes that make us FLAKEs... :)
Or :( dePending on your point of view?).
I've never been good with models or making them, so DNA being the
blueprint so to sPeak
has seemed murky for me.
Let's dive in.
Allelic heterogeneity:
The phenomenon in which different mutations at the same locus (or
gene) cause the same disorder. For example,β-thalessemia may be caused
by several different mutations in the β-globin gene.
http://en.wikipedia.org/wiki/Heterogeneous
I'm still flaky are you? LOL
------
What are those hate filled little monkeys again?
IL12B, IL13, IL23R, STAT2/IL23A, TNFAIP3, and ____TNIP1_____
Ok.. let's look at the last p gene in the above group? TNIP1
I'm game.
But nO monkey business dude.
OK, let's roll.
TNIP1 23 hits in pubmed including the above:
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=DetailsSearch&term=TNIP1&log$=activity
Wow, this gene TNIP1 and ARNTL, RBCK1, regulates p53 function, which
is turned off when cancer rears it's head.
http://www.ncbi.nlm.nih.gov/pubmed/19277210
And this gene was found in that big UofM derm department thing with
bowcock and krueger et al back in Feb/09.
http://www.ncbi.nlm.nih.gov/pubmed/19169254
I guess we'd turn up similar connections on all the rest of them.
And reveal that some of us early psor onsets got the trifecta. LOL :(
http://en.wikipedia.org/wiki/Trifecta
And we have xyz lining up for a perfect plaque coming in to the finish
line. <g>
GACK... i hit the genetic trifecta for psoriasis... Yikes...get the
OINTMENT?
Will it sooth my psor nerves?
========================
What do you do?
The stress is to much....
Find some mush?
Huh?
Rocket Seed toPical oil NOT rocket seed mush?
Whats a rocket seed?
http://www.ncbi.nlm.nih.gov/pubmed/19459144
Potential skin antiinflammatory effects of 4-
methylthiobutylisothiocyanate (MTBI) isolated from rocket (Eruca
sativa) seeds.
Yehuda H, Khatib S, Sussan I, Musa R, Vaya J, Tamir S.
Laboratory of Human Health and Nutrition Sciences, MIGAL-Galilee
Technology Center, Kiryat-Shmona 11016, Israel.
Isothiocyanates (ITCs), which are organosulfur compounds present in
cruciferous vegetables, have anticarcinogenic, antiinflammatory, and
antiproliferative activities. These biological activities, and the
knowledge that rocket seed (Eruca sativa) extract is used in skin
disorders in traditional Middle Eastern medicine, led to the isolation
and assessment of 4-methylthiobutylisothiocyanate (MTBI), the major
ITC in rocket seeds, for its potential in the prevention of
inflammatory skin diseases, such as psoriasis. MTBI was found to
depress the growth of activated keratinocytes and to arrest the
activated THP-1 monocytes in the G2 stage. Both MTBI and its oxidized
derivative sulforaphane (SFN), which was found in the rocket seed at a
low concentration, downregulated the expression of the proinflammatory
genes, tumor necrosis factor (TNF)-alpha and interleukin (IL)-12/23
p40, as well as that of intercellular adhesion molecule-1, in
activated THP-1 cells. These results demonstrate that MTBI may deter
the inflammation process, as has been reported for SFN. Furthermore,
pretreatment with MTBI hindered the induction of the inflammatory
state in the THP-1 cells, as shown by the inhibition of cytokine mRNA
expression of IL-1beta, IL-12/23 p40, and TNF-alpha. Overall, our
results imply that MTBI may represent a new family of natural
compounds possessing significant skin inflammation-preventive
activities. (c) 2009 International Union of Biochemistry and Molecular
Biology, Inc.
PMID: 19459144
You wonder what a rocket seed looks like?
So do i.
http://en.wikipedia.org/wiki/Eruca_sativa
OK, it's arugula. LOL
Besides eating the leaves, you can make an alcoholic beverage and an
aphrodisiac used by those Romans who knew how to throw a toga party or
two.
And i bet you can feed it to your horse in a pinch?
Whoa Trigger... off of my leg. LOL
Da*n he pulled the trigger...?
Yep, where's a cute little filly like Rachel Alexandra when you need
one? LOL
Hanging around the preakness tracks a few weeks back?
And now chewing some graPe leaves at Kendall Jackson?
I don't know where his trainder keePs her.
But it would sell a few thousand cases to keep her
around those cellars under napa/sonoma.
===================
So we have a good new potential toPical from eruca sativa (arugula
seeds), thats good news.
WhooPs, bad news for this next toPical..
It's dropPing to last place?
22-oxacalcitriol ointment
Bad news for this toPical?
Really?
If you get a pain in the pancreas then stOP using 22-oxycalcitriol?
But, but it's the vitamin D3 miracle craP? Isn't it?
Attention Manfred, please figure out this obvious conundrum? WE know
that calcipotriol= D3 right? Used in dovonex,
http://en.wikipedia.org/wiki/Calcipotriol
and that http://en.wikipedia.org/wiki/Vitamin_D is vitamin D3 or
cholecalciferol. With
pharma grade D3 in it.
http://en.wikipedia.org/wiki/Calcitriol
Calcitriol is like the ultimate tricked out D3 toPical isn't it?
Don't we KNOW via Cannell, Mark Lebwohl and Biggie D3 guru Michael
Hollick that D3 is like DUH
kind?
D3 is like BAM o RAMA duh KIND.... dude.
If you could smoke it, you'd like be duh dude and stoned. LOL
In this case it's another pain in the digestive organ that you CAN'T
live without dude.
I wonder if this affects Vectical Ointment (calcitriol in it?)
See for vectical ointment:
http://sev.prnewswire.com/health-care-hospitals/20090430/SF0838930042009-1.html
Ok so what's wrong with ointment 22-OXAcalcitriol (one would wonder
if O2 is gamed with calcitriol in this ointment to kill those pesky
BRET postulated virions (virals, viruses,et al) and fungi or
bioflilms? and bad bacteria (wondering if Bret includes nano bac's?)?
Ta dah!
http://www.ncbi.nlm.nih.gov/pubmed/19454832
Drug-induced acute pancreatitis associated with 22-oxacalcitriol
ointment for treatment of psoriasis.
Sato M, Takamura M, Sato Y, Yokoyama H, Nozawa Y, Masui Y, Miida H,
Hashimoto T, Ito M, Aoyagi Y.
PMID: 19454832
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Whoops no meat in this taco...
I'll find a link:
http://www.jbc.org/cgi/content/abstract/278/3/1463
------
22 hits for 22-oxacalcitriol ointment on pubmed:
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=22-oxacalcitriol%20ointment%20&itool=QuerySuggestion
Oh Well i've never used toPical till the wheat grass stuff showed up.
Even then I wasn't sure as i've shunned topicals forever.
======================
Stress, stress and more stress..
Gets on your nerves?
What haPPens THEN?
http://www.ncbi.nlm.nih.gov/pubmed/19453808
Neuronal changes in psoriasis exacerbation.
El-Nour H, Santos A, Nordin M, Jonsson P, Svensson M, Nordlind K, Berg
M.
Unit of Dermatology and Venereology, Department of Medicine, Solna,
Karolinska University Hospital, Stockholm, Sweden.
Abstract Background The nervous system contributes to inflammatory
skin diseases. Objective The aim of this investigation was to study
the neuronal contribution to psoriasis at the remission and
exacerbation phases. Methods We examined the expression of the
neuronal markers protein gene product 9.5 (PGP 9.5), growth-associated
protein-43 (GAP-43) and substance P, in addition to its receptor (R),
neurokinin-1R (NK-1R) in psoriatic skin from seven female patients at
remission and exacerbation, using immunohistochemistry. Results The
number of epidermal PGP 9.5 immunoreactive nerve fibres in the
involved skin during exacerbation was decreased (P < 0.01) compared to
involved skin at remission and non-involved skin at the exacerbation
phase. GAP-43-positive nerve fibres were decreased (P < 0.05) in the
involved skin in contrast to non-involved skin, during exacerbation.
Substance P expression was seen on both immunoreactive nerve fibres
and cells with a down-regulation (P < 0.01) in the number of positive
nerve fibres in the involved skin compared to non-involved skin, at
the exacerbation phase. The number of substance P-positive cells was
slightly lower in the involved skin at exacerbation than at remission.
The number of NK-1R immunoreactive cells was increased (P < 0.01) in
the involved skin in contrast to non-involved skin, at the
exacerbation phase. Conclusion Our findings suggest a crosstalk
between the nervous system and inflammation during psoriasis
exacerbation in the form of an altered expression of nerve fibres,
substance P and its NK-1R. Conflicts of interest None declared.
PMID: 19453808
======================
All this stress due to cold weather?
YeP, because of ZERO sunspots for the last year and half we may
be going back in to an ice age?
Yikes...
Big time Frigid stress?
What a MESS.
REALLY RANDALL?
Or are you gaming us?
No I must confess that our GOV wants
to game CAP and TRaDE to screw the small families
in to paying another $1,600.00 a year in TAX. Yikes
That is stress and a total obama MESS,
Well he clear it uP and us with gaming viruses and fungi
with oxygen and cesium like bret says?
All our health care costs will sink by 75% minimum.
According to the way i've read Bret and it postulates out
for HUGE Economic benefits. I'm sure obama is
on board or he would'nt be doing these punitive tax
hikes that will sink us like a million billion ton anchor
in a few years.
So don't confess when you don't see any sunsPots on the sun.
It's those pesky lying scum bag politicians who want to control the
world.
But the randall is using the SUN to screw them first. LOL
Ok and now save the poor psor folk randall?
HOw...
So you send a pack of psor heads to the canary islands for some R&R.
And that does what?
Takes the stress off and builds some Vitamin D3 from UV-b rays and and
and...
Eat the arugula salad and put the seed oil (rocket seeds) as a
topical. LOL
And do a few toga parties?
If you wish.... when in ROME. <W>
I bet if obama puts his hand in to the mouth of truth
he'll freak out and want bush to go first. LOL
Roman holiday
http://www.youtube.com/watch?v=G8Uoezs6Nm0
http://www.ncbi.nlm.nih.gov/pubmed/19453805
Effect of climate therapy at Gran Canaria on vitamin D production,
blood glucose and lipids in patients with psoriasis.
Osmancevic A, Nilsen LT, Landin-Wilhelmsen K, Søyland E, Abusdal
Torjesen P, Hagve TA, Nenseter MS, Krogstad AL.
Department of Dermatology, Sahlgrenska University Hospital,
Sahlgrenska Academy, Göteborg, Sweden.
Abstract Background Climate therapy (heliotherapy) of psoriasis is an
effective and natural treatment. Ultraviolet radiation (UVB) from the
sun improves psoriasis and induces vitamin D(3) synthesis. Objective
The aim of the study was to investigate the effect of climate therapy
on vitamin D(3) synthesis, blood glucose, lipids and vitamin B12 in
psoriasis patients. Methods Twenty Caucasian patients (6 women and 14
men; mean age, 47.2 years; range, 24-65) with moderate to severe
psoriasis [mean Psoriasis Area and Severity Index (PASI) score 9.8;
range, 3.8-18.8] received climate therapy at the Gran Canarias for 3
weeks. Blood samples were drawn before and after 15 days of sun
exposure. In addition, the patients' individual skin UV doses based on
UV measurements were estimated. Results Sun exposure for 15 days lead
to a 72.8% (+/- 18.0 SD) reduction in the PASI score in psoriasis
patients. Although no direct correlation was observed between PASI
score improvement and UVB dose, the sun exposure improved the vitamin
D, lipid and carbohydrate status of the patients. The serum
concentrations of 25-hydroxyvitamin D [25(OH)D] increased from 57.2
+/- 14.9 nmol/L before therapy to 104.5 +/- 15.8 nmol/L (P < 0.0001)
after 15 days of sun exposure; the serum levels of 1,25-
dihydroxyvitamin D [1,25(OH)(2)D] increased from 146.5 +/- 42.0 to
182.7 +/- 59.1 pmol/L (P = 0.01); the ratio of low-density lipoprotein
cholesterol and high-density lipoprotein cholesterol decreased from
2.4 to 1.9 (P < 0.001); and the haemoglobin A(1)c (HbA(1)c) levels
decreased from 5.6 +/- 1.7% to 5.1 +/- 0.3% (P < 0.0001). Conclusion
Climate therapy with sun exposure had a positive effect on psoriasis,
vitamin D production, lipid and carbohydrate status. Conflicts of
interest None declared.
PMID: 19453805
======================
OK, so your still stressed out after goiing to the canary islands for
R&R.
What do you do then?
Take Lithium?
Yikes.... no WAY... i'd rather eat sweet whey and OBEY
the randall gosPel of galactose.
NO de NOVO p for this mean machine...
Let's do the modern day stressed out lithium review.
Wow, after reading this below, i'm wondering if the de novo properties
of lithium are due to renal and kidney functions with vitamin D3?
Manfred, what do you think?
http://www.ncbi.nlm.nih.gov/pubmed/19453201
Lithium: Updated Human Knowledge Using an Evidence-Based Approach:
Part III: Clinical Safety.
Grandjean EM, Aubry JM.
Phidalsa Institute for Clinical Investigation, Geneva, Switzerland.
Lithium use in mental diseases has changed over the years but remains
a cornerstone of treatment in bipolar disorders. In two companion
papers, we have reviewed existing (and especially recent) data on
lithium efficacy and updated basic knowledge regarding the practical
fundamentals of lithium therapy. The present paper reviews safety data
on lithium available to date. Gastrointestinal pain or discomfort,
diarrhoea, tremor, polyuria, nocturnal urination, weight gain, oedema,
flattening of affect and exacerbation of psoriasis are typical
complaints of patients receiving long-term lithium therapy. Renal
involvement results in a reduced urinary concentrating capacity,
expressed as obligate polyuria, with secondary thirst. With long-term
therapy, this may result in nephrogenic diabetes insipidus. In
addition, glomerular filtration rate falls slightly in about 20% of
patients. The view that only a few patients receiving long-term
lithium are at increased risk of glomerular impairment and progressive
renal insufficiency should be regarded with caution. The risk is
increased in case of concomitant diseases or medications. Lithium
treatment may inhibit thyroid hormone release and induce goitre.
Consequently, the prevalence of both overt and subclinical
hypothyroidism is increased, with circulating thyroid auto-antibodies
frequently being found. Much less commonly, thyrotoxicosis may also
develop in association with lithium therapy. Long-term lithium
treatment may also be associated with persistent hyperparathyroidism
and hypercalcaemia, as well as with hypermagnesaemia. Overweight of up
to 4-10 kg is found in approximately 30% of lithium-treated patients.
Most neurological manifestations are benign, for example, the fine
postural and/or action tremor present in 4-20% of patients. This is
increased by high caffeine consumption and concomitant use of other
psychotropic agents. A number of rare, potentially serious
neurological adverse effects have been reported, including
extrapyramidal symptoms, 'pseudotumour cerebri' or occasionally
cerebellar symptoms. Severe neurological sequelae are exceptional.
Cognitive disturbances are often mentioned as a lithium-related
adverse effect. The few controlled studies do show a statistically
significant negative effect of lithium on memory, vigilance, reaction
time and tracking. There are frequent reports of mild effects of
lithium on cognition at therapeutic serum concentrations. A number of
deaths associated with lithium treatment have been reported. The most
serious issue is that of non-accidental overdose, i.e. either long-
term overdosage or acute overdose on long-term treatment. Progressive
renal insufficiency, an exceptional complication of long-term lithium
therapy, may also have a fatal outcome. In relation to pregnancy,
lithium salts are rated as category D (positive evidence of risk).
Therefore, prescription of lithium should be avoided during the first
trimester of pregnancy unless the benefit to the mother exceeds the
risk to the fetus. Although lithium transfer into breast milk is well
established, the long-term fate of babies breast-fed by mothers
receiving lithium therapy is unknown. Whether lithium therapy is safe
in breast-feeding women is controversial. Although there is no
absolute contraindication, it is known that the kidney is particularly
sensitive to lithium just after birth. Intoxication in patients on
long-term treatment with lithium in the absence of history of acute
ingestion is not rare. Contributing factors include change in daily
dose, long-term high dosage, kidney disease or drug interaction. In
suspected cases, serum concentrations should be obtained early and
repeatedly. In addition to supportive measures, haemodialysis is the
treatment of choice for severe cases. Thorough knowledge of the
limitations and drawbacks of lithium therapy is mandatory for its
optimal use, especially at a time when its risk/benefit profile needs
to be compared accurately with that of antiepileptic drugs and other
mood stabilizing medications.
PMID: 19453201
===========================
I wonder if we can use low dose lithium the way they have low dose
naltrexone?
================
What haPPened to bRET today?
I'm awaiting some viral thread already. LOL
No, no, i'm not looking for a fight.
Wink...
Anyway..
You can SUPPLEMENT or exercise BUT NOT BOTH?
Wow....
Can you believe that?
Do you mean that Durk Pearson and Sandy Shaw Pearson are WRONG?
Not sure.
Let's see:
http://www.nytimes.com/2009/05/12/health/research/12exer.html?_r=1&partner=rss&emc=rss
Vitamins Found to Curb Exercise Benefits
by nick wade
If you exercise to improve your metabolism and prevent diabetes, you
may want to avoid antioxidants like vitamins C and E.
That is the message of a surprising new look at the body’s reaction to
exercise, reported on Monday by researchers in Germany and Boston.
Exercise is known to have many beneficial effects on health, including
on the body’s sensitivity to insulin. “Get more exercise” is often
among the first recommendations given by doctors to people at risk of
diabetes.
But exercise makes the muscle cells metabolize glucose, by combining
its carbon atoms with oxygen and extracting the energy that is
released. In the process, some highly reactive oxygen molecules escape
and make chemical attacks on anything in sight.
These reactive oxygen compounds are known to damage the body’s
tissues. The amount of oxidative damage increases with age, and
according to one theory of aging it is a major cause of the body’s
decline.
The body has its own defense system for combating oxidative damage,
but it does not always do enough. So antioxidants, which mop up the
reactive oxygen compounds, may seem like a logical solution.
The researchers, led by Dr. Michael Ristow, a nutritionist at the
University of Jena in Germany, tested this proposition by having young
men exercise, giving half of them moderate doses of vitamins C and E
and measuring sensitivity to insulin as well as indicators of the
body’s natural defenses to oxidative damage.
The Jena team found that in the group taking the vitamins there was no
improvement in insulin sensitivity and almost no activation of the
body’s natural defense mechanism against oxidative damage.
The reason, they suggest, is that the reactive oxygen compounds,
inevitable byproducts of exercise, are a natural trigger for both of
these responses. The vitamins, by efficiently destroying the reactive
oxygen, short-circuit the body’s natural response to exercise.
“If you exercise to promote health, you shouldn’t take large amounts
of antioxidants,” Dr. Ristow said. A second message of the study, he
said, “is that antioxidants in general cause certain effects that
inhibit otherwise positive effects of exercise, dieting and other
interventions.” The findings appear in this week’s issue of The
Proceedings of the National Academy of Sciences.
The effect of vitamins on exercise and glucose metabolism “is really
quite significant,” said Dr. C. Ronald Kahn of the Joslin Diabetes
Center in Boston, a co-author of the report. “If people are trying to
exercise, this is blocking the effects of insulin on the metabolic
response.”
The advice does not apply to fruits and vegetables, Dr. Ristow said;
even though they are high in antioxidants, the many other substances
they contain presumably outweigh any negative effect.
Dr. Kahn said it might be that reactive oxygen is beneficial in small
doses, because it touches off the body’s natural defense system, but
harmful in higher doses.
Andrew Shao of the Council for Responsible Nutrition, a trade
association of dietary supplement makers, said the new study was well
designed but was just one bit of evidence in a complex issue. Most
available evidence points to the opposite conclusion, that
antioxidants benefit health by reducing oxidative stress, he said.
“I wouldn’t change recommendations for anyone based on one study,” he
said. “This is one small piece of the puzzle.”
=====================
randall... thanks for that last link J....made my day :)